Anxiety is a natural feeling of disorder that is characterized by feelings of year or
apprehension of deep and angoing. Symptoms of anxiety both acute and chronic nature is the main component for almost all psychiatric disorders. Immunization is an attempt at doing that intentionally provide immunity in infants or children so as to avoid the disease. Polio immunization is administering the polio vaccine containing polio virus that has been inactive again. The purpose of this research is to know the relation of mother’s knowledge about polio immunization with the level of anxiety to side effects of administering immunizations in infants in Clinic’s Delitua. The research was done on 16 to 17 June 2014, in Clinic Delitua in the study using the method of correlation of deskriftif. The population of this research totaled 201 mother who had a toddler and a sample was 35 mothers who have babies, and sampling by means of accidental sampling. Statistical analysis using Chi-Square test with significant values (p value) a <0,05 a the result of this research is the p value = 0,002 and a— 0,05 so the results is the p value is 0,002, a < 0,05 Ha in the receive and Ho is rejected, there is a significant relationship between mother’s anxiety level of knowledge due to the side effects of administering polio immunization. For it is in hope to midwives and other health worker to be more diligent in providing guidance to moms about the side effects of polio immunization.