OWNER’S NAME: Beth Lilly DOG’S NAME: Kurakuma Safari Chasin’ Dreams TEST DATE: January 31st, 2018

This certifies the authenticity of Welcome to the

Kurakuma Safari Chasin’ Dreams’s
Embark family!
canine genetic background as
determined following careful analysis
of more than 200,000 genetic markers.
WOLFINESS 0.8% MEDIUM
Schipperke
MATERNAL A17
HAPLOTYPE
Adam Boyko, Ph.D.
CHIEF SCIENCE OFFICER
Ryan Boyko
CHIEF EXECUTIVE OFFICER
KURAKUMA SAFARI CHASIN’ DREAMS
DNA Test Report Test Date: January 31st, 2018 embk.me/kurakumasafarichasindreams

BREED MIX GENETIC STATS

Schipperke: 100.0% Wolfiness: 0.8 % MEDIUM
Predicted adult weight: 16 lbs
Genetic age: n/a (Date of birth unknown)

TEST DETAILS
Kit number: EM-4323069
Swab number:

   
KURAKUMA SAFARI CHASIN’ DREAMS
DNA Test Report Test Date: January 31st, 2018 embk.me/kurakumasafarichasindreams

SCHIPPERKE
The Schipperke is a spirited little guy that has been around since the 1600’s. The
breed was developed in Belgium where they served as watch dogs on riverboats and
as rat hunters, or ratters. These dogs gained quite the popularity boost when Queen
Marie Henriette of Belgium brought attention to a particular Schipperke at a Brussels
dog show in 1885.This is an independent breed with a lot of energy. Schips are also
known to have long life spans, averaging more than 15 years! Today the breed
primarily serves as companions and have been bred to be more mellow than their
European ancestors. They still have a side for the mischievous, so the owner must be
firm and consistent. Deep down these are loving dogs that crave human
companionship.

Alternative Names

Fun Fact

Schipperke means “little captain” in

Flemish, a Dutch language.

RELATED BREEDS

Pomeranian Chihuahua Pekingese Chinese Crested Alaskan Klee Kai

Cousin breed Cousin breed Cousin breed Cousin breed Cousin breed

   
KURAKUMA SAFARI CHASIN’ DREAMS
DNA Test Report Test Date: January 31st, 2018 embk.me/kurakumasafarichasindreams

MATERNAL LINE

Through Kurakuma Safari Chasin’ Dreams’s mitochondrial DNA we can trace her mother’s ancestry back to where dogs and people
first became friends. This map helps you visualize the routes that her ancestors took to your home. Their story is described below
the map.

HAPLOGROUP: A1a HAPLOTYPE: A17

A1a is the most common maternal lineage among Western Part of the large A1a haplogroup, this common haplotype is
dogs. This lineage traveled from the site of dog domestication found in village dogs across the globe. Among breed dogs, we
in Central Asia to Europe along with an early dog expansion find it most frequently in Labrador Retrievers, Boxers, and
perhaps 10,000 years ago. It hung around in European village Mastiffs.
dogs for many millennia. Then, about 300 years ago, some of
the prized females in the line were chosen as the founding
dogs for several dog breeds. That set in motion a huge
expansion of this lineage. It's now the maternal lineage of the
overwhelming majority of Mastiffs, Labrador Retrievers and
Gordon Setters. About half of Boxers and less than half of Shar-
Pei dogs descend from the A1a line. It is also common across
the world among village dogs, a legacy of European
colonialism.

   
KURAKUMA SAFARI CHASIN’ DREAMS
DNA Test Report Test Date: January 31st, 2018 embk.me/kurakumasafarichasindreams

TRAITS
Coat Color  

E Locus (Mask/Grizzle/Red) EmE

K Locus (Dominant Black) KBKB
A Locus (Agouti) ata
D Locus (Dilute) DD
B Locus (Brown/Chocolate/Liver) BB

Other Coat Traits Other Body Features

Furnishings / Improper Coat (RSPO2) II Brachycephaly (BMP3) AA

Long Haircoat (FGF5) GG Natural Bobtail (T) CG
Shedding (MC5R) CC Hind Dewclaws (LMBR1) CC
Curly Coat (KRT71) CC

Performance
Body Size Altitude Adaptation (EPAS1) GG
Body Size - IGF1 II
Body Size - IGF1R GG
Body Size - STC2 TT
Body Size - GHR (E195K) GG
Body Size - GHR (P177L) CC

Genetic Diversity

Inbreeding Coefficient 33% MHC Class II - DLA DRB1 MHC Class II - DLA DQA1 and DQB1
Low Diversity High Diversity

   
KURAKUMA SAFARI CHASIN’ DREAMS
DNA Test Report Test Date: January 31st, 2018 embk.me/kurakumasafarichasindreams

CLINICAL TRAITS
These clinical genetic traits can inform clinical decisions and diagnoses. These traits do not predict a disease state or increased
risk for disease. We currently assess one clinical trait: Alanine Aminotransferase Activity.

Alanine Aminotransferase Activity result: Low Normal

Kurakuma Safari Chasin’ Dreams has two copies of a mutation associated with reduced ALT activity. Please inform your veterinarian
that Kurakuma Safari Chasin’ Dreams has this genotype, as ALT is often used as an indicator of liver health and Kurakuma Safari
Chasin’ Dreams is likely to have a lower than average resting ALT activity. As such, an increase in Kurakuma Safari Chasin’ Dreams’s
ALT activity could be evidence of liver damage, even if it is within normal limits by standard ALT reference ranges.

More information on Alanine Aminotransferase Activity:

Known to be highly expressed in liver cells, activity levels of alanine aminotransferase, or ALT, is a common value on most blood
chemistry panels and is known to be a sensitive measure of liver health. Dogs with two ancestral G alleles show "normal" activity.
Dogs that have one or two copies of the derived A allele may have lower resting levels of ALT activity, known as "low normal". If your
dog's result is "low normal" then when a blood chemistry panel is being interpreted the values that you and your veterinarian
consider "normal" may need to be adjusted. Please note that neither a "normal" nor a "low normal" result for this predicts a disease
state or increased risk for liver disease. Moreover, this mutation does not associate with increased levels of ALT: If your dog has
high ALT levels, please consult your veterinarian.

   
KURAKUMA SAFARI CHASIN’ DREAMS
DNA Test Report Test Date: January 31st, 2018 embk.me/kurakumasafarichasindreams

HEALTH
Good news! Kurakuma Safari Chasin’ Dreams did not test positive for any
of the genetic diseases that Embark screens for. 0 1
AT RISK CARRIER

CARRIER CONDITIONS

CARRIER status: This indicates the dog has inherited a recessive allele for a genetic trait or mutation. This is not enough to cause
symptoms of the disease, but is important to bear in mind if the dog ever has offspring.

Carrier System: Ophthalmologic

Condition: Canine Multifocal Retinopathy cmr1 (BEST1 Exon 2)

   
KURAKUMA SAFARI CHASIN’ DREAMS
DNA Test Report Test Date: January 31st, 2018 embk.me/kurakumasafarichasindreams

CANINE MULTIFOCAL RETINOPATHY

cmr1 (BEST1 Exon 2)

Carrier

BEST1 (Aka VMD2); Exon 2 CC CT TT

GENE NAME CLEAR CARRIER AT RISK

Kurakuma Safari Chasin’ Dreams is a carrier for a mutation in the BEST1 gene. As a carrier he or she is unlikely to show signs of the
disease. If you choose to breed Kurakuma Safari Chasin’ Dreams, we highly recommend genotyping any potential mates as breeding
to another carrier or an affected dog could produce affected puppies.

DESCRIPTION
This is a nonprogressive retinal disease that, in rare cases, can lead to vision loss. All known mutations lie in the BEST1 gene and are
inherited in an autosomal recessive manner. We test for mutations that have been identified in Bulldog and Mastiff breeds, the
Coton de Tulear, the Lapponian herder, the Finnish Lapphund, and the Swedish Lapphund. In all of these breeds, CMR is typically
only identified when a vet examines the eye with an ophthalmoscope: this magnifies and illuminates the retina which, in dogs with
CMR, exhibits multiple surface abnormalities that range from small, flat folds (called “retinal folds”) to larger, irregularly edged raised
lesions (called “geographic lesions”). Dogs with larger lesions can suffer from vision loss. CMR is fairly non-progressive; new
lesions will typically stop forming by the time a dog is an adult, and some lesions will even regress with time.

CITATIONS
Guziewicz et al 2007 (http://www.ncbi.nlm.nih.gov/pubmed/17460247), Hoffman et al 2012
(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3787078/)

   
KURAKUMA SAFARI CHASIN’ DREAMS
DNA Test Report Test Date: January 31st, 2018 embk.me/kurakumasafarichasindreams

OTHER CONDITIONS
Good news! Kurakuma Safari Chasin’ Dreams tested clear for 3 genetic conditions that are common in her breed.

Multidrug Sensitivity Progressive Retinal Atrophy (PRA)

(MDR1) Progressive rod-cone degeneration (PRCD Exon 1)

Degenerative Myelopathy
(SOD1A)

   
KURAKUMA SAFARI CHASIN’ DREAMS
DNA Test Report Test Date: January 31st, 2018 embk.me/kurakumasafarichasindreams

FULL TEST PANEL

To help ensure healthy breeds, every test includes analysis of our full panel of over 160 genetic diseases.

Kurakuma Safari Chasin’ Dreams is also clear of 161 other genetic diseases that
Embark tests for.