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Blood Flow the quantity of blood that passes a given point in the circulation in a given period time
Interrelationships of pressure, flow, and resistance :
o Blood flow is determined by pressure difference of blood between the two end vessels / pressure gradient,
and the impediment to blood flow through the vessel / vascular resistence
o The blood flow is directly proportional to the pressure gradient, but inversely proportional to the resistance
o In formula called Ohm’s law F (Flow) = ΔP / R
Control of Cardiac Output by Venous Return – Role of the Frank-Starling Mechanism of the Heart
When one states that cardiac output is controlled by venous return not the heart as primary as the primary
controller, it is the various factor of the peripheral circulation that affect flow of blood into the heart from the
veins, called venous return that are primary control.
That because heart has a built-in mechanism that normally allows it to pump automatically whatever amount of
blood that flows into the right atrium from the veins Frank-Starling law of the heart.
In this law : when increased quantity of blood flow to heart streches the walls of heart chambers cardiac
muscle contract with increased force.
Another important : streching the heart causes heart to pump faster – at an increase heart rate; causes by strech
of the sinus node and bainbridge reflex (a nervous reflex, passing first to the vasomotor center of the brain and
then back to the heart by way of the simpatetic nerves and vagi).
Cardiac Output Regulation is Sum of Blood Flow Regulation in All the Local Tissues of the Body – Tissue
Metabolism Regulates Most Loca Blood Flow.
Venous return is the sum of all the local blood flows through all the individual tissue segments of the peripheral
circulation, and so does cardiac output.
The long-therm cardiac output level also varies reciprocally with changes in total peripheal resistance, as long as
arterial pressure is unchanged.
For instance, any time the long term of total peripheral resistance changes, the cardiac output changes
quantitively in exactly the opposite direction.
The Heart has Limits for the Cardiac Output That it Can Achieve
Cardiac Output Curve to show the amount of blood that heart can pump; there are definitive limits.
The plateau level is about 13 L/min (while normal about 5 L/min) means that the normal human heart without
any special stimulation can pump an amount of venous return up to about 2.5 times the normal venous return
before the heart becomes a limiting factor.
The upper most hypereffective heart, the lowermost hypoeffective hearts.
Factor causes a hypereffective heart
o Effect of nervous excitation to increase heart pumping, by sympathetic stimulation and parasimpathetic
inhibition
o Increased pumping effectiveness caused by heart hypertrophy.
Factor causes a hypoeffective heart :
o Increased arterial pressure
o Inhibition of nervous excitation of heart
o Pathological factors
o Coronary artery blockage
o Valvular heart disease
o Congenital heart disease
o Myocarditis
o Cardiac hypoxia