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R. K. MALIK'S NEWTON CLASSES, RANCHI NEWTON CLASSES + BOARD, NDA, FOUNDATION
Reactions of HO RO
O anionic nucleophiles R X R OR R OH R CN SN2
HO CN
Cyanohydrin NaCN 12A P with alkyl halides CN
formation R R R R
O base O
O Enolate alkylation R X
Ketone or aldehyde HO H D SN2
NaBH4 (ketones or esters) R CH2R R R
reduction 12A P
or LiAlH4 R R R R R
O O O OH O
base HO H
Base-catalyzed aldol 12A 12E 12A P
D 12A P Reduction of esters LiAlH4
reaction R CH2R H R R R R OR R H
R
Addition of neutral O O
nucleophiles to acid RNH2 Grignard Reaction O HO R
12A 12E D + acid chloride, RMgX 12A 12E 12A P
halides or anhydrides R Cl R NHR
(e.g.amines, alcohols, water) ester, or anhydride R Cl R R
HI S S
O O O O R
O acid N
Addition of anionic nucleophiles HO RO
12A 12E Imine formation RNH2 P 12A PT 12E D
to acid halides or anhydrides
ES
R Cl H2N R OH R OR R NH2 R R R R
(e.g.RO , H2N , HO )
NC A K'
O O O O O acid O
base PT D
Claisen condensation D 12A 12E Fischer esterification ROH P 12A 12E
R CH2R R OR R R R OH R OR
R
O O
O R2CuLi O acid
1,4 addition of Gilman Amide hydrolysis H2O P 12A PT 12E D
14A P R NR2 R OH
reagent R R
RA C I R
O O O O O acid RO OR
base
Formation of acetals P 12A PT 12E 12A D
S
Michael reaction D 14A P ROH
R CH2R R R R R R R R
AL
R
O O RO OR acid O
Hydrolysis of acetals H2O P 12E 12A PT 12E D
RNH2 14A PT R R R R
1,4 addition of R R
neutral nucleophiles
RHN
O O acid O
L
Acid catalyzed aldol P T 12A PT T 14E D
R CH2R H R R R
ON M
O O O O O
O Nu O base Intramolecular acid-base reaction
R H
WT .