9th Mar 2018

Bengaluru
th
Company / Estd. Innov4Sight Health and Biomedical Systems Private Limited / 20 Nov 2014
• Therostics (Therapeutics & Diagnostics) www.therostics.com
Brands
• Vyabl (/ˈvaɪ.ə.bəl/)
Specialty Focus Infertility incl. overall Reproductive Health
A 30-year-old working female has a reproductive age of over 42 years resulting in
significantly reduced chance of having a child naturally. Inner organs are aging rapidly
due to life-style, environmental & occupational disorders in the life of most working
professional. Reports indicate ONE out of every FIVE couple globally are infertile.
The global average success rate in Assisted Reproduction Techniques (ART) such as
IVF, IUI & ICSI among others is about 24% and the highest in the world is seen in Japan
at 35%. India is estimated to have a success rate in fertility care outcome of ~18%.
• Lifestyle habits and inadequate sleep has caused the regenerative capability of
Problem(s) the reproductive system to be significantly compromised leading to over 1 in 5
couple in the reproductive age having difficulty in conceiving naturally
• Inadequate use of Health IT systems such as CIS, LIS, EMR etc. has led
majority of the decision being influenced by the biases of the practitioner as
against adopting Evidence Based Medicine practice in the specialty which
produces a dismal <20% successful pregnancy.
• With the physiological complications increasing in the reproductive system, the
need for adaptive hardware-software simulation system has been identified to
help save a large number of patients whose clinical outcomes are not good
owing to the learning happening on the patient rather than using a simulator.
India has over 3 Crore infertile couple in the reproductive age group. Japan is already
facing negative population growth. Over 20 countries globally are rapidly moving
towards negative population growth. About 18 countries globally are spending billions of
dollars in addressing infertility as a public health issue ranging from Singapore, Japan,
Israel, UK to more recently India.
BBC quoted ‘China has decided to end its decades-long one-child policy, the state-run
Market Size / Xinhua news agency reports. Couples will now be allowed to have two children, it said,
Opportunity citing a statement from the Communist Party.’
Government of Madhya Pradesh in May 2016 launched a 100 Crore scheme (co-funded
by National Health Mission) to offer free fertility care at District Health Centres across
the State. The scheme name ‘ROSHNI’ is intended to give hope & more certainty to
lakhs of people affected the State due to infertility challenges. Following this other States
such as Goa & Tamil Nadu have also initiative schemes to address infertility as a Public
Health initiative.
• Our solution to addressing the rapid reproductive aging problem is a
Regenerative Medicine Solution for Male & Female Infertility that improves the
physiological conditions and functions of the reproductive system for better
Clinical Outcomes during ART procedures.
o Our Regenerative Medicine based Therapeutics is addressing both
Male & Female Infertility conditions such as: (a) Endometrial Defects
incl. Thin Endometrium, Recurrent Implantation Failure (RIF),
Technology – Recurrent Pregnancy Loss (RPL) & Partial Asherman’s Syndrome, (b)
Products & Poor Ovarian Reserve (POR) & Primary Ovarian Insufficiency (POI),
Solutions (d) Erectile Dysfunction & (d) Sperm Quality disorders such as
Oligospermia & Azoospermia.
• Vyabl is a digital health platform that is intended to serve as an ecosystem for
fertility care from spreading awareness using questionnaire through diagnostics
screening to facilitation of actual fertility procedures through aggregation
service.
• Haptics based Medical Simulator for Fertility Procedures and Laparoscopic
Gynaecology serving as a Training, Assessment, Certification & Pre-op System

1 | 2018 © Innov4Sight Health and Biomedical Systems Private Limited | Sunday, January 21, 2018
 • Regen Med: A Clinical Study of over 130 patients have been concluded with a
>70% successful pregnancy rate. The male related clinical study is still in
progress. To date, we’ve served BAP.C to over 430 women and continue to
provide a significant success in the Clinical Outcome during ART procedures.
Traction
• Medical Simulators: Will be licensed to a biomedical devices or medical
simulator company after development.
• Complementing the B2C initiative i.e. Vyabl is a B2B toolset including a Fertility
EMR & CDSS that is being piloted across multiple partner clinics.
• Winner of the India-Israel Innovation Challenge awarded by Israel innovation
Authority & Department of Industrial Policy and Promotion, Government of India
• Winner @ ELEVATE100 – 2017 - Recognized as one of the 100 innovative
start-ups in the State of Karnataka
Awards &
• Second Prize Winner @ HITCON 2017 by Ahmedabad University
Recognition
• Recipient of Govt. of India, DBT-BIRAC SBIRI Grant towards a ₹ 50 Lakhs R&D
Project
• Finalist @ National Research Foundation (NRF) of Singapore Proof-of-concept
(POC) Grant in 2015
• The leadership team comprises of 4 members with average 19 years of
experience in IT, Healthcare, Biotech, Genomics and Sales.
• The Company today has 4 development centres with 40+ members:
o Information Technology >> 12+
Team o Biotechnology >> 11+
o Biomedical Engineering (Medical Simulators) >> 2 (inhouse) & 12+
(outsourced)
o Sales & Marketing >> 5+
o HR, Admin, Finance & Others >> 6+
• Bangalore – Biotech R&D
• Hosur – IT & Data Analytics
• Chennai – Biomed Simulator R&D
Presence
• Therapeutic Labs @ Bangalore, Chennai, Mumbai & Cochin
• Catering to clients in: Bangalore, Chennai, Coimbatore, Cochin, Hyderabad,
Mumbai & Pune
• We now believe that we're adequately equipped (technically) to create one of
the largest chain of technology driven Fertility Clinics across the globe within 4
years.
• We aspire to have 300 Vyabl Clinics in India & 150 Clinics outside India within
4 years. We estimate that to setup 450 Clinics (ranging from small OP based
fertility clinics to full service woman care nursing home) the budget can be well
Goal – Scope for over $ 200 million but using our technology stack we can roll-out and
Scalability commercially make it viable at a budget that is only 1/8th of the brick & mortar
setup but will still generate in excess of 50% revenue compared to a brick &
mortar.
• We now have 100+ Fertility Clinics across Bangalore, Chennai, Coimbatore,
Cochin, Pune & Mumbai using our flagship regenerative medicine i.e. BAP-C
(ref. www.therostics.com)
• While our venture is primary driven by profitability considering that about 70%
of infertile couple in India cannot afford the expensive treatment our technology
stack can enable PPP initiative PAN India reducing the cost of fertility care by
over 60%.
Impact
• General perception is that India is overpopulated but the reality is that it’s a
myth with India reaching replacement levels of fertility by 2020. Similar to India
many would presume that China is also overpopulated but the two-child policy
rolled out by Chin indicates that perception is not a reality. [ref. links in page 3]

2 | 2018 © Innov4Sight Health and Biomedical Systems Private Limited | Sunday, January 21, 2018
Ref. Links to understand out Company better:
1. EY Report on Indian Market: http://www.ey.com/Publication/vwLUAssets/EY-call-for-action-expanding-ivf-
treatment-in-india/$FILE/EY-call-for-action-expanding-ivf-treatment-in-india.pdf
2. Global Market Size for Therapeutics: http://www.prnewswire.com/news-releases/womens-health-
therapeutics-market-to-2018---unmet-need-for-safe-and-effective-treatments-due-to-unfavorable-riskbenefit-
profile-associated-with-hormone-replacement-therapy-179930621.html
o BAP-C is safer as compared to HRT & other drugs offered by Pharma cos.
http://www.cancerresearchuk.org/about-cancer/causes-of-cancer/hormones-and-cancer/hrt-and-
cancer
3. Articles/Links to indicative links of Governments globally sponsoring Fertility Care:
o https://timesofindia.indiatimes.com/city/indore/Infertility-gets-a-ray-of-hope-in-
Roshni/articleshow/52215571.cms - Madhya Pradesh
o http://www.newindianexpress.com/states/telangana/2017/nov/12/telangana-to-start-fertility-centres-at-
government-hospitals-1698928.html - Telangana
o https://www.ontario.ca/page/get-fertility-treatments - Canada
o http://www.hfea.gov.uk/fertility-treatment-cost-nhs.html - UK
o https://www.fertilityassociates.co.nz/treatment-costs-and-payment-options/public-funding-and-
eligibility/#public-fund – New Zealand
o https://www.ecitizen.gov.sg/topics/pages/mobile/topicsdetail.aspx?mpageId=209#section-2 -
Singapore
o http://www.irishexaminer.com/lifestyle/healthandlife/parenting/funding-fertility-new-proposals-will-help-
those-seeking-ivf-treatment-381372.html - Ireland
o https://www.health.gov.il/English/Topics/fertility/Pages/ivf.aspx
o https://www.thelocal.se/20160114/soon-single-women-in-sweden-will-be-entitled-to-ivf-treatment
o https://www.theguardian.com/world/2016/jul/15/the-right-thing-to-do-japanese-city-to-offer-egg-
freezing-on-public-purse
o http://www.euro.who.int/__data/assets/pdf_file/0018/312147/HiT-Slovenia_rev3.pdf?ua=1
o http://www.baltic-course.com/eng/markets_and_companies/?doc=128687
o https://www.rbth.com/articles/2013/01/09/moscow_bankrolls_fertilization_treatment_for_its_residents_
21729.html
4. Media Coverage of the Company:
o http://economictimes.indiatimes.com/small-biz/startups/karnataka-picks-up-100-most-innovative-
startups-to-give-rs-35-cr-in-funding/articleshow/60294651.cms
o https://www.biospectrumindia.com/news/20/9188/bangalore-based-startup-inks-a-3-m-deal-with-mmc-
pharma.html
o http://www.deccanherald.com/content/609147/vyabl-uses-technology-sow-seed.html
o http://www.newindianexpress.com/business/2017/feb/05/can-big-data-lead-to-big-cures-1567013.html
o http://economictimes.indiatimes.com/small-biz/startups/armed-with-data-i4s-takes-on-infertility-and-
cancer/articleshow/55238281.cms
o http://health.economictimes.indiatimes.com/news/health-it/the-biggest-challenge-in-healthcare-today-
is-the-explosion-of-scientific-knowledge-vijayagopal-r/54026626
o http://health.economictimes.indiatimes.com/news/health-it/innov4sight-health-and-biomedical-
systems/55265553

5. The myth of Indian Population Explosion

o India to reach replacement levels of fertility by 2020 http://www.thehindu.com/data/india-to-reach-
replacement-levels-of-fertility-by-2020/article6717297.ece
o https://qz.com/1051533/india-is-unprepared-for-a-near-future-when-it-will-be-the-worlds-most-
populous-country/ due to fertility declines to near replacement levels, India’s population is also ageing.
The proportion of elderly aged 65 years and older is expected to double to 13% by 2050, and the
number of working-age adults per elderly person is projected to fall from 11 to five.
o https://www.usnews.com/news/articles/2015/11/11/asia-faces-fertility-crisis Asia Faces Fertility Crisis
o https://blogs.timesofindia.indiatimes.com/staying-alive/the-myth-of-indias-population-explosion/

3 | 2018 © Innov4Sight Health and Biomedical Systems Private Limited | Sunday, January 21, 2018