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T Cell Receptor Signaling

TCR/CD3
Complex
Ca2+ α β

LFA-1
LAT ζ ζ δ ε ε γ

CD4

CD45
el

GRB2

CD28
CRAC
Chann

Clustering Zap-70
Actinin Talin SOS
Lck
PLCγ1 ADAP
PI3K
F-Actin

SLP76 HPK1
Ca2+ NCK Vav
Calpain DAG PIP3
CaM
Dlgh1 PDK1

WASP
Rac/cdc42 PKCθ Akt
Calcineurin CaMKIV Ca2+ IP3 PIP2

DAG
TAK1 c-Cbl MALT1 Bcl10 Carma1

CREB MEKK1
IP3R mTORC1
TAK1
RasGRP GADD45α
IKKγ
GβL Raptor
Intracellular IKKβ IKKα
Ca2+ Store MKK4/7 MKK7 mTOR
DEPTOR
Ras
Rel
IκB
NFAT JNK2 NF-κB
JNK
Raf
p38 MAPK Cell Proliferation
Survival
NFAT MEK1/2
IκB
Proteasomal
Erk1/2 Degradation

sm
opla
Cyt
s
leu Nuclear
Nuc IL-2 NFAT Fos Jun NF-κB Rel Membrane
Gene

Pathway Diagram Keys

Kinase Enzyme G-protein Direct Inhibitory Tentative Inhibitory Translocation
Modification Modification Transcriptional
Phosphatase pro-apoptotic Acetylase
Multistep Stimulatory Separation of Subunits Stimulatory Modification
Transcription Factor pro-survival Deacetylase Modification or Cleavage Products Transcriptional
Multistep Inhibitory Joining of Subunits Inhibitory Modification
Caspase GAP/GEF Ribosomal subunit Modification
Receptor Direct Stimulatory Tentative Stimulatory
GTPase
Modification Modification

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