Atorvastatin belongs to a class of drugs referred to as statins. Statins reduce total cholesterol as well as LDL cholesterol in blood. Atorvastatin also reduces the concentration of triglycerides in the blood.
Atorvastatin belongs to a class of drugs referred to as statins. Statins reduce total cholesterol as well as LDL cholesterol in blood. Atorvastatin also reduces the concentration of triglycerides in the blood.
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Atorvastatin belongs to a class of drugs referred to as statins. Statins reduce total cholesterol as well as LDL cholesterol in blood. Atorvastatin also reduces the concentration of triglycerides in the blood.
Copyright:
Attribution Non-Commercial (BY-NC)
Available Formats
Download as TXT, PDF, TXT or read online from Scribd
DRUG CLASS AND MECHANISM: Atorvastatin is an oral drug that lowers the level of cholesterol in the blood. It belongs to a class of drugs referred to as statins, which includes lovastatin (Mevacor), simvastatin, (Zocor), fluvastatin (Lescol) , and pravastatin (Pravachol). All statins, including atorvastatin, prevent the production of cholesterol in the liver by blocking HMG-CoA reductase, an enzyme that makes cholesterol. Statins reduce total cholesterol as well as LDL choleste rol in blood. LDL cholesterol is believed to be the "bad" cholesterol that is pr imarily responsible for the development of coronary artery disease. Reducing LDL cholesterol levels retards progression and may even reverse coronary artery dis ease. Atorvastatin also reduces the concentration of triglycerides in the blood and raises the concentrations of HDL ("good") cholesterol. High blood concentrat ions of triglycerides also have been associated with coronary artery disease. Th e FDA approved atorvastatin in December 1996. PRESCRIPTION: Yes GENERIC AVAILABLE: No PREPARATIONS: Tablets of 10, 20, 40, and 80 mg STORAGE: Tablets should be stored at room temperature, 20°-25°C (68°-77°F). PRESCRIBED FOR: Atorvastatin is used for the treatment of elevated total cholest erol, LDL, triglycerides and to elevate HDL cholesterol. The effectiveness of at orvastatin in lowering cholesterol is dose-related, meaning that higher doses re duce cholesterol more. Atorvastatin prevents angina, stroke, heart attack, hospitalization for congesti ve heart failure, and revascularization procedures in individuals with coronary heart disease. Atorvastatin reduces the risk of myocardial infarction, stroke, angina and revas cularization procedures in adults with multiple risk factors for coronary artery disease. Atorvastatin also prevents heart attacks and strokes in patients with type 2 dia betes with multiple risk factors for coronary artery disease. DOSING: Atorvastatin is prescribed once daily. The usual starting dose is 10-20 mg per day, and the maximum dose is 80 mg per day. Individuals who need more tha n a 45% reduction in LDL cholesterol may be started at 40 mg daily. Atorvastatin may be taken with or without food and at any time of day. DRUG INTERACTIONS: Decreased elimination of atorvastatin could increase levels o f atorvastatin in the body and increase the risk of muscle toxicity from atorvas tatin. Therefore, atorvastatin should not be combined with drugs that decrease i ts elimination. Examples of such drugs include erythromycin (E-Mycin), ketoconaz ole (Nizoral), itraconazole (Sporanox), clarithromycin (Biaxin), telithromycin ( Ketek), cyclosporine (Sandimmune), nefazodone (Serzone), and HIV protease inhibi tors such as indinavir (Crixivan) and ritonavir (Norvir). Large quantities of grape fruit juice (>1.2 liters daily) also will increase blo od levels of atorvastatin. Amiodarone (Cordarone), verapamil (Calan Verelan, Isoptin), cyclosporine (Sandim mune), niacin (Niacor, Niaspan, Slo-Niacin), gemfibrozil (Lopid) and fenofibrate (Tricor) also may increase the risk of muscle toxicity when combined with atorv astatin. Atorvastatin increases the effect of warfarin (Coumadin) and the blood concentra tion of digoxin (Lanoxin). Patients taking atorvastatin and warfarin or digoxin should be monitored carefully.
atorvastatin (cont.)
Cholestyramine (Questran) decreases the absorption of atorvastatin. Atorvastatin
should be given at least two hours before and at least four hours after cholest yramine. PREGNANCY: Atorvastatin should not be taken during pregnancy because the develop ing fetus requires cholesterol for development, and atorvastatin reduces the pro duction of cholesterol. Atorvastatin should only be administered to women of chi ldbearing age if they are not likely to become pregnant. NURSING MOTHERS: It is not known if atorvastatin is secreted in breast milk. Bec ause of the potential risk of adverse events, breastfeeding mothers should not u se atorvastatin. SIDE EFFECTS: Atorvastatin is generally well-tolerated. Minor side effects inclu de constipation, diarrhea, fatigue, gas, heartburn, and headache. Atorvastatin m ay cause liver and muscle damage. Serious liver damage caused by statins is rare . More often, statins cause abnormalities of liver tests, and, therefore, periodic measurement of liver tests in the blood is recommended for all statins. Abnorma l tests usually return to normal even if a statin is continued, but if the abnor mal test value is greater than three times the upper limit of normal, the statin usually is stopped. Liver tests should be measured before initiation, at 12 wee ks following initiation of therapy and dose changes, and periodically thereafter . Inflammation of the muscles caused by statins can lead to serious breakdown of m uscle cells called rhabdomyolysis. Rhabdomyolysis causes the release of muscle p rotein (myoglobin) into the blood, and myoglobin can cause kidney failure and ev en death. When used alone, statins cause rhabdomyolysis in less than one percent of patients. To prevent the development of serious rhabdomyolysis, patients tak ing atorvastatin should contact their healthcare provider immediately if they de velop unexplained muscle pain, weakness, or muscle tenderness. Reference: FDA Prescribing Information
BRAND NAME(S): Lipitor Medication Uses | How To Use | Side Effects | Precautions | Drug Interactions | Overdose | Notes | Missed Dose | Storage USES: Atorvastatin is an enzyme blocker (HMG-CoA reductase inhibitor), also know n as a "statin". It is used along with a proper diet to help lower cholesterol a nd fats (triglycerides) in the blood. In general, this drug is prescribed after non-drug treatment options have not been fully successful at lowering cholestero l (e.g., diet change, increase in exercise, weight loss if overweight). Reducing cholesterol and triglycerides help prevent strokes and heart attacks. Atorvasta tin is used in adults and children (10 years of age and older). Young girls must have had their first menstrual period before starting this medication. HOW TO USE: Take this medication by mouth usually once daily with or without foo d, or as directed by your doctor. This drug is best taken in the evening. Dosage is based on your medical condition, response to therapy, and use of certain int eracting medicines. Many of the drugs listed in the Drug Interactions section ma y increase the chances of muscle injury when used with atorvastatin. Consult you r doctor or pharmacist for more details. Avoid eating grapefruit or drinking gra pefruit juice while being treated with this medication unless your doctor instru cts you otherwise. Grapefruit juice can increase the amount of certain medicatio ns in your bloodstream. Consult your doctor or pharmacist for more details. If y ou also take certain other drugs to lower your cholesterol (bile acid-binding re sins such as cholestyramine or colestipol), take atorvastatin at least 2 hours a fter these medications. Use this medication regularly in order to get the most b enefit from it. Remember to use it at the same time each day. It may take up to 4 weeks before the full benefit of this drug takes effect. It is important to co ntinue taking this medication even if you feel well. Most people with high chole sterol or triglycerides do not feel sick