Professional Documents
Culture Documents
Academy of Medicine, College of Family Physicians, Endocrine and Metabolic Ministry of Health,
Singapore Singapore Society of Singapore Singapore
Obesity & Metabolic Surgery Obstetrical & Gynaecological Singapore Association for Singapore Nutrition and
Society of Singapore Society of Singapore the Study of Obesity Dietetics Association
June 2016
Levels of Evidence and Grades of Recommendation
Levels of Evidence
Level Type of Evidence
1 ++
High quality meta-analyses, systematic reviews of randomised controlled
trials (RCTs), or RCTs with a very low risk of bias.
1+ Well-conducted meta-analyses, systematic reviews of RCTs, or RCTs with
a low risk of bias.
1- Meta-analyses, systematic reviews of RCTs, or RCTs with a high risk of bias.
2+ + High quality systematic reviews of case control or cohort studies. High
quality case control or cohort studies with a very low risk of confounding
or bias and a high probability that the relationship is causal.
2+ Well-conducted case control or cohort studies with a low risk of
confounding or bias and a moderate probability that the relationship is
causal.
2- Case control or cohort studies with a high risk of confounding or bias
and a significant risk that the relationship is not causal.
3 Non-analytic studies, e.g. case reports, case series
4 Expert opinion
Grades of Recommendation
Grade Type of Evidence
A At least one meta-analysis, systematic review of RCTs, or RCT rated as
1++ and directly applicable to the target population; or
A body of evidence consisting principally of studies rated as 1+,
directly applicable to the target population, and demonstrating overall
consistency of results.
B A body of evidence including studies rated as 2++, directly applicable to
the target population, and demonstrating overall consistency of results; or
Extrapolated evidence from studies rated as 1++ or 1+
C A body of evidence including studies rated as 2+, directly applicable to
the target population and demonstrating overall consistency of results; or
Extrapolated evidence from studies rated as 2++
D Evidence level 3 or 4; or
Extrapolated evidence from studies rated as 2+
GPP Recommended best practice based on the clinical experience of the
(Good Practice guideline development group.
Points)
1
Key Guideline Recommendations
Details of recommendations are located in the main text at the pages indicated.
Assessment
2
Table: Clinical and laboratory assessment (pg 38)
GPP
Recommended items
3
Assessment for secondary causes:
• Thyroid function tests: Thyroid stimulating
hormone / free thyroxine
• Cushing’s syndrome: Screen only if clinically
suspected
• Hypogonadism: Screen only if clinically
suspected
Treatment: Introduction
Realistic weight loss should be safe and should preferably not exceed
A
0.5–1 kg a week. (pg 42)
Grade A, Level 1++
4
Treatment: Diet
5
Sugar-sweetened beverages should be avoided to prevent excess weight
A
gain. (pg 51)
Grade A, Level 1+
Dietary advice should consider foods that are locally available and
GPP
match culinary preferences to facilitate long-term compliance. (pg 51)
GPP
6
Screening:
For weight loss, a negative energy balance (approximately 1000 kcal per
C
day) achieved through both dietary restriction and physical activity is
encouraged. (pg 55)
Grade C, Level 2+
Frequency:
Physical activity should be established as a regular behaviour
GPP
throughout the week. (pg 55)
GPP
Intensity:
Moderate-intensity aerobic activity should be recommended for the
D
management of body weight. (pg 55)
Grade D, Level 3
Time:
For weight loss, adults should engage in 150–420 minutes of moderate-
A
intensity physical activity per week. (pg 56)
Grade A, Level 1+
7
To maintain weight loss, adults should engage in 200–300 minutes of
B
moderate-intensity physical activity per week. (pg 56)
Grade B, Level 1+
Type:
Low-impact physical activities and cross training may be recommended.
GPP
(pg 56)
GPP
8
Treatment: Behavioural modifications and related therapy
9
Treatment: Medical treatment of obesity and related comorbidities
10
Patients with BMI above 40 kg/m2, or above 35 kg/m2 with at least
A
one obesity-related comorbidity, especially if difficult to control with
lifestyle and pharmacological therapy, may be considered for bariatric
surgery as a medical treatment.* (pg 73)
Grade A, Level 1+
Close liaison between the obstetrician and the bariatric team is highly
C
desirable. For pregnant women who have undergone bariatric surgery,
nutritional supplements over and above the usual requirements in a
normal pregnancy are recommended. (pg 77)
Grade C, Level 2+
* Based on WHO BMI data, Asian BMI data is estimated to be about 2.5 kg/m2 lower.
11
Older population:
Adolescents:
12
Special focus: Children and adolescents
13
The vast majority (> 95%) will have common or primary obesity.
GPP
Pathological causes or secondary obesity (inclusive of monogenic
causes) are uncommon but should be carefully considered. If there are
no significant abnormalities in the history and examination indicative
of pathological causes of obesity, investigations for these pathologies
are generally not necessary. Testing may be limited to thyroid function.
If there are clinical suspicions of pathological causes, these patients
should be referred to tertiary centres for proper investigations and
interpretation of the results. (pg 87)
GPP
14
Parental involvement can enhance the effectiveness of lifestyle
A
interventions, particularly in pre-adolescent children, by changing
and adapting parenting styles, parenting skills and child management
strategies during the intervention, such as role modelling and active
parental participation. (pg 90)
Grade A, Level 1+
15
Sedentary activities (TV viewing, playing video games etc.) should be
D
limited to not more than 2 hours a day, or equivalent to 14 hours per
week for all children. (pg 93)
Grade D, Level 4
Screening:
16
Pregnancy weight management:
The range of desirable total weight gain and the rate of gain should be
B
discussed with the woman early in her pregnancy. A plan to achieve
these goals should be documented. (pg 96)
Grade B, Level 2+
17
All overweight or obese women should be screened for diabetes
B
with a 75 g oral glucose tolerance test at 24–28 weeks gestation. For
women with Class II and III Obesity (pre-pregnancy BMI ≥ 35.0 kg/m2),
consider an early oral glucose tolerance test (below 14 weeks gestation
if possible) to assess for pre-existing diabetes. If the initial oral glucose
tolerance test is negative, consider repeating at 28 weeks if the risk of
diabetes is significantly high or if the patient exhibits clinical symptoms
of diabetes. (pg 97)
Grade B, Level 2++
Post-natal management:
18
Offer obese women additional support for breastfeeding. Consider
D
referral to a lactation consultant, increasing supervision during
breastfeeding and providing early postpartum breastfeeding support.
(pg 99)
Grade D, Level 4
19
Copyright © HPB B E 816-16
August 2016