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Objectives:
1. Describe the organization of the Nervous system.
a. Define the common neuroanatomical terms.
b. Name the principal divisions.
c. Identify the component parts of the: Central nervous system
Peripheral Nervous system, Autonomic Nervous system.
d. Describe the functional components of the peripheral
nervous system.
2. Describe the general topology of the Brain: subdivisions,
lobes, gyri and fissures/sulci, and functional/Brodmann
areas.
3. Describe the brainstem.
a. Enumerate the parts of the brainstem.
b. Describe the important external landmarks on the anterior
and posterior aspects of the brainstem.
4. Describe the external and internal features of the spinal cord.
a. Describe its gross features and developmental changes
with respect to its relationship to adjacent structures.
b. Describe its cross-sectional anatomy: a. gray and white Figure 1. (A to E) Neurons with cell bodies in the CNS. Neuron A is
matter; differences between specific cord segments; fasciculi, confined to the CNS and terminates on neuron B at a typical chemical
funiculi, and fiber tracts; rexed laminae. synapse (C). Neuron B is a motor neuron; its axon extends to a peripheral
5. Describe the principles of Neuroanatomical Localization. nerve & innervates a striated (voluntary) muscle at the neuromuscular
junction (motor end plate, D). In E, the arrows indicate the direction of flow
of the action current ( Manter & Gatz’s)
LEGEND
Remember Lecturer Book Previous Presentation
Trans B. OVERVIEW OF THE NERVOUS SYSTEM
Central Nervous System
• Comprised of the brain and spinal cord
• Involved in the integration of information to and from the
I. ORGANIZATION OF THE NERVOUS SYSTEM periphery
A. NEUROLOGICAL TERMS • Receive information from the peripheral nervous system and
• Neurons send out impulses to direct actions or hormonal changes
® Main excitable cells of the nervous system • Interactions with other neurons to modulate or modify impulses
® Made of nerve cell body, axons, and dendrites within it.
® As to location, “neuron” refers to the location of the nerve cell
body Peripheral Nervous System
• Dendrites • Composed of cranial nerves, spinal nerves, and associated
® Carry nerve impulses towards the body ganglia (everything outside brain and spinal cord )
• Axons • Conducts information to and from the CNS
® Carry impulses away from the body
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5.06 Organization of the Nervous System LE 5 TRANS 6
• 12 pairs of cranial nerves that come from the brain (Table 1.) ® The dorsal and ventral roots join together to form a single
spinal nerve that exits the vertebral column via the
intervertebral foramina
• Spinal nerves are named based on location
• Naming convention changes at C7/T1
® CN1-CN7: exits above the vertebra
® CN8: exits between C7 and T1
® T1 onwards: exits below the vertebra
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5.06 Organization of the Nervous System LE 5 TRANS 6
® E.g. multipolar neurons conduct impulses to muscles (an Motor General Somatic General Visceral
effector organ) (Efferent) Efferent (GSE) – Efferent (GVE) –
® Effector organs – receiver of motor impulse from CNS Motor impulses to Control glandular
skeletal muscle secretion, movement of
Editor’s Note: Here’s another way to remember SAME groups smooth muscles
No Special Somatic Special Visceral
Efferent (SSE) Efferent (SVE) –
Muscles of
branchiomeric origin
(neck muscles, muscles
2. Embryologic origin of innervated tissue of mastication, muscles
• Somatic – body wall of facial expression)
• Visceral – organs
Note Question ( 2020C) :
Table 3. Classification of nerves based on embryologic origin of innervated What are the functional components of a specific nerve?
tissue. Remember: Nerve – w/ >1 functional component.
Attribute Somatic System Visceral System e.g. Radial nerve
Embryologic “Body Wall” “Organs” - GSA: w/ nerve fibers for the sensation of skin +
origin of Somatic (parietal) splanchnic (visceral) blood pressure & oxygen content detection of blood
tissue mesoderm mesoderm/endoderm vessels.
(dermatome – - GSE: w/ motor fibers for some muscles.
sensory, - GVE: w/ nerve fibers that affect sweat & sebaceous
myotome – motor) gland activity (ANS controlled)
Examples of Dermis of skin, Glands, cardiac -2021A Trans
adult tissue skeletal muscles, muscles, smooth
connective tissues muscles Note ( 2020C) :
Perception Conscious, Voluntary Unconscious, Some cranial nerves are purely sensory (contain PURELY
Involuntary sensory nerve fibers), others are considered purely motor
(contain PURELY motor fibers), and several are MIXED
3. Particular functions (General & Special functions) (contain both sensory and motor fibers)
• General Function -Moore
(Discussed in depth in Peripheral and Nervous System)
® ALL Nerve fibers of SPINAL NERVES and SOME cranial
nerves with similar functions
®
In the head, there are nerve fibers that have the same D. AUTONOMIC NERVOUS SYSTEM
fxn as o/ nerve fibers (NF) in the body.
® e.g. NF of sensation - pain, temperature & touch: felt by
the face just the same as o/ body parts.
• Special Function – specialized functions exemplified by
some cranial nerves
® Special sense organs of the eye and ear ( including
balance)
® Olfactory and gustatory receptors (eg. Mouth, tongue,
nose, nasal cavity, pharynx)
® Motor for muscles of branchiomeric origin ( pharyngeal
pouch) – special skeletal muscles derived from branchial
arteries and are related to the development of the head
(eg. Muscles of mastication, facial expression, pharynx
and larynx, Muscles of the neck: trapezius and SCM etc.)
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5.06 Organization of the Nervous System LE 5 TRANS 6
® Forebrain
§ Cerebrum/Telencephalon – “brain” in layman’s terms
§ Diencephalon – thalamus, hypothalamus, epithalamus
® Midbrain
§ Connects forebrain and hindbrain
® Hindbrain
§ Composed of the pons, cerebellum, and medulla
oblongata
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5.06 Organization of the Nervous System LE 5 TRANS 6
Figure 12. Central Sulcus (of Rolando), Lateral Fissure/ sulcus (of
Sylvius), Parietoocipital Sulcus, and the Precentral & Postcentral
Sulculs and the Preoccipital Notch in Left (Top figure) and Right (middle
and bottom fig.) cerebral hemispheres.
Minor Lobes
• Central Lobe / Insular Lobe / Island of Reil
® Not visible on the outside
® Revealed by separating the lateral sulcus
® Superomedial surface of the temporal lobe will also be seen
® Opercular portions – portions of the frontal, parietal, and
temporal lobes overlying the insula that form the lips of the
lateral sulcus
® Functions with regards to consciousness and control of
emotions
• Limbic Lobe
® Not really an identifiable lobe but more of structures that Figure 15. Sulci and Gyri
are functionally related and involved in the limbic system
® Consists of a dorsally cingulate gyrus, the ventrally located • Central Sulcus – separates the frontal and parietal lobe
parahippocampal gyrus and a narrow cortical area that • Precentral Sulcus – found anterior to the precentral gyrus
connects them, the isthmus • Postcentral Sulcus – found posterior to the postcentral gyrus
® The Hippocampus and dentate gyrus are also parts of the • Precentral Gyrus – found anterior to the Central Sulcus of
limbic lobe, but cannot be seen unless the temporal lobe is Rolando
further dissected
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rd
Thalamus in (3
Ventricle)
Hypothalamus
Brainstem
Cerebellum
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5.06 Organization of the Nervous System LE 5 TRANS 6
Optic
Chiasma
Uncus
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5.06 Organization of the Nervous System LE 5 TRANS 6
Summary of Important Cortical Areas (in terms of • Schematic representation of human body on a specific area
location): of the CNS
Table 5. Frontal Lobe • e.g. the sensory/motor areas of the cerebral cortex, with
Gyrus Name Brodmann Function respect to its relative weight dedicated to each body region
Area • The size of each body part in the figure shows how much
Pre-central Primary 4 Movement area of the brain is devoted to it
Motor Cortex ® Ex: the lips and tongue are so large as compared to the
Parts of: Pre-Motor 6 Movement knee. This is because a person’s lips and tongue are
- Superior Frontal Area Planning specialized for making small and precisely controlled
- Middle Frontal movements as compared to your knee which makes larger
and less precise movements.
- Pre-central
Inferior Frontal Motor 44-45 Motor ® The bigger the representation of the organ, the richer the
Speech Area Aspect of innervation in its corresponding area in the cortex.
(of Broca) Speech
E. THALAMUS
Table 6. Parietal Lobe • Large ovoid mass of gray matter
Gyrus Name Brodmann Function • Dorsal and largest portion of the diencephalon (the thalamus
Area is its largest part)
Post- Primary Somatosensory 3, 1, 2 General • A pair on either side of the 3rd ventricle connected in the
central Cortex/ Primary Somatic midline by the interthalamic adhesions/connections at
Somesthetic Center Afferent midline
Fibers • Covered by white matter:
® superiorly by the stratum zonale
Table 7. Temporal Lobe ® laterally by the external medullary lamina :
Gyrus Name Brodmann Function • Divided into 3 parts (Anterior, Medial, and Lateral) by the
Area internal medullary lamina (y-shaped)
Anterior Primary 41-42 Auditory Input ® Within the internal medullary lamina, there are nuclear
Transverse Auditory Cortex groups (+ intralaminar group) that send to and receive
Temporal impulses from specific parts of the CNS.
Gyrus (of • Functions:
Heschl) ® Relay center for sensory impulses (EXCEPT SMELL)
Superior Auditory 22 Speech ® Modifies and integrates afferent impulses
Temporal Association Comprehension ® Adds emotional tone
Area (of § Receives impulses for sensation then sends this
Wernicke) information to the cortex and basal nuclei already modified
and integrated (tells the cortex and basal nuclei what the
Table 8. Occipital Lobe
sensation means)
Gyrus Name Brodmann Function
® Regulates cortical activity
Area
Parts of: Primary 17 Visual Input
- Cuneus Visual Area
- Lingual
Parts of: Visual 18-19 Interpretation
- Cuneus Association of Visual
- Lingual Area Input
- Middle occipital
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F. HYPOTHALAMUS
• Located above the midbrain and below the thalamus
• Makes up the ventral diencephalon
• Extends from the optic chiasm to the caudal border of the
mammillary bodies and lies below the hypothalamic sulcus on
the lateral wall of the 3rd ventricle
• Controls and integrates the ANS and endocrine system
• Plays a vital role in maintaining body homeostasis
® emotional states
® fat, carbohydrate, and water metabolism
® Body temperature, genital functions, sleep, & food intake
® Release of pituitary hormones (closely associated with the
pituitary gland)
Figure 27. Caudate Nucleus of the Basal Ganglia Caudate Nucleus, Globus
Pallidus, Putamen.
H. CEREBELLUM
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5.06 Organization of the Nervous System LE 5 TRANS 6
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5.06 Organization of the Nervous System LE 5 TRANS 6
§ Both trigones are medial to sulcus limitans - CN XII – in between pyramid and olive
® Facial Colliculus
§ Underneath is the nucleus for the Abducens Nerve Cross-Sectional Anatomy (Handout of Dr. Esguerra)
§ Called the “facial” colliculus because the motor fibers of • Identify the important internal structures (appearance and
the facial nerve are the ones that pass on top of the location of specific nuclei and nerve tracts) at the representative
abducens nucleus and the colliculus sections of the brainstem.
® Obex • The cross-section of the brainstem is divided into 3 regions:
§ Caudal end of the 4th ventricle as it continues as the ® Tectum – the roof
central canal in the caudal medulla and spinal cord ® Tegmentum – the cover or floor
§ Foramen of Magendie - single dorsal midline opening of ® Basis – the base
the obex where CSF exits into the cisterna magna
• Ventral View
® Origins of the cranial nerves III to XII except CN IV which
arises from the dorsal surface.
® Four Major Landmarks:
§ 2 Pyramids
- Contain axons of the corticospinal tract of the motor
system carrying signals from the cerebral cortex to the
spinal cord Figure 34. Transverse section of the midbrain at the level of the superior
- Note the area in the caudal medulla where these axons colliculus
cross the middle (decussate) to the contralateral side
- Anterior or ventral median fissure – separates the
two pyramids
§ Olives
- Eminences lateral to the pyramids which indicate the
area of the inferior olivary nucleus
- Inferior olivary nucleus – receive and transmit
impulses towards the cerebellum
- Pre-olivary sulcus - groove medial to the inferior
olivary nucleus which separates it from the pyramids
- Post-olivary sulcus – groove lateral to the inferior
olivary nucleus
§ Basal surface of the pons
- Also called basis pontis
§ Cerebral peduncles
- Also called basis pedunculi Figure 35. Photomicrograph of a transverse section of the midbrain at the
- At the area of the midbrain level of the superior colliculus
- Carry axons of the corticospinal tract from the
cerebrum to the brainstem through the base of the • Rostral (Upper) Midbrain
pons to emerge on the medullary surface as the ® Cut at the level of the superior colliculus
pyramids ® 3 regions: tectum, tegmentum, and basis pedunculi
® Origins of CN III, V, VI, VII, VIII, IX, X, XI, XII ® Fluid cavity: Cerebral aqueduct (of Sylvius) or Iter
§ VI, VII, VIII (surrounded by periaqueductal gray matter)
- Corticomedullary Junction ® Tectum
- CN VII has 2 components § Superior colliculus
- CN VIII will become the vestibular and cochlear nerve § Mesencephalic nucleus of CN V
in the inner ear ® Tegmentum
§ IX, X, XI, XII § Edinger-Westphal + Oculomotor nuclei
- CN XI – has contribution from the spinal cord (spinal § Medial longitudinal fasciculus (MLF)
accessory nerve) § Red nucleus
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Figure 36. Transverse section of the midbrain at the level of the inferior Figure 39. Photomicrograph of a transverse section of the pons at the level
colliculus of the trigeminal nuclei
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Figure 43. Transverse section of the medulla oblongata at the level of the
middle of the olivary nuclei
Figure 41. Transverse section through the caudal part of the pons at the
level of the facial colliculus
Figure 44. Transverse section of the medulla oblongata at the level of the
superior part of the olivary nuclei just inferior to the pons
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5.06 Organization of the Nervous System LE 5 TRANS 6
J. SPINAL CORD
• Surrounded by the 3 meninges:
Figure 48. Transverse section of the medulla oblongata at the level of ® Dura mater
decussation of the pyramids ® Arachnoid mater
® Pia mater
• Caudal (Lower) Medulla • Subarachnoid space is surrounded by cerebrospinal fluid for
® At the spinal cord-medullary junction further protection
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Developmental Changes
• Occupies only upper 2/3 of adult vertebral canal
• 3rd month of fetal life: rate of growth is higher in vertebral
column than in spinal cord
• At birth: L2-L3 IV disc; Adult: L1-L2 IV disc
• Clinical significance: lumbar puncture (spinal taps)
® L3-L4: adults
® L4-L5: children
Spinal Nerves
• Has 31 pairs of spinal nerves, formed by dorsal and ventral Figure 52. Cross-section of the anatomy of the spinal cord
roots
® 8 cervical ® Gray Matter
® 12 thoracic § Centrally located H-shaped pillar with ventral (anterior)
® 5 lumbar and dorsal (posterior) gray columns/ enlargements
® 5 sacral called dorsal and ventral horns
® 1 coccygeal - These are united by a thin gray commissure
® Note that 31 pairs means there are a total of 62 spinal containing the small central canal
nerves § Contains groups of neurons/ unmyelinated nerve cell
• C1 spinal nerve exits between atlas and occipital bone bodies
® C1 spinal nerve is ABOVE C1 vertebrae § Small lateral horns are present in the thoracic and
upper lumbar (L1-L2/L3) segments where cell bodies of
® C7 is ABOVE C7 vertebrae
the preganglionic neurons of the sympathetic nervous
• C8 emerges between C7 and T1 vertebrae system are located
® C8 is BELOW C7 vertebrae o Note: Lateral horns of the thoracic segment are
• Spinal nerves starting from T1 going down emerge from the NOT found on any other vertebra
IV foramina below the vertebra of the same number
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§ The amount of gray matter and the amount of muscles § Neurons that innervate the skeletal muscles have
innervated at a vertebral level are related greater masses on the limbs as compared to the trunk
- Cervical and lumbar enlargements have the greatest ® Cervical regions have more white matter than
size of gray matter since they innervate the upper and lumbosacral regions because all fibers connecting the
lower limbs, respectively. entire cord to the brain are passing through this region
® White Matter
§ Periphery
§ Carries the different fiber tracts to and from the spinal
cord which are arranged in specific regions in particular
funiculi
§ Myelinated axons either ascending and descending
§ Three funiculi:
- Anterior (Ventral)
- Lateral
- Posterior (Dorsal)
§ Sulci/ Fissures marking the surface:
- Anterior/ Ventral Median Fissure (Deep)
o Located between 2 ventral funiculi
- Antero-/ Ventro-Lateral Sulcus
o Located between ventral and lateral funiculi
o Where ventral root fiber arises
- Postero-/ Dorso-Lateral Sulcus
o Are between dorsal and lateral funiculi
o Where dorsal root fibers enter
- Posterior/ Dorsal Intermediate Sulcus
o Located in cervical and 5 thoracic segments
o Divides each dorsal funiculus into 2 white
columns: inner gracile & outer cuneate fascicles
- Posterior/ Dorsal Median Sulcus (Shallow)
o Located between 2 dorsal funiculi
§ There is a ventral white commissure deep in the
ventral median fissure beside the gray matter,
surrounding the central canal
§ Gracile and cuneate fascicles can only be found up to
T6 upwards, supplying the upper limbs. Below the 6th Figure 54. Spinal Cord Segments
thoracic, it is only the gracile fasciculus that would be
supplying the lower limbs K. REXED LAMINAE
• When the cord is cut along its length (longitudinally), nuclei in
Spinal Cord Segments the gray matter are arranged in cell columns or laminae
• By comparing the composition and proportion of the gray & • 10 laminae according to cell structure and have consistent
white matter, one can differentiate the segments of the SC: location
® Ventral horns in gray matter are larger in cervical and • Laminae I-VI: Dorsal horn
lumbar segments Lamina VII: Intermediate gray horn
Laminae VIII & IX: Ventral horn
Lamina X: Surrounding the central canal
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5.06 Organization of the Nervous System LE 5 TRANS 6
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5.06 Organization of the Nervous System LE 5 TRANS 6
Aswers: b,d,a,b,d,b,a,b,d
REFERENCES
[Anatomy] 2018/15/03. Nervous System Organization. Dr.
Esguerra
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