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ORIGINAL ARTICLE
a
Department of Dentistry, Tainan Municipal An-Nan Hospital, China Medical University, Tainan,
Taiwan
b
Department of Public Health, College of Medicine, National Cheng Kung University, Tainan, Taiwan
c
Department of Health Care Management, National Taipei University of Nursing and Health Sciences,
Taipei, Taiwan
d
Department of Surgery, Zhong-Xing Branch of Taipei City Hospital, Taipei, Taiwan
e
School of Medicine, National Yang-Ming University, Taipei, Taiwan
f
Department of Public Health, College of Public Health, China Medical University, Taichung, Taiwan
Received 16 November 2013; received in revised form 30 June 2014; accepted 1 July 2014
KEYWORDS Background/purpose: To investigate the mobile phone (MP) use for talking in relation to health
cross-sectional study; symptoms among 2042 children aged 11e15 years in Taiwan.
electromagnetic Methods: A nationwide, cross-sectional study, using the computer assisted telephone inter-
fields; view (CATI) technique, was conducted in 2009 to collect information on children’s utilization
exposure assessment; of MPs and the perceived health symptoms reported by their parents.
radiofrequency; Results: The overall prevalence of MP use in the past month was estimated at 63.2% [95% con-
subjective symptoms fidence interval (CI) Z 61.1e65.3%]. MP use was associated with a significantly increased
adjusted odds ratio (AOR) for headaches and migraine (1.42, 95% CI Z 1.12e1.81) and skin
itches (1.84, 95% CI Z 1.47e2.29). Children who regularly used MPs were also considered to
have a health status worse than it was 1 year ago (b Z 0.27, 95% CI Z 0.17e0.37).
Conclusion: Although the cross-sectional design precludes the causal inference for the
observed association, our study tended to suggest a need for more cautious use of MPs in chil-
dren, because children are expected to experience a longer lifetime exposure to radiofre-
quency electromagnetic fields (RF-EMF) from MPs.
Copyright ª 2014, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.
Conflicts of interest: The authors have no conflicts of interest relevant to this article.
* Corresponding author. Department of Surgery, Zhong-Xing Branch of Taipei City Hospital, Taipei, Number 145, Zhengzhou Road, Datong
District, Taipei City 10341, Taiwan.
E-mail address: mingchung77@gmail.com (M.-C.Ko).
g
These two authors contributed equally to this study.
http://dx.doi.org/10.1016/j.jfma.2014.07.002
0929-6646/Copyright ª 2014, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.
Mobile phone use and health symptoms 599
health status. The above three questions were originally was the main reason for their children to own MPs. Forty-
used in a previous study that assessed the general health of five percent of children used MPs for calling or receiving
school children who attended elementary schools with every day, 30.7% talked >2 days/week, and 18.9% used MPs
high-voltage (HV) power lines hovering over the campus.18 1e2 days/week. More than half (45%) of children had used
The questionnaire used in the telephone interview was MPs for calling or receiving daily, 34.8% reported daily MP
evaluated by a panel of six experts (3 epidemiologists, 2 use of 21e40 minutes, and 4.4% of children used MPs for at
environmental health scientists, and 1 pediatrician) for its least 1 hour every day. During weekdays, children often
content validity. All four interviewers were trained and (41.7%) talked on MPs in the evening. The MP use pattern
standardized to further ensure the reliability of the during the weekend was somewhat different; children
questionnaire. often used their MPs for calling or receiving in the after-
The potential confounders considered in this study noon (33.3%), and then in the evening (24.6%). Of the
included children’s age, sex, residential area (North, children studied, 9.8% frequently used MPs for calling or
Central, South, East, and remote islands), guardians’ receiving after 10:00 PM, a time of lights out for many
educational level (12 years vs. >12 years), and density of families during weekdays, and the corresponding figure for
HV transmission lines (HVTL) in each district, which is the weekend was 6.7% (Table 2).
calculated as the ratio of area (in km2) for the region within Table 3 shows the use of MPs in relation to the preva-
100 m distance away from the transmission lines (69 kV) lence of various selected health symptoms. Children who
to the total area of that particular district.19 Controlling for used MPs experienced a significantly increased prevalence
density of HVTL was due to the fact that previous studies of headaches/migraine and skin itches with an AOR of 1.42
reported relationships between exposure to higher (95% CI Z 1.12e1.81) and 1.84 (95% CI Z 1.47e2.29),
extreme-low-frequency (<300 Hz) EMFs and the health respectively. By contrast, MP use was associated with a
symptoms analyzed in this study.20 significantly reduced AOR of insomnia (AOR Z 0.55, 95%
CI Z 0.37e0.82).
Statistical analysis Table 4 shows MP use in relation to children’s general
health. The MP users were more likely to be considered as
We first calculated the overall and socio-demographic having a health status worse than it was 1 year ago
characteristics specific prevalence of MP use by weighing
the district specific prevalence, where the weight was
estimated by the proportion of child population (11e15 Table 2 Mobile phone use pattern in study children
years) of a particular district to the total national children’s (n Z 1292).
population. The 95% CI of binomially distributed prevalence Pattern n %
was calculated under the normal approximation. The lo-
gistic regression model with the Generalized Estimation Leading reasons for mobile phone usea
Equation (GEE) method that accounts for correlation in the Safety consideration 919 71.1
error term due to clustering of individuals living in the same Easy to contact 888 68.7
district to obtain robust standard error estimates was used Peer pressure 357 27.6
to estimate the covariate adjusted odds ratio (AOR) and Frequency of mobile phone use for calling or receiving
corresponding 95% CI for various health symptoms in rela- Daily 582 45.0
tion to MP use.21 To assess the association of MP use with a 3e6 d/wk 396 30.7
child’s health status, we performed multiple linear 1e2 d/wk 244 18.9
regression models also with the GEE method. The statistical <1 d/wk 70 5.4
significance level of analyses was set at an a level of 0.05, Daily average min spent for mobile phone use
and all the analyses were performed with the SPSS software 20 718 55.6
(version 17; SPSS Inc., Chicago, IL, USA). 21e40 449 34.8
41e60 68 5.3
60 57 4.4
Results Time period within which mobile phone most frequently
used for calling or receiving
The overall prevalence of MP use for Taiwanese children Weekdays
aged 11e15 years was estimated at 63.2% (95% Morning (7:00e11:59 AM) 28 2.2
CI Z 61.1e65.3%). The prevalence showed a small sex Afternoon (12:00e4:59 PM) 285 22.0
difference, but presented evident age and geographic Evening before 10:00 PM (5:00e9:59 PM) 539 41.7
variations. The prevalence increased steadily from 45% for After 10:00 PM 126 9.8
11-year-old children to 71.7% for children aged 15 years. Not sure 314 24.3
Children living in the Central area showed the highest Weekend
prevalence (69.3%), whereas those from the South area had Morning (7:00e11:59 AM) 47 3.6
the lowest prevalence at 58.3%. We also noted that children Afternoon (12:00e4:59 PM) 431 33.3
who attended private schools had a higher prevalence of MP Evening before 10:00 PM (5:00e9:59 PM) 317 24.6
use than public school students. After 10:00 PM 86 6.7
Some 71.1% of guardians reported that the main reason Not sure 411 31.9
for their children to use MPs was because of safety con- a
More than one choice was allowed.
siderations. However, 27.6% admitted that peer pressure
602 C.-T. Chiu et al.
Belgian study noted that use of the phone right after lights them, which does not make it possible for our data to
out increased the odds of being very tired during day time substantiate or refute the previous observation.
by 2.2-fold (95% CI Z 1.4e3.4); between 00:00 AM and There are some weaknesses in this study. First, this
03:00 AM the odds were 3.9 times higher (95% survey had a response rate of only 25%, which is considered
CI Z 2.1e7.1), and in those who used it at any time of the low. A number of factors contributed to this including un-
night the odds were 3.3 times higher (95% CI Z 1.8e6.0). availability of the guardians, concerns over study legiti-
Although the prevalence of using MPs in the late evening in macy, fear of deception, lack of adequate incentive for
Taiwanese children was not as high as that reported in the participation, time constraints, and communication diffi-
Belgian study, the potential adverse effects associated with culty with foreign born mothers who comprised nearly 10%
using MPs after lights out among Taiwanese children of all Taiwanese mothers.32 Although there is no obvious
deserve further attentions. reason to believe that an unsuccessful interview is related
We noted that the use of MPs by children was signifi- to both the MP use and selected health symptoms, the
cantly and positively associated with headaches/migraines potential selection bias might have influenced our study
and skin itches by an elevated risk of 42% and 84%, results, at least to some extent. Second, we were unable
respectively. A wide range of subjective symptoms has been to validate the information on MP use and children’s
attributed to exposure to various sources of RF-EMF both at health symptoms obtained from the guardians who might
home and at work. Some individuals reported that they have a recall bias, therefore, exposure and outcome mis-
suffered a variety of complaints, including headaches and classifications might occur in our study. Exposure misclas-
migraines, fatigue, skin itches, and sensations of warmth.24 sification might also result from inadequate coverage of all
Our study is consistent with findings in some previous possible indoor and outdoor sources of RF, such as cordless
studies. For example, Oftedal et al25 sent a questionnaire telephone and MP base stations. No information on whether
to 12,000 Swedes and 5000 Norwegians and found that the children used hand-free devices in calling or receiving
longer calls and a higher number of calls were associated also limits the exposure measures. It is, however, difficult
with a higher prevalence of warmth behind, around, or on to tell to what extent such exposure and outcome mis-
the ear and with headaches and fatigue. However, in classifications may affect our results. Third, due to time
provocation studies, a causal relation between RF exposure constraints, we were unable to collect from the telephone
and the above complaints symptoms has not been interview the information on all risk factors, including
convincingly demonstrated, suggesting that psychological lifestyle, physical activities, and stress at schools, for the
factors, such as the conscious expectation of effect, may selected health symptoms, which might have biased the
play a role in the relationship between MP use and health study results. Lastly, the nature of the cross-sectional study
symptoms.24 In addition, some studies also argued that a design might have entailed a certain degree of causal
higher prevalence of health symptoms observed in MP users reverse bias. We did note a higher prevalence of certain
could be due to an increasing number of people with these health in children with MP use. It is also likely that some
symptoms considering themselves “electromagnetically parents allowed their children to own/use an MP due to the
hypersensitive”.26,27 An earlier Taiwanese population- fact that their children are relatively unhealthy and need
based study estimated that 13.3% (95% CI Z 11.2e15.3%) an MP to keep in close contact with their parents.
of Taiwanese adults had self-reported EMF sensitivity. The Utilization of modern technologies including wireless
study also found that people with a very poor self-reported communication devices for monitoring and managing dis-
health status, those who were unable to work, and those eases has increased in recent years.33 Even though it is
who had psychiatric morbidity were associated with a lower than the prevalence rate reported from many other
higher risk of having self-reported EMF sensitivity.28 None- developed nations, the prevalence of MP use is still
theless, comparison of our study with previous ones might considered high in Taiwanese children aged 11e15 years.
not be appropriate, because the majority of previous Some 10% of children often used MPs for calling or receiving
studies were conducted to investigate health symptoms in in the late evening or after lights out, which may have led
adults, who may have a different biological response to to increased levels of tiredness in children. Although the
RF-EMF. Interpretations in the studies of adults may have cross-sectional design precludes the causal inference, our
been further limited, because a number of work-related study tends to support findings from some previous studies
confounding factors such as psychosocial workload and linking higher MP use and prevalence of certain health
occupation might affect the prevalence of symptoms.29 complaints/symptoms, including headaches/migraine, fa-
Our study found a positive relationship between MP use tigue, and skin itches.24,30 We suggest that continuing to
and risk of skin itches. A review by Rajpara and Feldman30 monitor children’s health in relation to MP use is essential,
noted that recent reports of facial allergic contact not only because the prevalence of MP use is increasing in
dermatitis to cell phone metals have begun to emerge. This children, but also because children might be more sensitive
is particularly enhanced by the combination of increased than adults to potential adverse effects from exposure to
cell phone ownership and unlimited usage plans, which led RF-EMF.
to a situation in which metal cell phone parts may come
into contact with the cell phone user’s ear and face for
prolonged periods of time. A previous study also presented Acknowledgments
a case of allergic contact dermatitis to cell phone metal.31
In our telephone interview, we did not request information This study was supported by a grant from the Bureau of
on the body parts that presented skin itches. Nor did we ask Health Promotion, Department of Health, Taiwan (DOH98-
about how close MPs were to the face while children used HP-1408).
604 C.-T. Chiu et al.