Professional Documents
Culture Documents
Vivek Joshi
Ph.D Scholar
Division of Medicine
Overview
1. Introduction
2. Types
3. Predisposing Factors
4. Aetio-pathogenesis
5. Clinical signs
6. Diagnosis
7. Differential diagnosis
8. Treatment
9. Control
10. Conclusion
Introduction
1. Closed pyometra
2. Open pyometra
3. Stump pyometra
inflammation/ bacterial infection→uterine body
remnant
Parity
nulliparous, intact bitches
Oestrous characteristics
long diestrus
Breed
wire-haired Dachshund/ Mongrels: ↓ risk
pap P fimbriae
sfa S fimbriae
hlyA α-haemolysin
iuc aerobactin
Vomiting + +
Polyuria/ polydipsia + +
Open-cervix pyometra
thickened, irregular & slightly turgid uterine horns
Closed-cervix pyometra
greater degree of uterine distension
visible abdominal enlargement
Leukocytosis
TLC : 15,000- 60,000/mm³
(Bigliardi & Pamigiani, 2004)
Neutrophilia (degenerative left shift) : PBN >3%
Anemia
Normocytic, normochromic, non-regenerative
Hyperglobulinemia
Hypoalbuminemia
↑ ALP, BUN
Surgical
Ovariohysterectomy is treatment of choice
Indications:
further breeding
Quinolones (Enrofloxacin/Marbofloxacin)
Gentamicin
Cefalosporins
2. Prostaglandin F₂α/ PGE
Natural
0.02 mg/kg SC PGF₂α Synthetic
bid 7-10 days 0.001– PGF₂α
0.002 mg/kg SC OD
7-10 days
Dinoprost Cloprostenol
(Lutalyse®) (Cyclix®)
3. Antiprogestins
Aglepristone
10 mg/kg SC
once a week
4. Antiprolactins
Cabergoline (Cabgolin®)
0.005 mg/kg PO OD 7-10 days
5. Supportive therapy
Complete 94 % 31 %
resolution
Whelped litter 88 % -
OH : therapy of choice