Nutrition and cancer 2
MON-PP084
ORAL GLUTAMINE SUPPLEMENTATION REDUCES THE
SEVERITY OF MUCOSITIS IN PATIENTS WITH HEAD AND NECK
CANCER DURING RADIOTHERAPY
D. Mirea1 , L. Mirea2,3 , D. Safta1 , C. Nitipir3,4 , M. Barna4 ,
D. Pavelescu2 , I.C. Grintescu2 , R. Ungureanu2,3 ,
I.M. Grintescu2,3 . 1 ENT Department, Elias University
Emergency Hospital, 2 Anaesthesia and Intensive Care,
Clinical Emergency Hospital of Bucharest, 3 Carol Davila
University of General Medicine, 4 Oncology Department,
Elias University Emergency Hospital, Bucharest, Romania
Rationale: Radiation induced mucositis (RIM) is a complication
for head and neck cancer patients (pts), and in severe form
(grade 3, 4 WHO Scale) affects nutritional status, leading
to lost weight and malnutrition. The aim of the study was
to determine the risk and the severity of RIM and the
impact on quality of life (QOL) in case of oral glutamine
supplementation.
Methods: It was a prospective, observational study; pts in
glutamine group (group G) received 30 g of oral glutamine
daily, 5 days before starting and during the entire period
of radiotherapy. We monitor weight loss, the severity of RIM
(by weekly videofibroscopy), and quality of life (using EORTC
QOL H&N 35 questionnaire). In the control group (group C),
pts have received only nutritional advisory.
Results: The groups’ demographic data were similar: age
58±11.04 y in group G (n = 21) vs 58.5±12.4 y in group C
(n = 20), p > 0.05; sex ratio M:F 16:5 vs 15:5. Weight loss
was 1.56±2.71 kg in group G at the end of monitoring vs
4.15±2.63 kg in group C (p < 0.05). In group C 40% of pts
developed severe RIM, and 60% developed moderate RIM.
In group G 57.1% of pts developed only mild RIM and
42.8% moderate RIM. We noticed a worsening of QOL in
group C, median QOL score being with 15.5±4.8 p higher at
the end of radiotherapy, whilst in group G median QOL score
increased only with 9.6±4.7 p.
Conclusion: Patients receiving oral glutamine tolerated better
radiotherapy, maintaining a better nutritional status, quality
of life being less affected.
Acknowledgement: This paper was co-financed from the
European Social Fund, through the Sectorial Operational Pro-
gramme Human Resources Development 2007 2013, project
number POSDRU/159/1.5/S/138907 “Excellence in scientific
interdisciplinary research, doctoral and postdoctoral, in the
economic, social and medical fields EXCELIS”, coordinator
The Bucharest University of Economic Studies.
Disclosure of Interest: None declared
MON-PP085
PATIENTS WITH HOME PARENTERAL NUTRITION: CATHETER-
RELATED COMPLICATIONS
L. Knauer1 , M. Drissi1 , K. Hengst2 , M. Masin1 . 1 Clinical
Nutrition, 2 University Medical Center, Münster, Germany
Rationale: The purpose of this survey was to analyze catheter-
related complications for different catheter-systems and
management of home parenteral nutrition (HPN).
Methods: A retrospective analysis of patients with HPN
was conducted at the University Hospital of Muenster
from 03/2014 to 03/2015. Questionnaires completed by
S159
nursing staff were used to investigate the frequency of
complications. The number of HPN-patients was 387 (218
women; mean age 61±13.7). The patients underwent 195.6
(±SD 143.9) catheter days on average. Of all patients 51.2%
had an oncologic diseases, 27.6% a short bowel syndrome, 4.4%
an inflammatory bowel diseases, 15.5% other diseases.
Results: Most of the patients had a Port-system (70.5%), 12.0%
Broviac catheters, 8.2% a Groshong, 2.9% Hickman catheters
and 6.4% others. The majority of the patients (62.5%,
n = 242) had no complications, whereas 27.4% developed
complications, rest is missing. The majority had a superficial
flush (20%), other complications were sepsis (2.4%), pocket
infections (2.1%), occlusion (0.9%), dislocation (0.3%) and
others (3.6%). Eighty-five patients with a Port-system, 10
patients with a Broviac catheter, 6 patients with a Groshong
and 3 patients with a Hickman catheter developed a
complication, but with no statistical significance (p = 0.485).
Home care services mainly managed dis-/connection of PN
(76.2%); patients themselves (16.3%), relatives (5.5%) or
others (0.6%). Complications occurred in 85 cases provided by
home care services, 16 provided by themselves and 2 relative-
managed HPN-cases, but without significance (p = 0.121).
Conclusion: The results suggest that the applied catheter-
system has no effect on complications as well as the
person who manages HPN. We recommend individual patient
application of catheter-systems for HPN, but proper care
of catheters and PN application are unalterable for HPN-
management.
Disclosure of Interest: None declared
MON-PP086
SEVERELY IMPAIRED NUTRITIONAL STATUS IN PATIENTS
WITH LOCALLY ADVANCED PANCREATIC CANCER
J. Witvliet1 , C. Lochtenberg-Potjes1 , H. Scheffer2 ,
G. Kazemier3 , N. Wierdsma1 , M. Meijerink2 ,
M. de van der Schueren1 . 1 Section of Nutrition and
Dietetics, Department of Internal Medicine, 2 Department
of Radiology and Nuclear Medicine, 3 Department of Surgery,
VU University Medical Center, Amsterdam, Netherlands
Rationale: Although malnutrition is frequently described in
patients with locally advanced pancreatic cancer (LAPC), little
quantitative data is available on the nutritional status and
gastrointestinal functioning of these patients.
Methods: Patients with LAPC included for experimental
treatment by Irreversible Electroporation (IRE) were included.
Weight loss in the past 6 months (kg), body mass index
(BMI), nutritional intake (4-d diary), fat free mass index
(FFMI), handgrip strength, resting energy expenditure by
indirect calorimetry (REE) and gastro intestinal functioning
measured by intestinal absorption capacity of energy and
macronutrients (3-d faeces collection and bomb calorimetry)
and exocrine pancreatic function by faecal elastase-1 (FE1)
were measured before IRE.
Results: Sixteen patients (50% male; mean age 60.3±9.5 y)
were included.
Median weight loss over the past 6 months amounted 10.1 kg
[IQR 4.8 14.3], mean BMI was 23.9±2.5 kg/m2 . Energy and
protein intake were 27±10 kcal/kg and 1.1 g/kg [IQR 0.8 1.5]
respectively.
In 7 patients the FFMI and in 8 patients the handgrip strength
was Median REE as % of predicted REE by the Harris & Benedict