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COLLEGE OF MEDICAL LABORATORY SCIENCE

City of Dasmarinas, Cavite, Philippines

Cavite: (63) (46) 481-8000 Manila: (63) (2) 988 3100

www.dlshsi.edu.ph

SEMINAR II

ASSESSMENT EXAMINATION RATIONALIZATION


IMUNOLOGY AND SEROLOGY
2nd SEMESTER A. Y. 2017 – 2018

1. Humoral immunity is mediated by antibodies from_______ and is involved in the elimination


of_____________ pathogens. Cell mediated immunity is mediated by________ and is involved in the
elimination of___________________ pathogens
Choices: B lymphocytes; Intracellular; T lymphocytes; Extracellular

2. In a resting lymphocyte, B cells and T cells can be distinguished from each other via a simple blood
smear
Answer: False
________________________________________________________________________________

3. Which of the following types of antigen presenting cells (APCs) has immunoglobulin that functions as
a receptor, then the antigen is internalized, degraded, and presented to T cells?
Answer: B cell

4. The purpose of C3a, C4a, C5a, the split-products of the complement cascade, is to:
Answer: Cause increased vascular permeability, contraction of smooth muscle, and release of
histamine from basophils (Anaphylaxis)

5. Given the following results, what is the immune status of the patient?
HBsAg: negative HBeAg: negative
Anti-HBc: positive Anti-HBs: positive
________________________________________________________________________________

6. Which of the following are useful serological tests to document antecedent Streptococcal infections?
I. ASO II. anti-DNAse III. M-antigen IV. Hemolysin
________________________________________________________________________________
________________________________________________________________________________

7. A cause of FALSE-POSITIVE results in the rapid plasma reagin (RPR) test for syphilis is:
________________________________________________________________________________
________________________________________________________________________________

8. An immunodeficiency in a 5 year old boy with chronic granulomatous disease is


________________________________________________________________________________
________________________________________________________________________________

9. IL-12 is important for which of the following?


________________________________________________________________________________
________________________________________________________________________________

10. Chemokines are


Answer: Low molecular weight cytokines important in inflammation

11. Which category of hypersensitivity best describes hemolytic disease of the newborn due to Rh
incompatibility?
________________________________________________________________________________
________________________________________________________________________________

12. The principal difference between cytotoxic (type II) and immune-complex hypersensitivity (Type III) is
Answer: The site where antigen-antibody complexes form

13. Privileged site


_____________________________________________________________________________

14. An elderly woman presents with chronic fatigue, difficulty sleeping, a rapid heartbeat, and bulging eyes.
Lab tests revealed autoantibodies to thyroid-stimulating hormone. The most likely diagnosis is
_____________________________________________________________________________

15. An individual is known to have chronic hepatitis disease. Which serological marker should be monitored
to determine if the blood contains the infectious virus?
_____________________________________________________________________________

16. IgA is largely responsible for protection of the respiratory and intestinal mucosal tract.
Effective protection is dependent on the action of secretory piece which
Answer: Is a poly- immunoglobulin transport receptor on mucosal epithelial cells

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COLLEGE OF MEDICAL LABORATORY SCIENCE
City of Dasmarinas, Cavite, Philippines

Cavite: (63) (46) 481-8000 Manila: (63) (2) 988 3100

www.dlshsi.edu.ph
17. Goodpasture’s syndrome is characterized by glomerulonephritis in genetically susceptible individuals.
The responsible antigen is
_____________________________________________________________________________

18. An ASO titer and a Streptozyme test are performed on a patient’s serum. The ASO titer was negative,
showing hemolysis in all patient tubes. The Streptozyme test is positive, and both the positive and
negative controls react appropriately. What can you conclude from these test results?
Answer: The patient has an antibody to a streptococcal exoenzyme other than streptolysin O

19. In a precipitation reaction, how can the ideal antibody be characterized?


Answer: High affinity and high avidity

20. Precipitation differs from agglutination in which way?


_____________________________________________________________________________

21. Which technique is typified by radial immunodiffusion combined with electrophoresis?


_____________________________________________________________________________

22. Immunofixation electrophoresis differs from immunoelectrophoresis in which way?


_____________________________________________________________________________

23. Which part of the radial immunodiffusion (RID) test system contains the antisera?
_____________________________________________________________________________

24. The absorbance of a sample measured by ELISA is greater than the highest standard. What corrective
action should be taken?
_____________________________________________________________________________

25. A patient was suspected of having a lymphoproliferative disorder. After several laboratory tests were
completed, the patient was found to have an IgM k paraprotein. In what sequence should the laboratory
tests leading to this diagnosis have been performed?
_____________________________________________________________________________

26. What has happened in a titer, if tube Nos. 5–7 show a stronger reaction than tube Nos.1–4?
_____________________________________________________________________________

27. The directions for a slide agglutination test instruct that after mixing the patient’s serum and latex
particles, the slide must be rotated for 2 minutes. What would happen if the slide were rotated for 10
minutes?
_____________________________________________________________________________

28. What is the most likely explanation when antibody tests for HIV are negative but a polymerase chain
reaction test performed 1 week later is positive?
_____________________________________________________________________________

29. Interpret the following results for EBV infection: IgG and IgM antibodies to viral capsid antigen (VCA)
are positive.
Answer: Current infection

30. An antinuclear antibody test is performed on a specimen from a 55-year-old woman who has
unexplained joint pain. The IFA result is a titer of 40 and a homogeneous pattern. The appropriate
follow-up for this patient is:
Answer: Retest ANA in 3–6 months

31. Which of the following conditions will most likely result in a false-negative DAT test?
Answer: Insufficient washing of RBCs

32. A patient deficient in the C3 complement component would be expected to mount a normal:
Answer: Type I and IV hypersensitivity response

33. Recombinant Immunoblot Assay (RIBA) is a new method designed to detect which of the following
viruses?
Answer: Hepatitis A virus

34. Cholesterol is added to the antigen used in flocculation tests for syphilis to:
_____________________________________________________________________________

35. The Treponema pallidum immobilization (TPI) test requires:


_____________________________________________________________________________

36. The serologic test for syphilis RECOMMENDED for detecting antibody in cerebrospinal fluid is:
_____________________________________________________________________________

37. Antigen used in FTA-ABS

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COLLEGE OF MEDICAL LABORATORY SCIENCE
City of Dasmarinas, Cavite, Philippines

Cavite: (63) (46) 481-8000 Manila: (63) (2) 988 3100

www.dlshsi.edu.ph
38. Which of the ff is considered as the reference method for serological tests for syphilis?____________

39. Titer refers to the ___ dilution of serum which still produces a visible reaction with a particular Ag
a. Lowest
b. Highest
c. Equal
d. none of the above

40. Function of memory cells: for anamnestic response

41. This type of immunization involves administration of vaccines (killed or attenuated microorganisms) to
recipients. They are unable to cause disease but are still immunogenic.
_____________________________________________________________________________

42. A family of glycoproteins produced by all animal cells that exert virus non-specific but host-specific anti-
viral activity:
_____________________________________________________________________________

43. The random movement of antigen or antibody to form antibody-antigen complexes in a semi-solid
medium occurs in:
Answer: Precipitation

44. The first antibody to be observed in an HIV infected individual is a directed against:
_____________________________________________________________________________

45. Which of the following mediator is released during T-cell activation?


a. Immunoglobulin
b. Lymphokines
c. Serotonin
d. Prostaglandin

46. The chemical basis of specific antigen-antibody reaction is explained by what theory?
_____________________________________________________________________________

47. What method of gel precipitation is able to detect serologic identity of antigen-antibody system reacting
in adjacent wells? __________________________________________

48. In an agglutination reaction, if cells are not centrifuged long enough, which of the ff might occur?
a. false-negative result
b. false-positive result
c. no effect
d. tolerable effect and can be ignored

49. MHC molecules are associated with which of the following?


a. graft rejection
b. autoimmune diseases
c. determining to which agents an individual respond
d. all of the above

50. Which of the following is true?


a. The specimen for Class II HLA typing is pure B cells
b. The specimen for RID C3 assay is inactivated serum
c. Eosin is added to neutrophil-bacterial suspension in the intacellular killing assay
d. ABO blood typing is an example of an indirect agglutination reaction

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