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JCA-BM6010/C

BioMajesty

Course Material

JEOL Co., Ltd.

Version 3
INDEX

BASIC OPERATION 5
ROUTINE OPERATION ...................... 1-1 ISE UNIT
BASIC STEPS FOR ROUTINE OVERVIEW ......................................... 5-1
OPERATION (FLOW CHART) ........ 1-19 ANALISYS OPERATION ................... 5-1
ORDER ENTRY ................................. 1-20 ROUTINE OPERATION AND
AUTO SYSTEM AUTO SYSTEM CALIBRATION.................................... 5-1
STARTUP/SHATDOWN..................... 1-22 SETTINGS ........................................... 5-5
MAINTENANCE ................................. 5-8
2 ISE UNIT LAYOUT ........................... 5-15
DATA ISE MODULE SCHEMATIC
RERUN SAMPLES .............................. 2-1 DIAGRAM ......................................... 5-15
REACTION PROCESS......................... 2-7
REALTIME MONITOR 6
(STANDARD OUTPUT FORMAT) .. 2-10 USER INTERFACE
FLAGS FOR CALIBRATION AND SYSTEM .............................................. 6-1
CONTROL DATA .............................. 2-11 OPERATION PANEL WINDOW .......... 6-3
ALARM FLAGS ................................ 2-13 MENU WINDOW ................................ 6-9
REQUEST .......................................... 6-9
3 CALIBRATION................................ 6-22
SETTINGS QUALITY CONTROL...................... 6-27
VARIOUS SETTINGS.......................... 3-1 REGENT .......................................... 6-33
NEW REGISTRATION ...................... 3-17 MAINTENANCE ............................. 6-37
SETUP ............................................. 6-46

4 7
MAINTENANCE OTHERS MATERIALS
MAINTENANCE CHECKLIST........... 4-1 HbA1c .................................................. 7-1
BEFORE STARTING OPERATION...... 4-4 NEW SAMPLE CONTAINER
DAILY AND WEEKLY WASH ............. 4-8 SETTING ............................................. 7-7
REGULAR MAINTENANCE............. 4-10 ALARM TABLES .............................. 7-10
REGULAR PARTS DETARGENT DESCRIPTION ........... 7-26
REPLACEMENT................................ 4-25
OTHER MAINTENANCE .................. 4-27

FOOTER I-1
BASIC OPERATION
1
1.1 ROUTINE OPERATION ................................................................................... 1-1
1.1.1 STARTUP PROCEDURE .......................................................................... 1-1
1.1.1a Turning on the main power switch on the Analyzer unit. ................... 1-1
1.1.1b Starting the Water Supply Unit ........................................................... 1-1
1.1.1c Setting the Main Power on the Analyzer to PC CONTROL............... 1-1
1.1.1d Turning On the Main Power on the Workstation................................. 1-2
1.1.1e Starting Up the Workstation................................................................ 1-2
1.1.1f Setting the Analyzer Unit to READY ................................................. 1-3
1.1.2 PREPARATION ......................................................................................... 1-3
1.1.2a Completing the Checklist before Startup ............................................ 1-3
1.1.2b Adding Reagents and Detergent.......................................................... 1-4
1.1.2c Prime ................................................................................................... 1-5
1.1.2d Startup Wash ....................................................................................... 1-5
1.1.3 ANALYSIS................................................................................................. 1-6
1.1.3a Calibration and Quality Control.......................................................... 1-6
1.1.3b Analyzing an Patient Sample .............................................................. 1-9
1.1.3c Adding samples and interrupting analysis with a priority sample .... 1-12
1.1.3d Check the data and the status of analysis. ......................................... 1-15
1.1.4 SHUTTING DOWN THE ANALYZER.................................................. 1-17
1.1.4a Shut Down Wash ............................................................................... 1-17
1.1.4b System Exit ....................................................................................... 1-17
1.1.4c Shutting down the Workstation and the Analyzer unit...................... 1-18
1.1.4d Turning off the Water Supply Unit. ................................................... 1-18
1.2 BASIC STEPS FOR ROUTINE OPERATION (FLOW CHART)................... 1-19
1.3 ORDER ENTRY............................................................................................... 1-20
1.3.1 Steps to start analysis per cup position..................................................... 1-20
1.3.2 Using Batch Entry to register samples ..................................................... 1-21
1.4 AUTO SYSTEM STARTUP/SHATDOWN ..................................................... 1-22
1.4.1 Standard Operation................................................................................... 1-22
1.4.1a Check the settings ............................................................................. 1-22
1.4.1b Executing Automatic Startup from Auto Shutdown.......................... 1-23
1.4.1c Standing by for auto-startup.............................................................. 1-24
1.4.1d Completing Auto Startup procedure.................................................. 1-24
1.4.2 Other Functions ........................................................................................ 1-25
1 BASIC OPERATION

1.1 ROUTINE OPERATION


1.1.1 STARTUP PROCEDURE
BM6010/C

Power panel

Analyzer Workstation

1.1.1a Turning on the main power switch on the Analyzer unit.


Check that the main power switch at the back of the analyzer is ON. This switch must
be kept ON under normal use. This is to maintain the refrigerator units for Reagent Tray
(RTT) and Sample Tray (CTT) at the set temperature.

1.1.1b Starting the Water Supply Unit


Open the faucet fully and press the switch to run.

1.1.1c Setting the Main Power on the Analyzer to PC CONTROL


Set the Operate/Standby switch on the Analyzer
to PC CONTROL. ‘PC COTNROL’ means that
turning ON/OFF the Analyzer is synchronized
with Startup/Shutdown of the Workstation.
Operate/Standby
Switch
To turn ON or OFF the analyzer independ-
ently from the workstation, turn the switch
to left ( ) to turn it ON or right ( ) to
turn it OFF.

Power panel

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1.1.1d Turning On the Main Power on the Workstation


Turn on the main power switch on the computer rack.This turns on the computer, monitor
and printer.
If the main power switch on the computer is not connected to the computer rack,
turn on the main power switch on the computer.)
After about 1 minute, the BioMajesty Startup Window appears.

1.1.1e Starting Up the Workstation


1. Select Start Mode.
Click the desired Startup mode in the BioMajesty Startup Window.
• New Start: The current date (today) is displayed in System Date. Any ordered
tests and data for today are deleted before the system starts.
A dialog box below appears if you perform a second New Start on the same
day.

• Re-Start: The date that the system was previously started is displayed in System
Date. The ordered tests and data for that day are maintained when the
system starts up. You can resume the existing work orders and analyses.
2. Click OK.
Click OK to start the workstation and turn on the switch on the Analyzer. The Menu
Window and the Operation Panel Window appear (refer to the screenshot below).

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The operation mode display in the Operation Panel Window changes from
SYSTEM INIT to WAIT.
Enter the user name and the password if you set in User Code Settings.
If you leave the system power on overnight and want to change the system date to
today’s date, perform the shutdown operation described in P 1-17, 1.1.4b. Check
that the today’s date appears in System Date in the BioMajesty Startup Window,
then select New Start.

1.1.1f Setting the Analyzer Unit to READY


Click the INITIALIZE button in the Operation Panel Window.

Menu window Operation Panel window

Operating status display

Through initialization, the unit returns to its original state and after about 1 minute, it is
ready for use. The operation mode display in the Operation Panel Window changes
from WAIT to INITIALIZE and when initializing is completed, it changes to READY.
On the Power Panel of the analyzer, only ‘READY’ display is turned on.
After successfully completing an operation, the analyzer mode returns to
READY (except when connected to a rack handler or LAS). When the ana-
lyzer is in READY mode, no units are in operation, therefore, it is safe to per-
form some maintenance work that is allowed with the analyzer power on or re-
plenish the reagents. (You can also replenish the reagents when the analyzer is
in WAIT mode.)
If a problem occurs while starting the system, an alarm goes off and a message
appears in the Operation Panel Window. The operations are stopped and the
red light of ALARM on the Power Panel is turned on. After fixing the prob-
lem, click INITIALIZE again to set the analyzer mode to READY. Click the
ALARM button in the Operation Panel Window to clear the message and
open the Error Report window to check the details of the error (see P 6-43
10.Error Report and 7-10 Alarm Table).

1.1.2 PREPARATION
1.1.2a Completing the Checklist before Startup
See P4-4 Before starting operation

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1.1.2b Adding Reagents and Detergent


1. Refilling reagents.
Visually check the amount of reagent remaining in the Reagent Tray and refill
as required.
2. Refilling detergent. (see P7-26)
Visually check the amount of detergent remaining in the Reagent Tray (RTT1,
2), Refrigerated Sample Tray (CTT), and detergent container and refill as re-
quired.
Types and Positions of Detergent
Use Position Type
To prevent contamination (al- No. 42 in RTT1,2 REAGENT PROBE WASH-1
kaline)
To prevent contamination No. 43 in RTT1,2 REAGENT PROBE WASH-2
(acid)
Cuvette Blank Detergent container CUVETTE CONDITIONER-EX
measurement liquid (far right)
Cuvette detergent (alkaline) Detergent container CUVETTE WASH SOLUTION-7
(second from right)
Incubation bath oil Detergent container Reaction Bath Oil
(third from right)
ISE Buffer Solution Detergent container ISE BUFFER
(far left)
ISE Internal standard Solution Left side ISE Internal standard

Types and Location of Detergent to be used during Wash3 and Wash2


Use Location Type
WASH3 No. 45 in RTT1, 2 Pure water
(See p.1-5)
WASH2 No. 44 in RTT1, 2 REAGENT PROBE WASH-K(20%)
(See p.1-17) 5% REAGENT PROBE WASH-S once a week
No. 45 in RTT1, 2 Pure water
CTT-specified location ISE DETERGENT SOLUTION
(See p.5-5)

Daily and weekly cleaning methods differ depending on the type of analysis. Please ask
your local service agent for details.
As the hypochlorous acid soda in REAGENT PROBE WASH-S is easily decom-
posed, make 5% solution every time before use. Set the 5% solution of PROBE
WASH to RTT just before use and remove it immediately when the wash is com-
pleted.
Prepare the ISE Detergent Solution every time before use and change it every day.

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1.1.2c Prime
If the analyzer is left unused overnight or for a long period of time, air bubbles may be
formed in the lines of the sampling pump, reagent pumps, and wash pump. Remove any
air bubbles by performing Prime.
1. Click PRIME in the Operation Panel Window.

2. Select PRIME1 and click Execute. PRIME1 (consists of 5 cycles) is com-


pleted in about 1 minute.
If you think a large amount of air bubbles have entered the pump lines, also perform
PRIME2 and 3. Enter the number of times in PRIME2 and 3 fields. Then, press
Save and Execute.

1.1.2d Startup Wash


The cuvettes and probes may dry out if the analyzer is left unused. In that case, rinse them
with pure water.
1. Place the pure water in No. 45 on RTT1 and 2.
2. Click WASH in the Operation Panel Window.

3. Select WASH3 and click Execute.


WASH3 is completed in about 27 minutes.
Execute WASH2 each evening after completing analysis (see P 1-17).

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1.1.3 ANALYSIS
1.1.3a Calibration and Quality Control
Follow the instructions below to measure the reagent blank, calibrator for
standard measurement, and control serum for cumulative QC.

① Dispense the samples.


Place a calibrator for Single point calibration and a control sample on the CTT posi-
tions and a calibrator for Multipoint calibration on the STT position.
Ensure that there are no air bubbles on the surface or the base of the samples.

② Start measurement.
a. Click START in the Operation Panel Window.
The Start Condition dialog box appears.

b. Click Analyze for Multipnt.smp under Calibration.


Select this measurement type when measuring the samples for multipoint
calibration. Select 98 or 99 for TTNo.
c. Click Analyze for Singlepnt.smp under Calibration.
To check or change the tests for measuring calibrations, select Temp.test select
button. (To check or change the tests for measuring controls, also select
Temp.test select button and the same dialog box opens.)
To check the position of calibrator, select Temp.sample select button.

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Temp.test select
d. Click Analyze for Control smp. under Control.
e. Click Start.
Analysis starts and data is acquired.

You can check the progress of the analysis in Test Result Monitor in Request list
(see P 1-15).
The analysis results are displayed in Real Time Monitor in Request list (see P
1-15).
Patient sample can be started at the same time as other samples. However, it cannot
be started at the same time when multipoint calibration is selected. (Patient sample
and calibrator for multiple calibration use different STT numbers)

Set the Test Select and Sample Select in advance.


To select the tests to be measured, press Calib. from Menu. In Calib. list, press Test
Select (see P 6-16) . When Test Select dialog box is displayed, check the following ra-
dio buttons to select the tests for each measurement type: 2. Control Samp.meas., 5.
Calibration meas. (BLK), and 6. Calibration meas. (STD).
To select the positions to set samples, press Sample Select (see P 6-24) to open Sample
Select dialog box.
Test Select and Sample Select opened from Calib. list are same as those opened
from QC list.

③ Check the control sample data.


a. Check the measured data in Daily Precision Control (see P 6-27) in QC list
in Menu. If the result deviates from control data that are set for each control
sample and each test by ±3SD, the graph color changes to red. Check the
result data as required.
b. Perform QC Cumulative calculation. (This is a method for registering the
average value and fluctuation range of the measured data of the current day
in QC Cumulative.) When you click Exit to close the Daily Precision
Control dialog box, the message Add Daily to QC Cumulative Data? ap-
pears. Click Yes and in the next dialog box, select the control names and

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click OK (selected control names are highlighted in blue). Use this opera-
tion to register the current day’s average data and fluctuation range in the
QC Cumulative dialog box. (If you do further analysis of the control sample
after that, open the Daily Precision Control dialog box again and after
checking the data, repeat the same procedure as above and overwrite the
average value and fluctuation range in the QC Cumulative dialog box. see
P6-29)

④ Check the calibration data.


Go to View Calibration Curve in Calib. list in Menu to check the calibration
curves (see P 6-22). You can check a test's calibration curve by selecting Test
name. In Calib. summary, you can check the calibration results for all tests and
in Calib history, you can check the calibration results for the previous 60 times.
(The most recent data is displayed on the left side of the graph.) If you need to check
only the measured data, go to Real Time Monitor in Request list (see P 1-15).

⑤ Recalibration
If the result data is poor, find the cause, solve the problem, and start again from step
2 listed above. After selecting Analyze under Calibration in the Start Conditions
dialog box, configure the necessary options for recalibration in Temp. test select.
Repeat the same procedure for Control and click Start. (It is also possible to select
Special calib. and configure the tests for recalibration.)

Be sure to always check the precision control data of the recalibrated test and
delete data as necessary by using Omit function (see P 6-29). (Data cannot be
modified.)

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1.1.3b Analyzing an Patient Sample


1. Place the sample in the Sample Tray.
Place the sample in the Sample Tray when “SMP LOAD OK” appears in the Oper-
ating Status Display. If “SMP LOAD NG” appears, SPP may move. After selecting
PAUSE button, place the sample in STT (see P 1-12). If you are going to move the
sample to a sample cup, ensure that there are no air bubbles on the surface or base of
the sample cup and check the container type before placing it.

2. Start measurement
Barcode Analysis
a. Click START in the Operation Panel Window. The Start Condition dialog
box appears.

b. Click Analyze for Routine smp. under Patient sample.


c. Select Barcode in Analyze mode.
It is not necessary to enter Tray No. or Range of sample positions when Bar-
code analysis is selected. However, if the range is entered, barcodes of the
samples in the designated range will be scanned.
d. Click Start.
Barcode reading begins and the Sample Confirmation dialog box appears (next
screen print). Check the displayed samples ID. You can modify the ID numbers or
put check marks for samples that need to be processed as priority samples in this
dialog box.

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Barcode No.

Select for priority

e. Click OK.
Analysis starts and the data is acquired.

You can set the timer to automatically start analysis when the barcode reading is
completed. Configure its setting in 34. Sample Barcode Confirm Time in Set-
ting System Parameters in Setup (see P 6-61). The set time (in seconds) is dis-
played in Starting in in the upper right corner of Sample Confirmation dialog box.
The analysis begins when this timer reaches zero.
To fix barcode read errors, see P 6-5.

Analysis by Cup Position


This is a procedure to start analysis for samples whose workorders are already reg-
istered in the analyzer. See P 1-20 Order Entry.)
a. Click START in the Operation Panel Window. The Start Condition dialog
box appears.

b. Click Analyze for Routine sample under Patient Sample.

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c. Select Cup posi in Analysis mode.


d. Enter the TTNo. that was set during workorder registration into Tray No.
field. Enter the range of sample positions (range of positions where the
samples are set) into the two fields connected by hyphen.
e. Click Start.
Analysis starts and data are acquired.

RACK Handler or LAS (Laboratory Automation System) analysis


a. Click Start in the Operation Panel Window. The Start Conditions dialog box
appears.

*his window comes up when


RACK Handler or LAS is
selected on System Speci-
fication Setting – Sample
Delivery window.

b. Select Analyze in the Routine smp. column under Patient sample.


c. Click Start.
Analysis starts and data are acquired.

When a rack handler or LAS (Laboratory Automation System) analysis is started, the
analyzer’s mode continuously changes among START, HOLD, and WAIT. Sam-
ples must be added from the rack handler or LAS during this time. If you need to
add samples directly to the Sample Tray, always follow the procedure 3-2 described
below. After the additional samples are aspirated on the Sample Tray, the analyzer
automatically returns to the rack handler or LAS analysis. However, the analyzer
mode does not automatically go to READY when the analysis from rack handler and
LAS is selected in Start Conditions. To return to READY mode, press STOP.

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1.1.3c Adding samples and interrupting analysis with a priority sample

Analyzing additional samples during Processing mode


The analysis of additional samples can be started anytime during Processing mode
by pressing START button.

Check the SMP LOAD OK (Append) indicator in the Operation Panel Win-
dow before changing the samples. Follow the step 2 “Start measurement”
listed above to start the analysis after changing the samples.

Adding a sample to the Sample Tray or analyzing a priority sample during


START mode (during sampling) or when rack or LAS are online
① Using the PAUSE button
a. Click the PAUSE button.
The analyzer changes from PAUSE Shift mode to PAUSE mode.
PAUSE mode temporarily stops sampling (SPP operations).

b. Check that the analyzer is displaying SMP LOAD NG(Append) (when the
rack and LAS are online, the analyzer displays SMP LOAD OK(Append)),
then place the sample in the Sample Tray. Follow the step 2 “Start meas-
urement” listed above to continue the analysis.
When the analyzer is in START mode, HOLD mode, or WATCH mode,
PAUSE or STOP button can be selected. If STOP is selected, SPP stops as-
pirating new samples and the analyzer goes to STOP mode. The analyzer can
be restarted at this point. If you do not restart the analyzer, it changes from
END mode to READY mode.

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② Using the SmartPAUSE function (this can only be used during barcode analy-
sis).
This function cannot be used during analysis by cup positions and multipoint
calibration measurement. Do not open the Sample Tray cover in these situa-
tions.
a. Open the Sample Tray cover.
The Shift to PAUSE・STT impossible to remove(Add impossible) dialog box ap-
pears.

Do not close the Sample Tray cover when the Shift to PAUSE・STT impossible
to remove(Add impossible) dialog box is displayed.

b. When the analyzer changes to Smart PAUSE mode, place the sample and
close the Sample Tray cover.
c. The analyzer automatically starts reading all the barcodes of the STT and
the Sample Confirmation dialog box appears. Check the displayed sample
IDs and make changes as necessary. Put check marks to the samples that
need to be processed as priority samples. (see P 1-10)
Smart PAUSE function can be used only during the barcode analysis. Also, fol-
lowing settings must be configured before using Smart PAUSE:
Select Setup in Menu. From the Setup list, select System Specification Settings.
(see P6-46)
In the System Specification Set dialog box, select as follows:
Under System Basic Configuration, select Avail. for Sample Barcode.
Under Basic System Operation Mode, select Rerun tests or Incomplete tests for
Rerun Flag.
Under Smart Pause, select Avail for STT Cover.

③ Using the STAT function


You can use the STAT operation to interrupt measurement while the analyzer is in
START, READY, Processing, PAUSE, HOLD or WAIT mode (when the STAT
lamp on the analyzer is green).
a. Place the sample in the STAT port and use the lever to push the port in. (The
STAT lamp on analyzer unit turns orange. When the lamp is orange, do not
take the sample out of the STAT port.)
b. When the analyzer recognizes the STAT sample, STAT Port dialog box ap-
pears.
c. The barcode number appears in Sample No.

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d. Check the sample ID and click Start to start the analysis of the STAT sample.
The analysis is started automatically when the set time has passed. The
default setting of the timer is 15 seconds.
You can check and change the timer settings in Setup–Setting System Pa-
rameters–39:STAT Port Request Screen Timer (see P 6-61).
e. STAT Port dialog box will close when the aspiration of the STAT sample is
completed. When the STAT lamp on the analyzer changes back to green,
you can pull the lever to take the port out and set a next STAT sample.

If you are going to measure barcode samples with STAT, you need to configure
Avail. in advance in Setup–System Specification Set–STAT Port Barcode (see
P6-46).
When you are setting a sample with no barcode for STAT analysis or when the
STAT Port Barcode setting in System Specification Set is N.A., workorders can
be selected in STAT Port dialog box under STAT Set Specification (Configure it
in advance in Request–STAT Order Setup (see P 3-2)). The samples ID incre-
ment from S01 to S100. You can change the Container Type and Order Test by
clicking the Temporary Change button (see P 6-6).

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1.1.3d Check the data and the status of analysis.

Checking the status of analysis


You can check the status of analysis for the samples you placed into the current Tray in
Request–Test Result Monitor (see P 6-11).

These are displayed


only when Auto
rerun is set.

The latest data are displayed in Test Result Information. The remaining analysis time
and finish time will be displayed when you double click on the sample positions. Click
Analyzing Sample Info. button to display the status of samples being analyzed from the
rack handler or LAS.

Checking the data and analysis history


You can check data and analysis history in Request–Real Time Monitor (see P 6-18).
In the left-hand panel, click a sample ID and highlight it in blue. Result data of the
highlighted sample will be displayed in the right-hand panel.

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You can specify the range of data to print by clicking Print. (There are 2 types of displays
and print formats.) You can change them in Maint–System Monitor (see P 3-12).

Checking the information of the measured sample


You can check the measurement history in Request–Sample Log (P 6-18).

Checking a rerun sample or untested tests


Go to Request–Review/Edit dialog box to check the status of reruns and untested tests.
Click the sample ID in the left side of the screen to display the selected sample’s workor-
der and data on the right side of the screen under Sample Information. If an asterisk is
displayed in the “R” column in the left side pane, perform a rerun as required (see P 2-1).

The color code for the Order # is as follows:


Gray: Untested (the sample has not been analyzed yet)
Pink: Analysis is in process.
Blue: Analysis is completed.
Yellow: Flags were posted to some tests and they need to be rerun.
Cyan: Some tests remain untested.

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1.1.4 SHUTTING DOWN THE ANALYZER


If the RACK Handler and LAS are online, click STOP and set the analyzer to
READY mode.

1.1.4a Shut Down Wash


① Place REAGENT PROBE WASH-K (20%) into no.44 of RTT1 and 2, and pure
water into No.45 of RTT1 and 2.
For ISE electrode wash, place ISE Detergent Solution into the position that is
selected in Detergent Position of ISE Parameters Setting in Setup. (see P
5-5).
② Click WASH in the Operation Panel Window.

③ Select WASH2 and click Execute.


WASH2 is completed in about 39 minutes.

1.1.4b System Exit


System : BioMajesty control program
Shut down the system in READY or WAIT mode.

① Click System—Exit.

The exit confirmation window appears.

② Click Yes.
The exit confirmation window appears again.

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③ Click Yes.

After about 15 seconds, the BioMajesty Startup


Window appears.

1.1.4c Shutting down the Workstation and the Analyzer unit.


① Click Shutdown.
The computer and the analyzer unit are turned off.

② Turn off the main power switch on the computer rack.


The LCD monitor, printer, and computer are turned off.

1.1.4d Turning off the Water Supply Unit.


① Turn off the switch.
② Close the faucet.

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1.2 BASIC STEPS FOR ROUTINE OPERATION (FLOW


CHART)

Start Up Analyze

Open the faucet and Start Water Supply Unit


*Calibration/QC*
Turn on Workstation (computer rack)
Dispense/Set the samples
Computer power on
START
(after BioMajesty Startup Window)

OK Calibration
Run single point calibration and multip
INITIALIZE point calibration Temporary change f
Auto Startup

Test Select BLK and STD)


After READY mode
*check the check items Run Control
before starting the operation
*Check that reagent and detergent have START
been adequately replenished
(Start analyses)
PRIME 1 “Daily Precision Control”
”QC Cumulative”
WASH3

* Patient Sample*
Analyze (Set the samples)
START
1
- Barcode analysis
Completion START
(After reading the barcodes)
Confirmation
WASH 2

Use REAGENT PROBE WASH-K once a week (After entering work orders)
2
Auto Shutdown

Shutdown the system - Cup Position


Analysis
(BioMajesty Startup Window) Tray number
START
Shutdown

(The computer is automatically turned off) (Start analyses)

Workstation (computer rack) is turned off For STAT/Priority samples,


execute PAUSE (or STAT)
(Turn off the Water Supply Unit
and close the faucet) Check the data in Review and Edit Window.

Enter password(manager)

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1.3 ORDER ENTRY


To enter a workorder in the analyzer, select Order Entry in Request.
1.3.1 Steps to start analysis per cup position
① Verify that No Regist. is displayed on Sample Workorder Information.
(No Regist. means that the Order no. is not used for any other workorders.
If Registered is displayed, click New to display an unregistered Order no.)
② Enter the Posi. no.
Example:
For the box on the left, enter the TT (STT Tray) number 1 (Select a
number from 1 to 97).
For the box on the right, enter STT position number 1 (Select a number
from 1 to 84)Enter the Samp. no. (numbers only)
③ Enter the Samp. no. (numbers only)
④ Select the Container type.
The data here supersedes the container type configured in Request–Cup/Tube
Assign for the STT position. (see P3-1)
⑤ Select the tests to run from the Test table.
⑥ Click the Enter button.
⑦ The Order no., Posi no., and Samp. no. are all incremented by 1. You can
repeat step 4, 5 and 6 to continue registering workorders unless you want to
specify different numbers for the workorder.

If you use the same number for Order no., Posi no., and Samp. no. on the same day,
the data of workorder that is already registered is displayed in the fields. If you
click the Enter button, a message dialog box is displayed to prompt if you want to

1-20
1 BASIC OPERATION

overwrite the data. If you do not want to overwrite the data, click New and enter
the workorder from step 1).
• Enter Samp. type, Dil. factor, and Comment, if required.
• Note that Container type, Samp. type, Dil. factor and Sex remains the same on the
display once they are changed and registered in a workorder. These information do
not automatically go back to the default settings.
• If you have set a group of tests in Profile set in Profiles, you can select tests in the
registered set of tests by clicking one test name. Click the Create Profile button to
create a set of tests.
• To review the registered samples, click the View worklist button, select all and click
OK. You can check the sample volume required for the workorders.

1.3.2 Using Batch Entry to register samples


(When registering same tests for multiple samples)
① To register same tests for multiple samples, complete steps 1 to 5 described
above and then click the Batch Entry button.
② Select the Last no. entry format from Samp. no., Posi. no., or Number of
samples, and enter the necessary data for the tests. Click Execute.
③ The Order no. is incremented according to the number of samples registered
in batch. The window then displays the next unregistered number for the
next workorder.

1-21
1 BASIC OPERATION

1.4 AUTO SYSTEM STARTUP/SHATDOWN


1.4.1 Standard Operation
When Auto System Startup/Shutdown is executed after completing the analyses, the ana-
lyzer will perform the shutdown operation according to the settings and start up on the
specified date to complete the preparatory operations and to be ready for the analyses.
Configure the settings in the System Startup/Shutdown Setting dialog box in Maint. to
execute Auto System Startup/Shutdown. (Ensure that the switch on the Power Panel is set
to PC CONTROL.)

1.4.1a Check the settings


Set the settings in the System Startup/Shutdown Setting in Maint.

(b) (d) (a)

(c) (e) Fig. 1

① Auto Startup Settings


The settings can be configured per day. Check the checkbox for every day to
automatically start up the analyzer everyday. (See Fig. 1-(a)) The analyzer starts
up on the specified date and time that are closest to the date and time when the Auto
Shutdown was performed.
• Example: Check the day to start up the analyzer (Mon – Fri or Sat). Enter the
start up time (4-digit number). Check ‘Do’ in Wait reaction bath to
warm and select ‘New Start’ for System Start. Select PRIME1, check
WASH3 and check Cuvette Blank for once a week.

② Auto Shutdown Setting


Set Mode set to Shutdown and select Set1, Set2 or Set3 in Proc. Set. (Refer to Fig.
2 on the next page.)

1-22
1 BASIC OPERATION

• Example: Select Proc. Set to ‘Set1’ to combine the Auto Shutdown with Auto
Startup. Set System p.s. to ‘Power off’ and System end to ‘System end’.
Set WASH2 and End ISE operation as required.
If combining Auto startup and Auto Shutdown, do not select Shutdown or
Nothing in System End. If System end is set to Shutdown, the system cancels
the Auto startup during the shutdown process. If Nothing is selected, the
computer remains turned ON and Auto startup does not take place.

Fig. 2

1.4.1b Executing Automatic Startup from Auto Shutdown


① Set the wash solutions and pure water for the evening wash (WASH2) and
wash for the next morning (WASH3).
• ShutDown wash (WASH2)
Set REAGENT PROBE WASH-K(both 20%) in No. 44 on RTT1 and RTT2
Set pure water in No.45 on RTT1 and RTT2.
CTT setting position:ISE DETERGENT SOLUTION (see P5-6)
• Startup Wash (WASH3)
Set pure water in No.45 on RTT1 and RTT2.
② Open System Startup/Shutdown in Maint.
③ Check if Activate Auto startup is selected for the day to start up the analyzer
automatically. (Fig. 1-(a))
To stop Auto Startup on holidays, uncheck the Do checkbox of the day. Save
the setting after the change. (Fig. 1-(b))
④ Click On in Enable auto start to display On in State (Fig. 1-(c) ).
⑤ Check Proc. Set for Shutdown in Select wash routine. (Fig. 1-(d))
⑥ Click Yes in Select wash routine. When a dialog box with the question
“Start the shutdown process?” appears, click Yes. (Fig. 1-(e)).
The auto shutdown program is executed according to the configured settings.

If you configure the Shutdown settings as up to the step (6) above while the analyzer
is in a mode other than READY, Start is will be displayed in Time remaining to
indicate that the Shutdown process is pending. The Shutdown process automatically

1-23
1 BASIC OPERATION

starts when the analyzer mode changes to READY. Click Cancel to cancel the
pending Shutdown process.

If you want to stop the Auto Startup process after it has begun, click Stop in the top
left-hand corner of the System Startup/Shutdown Setting dialog box. When the
current step is completed, the Auto Startup process stops.

If you need to cancel Auto Startup after On button under Enable auto start is se-
lected, click Off and ensure that the Start field is blank. If the System
Startup/Shutdown Setting dialog box is closed without selecting Off, the Auto
Startup is still on.

1.4.1c Standing by for auto-startup


When the analyzer enters Auto Startup standby mode, the Standing by for auto-startup
dialog box displaying the Auto Startup time appears in the screen. When this dialog is
displayed, the analyzer is in Sleep mode with the power supplied only to the Chiller.
The analyzer will start up according to the Auto startup settings.

To cancel auto startup, click Cancel in the above dialog box and the BioMajesty
startup window will appear. If you cancel Auto Startup as soon as the analyzer
starts up, it takes about 5 minutes for the BioMajesty startup window to appear.
Check that New start or Re-start has been selected and click OK to perform the
normal startup procedure. (Click the OK button to activate the analyzer from Sleep
Mode.)

1.4.1d Completing Auto Startup procedure


When Auto Startup process is completed, the dialog box on the right appears. Enter the
user name and the password if you set in User Code Settings, and Click OK. The ana-
lyzer then enters READY Mode.
You cannot perform any operations on the screen while the analyzer is automatically
starting up.
Do not click × to exit the screen. If you
accidentally click ×, click Change User from
System .(see P1-17 System Exit.)

1-24
1 BASIC OPERATION

1.4.2 Other Functions


Using Startup
This function can be executed when the analyzer is in READY mode.

① Select Startup in Mode Set and configure the PRIME, WASH, and Cuvette
Blank processes in Set 1 to 3.
② Ensure Startup under Select wash routine is selected, select the Proc. Set.
and click Yes to execute it.

When all the settings in Startup process set are completed, the analyzer returns to
READY mode.

1-25
2 DATA
2.1 RERUN SAMPLES............................................................................................ 2-1
2.1.1 Checking data ............................................................................................. 2-1
2.1.2 Checking reaction process.......................................................................... 2-1
2.1.3 Checking reanalysis conditions .................................................................. 2-2
2.1.3a Flag settings ........................................................................................ 2-3
2.1.3b Setting reanalysis conditions............................................................... 2-4
2.1.3c Confirming reanalysis conditions........................................................ 2-4
2.1.4 Automatic rerun.......................................................................................... 2-5
2.1.4a Rerun settings...................................................................................... 2-5
2.1.4b Reruns ................................................................................................. 2-6
2.1.5 Rerun data................................................................................................... 2-6
2.2 REACTION PROCESS...................................................................................... 2-7
2.3 REALTIME MONITOR (STANDARD FORMAT)......................................... 2-10
2.4 FLAGS FOR CALIBRATION AND CONTROL DATA................................. 2-11
2.4.1 Calibration ................................................................................................ 2-11
2.4.2 Precision control....................................................................................... 2-12
2.5 ALARM FLAGS .............................................................................................. 2-13
2 DATA

2.1 RERUN SAMPLES


Follow the procedure below if the result of sample analysis is abnormally high or low.
(Reruns cannot be performed for calibration and control results)

2.1.1 Checking data


You can check the analysis data in the Review/Edit window.
Go to Request and select Review/Edit.

Review/Edit

The samples with yellow icons in the Order # column or asterisks (*) in the R column
have rerun flags. If you click the order number, the ordered test and information on the
measured data appear in the middle of the window. The tests with check marks (√) dis-
played in the R checkboxes will be rerun.

The colors in the Order # column show the following.


Gray: Untested Pink: In process Blue: Complete
Yellow: Data set has an abnormal flag and there are tests to be rerun.
Cyan: There are untested tests.

2.1.2 Checking reaction process


Check the reaction process in the Reaction Monitor window.
Go to Request and select Reaction Monitor.

① Go to Reaction Monitor window (the figure below). Select Sample Type and en-
ter necessary information such as a sample number in Sample list.

2-1
2 DATA

② Select a test name from the Test name list to display the reaction process (the
curve displayed in green). Detailed data of the reaction process is displayed in
React.proc.data box.
③ Check Approx.curve box to display detection points on the reaction process curve.
Check M/S-WL box to display main wavelength in red and sub wavelength in blue
on the curve.
④ Check the reaction process.

The following example shows the reaction process when AMY is 10926 IU/L and data is
flagged “H”, “u”, and “n”.

Reaction Monitor

2.1.3 Checking reanalysis conditions


Use the Analytical Parameters (Chemistry) window to set and verify the analysis and
rerun conditions.
Go to Setup and select Analytical Parameters (Chemistry). (see P6-47)
You must log on as ‘manager’ to access window under the Setup button. (see P3-1)

2-2
2 DATA

Analytical Prameters (Chemistry)

2.1.3a Flag settings

Configure settings for posting flags.


Press Abnormal value setting button to display the dialog box.
Use this dialog box to set Abnormal value (L1) and Abnormal value (H1) for Main (M).
If analysis results are outside this range, the analyzer posts flags “H” or “L” to the result
to indicate abnormality.
In this example, since the measured value is greater than 1500, which is the value set for
Abnormal value (H1), the analyzer flags the data “H.”

Abnormal value setting

In the initial analysis (M), if the data are outside the range from Abnormal value
(L1) to Abnormal value (H1), the analyzer posts “H” or “L” flags to the result.
For the reruns (using Dilute1 (D1)), if the data are outside the range from Abnor-
mal value (L2) to Abnormal value (H2), the analyzer posts “H” or “L” flags to the
result. (The settings for Dilute 2 to Dilute 4 are for immunoassay tests.)

2-3
2 DATA

Refer to the Calculation method setting in Analytical Parmaeter (Chemistry) screen.


The absorbance is calculated using the data M-DET.P.m (28) to M-DET.P.n (37). How-
ever, the data whose absorbances are 1.6000 or more (setting for Sample (u)) are not
used for the calculation. Since the number of detection points for the calculation is not
sufficient, the analyzer uses the data points back to M-DET.P.l. Even so, the number of
detection points is four. Since it is less than six, the analyzer flagged the data “u” and
“n.”

2.1.3b Setting reanalysis conditions

Configure conditions for reruns.


Use Reanalysis Conditions Set dialog box to set rerun conditions for M or D1 (D2, D3,
D4). (You can set multiple conditions.)
•M The same conditions as the initial run
• D1–D4 In the Reanalysis conditions dialog box, you can set up to four rerun
conditions. Normally, use only D1 for the chemistry tests. D2 to D4
are mostly used for analysis of immunoassay tests with multiple
dilutions. (Refer to the next page for Reanalysis Conditions.)

Reanalysis Conditions Set

In this example, if the data are flagged “H” (Abnormal value (H): 1 in the above dialog
box), the test will be rerun using conditions D1.
(If you specify multiple rerun conditions to one flag, the test will be rerun using all se-
lected conditions. If data has multiple flags, the test will be rerun using all conditions
selected for each flag.)

2.1.3c Confirming reanalysis conditions

Check the rerun conditions you configured.


Use Reanalysis conditions dialog box to confirm the conditions you selected for reruns.

2-4
2 DATA

Reanalysis conditions

When you are using multiple dilution conditions, set them in the order of low dilu-
tion ratio to high dilution ratio: from Dilute 1 (D1) to Dilute 4 (D4).

If you set the conditions as discussed in setps (a) to (c), the selected reanalysis conditions
will appear in Dil.cond box in Review/Edit screen (P 2-1) when the result data is flagged.
You can start reruns immediately or you can change the Dil. Cond, save it, and start re-
analysis.

2.1.4 Automatic rerun


You can set the analyzer to start reruns automatically by using the following settings.
2.1.4a Rerun settings
Go to Setup and select System Specification Settings. (see P6-46)
Check the reanalysis settings in Basic System Operation Mode.
You must log on as ‘manager’ to access window under the Setup button.

System Specifications Set

2-5
2 DATA

Auto.retest
• N.A.: The analyzer does not start the rerun automatically. You need to start it
manually. The analyzer performs the rerun according to Rerun Flag. Settings.

• STT Retest: When the rerun is ordered, the analyzer automatically dispenses the
sample from STT and dilutes it according to the rerun conditions (settings in the Re-
analysis conditions dialog box), and then analyzes it. You cannot remove the sample
from the analyzer until dispensing has been completed. (SMP load NG)
Rerun Flag (When N.A. is selected for Auto.retest)
• Rerun tests: After the analyzer runs all tests, it reruns the tests with no result values
and the tests with rerun ordered. .
• Incomplete tests: After the analyzer runs all tests, it reruns the tests with no result
values.
• All tests: After the analyzer runs all tests, it reruns all tests.

The settings you have changed in the System Specifications Set window take effect
after you click the Save button and perform New Start in the BioMajesty startup
window. (Refer to P 6-46.)

2.1.4b Reruns
If you select N.A. for Auto.retest as shown in the example, you need to start the analysis
manually.
If the computer is connected to the host computer system, check in advance how the
host computer handles the rerun data.

2.1.5 Rerun data


Since the analyzer multiplies the rerun result by the dilution factor, you can compare it
with the initial result, which is the value before dilution. The results appear in the Re-
run val. boxes in the Review/Edit window in Request.

In the example analysis result shown above, the information on the data is as fol-
lows:
Sample vol of AMY: 1.3 μL
Concentration at the initial run: 10926 IU/L
Flag: H, u, n
(The absorbance is greater than the value set for Abnormal value (H1) and the
number of data points used for calculation is only four.)

For the rerun data that were analyzed using the D1 conditions, if the data is greater
than or equal to the value set in the H2 box for Dilute 1 (D1) in the Abnormal
value setting dialog box (refer to P 2-3), the analyzer flags the data “H.” If the
data is less than or equal to the H2 setting, the analyzer flags the data “L.”

2-6
2 DATA

2.2 REACTION PROCESS

End Point Assay (EPA)


Main
OD wavelength
596nm
0.2 R2
Five min Detection
10 min

Sub
w av elength
694nm

S-DET.P.p S-DET.P.r M -DET.P.m M -D ET.P.n


17 19 40 42
If you specified S-DET.P, the system calculates the concentration after subtracting the mean
absorbance in the range from S-DET.P.p to S-DET.P.r from the mean absorbance in the range
from M-DET.P.m to M-DET.P.n. The system performs the blank correction for the subtracted
data. The system calculates the mean value after excluding the highest and lowest values.
(In the one-part reagent, S-DET.P.p and S-DET.P.r are zero.)

Reaction Rate Assay (RRA)


Example: NADH reaction

R2
OD Five min

1.0
Main
wavelength
340nm
Blank (d)
Detection
6–10 min

Sample (d) Sub


wavelength
410nm
E2(Serum indices) M-DET.P.l M-DET.P.m M-DET.P.n
Mean OD at detection points 4 and 5 23 26 42

The system calculates the concentration using the mean of the changes in OD per minute that
is calculated using all the data from M-DET.P.m to M-DET.P.n. The system performs the
blank correction for the mean value before calculating the concentration.

2-7
2 DATA

Example: When the activity is high (in decreasing reactions)

Since the system has only three data


OD points it can use for the calculation
even if the system goes back to find
1.0 Reagent blank data, the system flags the data “d.”

Blank (d)
Since the OD of the
sample is greater (darker)
than the OD of the reagent
blank, the system adds the M ain
difference between the two w avelength
OD values to sample (d).
340nm
Detection
Sample (d) 6–10 min
Sub
wavelength

M-DET.P.l M-DET.P.m M-DET.P.n


410nm
E2(Serum indicens)
Mean OD at detection points 4 and 5 25 27 42

The system does not use the detection points whose OD values are less than sample (d) (in a
decreasing reaction) or are greater than sample (u) (in an increasing reaction). If the number
of detection points in the range from DET.P.m to DET.P.n is five or less, the system goes back to
find a total of six detection points for the calculation, but does not use the data beyond the point
DET.P.l. If the number of detection points is five or less, the system flags the data “d” (in a
decreasing reaction) or flags the data “u” (in an increasing reaction).

Main
wavelength
Example: When the activity is high (in increasing reactions) 410nm
Detection
6–10 min

Sample (u)
Since the system has
only three data
OD points it can use for
the calculation even
1.0 if the system goes
back to find data, the
system flags the data
“u.”

Sub
Reagent blank wavelength

505nm
E2 M-DET.P.l M-DET.P.m M-DET.P.n
Mean OD at detection points 4 and 5 25 27 42

2-8
2 DATA

Prozone check

The following example of setting M-DET.P and S-DET.P is for checking prozone. These are different
settings from those for calculating OD.
Example 1 Rate assay: As the following figure shows, the system compares both variations
from M-DET.P.m to M-DET.P.n and from S-DET.P.p to S-DET.P.r. (Apr and
Amn are variations.) If the difference between the two variations is big, the
system judges that the data is in the prozone and flags the data “P.”

Apr Amn
0.8

OD

S-DET.P.p S-DET.P.r M-DET.P.m M-DET.P.n


24 27 34 37
If the calculated value Amn/Apr is greater than or equal to Prozone limit (for example,
0.35), the system judges that the data is in the prozone and flags the data “P.” (Prozone
judgment: lower limit)
If the absolute value Apr is less than or equal to Judge limit, the system does not flag the
data “P.”

Example 2 Prozone formula: If the calculated value Amn/Apr − K × Apr is greater than or
equal to Prozone limit, the system judges that the data is in the prozone
and flags the data “P.” The value K is automatically calculated when the
system performs the liquid volume correction. (Prozone judgment: upper
limit) (Refer to the right figure below.) At this time, the system performs
the liquid volume correction for the OD value at S-DET.P.r.
However, since S-DET.P.p and S-DET.P.r are usually zero, the system judges it
using the median of the data between M-DET.P.m and M-DET.P.n. (Prozone
judgment: upper limit) (Refer to the left figure below.)

Amn
2
Amn
OD Prozone limit value 0.8 Abnormal sample
Apr
OD
Adding antigens
and so on

Normal sample
M-DET.P.m n S-DET.P.p r M-DET.P.m n
27 29 17 19 40 42

2-9
2 DATA

2.3 REALTIME MONITOR (STANDARD FORMAT)

検体番号
Samp.no 位置番号 コメ ント 1コメ ント
Comment 性別 年齢 検体種別
Samp.type 希釈係数
Dil.factor 採血日
Positionnumber
Position number Comment1 Comment
Comment22 Sex Age
Date of taking blood

Flag

Samp.no Sample ID number is displayed. Below is the example how some IDs are
displayed.
Patient samples: ID number from sample barcodes or manually entered ID
number
One-point calibration: ‘C’ for calibration, CTT position number, number of
analyses (e.g. C0101).
Multipoint calibration: ‘M’ for multipoint, turn table number, position num-
ber, number of analyses (e.g. M980101)
Control: type of control, number of analyses (e.g. PA001)
Conc. Measured values appear for control samples and routine samples.
For reagent blanks, the value 0 appears. The FVs appear for the standard
samples.
Flag If the data have flags, they appear in this column.
ABS-RB The calculated absorbance from which the reagent blank has been sub-
tracted.
ABS ABS is the result of ABS1 – ABS2, where ABS2 is corrected for the liquid
volume. (In RRA, the changes in OD are used for calculating absorbances.
In EPA, the OD values are used for calculating absorbances.)
For the reagent blank, the OD values of the measured reagent blank appear.
E1 In RRA, if you specified Check D.P., the OD value at the main wavelength
appears. Otherwise, the OD value at the main wavelength at M-DET.P.m
appears.
In EPA, the OD values at the main wavelength at M-DET.P.m appear.
E2 E2 data (the mean of the 4th and 5th detection points), which is the OD value
at the main wavelength.
ABS1 The calculated value at M-DET.P (OD value)
ABS2 The calculated value at S-DET.P (OD value)
N Number of data points used for calculation
S The dispersion of absorbances used for calculation, expressed as a percent-
age of absorbances.
P The calculated value of prozone check
RRV Number of the reaction cuvettes used

2-10
2 DATA

2.4 FLAGS FOR CALIBRATION AND CONTROL DATA


2.4.1 Calibration
Go to Setup and select Analytical Parameters (Chemitry). Under Standards setting in
this window, you can set BLK H, BLK L, STD H, and STD L. If the data are outside of
the range specified here, the H or L flag appears in the Flag column in the Realtime
Monitor dialog box.

• Example: ALB
Reagent blank (ABS) 0.05575
Standard (ABS-RB) 0.11501

You can check the values in the Calibration Summary dialog box.
Go to Calib. and select Veiw Calibration Curve. Click Calib. Summary button.

For the tests of the reaction rate assay (RRA analysis method), if the data are outside of the
range defined by Blank (u) and Blank (d) in the Analytical Parameters (Chemistry) window,
the analyzer flags data “U” or “D”. Go to Setup to open Analytical Parameters (Chemis-
try) window.

Reaction Monitor

Go to Setup and select Analytical Parameters (Chemitry) to open Error judge rate (vs.
previous data). (see P6-47) In this dialog box, set the acceptable value (%) for the difference
between the current calibration data set and the previous one. If the difference is greater than

2-11
2 DATA

the acceptable value, an error occurs and the analyzer


flags the data “Z.” At this time, the calibration data
are not updated.

If you want to activate this function, select


the Do check box for Error judge rate
(vs.previous data) in the System Monitor
window. Go to Maint. and select System
Monitor.

Error judge rate (vs. previous data)

2.4.2 Precision control


For each control (total of 26, A-Z), you can set the mean and the standard deviation for
the daily precision control purpose (refer to P6-37). Go to QC and select Control Data
Definition dialog box to set the mean and SD values. The result data is flagged accord-
ing to the rule below and the flags are displayed in Realtime Monitor next to the result.

H
3 × Standard deviation (3SD)
h 2 × Standard deviation (2SD)

No flag Mean (X)

l 2 × Standard deviation (2SD)


3 × Standard deviation (3SD)
L

• If the result is within ± 2 × SD of the mean, the data is not flagged.


• If the result is within the range between ± 2 × SD of the mean and ± 3 × SD of the
mean, the data is flagged with “h” or “l”.
• If the result is out of ± 2 × SD of the mean, the data is flagged with “H” or “L”.

Example: Control A (data)


GOT 64.2
GPT 34.6
AMY 87.9 h
TP 8.45 H
ALB 4.96

Control Data Definition in QC

2-12
2 DATA

2.5 ALARM FLAGS

Flag Alarm name Judgment conditions

/////// Overflow Analyzer is unable to perform the calculation


S Safety When an error occurs, the analyzer judges that the error in-
(uppercase) fluences the data.
S Sample shortage
(lowercase)
t Diluent shortage
(lowercase)
R Reagent shortage
(lowercase)
N Cuvette blank Difference between the two values of the cuvette blank used
(uppercase) for measurement is too large

u,d Absorbance limit In the RRA and IMA methods,


(lowercase) Number of data points usable for calculation is insufficient
due to abnormally high value
The data is flagged “u” in the increasing reaction, “d” in
the decreasing reaction.
In the EPA method,
If the data set has an abnormally high value, the analyzer
flags the data “u.”
If the data set has an abnormally low value, the analyzer
flags the data “d.”
* Variance The data during reaction process fluctuates greatly
n Effevt.nbr.o.pnts In the RRA and IMA methods,
(lowercase) Number of data points usable for the calculation is insuf-
ficient
P Prozone The result value exceeds the prozone limit value
(uppercase)
h,l Normal value For routine samples,
(lowercase) the result value is outside the normal value range
For control samples
the value is within the range from 2SD to 3SD or from
–3SD to –2SD of the saved statistics value

H,L Abnormal value For routine samples,


(uppercase) the value is outside the abnormal limits
For control samples
the value is outside the range ±3SD of the saved statis-
tics value

R Reanalysis The result data are rerun data


(uppercase)
C Calib.Error The analyzer cannot calculate the concentration due to bad
(uppercase) calibration results. (e.g. no calibration data, unable to
calculate the approximation curve, etc)
A Clot Error Clot sensor has detected a clot
(uppercase)

2-13
2 DATA

M Mix Error The rotation and reciprocation movement of the mixing rod
(uppercase) is less than the specified number of times
Q Liquid level sen- Air is aspirated while aspirating sample from SPP
(uppercase) sor error
G Crash The edge of the probe has collided with something when
(uppercase) SPP was descending.
If a crash occurs, the analyzer mode changes to WAIT.
Z Abnormal cali- The difference between the currently measured calibration
(uppercase) bration data ABSs and the previously measured one is outside the ac-
ceptable range.
Acceptable range (%) < | previous ABS – new ABS | / previous
ABS × 100 (%)
Refer to the instruction manual for the details.

2-14
3
SETTINGS
3.1 VARIOUS SETTINGS....................................................................................... 3-1
3.1.1 STAT Sample Operation and Sample Container Settings .......................... 3-1
3.1.1a Priority settings ................................................................................... 3-1
3.1.1b Setting the container shape.................................................................. 3-1
3.1.2 STAT Order Setup ...................................................................................... 3-2
3.1.3 Reagent PAUSE .......................................................................................... 3-2
3.1.4 Reagent ....................................................................................................... 3-3
3.1.4a Check the remaining amount of reagent in Reagent — Reagent
Test Monitor. ....................................................................................... 3-3
3.1.4b If the reagent becomes empty during analysis without using the
settings from the Auto Reagent PAUSE function ................................ 3-4
3.1.5 Change of Reagent Bottle Size................................................................... 3-4
3.1.6 Change of Reagent Bottle Position............................................................. 3-5
3.1.7 Reagent Barcode Setting ............................................................................ 3-5
3.1.8 Change of STD........................................................................................... 3-6
3.1.8a One-Point Calibration Curve............................................................... 3-6
3.1.8b Multi Standard..................................................................................... 3-6
3.1.9 Change of Calibration Curve...................................................................... 3-7
3.1.10 QC Sample Definition ................................................................................ 3-8
3.1.11 Control Data Registration......................................................................... 3-10
3.1.12 Changing RealTime Monitor Window Display (Same as in Batch
Print)......................................................................................................... 3-12
3.1.13 Batch Print................................................................................................ 3-13
3.1.14 Save of Text File....................................................................................... 3-13
3.1.15 Screen Print .............................................................................................. 3-13
3.1.16 Setting of Analytical Parameters (Serum) ................................................ 3-14
3.2 NEW REGISTRATION ................................................................................... 3-17
3.2.1 New Test Registration (Chemistry) .......................................................... 3-17
3.2.2 New Test Registration (Ratio)................................................................... 3-21
3 SETTINGS

3.1 VARIOUS SETTINGS


■ Windows, in which you can change the settings (e.g. Setup), do not appear
in usual start-up operations. In order to open the setup window, perform the
following operations:
① Click System(S) in the menu window.
② Click Password from the menu.
③ Enter “manager” in User Name and click OK.

The Setup menu is added to the menu window, and the window where you can change the
settings is added to the menu. By opening the window, you can perform confirmations,
entries, and changes to the settings. In order not to open the window (return to the original
state), enter “user” in the same place.

3.1.1 STAT Sample Operation and Sample Container Settings


You can make the priority settings or specify a container in advance for the STT position.
You can make this setting in Request – Cup/Tube Assign (password: manager).
3.1.1a Priority settings
Click the “I” column of the STT position
number and place the check flag[√], to
register the position as a priority.
Example: The STT position numbers 81
to 84 are specified as priority positions
(example on the right).
3.1.1b Setting the container shape
You can set and fix the Container type
for each STT position.
Example: The STT position numbers 76
to 80 are fixed as 2:JCUP/10mlT (ex-
ample on the right).

The setting in this window is given priority


over Container type in Request – Order Entry.
You can make a change to the container or
make a temporary change of the priority in
Tempo.cup/tube select in the Start condi-
tions window from START.

3-1
3 SETTINGS

3.1.2 STAT Order Setup


When you analyze a sample without a barcode at a STAT port, you can perform a measurement
by selecting it from STAT Set. You can use up to 10 types of test profiles.
You can set test profiles in Request – STAT registration (password: manager). Enter
comments (STAT set name), Samp.type, Container type, Test name, and other informa-
tion in each STAT set (0-9) in advance. (They can be temporarily changed during meas-
urement.)
For usage, see P1-13.

3.1.3 Reagent PAUSE


This is a function to refill or replace the reagents during analysis.
① Click the R-PAUSE button in the operation panel, to change the analyzer from
the R-PAUSE SHIFT to R-PAUSE mode. The following Reagent Bottle Scan
window appears.

3-2
3 SETTINGS

② The RTT position number without enough reagent turns red and is automati-
cally displayed with a check flag. Check for other tests to scan for remaining
levels. (The RTT position of the test, in which its number of remaining test
times falls below the setting, turns yellow.)
The bottle position of a test using a reagent barcode is not checked automatically. Be
sure to check to see if the test is checked if the reagent returns to the same position
after refill or replacement.

③ Refill or replace the reagent.


④ Select Barcode scan Bottle scan or Bottle scan and click Start. Analysis
resumes after scanning.
Auto Reagent PAUSE
By using the Auto Reagent PAUSE function, if the reagent runs out during analysis, the
analyzer automatically enters the R-PAUSE mode, and you can add the reagent. Set Avail.
in Auto Reagent PAUSE in Setup – System Specification Settings (Password: manager).
After that, follow the same steps from ②.

3.1.4 Reagent
3.1.4a Check the remaining amount of reagent in Reagent — Reagent Test
Monitor.

• For each test, the number of remaining test times, RTTNo. and Remain vol.(ml) of the
first to third reagents are displayed. (If several reagents are set for the same test, * is
placed in the top number displayed.)
• When the number of remaining test times falls below 100, the test name and graph are
displayed in yellow (You can change the set value for each test in Remain Test.)
• If the reagent becomes empty in Test Name, the test name appears in red and an E ap-
pears for the test number.

3-3
3 SETTINGS

• The test name appears on a button. The number of remaining test times and the reagent
position appear for the R1 or R2e reagent. (see P6-34)

3.1.4b If the reagent becomes empty during analysis without using the set-
tings from the Auto Reagent PAUSE function
An alarm sounds, and a message appears in the window. Only that test is processed as un-
finished, while the other analyses are continued. Click the ALARM button to open the
Error Report window in which you can check Sample no. and Test name (See P 6-43).
In the START mode,
click the R-PAUSE button in the operation panel to change the analyzer from
R-PAUSE SHIFT mode to R-PAUSE mode, and perform the operation in P 3-2.
In the STOP mode, the R-PAUSE button does not function.
Wait till the analysis is finished and the analyzer enters the READY mode. Then,
open the Reagent – Reagent Test Monitor window and click Reagent Scan. When
the Reagent Bottle Scan window appears, perform the same operation as P 3-2. The
analyzer enters the READY mode after scanning. Perform the START operation to
resume analysis.
In the READY mode, select Specif.no.
or All using the Reset button in Re-
agent – Reagent Test Monitor, and
click OK to reset the remaining level
of the reagent (Full display). You can
perform the measurement without
scanning.
(After that, if RPP aspirates the reagent
during measurement, the display for the re-
maining level changes.)

3.1.5 Change of Reagent Bottle Size


You can change reagent containers in Reagent – Reagent Bottle Settings.
The size of the reagent bottle is set to 40, 20, or 7ml. If the size of the reagent bottle has been
changed, change the settings in this window.

3-4
3 SETTINGS

3.1.6 Change of Reagent Bottle Position


You can change the position of the reagent bottle in Setup – System Test List (Password:
manager).
Make the settings for the R1 (RTT1) and R2e (RTT2) setting positions.

If you want to install two or more reagents of the same test, enter multiple numbers in
the position column. In case of installing reagents in positions 1 and 2, enter 1, 2. In the
case of installing in positions 1 to 3, enter 1- 3. The reagents are used in order, starting
from the smallest position number, and if they are used up, the reagent bottle with the
subsequent number is used.

3.1.7 Reagent Barcode Setting


Use this setting when the reagent position is determined by scanning the barcode of the reagent
bottle.
① Set the barcode number in Setup — System Test List (Password: manager).
Enter and register the first five digits in the barcode number on the reagent
bottle in R-code for the R1 (RTT1) and R2e (RTT2) settings.
② Click Reagent Scan in the Reagent — Reagent Test Monitor window to per-
form Barcode Scan/Bottle Scan. (see P 3-3)
Or, click Barcode Scan in the Reagent – Reagent Bottle Settings window to per-
form Barcode Scan only.

3-5
3 SETTINGS

3.1.8 Change of STD


Calib. – Calibration Setup (Password: manager) is used to change the concentration of the
standard solution or to change the position to place the standard solution.
Make sure to change STD right before analisis Calibration.

3.1.8a One-Point Calibration Curve


• Enter the concentration change in Coeff(FV) of each test and Save it.
• Also, enter the changes for the Blank position or STD position in each column and
Save it. If the position has been changed, click the CTT Set button to check and
change Cup/Tube Type, Reps, and comments on that position number.

3.1.8b Multi Standard


Only for Multi-point tests, the Setting
button is displayed beside the test name.
Change the settings in the window.
(This button is displayed by setting
Calc.mthd. of each test to MSTD in the
Setup – Analytical Parameter (Chem-
istry) window.)

3-6
3 SETTINGS

• Enter the concentration change in the Coeff(FV) column of each sample, Return, and
Save it.
• Enter the changes for the Blank position or STD position in the column of each sample,
Return, and Save it. If the position has been changed, click the STT Setting button to
check and change Container, Meas.times, and comments on that position number.

Coeff(FV) is linked in the Analytical Parameters (Chemistry) and Calibration


Setup windows, so the concentration can also be changed in the following window.

Setup-Analytical Parameters (Chemistry)

3.1.9 Change of Calibration Curve


The calibration curve is updated in real time after measuring calibration. If you enter data
manually in order to rewrite the calibration curve, follow the instructions below. (Only per-
formed in READY or WAIT state.)
① Change is made in Calib. — View Calibration Curve.
Select a test from Test name to display Statistical data and Calibration curve for
that test.

② Change the values of the statistical data.


③ Click Reapproxim. The dialog box on the
right appears. Click Yes.

3-7
3 SETTINGS

④ Only for Multi-point test, the message,


Carry out simplified re-approximation
processing?, appears in the dialog
box. Click No. (Click Yes only if you
want to reflect the simplified correction
data.)
⑤ The calibration curve is rewritten.
Check the results, and if they are satisfactory, click Save to register them and end the
operation.

3.1.10 QC Sample Setting


3.1.10a QC — QC Sample Definition (Password: manager) to set or to add QC
Sample.
You can register 26 types of control samples from A to Z.

① Click A (or unset control ID) in Ctrl.ID of QC Sample Definition and click Test
name from Test table.
② Set the CTT position number to place a control during measurement in CTT
Posi.no.
③ Enter the control name in Comment 1, the lot number and other information
in Lot.No./Data.
(This comment appears in RealTime Monitor or in print.)
④ Usually, set 1 in Dil.factor, and set Samp.type, Container, and Replicates.
For setting the control serum for urine, set Samp.type to Urine.
⑤ Click the CTT Set button to check the position of the Container and Reps.
and enter the control name and other information in the comment column.
(This comment appears in the Sample Select or CTT Set window.)

3-8
3 SETTINGS

⑥ Click the Return button to close the CTT Set window and click Save in the
QC Sample Definition window to register it. (The definition will not be saved
if selecting the Cancel button.)
⑦ In order to set the subsequent control sample, click B in Ctrl.ID, select the
test, and make the settings as in ②.
3.1.10b Click the CTT position set in 1 above in QC — Sample Select to register the
CTT position. ( See P6-24)
3.1.10c Click the measurement test in 2.Ordinary control samp.meas in QC — Test
Select to register the measurement test. (See P6-16.)
3.1.10d Register control values in QC — Control Data Registration.
• If control serum has been newly registered, enter Mean and SD in Daily QC and QC
Cumulative for each control.
• If the reagent or control sample has been changed, the control value also changes and a
value shifts on the graph for precision control. You can change the control value ac-
cordingly.

3.1.10e Select the test to be displayed in the Daily Precision Control and QC Cu-
mulative windows in order to reflect the data of selected test.
① Click the Display order test button in QC — Daily Precision Control.
② Select the test from the Meas.Test column to turn it blue, click ≫ to move
it to the Select Test column, and click OK. (The test in the Select Test column
appears.)

3-9
3 SETTINGS

③ A graph (X-Chart) appears for each test.


Take the same procedure in the Daily QC Precision window.
Also follow the same procedure when a new test is added to the control sample.

3.1.11 Control Data Registration


If you already know the control value, register it in QC — Control Data Registration,
and click Save.(see P3-9)
In the case of storing the measurement data as a control value
① Measure the new control serum as a control for several days.
② Open QC — QC Cumulative to check the data and the period.
• The average values and standard deviations in the display period are displayed. In
order to change the display period, click System in the upper left of the window,
click Specification at date from the menu to change the Beginning day and the
End day, and click OK.

• Change the window display from X-Chart to Control Data and check or delete
the data. (For deleting the data, see P6-28 Omit operation, User Interface). Be sure
to click Save after deletion.

3-10
3 SETTINGS

③ Change the window display to QC List and check the average values and
standard deviations.

④ In order to employ this data as a control value, click the Save control data
button. Select the test to be stored in the Save control data — Test select
window and click OK.
⑤ Check that the test has been copied to the QC Cumulative column of that
control in QC — Control Data Registration. (Click the Copy button as nec-
essary, to copy the test to Daily QC. The Copy button copies the control val-
ues of all the controls at the same time.)

Perform the Save Control Data operation for each control.


You can also perform Save Control Data from the Daily Precision Control win-
dow. In that case, the copy is made to Daily QC column of that control.

3-11
3 SETTINGS

3.1.12 Changing RealTime Monitor Window Display (Same as in


Batch Print)
You can select data print from Standard or Conc.
Switching between these two can be made in Maint. – System Monitor.

Standard

Simplified (concentration)

You can set the word size (big or small) for the Request – RealTime Monitor display (P
1-15).

3-12
3 SETTINGS

3.1.13 Batch Print


In order to print data, set Sample type, Date, and Print range in the Batch print column in
the Maint. – User Maintenance window and click Start print. (You can also print data by
selecting Request – RealTime Monitor.)

3.1.14 Save of Text File


In order to store data in a floppy disk or other media, set Sample type, Date, Output Form,
and Save Range in the Save of Text File column in the Maint. – User Maintenance win-
dow, click Save, select the location to store and enter a file name to store it.

3.1.15 Screen Print


The workstation window can be printed as it is.
Click System(S) in the Menu Window menu
and click Screen print from the menu. Printing
will start immediately.

3-13
3 SETTINGS

3.1.16 Setting of Analytical Parameters (Serum)


In order to determine chyle, hemolysis, or icterus by the analyzer, use the measurements from a
test of a transparent first reagent and calculate from absorption of 478 to 694 nm. It is neces-
sary to make settings in accordance with the following procedures.
3.1.16a In order to handle the serum index tests in Various system operation spec.
in Setup — System Specification Settings (Password: manager), select
them from Request.test.range or Compulsory test analysis.
If this setting has been changed, the changed contents will take effect from New
Start subsequent to Save. See P 6-46.)

• Request.test range・・・In order to optimize the Analyzer’s throughput, serum indices are
calculated only when the serum indices are already required in a test
in the workorder for the sample.
• Compulsory test analysis・・・Serum indices for all of the samples are calculated. If the
settings for serum indices are already required in a test in the wor
korder for the sample, it will be measured as per the settings. If not,
the analyzer refers to the test set in No1 in Analytical Parameters
(Serum) window and automatically generates a workorder as set in
No1 to calculate the serum indices.

3.1.16b Register the analytical conditions of the test for the serum index measure-
ment.
In the case of setting Compulsory test analysis in 1 above, if the sample request does not
include a test available for serum index measurement, a request is automatically generated
for a test available in the setting No1. In order to avoid this, set a new test for the serum in-
dex measurement.
See 1. New Test Registration (Chemistry), P 3-17.
① Setup — Analytical Parameters (Chemistry) (Password: manager)
Enter R1=100 ㎕ , R2=0 ㎕ , SV=2 ㎕ , reaction time = 3minutes, test name
(e.g.: TEST), main DET.P.m=12 (main DET.P.l,n,p,r has not been entered yet)
in the number without any analytical conditions, and save them.

3-14
3 SETTINGS

Analytical conditions of the serum index measurement test in ①

② Setup — System Test List (Password: manager)


Register the above test in the analyzer, enter the position of R1, and save it.
③ Setup — Process Sequence (Password: manager)
Check System test no. of the above test and save the number so that the
test does not interrupt the other measurement tests.
④ Calib. — Calibration Setup (Password: manager)
Set the same reagent blank measurement position ([1]) as the other tests in
BLK pos. of the above test, and save it.
⑤ Request — Test Select
Check the test names in 1. Routine/Interrp./STAT samp.meas. and 5. Ordi-
nary calibration meas.(BLK), and save them.
⑥ Install a reagent bottle filled with saline in the position set in (2).

3.1.16c Measure the reagent blank for calibration in the serum index measurement
test as set in 2.
3.1.16d Set in Setup — Analytical Parameters (Serum) (Password: manager).
① ②

3-15
3 SETTINGS

① Register the tests which can be used for serum index measurements in the
test column (up to 10 tests).
If you made the settings in Compulsory test analysis in 1 above, enter the
test set in 2 above in test No.1. Set usual tests in test No. 2 and after.
② Set coefficients a to f for each test.
- In the case of the test for serum index measurement (R1=100 ㎕ , SV=2 ㎕ ),
a=1128.90, b=167.54, c=39.08, d=0.8987, e=0.1488, f=1.3289
- In the case of setting the other tests in No.2 and after, if R1 volume, Sample volume
(Serum) are different from the saline test, calculate the coefficients a to c for each
test, and set them.
Calculation formula a’={(R1+SV)/102}×(2/SV)×a (same for b’ and c’)
e.g.: Where 80 ㎕ to AST R1, 4 ㎕ to SV,
a'={(80+4)/102}×(2/4)×1128.90=464.84

Serum indices are calculated as follows:


• lipemia=a×ABS(lipemia measurement absorbance)
• hemolysis=b×{ABS(hemolysis measurement absorbance)-d×ABS(lipemia measure-
ment absorbance)}
• icterus=c×{ABS(icterus measurement absorbance)-e×{ABS(hemolysis measurement
absorbance)-d×ABS(lipemia measurement absorbance)}-f×ABS (lipemia measurement
absorbance)

③ Set Qualit.judge of chyle, hemolysis, and icterus to Not do, and set Digits
to 2 and analyze samples at the borders of chyle, hemolysis, and icterus, re-
spectively. From the results, set the respective Qualit.judge to Do. In the
Qualitative Judgement set window, set the characters to be used in Char-
acters, and set printed values of the samples at the borders in Border val-
ues.

Request the analysis of the samples that have chyle, hemolysis, and icterus, and then
check that the results of the Characters are correct for each sample.
In the above example, ± is displayed for data with a measured value of 1 to 2.

3.1.16e Measure routine samples again and check the signs.

3-16
3 SETTINGS

3.2 NEW REGISTRATION


3.2.1 New Test Registration (Chemistry)
Register to add the chemistry tests according to the procedure of Setup – New Test Registra-
tion (Password: manager). Click the button to open the window and enter the information re-
quired. By closing the window, the button of the window to be opened next turns blue. Make
the settings in the following order.

3.2.1a Setup — Analytical Parameters (Chemistry) (Password: manager)


Enter the analytical conditions. Display Analy.Cond.no. whose name is set to None. En-
ter Test name, Reagent volume, Sample volume, factor, Reanalysis condition and
other information. (See P 6-47.)

3-17
3 SETTINGS

3.2.1b Setup — System Test List (Password: manager)


Select the measurement tests from the list and register their number in Anal.cond#. (This regis-
tration order becomes the analysis order.) Also, set the position of the reagent bottle in setting
positions of R1 and R2. You can change the analysis order in Analysis order.(See P 6-49.)

3.2.1c Setup — Process Sequence (Password: manager)


To determine the processing test order, enter the Cond.no. in the Seq.no. column and register
the Test name. This becomes the sequence in the other windows. (See P 6-49.)
The Processing test order is the number relating to Order Entry, Online Settings,
Serum indices, Ratio, and QC. You can perform interruption by <-SP or deletion
by Delete, but avoid making unnecessary changes. To only change the Print Moni-
tor Order, use the arrow in the right of Print Monitor Order.

3-18
3 SETTINGS

3.2.1d Reagent — Reagent Container Setting


Enter the reagent container type.
Usually, it is 4:40ml.
(This setting is for correctly displaying
the remaining amount of reagent. If you
use the reagent barcodes, they can be
read here.) (See P 6-35.)

3.2.1e Calibration — Calibration Setup (Password: manager)


Enter the positions of Blank and STD and Coeff(FV). Enter the Multi-point test by clicking Set-
ting (see P 3-6). Enter the Multi-STD Setting in Analytical Parameters (Chemistry) – Multi-STD
Setting. After that, enter Blank and STD, Container Type, means time, and comments in the CTT
Set and STT Set windows.

3.2.1f QC — QC Sample Definition (Password:manager)


You can set a maximum of 26
types of control samples to
be analyzed from A to Z.
Enter Position no. of CTT,
comments, Lot.No./Date,
Container type, and Repli-
cates, and select Test test.
After that, enter comments in
CTT Set.
(See P 3-8.)

3-19
3 SETTINGS

3.2.1g Request, Calib., QC — Test Select


Select the analysis tests in:
• 1.Routine/Interrp./STAT smp.meas.
• 2.Ordinary control samp.meas.
• 5.Ordinary calibration meas.(BLK)
• 6.Ordinary Calibration meas.(STD) (You can make a temporary change in Ordinary
control and Ordinary calibration at START.)

3.2.1h Calib., QC — Sample test


Select the CTT positions of Blank,
STD, control to be analyzed in ad-
vance. (Temporary changes can be
made in START.)

3.2.1i Setup — Online Settings (Password: manager)


In order to set the tests entered to online, enter the code in Set Test.

3-20
3 SETTINGS

3.2.2 New Test Registration (Ratio)


3.2.2a Setup — Ratio Parameters (Password: manager)
Set the calculation formula. 20 tests can be set from 101 to 120. Set Test name, Digits, and
the presence of Qualitative in the column number that does not have a test name. Select the
tests to be used for calculation from the test list, substitute them into S: to Z: of Real-time
calculation Ratio
Parameters,
substitute the
coefficients into a to f,
and then create a cal-
culation formula
using +, -, *
(multiplication), /
(division), and
parentheses (). After
that, click simulation
to check the formula
and register it.

3.2.2b Setup — Process Sequence (Password: manager) (Same as in 3.2.1c,


P3-18.)
Determine the Processing Test Order. Enter Cond.no. in the Cond.no. column and regis-
ter Test name. This becomes the sequence in the other windows.
Note: Processing Test Order is
the number relating to Order
Entry, Online, Serum in-
dices, ratio, and QC. You
can perform interruption by
using <-SP or deletion by
Delete but avoid making
unnecessary changes. To
only change the Print
Monitor Order, use the ar-
row in the right of Print
Monitor Order.

3.2.2c Request, Calib., QC - Test Select (Same as in 3.2.1g, P 3-20.)


Select the analysis test in 1.Routine/Interrp./STAT samp.meas.

3.2.2d Setup — Online Setting (Same as in 3.2.1i, P 3-20.)


Enter the numbers and other information in Set test in order to set the tests you entered to
online.

3-21
MAINTENANCE
4
4.1 MAINTENANCE CHECKLIST ................................................................. 4-1
4.2 BEFORE STARTING OPERATION.................................................................. 4-4
4.2.1 Check the purity of water in the Pure Water Supply Unit .......................... 4-4
4.2.2 Check and clean the tips of probes (SPP, RPP1 and RPP2) ....................... 4-4
4.2.3 Check and clean the mixing rods................................................................ 4-6
4.2.4 Check and clean the splash covers ............................................................. 4-6
4.2.5 Check WUD and RRV Top Cover .............................................................. 4-6
4.2.6 Check and clean Wash Ports Check overflow of Pure
Water and Wash Solutions Check and clean the Overflow Sensor.......... 4-7
4.2.7 Check the pumps for leak Check the cylinder for air
bubbles ....................................................................................................... 4-7
4.2.8 Check and clean the ISE dilution bowl ...................................................... 4-8
4.3 DAILY AND WEEKLY WASH ......................................................................... 4-8
4.4 REGULAR MAINTENANCE ......................................................................... 4-10
4.4.9 Lamp Energy Check................................................................................. 4-10
4.4.10 Cuvette Blank ........................................................................................... 4-12
4.4.11 Shutdown Operation................................................................................. 4-14
4.4.12 Cleaning ISE Dilution Bowl..................................................................... 5-10
4.4.13 ISE Line Wash .......................................................................................... 5-11
4.4.14 Lamp Coolant Refill ................................................................................. 4-14
4.4.15 Cleaning Waste Fluid Lines for Probe Wash Ports and Mixer Wash
Ports.......................................................................................................... 4-14
4.4.16 Cleaning LWP Line Filter ........................................................................ 4-15
4.4.17 Cleaning Mixing Rods.............................................................................. 4-16
4.4.18 Disk defragmentation for PC with WindowsXP ...................................... 4-18
4.4.19 Cleaning ISE waste drain nozzle.............................................................. 5-10
4.4.20 Cleaning RTT, CTT and STT trays .......................................................... 4-19
4.4.21 Cleaning filter for cooling part of the chiller............................................ 4-20
4.4.22 Cleaning the cuvette wash solution bottle and cuvette conditioner
bottle......................................................................................................... 4-20
4.4.23 Cleaning line filter for consumable bottles .............................................. 4-21
4.4.24 Cleaning Detergent Lines (WUD)............................................................ 4-21
4.4.25 Cleaning fans ............................................................................................ 4-24
4.5 REGULAR PARTS REPLACEMENT ............................................................. 4-25
4.5.26 Replacing Lamp........................................................................................ 4-25
4.5.27 Replacing ISE Electrodes ......................................................................... 5-13
4.5.28 Replacing Reaction Cuvettes (this should be done when the power is
off) ........................................................................................................... 4-26
4.6 OTHER MAINTENANCE............................................................................... 4-27
4.6.29 When the pure water tank is empty .......................................................... 4-27
4.6.30 Removing air from cuvette wash solution line and cuvette
conditioner line ......................................................................................... 4-30
4.6.31 Replacing the SPP probe........................................................................... 4-30
4.6.32 Replacing RPP1 and RPP2 probes............................................................ 4-33
4.6.33 Replacing L-Ring set (1 mm) of sample pump(SP) ................................. 4-35
4.6.34 Replacing L-ring sets (5mm) of RP1 and RP2, and OMNISEAL
(14mm) for SRWP .................................................................................... 4-36
4.6.35 Replacing mixing rod................................................................................ 4-40
4.6.36 Removing clot in WUD ............................................................................ 4-41
4.6.37 Backing up system file to DVD ................................................................ 4-43
4.6.37a How to perform a backup .................................................................. 4-43
4.6.37b Restoring data from a backup disk .................................................... 4-44
4.6.38 Recovering from a power failure and computer maintenance .................. 4-45
4.6.38a Recovery from an unexpected power failure..................................... 4-45
4.6.38b Checking the behavior of the workstation......................................... 4-45
4.6.38c Workstation problems........................................................................ 4-45
4.6.38d Using the manual for the JCA-BM6010/C Automatic Analyzer....... 4-46
4.6.38e Others ................................................................................................ 4-47
4.6.39 Before a long period of nonuse................................................................. 4-47
4 MAINTENANCE

4.1 MAINTENANCE CHECKLIST


The following table shows the regular maintenance, regular replacement of parts and
other service. Perform maintenance according to the information on the table.
Depending on the workload of the analyzer, interval of required maintenance may
differ.

■ Check Before Starting Operation (See P4-4~)

REQUIRED
MONTHLY

MONTHS

MONTHS
WEEKLY

REFER
EVERY 3

EVERY 4
DAILY

TO
REMARKS

AS
ITEM

Check the purity of the water of


1 √ 4-4
pure water supply unit (cleaning)
Check if the sample probes are Clean every
2 √ √ 4-4
clean. (cleaning) week.
Check if the mixing rods are clean. Clean every
3 √ √ 4-6
(cleaning) week.
Check if the splash covers are Clean every
4 √ √ 4-6
clean. (cleaning) week.
Check if the WUD (reaction tray Clean every
5 √ √ 4-6
washer) is clean. (cleaning) week.
Check if the wash ports for probes
Clean every
6 and for mixing rods are clean √ √ 4-7
month
(cleaning)
Replace the
7 Check the pumps against leak √ L-ring set if 4-7
leak is observed
Check if the ISE dilution bowl is Clean every
8 √ √ 4-8
clean. (cleaning) week.

■ Daily and Weekly Wash (See P4-8)

■ Regular Maintenance (See P4-10~)


* The daily checks (and cleaning) before starting operation are also considered as the Regular
Maintenance.
REQUIRED
MONTHLY
MONTHS

MONTHS
WEEKLY

REFER
EVERY 3

EVERY 4
DAILY

TO

REMARKS
AS

ITEM

9 Check lamp energy √ 4-10


10 Measure cuvette blanks √ 4-12
11 Shutdown Operation √ 4-14
12 Clean the ISE dilution
bowl
√ 5-10

4-1
4 MAINTENANCE

Depends on how many dialysis


samples are processed:
500 or more samples /month ->
every 3 days

See remarks
100 or more samples /month ->
13 Clean the ISE line every week 5-11
Less than 100 samples /month
-> every 2 weeks
Note: if there is no dialysis
sample ->every 1 to 3
months
14 Add lamp coolant √ 4-14
Avoid clogging in the waste Maintenance frequency
15 fluid line for wash ports for √ depends on how many 4-14
probes and mixing rods analyses are run.
Clean the LWP line filter Frequency depends on the
16 √ quality of water
5-15

Clean mixing rods by


17
soaking in detergent
√ 4-16

Disk defragmentation for


18 PCs with Windows XP op- √ 4-18
erating systems
Clean ISE waste drain
19 √ 5-10
nozzle
Clean RTT, CTT
20 (Refrigerated sample tray) √ √ 4-19
and STT trays
Clean the filter for the
21 √ 4-20
cooling part of the Chiller
Cleaning the cuvette wash
22 solution and cuvette √ 4-20
conditioner tanks
Clean the aspiration line
filter in the cuvette wash
23 √ 4-21
solution bottle and cuvette
conditioner bottle
Clean the cuvette wash The frequency depends on
24 √ 4-21
aspirate line (WUD) how many analyses are run.
Clean the external panel
25 and the cooling fans at- √ 4-24
tached to the analyzer

■ Regular Part Replacement (P4-25~)


REQUIRED
MONTHLY

MONTHS

MONTHS
WEEKLY

REFER
EVERY 3

EVERY 4
DAILY

TO

REMARKS
AS

ITEM

Replace the Alternatively, replace the lamp approximately


26 √ 4-25
lamp every 2000 consecutive running hours.

4-2
4 MAINTENANCE

Or replace electrodes after running 30000


samples, whichever period lapses first.
For dialysis samples, samples left
unprocessed for more than 24 hours, or
Replace Na,
decomposed samples, replace the
27 K, and Cl √ 5-13
electrodes after 2 months or after 20000
electrodes
measured samples, whichever period
lapses first.
Or replace the electrodes whenever poor
slope or selectivity is experienced.

28 Replace Frequency depends on how many


reaction √ analyses are run. 4-26
cuvettes

■ Other Maintenance (P 4-27~)

REQUIRED
MONTHLY

MONTHS

MONTHS
WEEKLY

REFER
EVERY 3

EVERY 4
DAILY

TO
REMARKS

AS
ITEM

Procedure for empty pure


29
water tank
√ 4-27

Remove air from cuvette


30 wash solution and cuvette √ 4-30
conditioner lines
Replace SPP probe Preferably every
31 √ 4-30
12 months
Replace RPP1 and 2 probe Preferably every
32 √ 4-33
12 months
Replace L-Ring set for SP Preferably every
33
pump
√ 12 months 4-35

Replace L-ring sets for RP1, Preferably every


34
RP2 and SWRP pumps
√ 12 months 4-36

Replace mixing rod Preferably every


35 √ 4-40
12 months
Remove clogging in the WUD
36
nozzle
√ 4-41

Back up the system to a When there is a


37 medium such as DVD √ modification of the 4-43
specifications
Recover from a power failure/
38
PC maintenance
√ 4-45

Procedures before and after


39
long period of non use
√ 4-47

Lift the top cover if necessary and perform the checks described below.

4-3
4 MAINTENANCE

反应杯冲洗站WUD

ISE单元 样本条码阅读器 样本针SPP 反应盘PRV 搅拌MIX1 搅拌MIX2

灯室冷媒

样本盘 急诊位
试剂针RPP2
内圈稀释样本盘CTT 试剂针RPP1
试剂盘RTT2 试剂盘RTT1
外圈初始样本盘STT

4.2 BEFORE STARTING OPERATION


4.2.1 Check the purity of water in the Pure Water Supply Unit
See the control panel display to check the water purity. The purity is shown on the dis-
play when the water is sampled. Replace the cartridge filter before the water quality de-
teriorates to 1μS/cm or worse. If the puritye becomes 1μS/cm or worse, the alarm will
go off. To stop the alarm buzzer, press the alarm button on the Operation Panel.
Clean the pure water bottle regularly. To clean the pure water bottle, close the faucet,
turn off the power of Pure Water Supply Unit, and then remove the bottle to wash it using
a sponge.

4.2.2 Check and clean the tips of probes (SPP, RPP1 and RPP2)
Cleaning method:
① Lift the shaft of the probe arm and manually rotate the probe into a position
where you can wipe the tip of the probe easily. When you rotate the probe,
be careful not to crush it against the V-block.
If necessary, remove the STT, CTT or RTT cover when cleaning the probe.
Alternatively, select Manual Operation in Maint. (see P6-39) and double-click
16.SPPLR, 37.RPPLR-1, or 49.RPPLR-2 when the analyzer is in READY
mode. Click Move in the dialog box to move the probe to the preferable po-
sition for cleaning.)

4-4
4 MAINTENANCE

• When you clean the tip of the SPP, move the SPP over the STT.
• When you clean the tip of the RPP, move the RPP over the RTT where reagents
are not loaded.
② Wipe the exterior of the probe with gauze moistened with pure water.

Cleaning the SPP

Cleaning the RPP1 and RPP2

③ Move the probe right and left to see if the tip of the probe can move without
crushing to the V-block.
④ Exit the Manual Operation window and select INITIALIZE to return to
READY mode.
You can also check if pure water is coming out straight from the tip of the
probe during initialization to see there is no clogging in the probe.

When cleaning the probe with the power of the analyzer turned off, the arm of the
probe may go down due to its own weight. Lift the unit and carefully move it so
that you will not crush the tip against other components.
During initialization, the arm of the probe goes down two to three millimeters from
the original position. After cleaning, move the probe to a position where nothing is
underneath before performing INITIALIZE to prevent probe crush against other
components on the analyzer.

4-5
4 MAINTENANCE

4.2.3 Check and clean the mixing rods


To clean the mixing rods, wipe only the top of the rods using gauze moistened with pure
water.
Do not wipe the tip of the mixing rod as it can be easily bent.

Leak sensor

4.2.4 Check and clean the splash covers


Splash covers are mounted along the track of each probe movement in order to prevent
splattering water and reagent into the reaction cuvettes. If they are not clean, wipe them
clean. If you notice splattering of reagent on the splash covers more than usual, it may
be due to some failure of the analyzer.

4.2.5 Check WUD and RRV Top Cover


Check if the WUD is clean and with no leak and check if the RRV Top Cover is dry.
To clean the WUD and the top cover of RRV, use gauze moistened with pure water.

4-6
4 MAINTENANCE

4.2.6 Check and clean Wash Ports


Check overflow of Pure Water and Wash Solutions Check
and clean the Overflow Sensor

Overflow sensor

V block

Check the 4 wash ports (SPP, RPP1, RPP2 and ISE wash port) as well as the 2 mixing rod
ports (MIX 1 and MIX 2).
Move the arm of the probe as described in “Check and Clean the Tip of Probes” in this
section. Clean the V-block, the overflow sensor and the surrounding areas with cotton
buds or gauze.

4.2.7 Check the pumps for leak


Check the cylinder for air bubbles
Use dry gauze to check if the connecting area of each pump is dry. If it is wet, there
may be some leak. Wipe the arear and take some countermeasure immediately (e.g.
changing the seal of the connector).

SP SRWP RP1 RP2

4-7
4 MAINTENANCE

4.2.8 Check and clean the ISE dilution bowl


Clean the ISE dilution bowl if there is any cristalization in it.
Refer to Chapter 5. Section 5.5.4 Clean the ISE Dil.Bowl.

Cotton bud
ISE nozzle
給液ノズル

4.3 DAILY AND WEEKLY WASH


◎ WASH 2 and WASH 3
Perform WASH 3 to rinse dry cuvettes and probes with pure water when the analyzer is
not used over night or for a long period.
Or perform WAHS 3 to check the analyzer operations after maintenance.
Perform WASH2 to clean the cuvettes and lines after completing all analyses for the day.

Purpose Location Type

WASH3 RTT1, 2-45 Pure water


Refer to P 1-5
Reagent Probe Wash-K (20%)
RTT1, 2-44
(Use 5 % Reagent Probe Wash
WASH-S once a week)
WASH2 Pure water
Refer to P 1-17 RTT1, 2-45

ISE Detergent Solution


CTT – specified location
(refer to P 5-5)

Please contact our service personnel about the daily and weekly wash. Frequency and
type of wash depends on the analyses you run.
As the hypochlorous acid soda in Reagent Probe Wash-S is easily decomposed, make 5%
solution every time before use. Set the 5% solution of Probe Wash on RTT just before
use and remove it immediately when the wash is completed.
Apply the same method to the ISE electrode wash solution: Set the wash solution just
before use and replace it everyday.

4-8
4 MAINTENANCE

Other Wash Solutions


Reguarly check the wash solutions in the table below for replenishment or replacement.

Purpose Location Type

To prevent contamination
No.42 in RTT1 and RRT2 REAGENT PROBE WASH-1
(alkali)

To prevent contamination
No.43 in RTT1 and RTT2 REAGENT PROBE WASH-2
(acid)

Detergent container CUVETTE


Cuvette Blank measurement
(far right) CONDITIONER-EX

Cuvette wash detergent Detergent container


CUVETTE WASH SOLUTION-7
(alkali) (second from right)

Detergent container
Incubation bath oil Reaction Bath Oil
(third from the right)

Detergent container
ISE buffer solution ISE BUFFER
(far left)

ISE Internal standard solution ISE Internal standard

Regularly check the joint of the tubing for loosening and perform visual check if
there are any air bubbles in the bottles.

4-9
4 MAINTENANCE

4.4 REGULAR MAINTENANCE


4.4.9 Lamp Energy Check
Check the lamp energy once a week after washing the cuvettes or replacing the energy
lamp and/or reaction cuvettes.
① Perform INITIALIZE. (This will move the reaction cuvette no. 1 to the RPP
position 1.)
② In the Menu window, select Maint. and then select Lamp Energy Monitor.
③ Click Check Energy. (Figure 1)
④ Verify that ‘45’ is shown on RTT1 water posi. Click Start.

[Figure 1]
This will start the RPP1 (Reagent Probe 1) to aspirate pure water from Position 45 on
RTT1 and to dispense it into the Reaction Cuvette no.1. The RRV (Reaction Carousel)
rotates until the cuvette is in the position for the lamp energy measurement. When these
operations are completed, the System Status display in the Operation Panel window
changes from LUMI.CHECK to WAIT.

⑤ Set 1000 and 100 (µ sec) in Meas.times and Meas.cycle respectively for
Luminous energy check as shown in Figure 2.
⑥ Click Meas. Energy and then click OK for the message ‘Execute the lamp
energy check?’. Measurement will finish in approximately one second.

[Figure 2]

4-10
4 MAINTENANCE

⑦ Select ‘340nm’from the dropdown, select ‘AD’ radio button and select ‘Auto’
radio button. Then click Collect Data to display the data. Check the AD
value at 340nm.

⑧ Check the data.


Horizontal axis shows the number of runs.
Vertical axis shows the AD value. Check the AD value.
- The difference between the upper limit value and the lower limit value is
within approximately 100.
- The luminous energy is within the range between 10000 and 30000.
You can check how much luminous energy has attenuated since replacement
of the lamp or a reaction cuvette from the Intensity (100%) (attenuation rate).
⑨ If the lamp or a reaction cuvette has been replaced, click Regist Data and OK
to check the lamp energy. The Intensity becomes 100%.
⑩ The system mode is WAIT during this operation. When you complete lamp
energy check, perform INITIALIZE to change the system mode to READY.

Do not use Offset AD transfr, Offset meas., Offset AD collect oand Offset AD
regist. buttons in this operation.

4-11
4 MAINTENANCE

4.4.10 Cuvette Blank


Cuvette blank MUST BE measured once a week after WASH.
Also perform cuvette blank after replacing the lamp or a reaction cuvette.
① In the Menu window, select Maint. and then click User Maintenance to open
the User Maintenance window.

② Click Start CB on Cuvette blank meas.check.


The measurement of cuvette blank starts. The measurement will finish in
approximately 17 minutes.
③ When the measurement of a cuvette blank has finished, ‘Please save cuvtte
blank if cuvette blank is normal’ is displayed in the dialog. Click Save.

④ Check the results of the measurement.


In Cuvette blank Batch Print, select Saved run for Data type and select
Statistics and Abnormal Cuvette check boxes for Print, and then click Print
start. (You can also start printing in RealTime Monitor from Request but-
ton.)

4-12
4 MAINTENANCE

Flags
Setting the meadian of the cuvette blank values for all 231 cuvettes as the standard,
[H] or [L] flag is generated against the OD value that exceeds either +0.4OD or
–0.4OD.
[H] and [L] flags indicate that the cuvette is defective. Check the measurement
value for the cuvette in [RealTime Monitor] window.

⑤ After registering the cuvette blank values


- Abnormal cuvettes flagged with [H] or [L] are registered as abnormal cu-
vettes that should not be used for the analysis, therefore, will not be used
from thereon. However, please note that all the cuvettes are washed in
preparation for an analysis so that the ‘abnormal’ cuvettes may become us-
able again after the next wash and cuvette blank measurement.
- The cuvette blank is normally run for cuvettes that have been washed before
they are used in the next analysis. The result values of the cuvette blank are
compared with the registered cuvette blank values. If the new result value
exceeds 0.04 or greater in the OD value, the cuvette will not be used for the
next analysis. To check the cuvettes that are not used, click ALARM in the
Operation Panel and switch Disp.switch to Extend in the Extend window.
(See P 7-10.)
* Refer to 2.6 Cuvette Skip by using cuvette blank value in Application of the
instruction manual.
⑥ Save the results of Statistics and Abnormal Cuvette in a file.
The results can be used as a indication for when to replace the cuvettes.

4-13
4 MAINTENANCE

4.4.11 Shutdown Operation


Perform normal shutdown. (See Shutdown the Analyzer on P 1-17.)
Wait 10 seconds and then restart the workstation, select INITIALIZE to initialize the
analyzer and to display READY mode in the workstation.

4.4.12 Cleaning ISE Dilution Bowl


For information about cleaning the ISE dilution bowl, see 5.5.4. Cleaning ISE Dil.Bowl
on P 5-10 of Chapter 5 ISE Unit (ISE09).

4.4.13 ISE Line Wash


For information about cleaning the ISE lines, see 5.5.6. Washing ISE Line on P 5-11 of
Chapter 5 ISE Unit (ISE09).

4.4.14 Lamp Coolant Refill


Lift the cover to see the remaining volume of lamp coolant. If the level is below half of
the bottle, replenish the lamp coolant.
① Prepare undiluted LAMP COOLANT-C.
② Open the top cover of the analyzer.
③ Twist the upper lid of the tank to remove it.
④ Refill the tank with the lamp coolant up to the upper line in the tank.
⑤ Replace the lid and tighten it.

Lamp coolant

4.4.15 Cleaning Waste Fluid Lines for Probe Wash Ports and Mixer
Wash Ports
This operation is to prevent clogging in the waste fluid line probes.
① Carefully inject about 20 ml of REAGENT PROBE WASH-S (undiluted) into
the wash port with syringe. Avoid overflowing. Be careful not to crash into
the probe.

4-14
4 MAINTENANCE

Syringe with REAGENT PROBE V-block


4x6 tube WASH-S

② Leave it for three to five minutes.


③ Carefully inject water approximately double amount of the wash solution.
Make sure not to overflow the wash port.
④ If the V-block is not clean, clean it as described in P4-7.
⑤ Perform INITIALIZE.

4.4.16 Cleaning LWP Line Filter


The analyzer uses the water in LWP for cleaning probes, mixing rods, reaction cuvettes,
and for backwash of the pumps. In order to maintain a constant amount of washing wa-
ter, the water pressure is adjusted between 70 and 72 kpa by the LWP Flowrate Adjust-
ment valve.
A filter is installed on the LWP line to remove dirt and foreign substances. Remove and
clean the filter in the LWP line to avoid clogging and to stabilize the amount of circulat-
ing water.
① Check that the analyzer is in Ready mode.
Place a towel under the filter case.
② Unscrew the filter case and remove the mesh filter. Be aware that some
water may be left in the filter case.
③ Use a toothbrush for cleaning the filter case, mesh filter and packing. (If
needed, leave them in 5% Reagent Probe Wash S for about 10 minutes and
rinse them throughly.)

Filter Case Mesh Filter

4-15
4 MAINTENANCE

④ Put the mesh filter back into the filter case and install the filter case in the
original position.
⑤ In the Menu window, select Maint. and then Manual Operation. Double-click
71.LWP and check that there is no water leak from the pipe joints and the fil-
ter case.
⑥ Turn the LWP Flowrate Adjustment valve to set the LWP Pressure gauge to a
range between 70 kpa to 72 kpa.

Pressure gauge Flow rate adjustment valve

⑦ Exit the Manual Operation window and initialize the system to READY mode.

4.4.17 Cleaning Mixing Rods


The mixing rods must be kept clean to prevent data troubles. Check the mixing rods
every day and clean them approximately once a month by soaking them in detergent.
① When the analyzer is in READY mode, verify that the mixing rods are in ‘up’
position.
② Use a dropper to remove the water remaining in the MIX 1 and MIX2 wash
ports. (Be careful not to bend the mixing rods.)
③ Using a dropper, pour about 1 ml of undiluted REAGENT PROBE WASH-K
into the wash ports.

4-16
4 MAINTENANCE

④ Open the Manual Operation window.

⑤ Double-click 44.MUD1 to open the window to operate MIX1 (up and down).
⑥ Click the Init. button to put MIX1 into its wash port.
⑦ Do the same operations for 56.MUD2 to put MIX2 into the wash port.
⑧ Leave the mixing rods in the wash ports for about 10 minutes.

⑨ Double-click 40.MIXR1 to open the MIX1 (rotate) window.


⑩ When you click Move, MIX1 starts to rotate in the wash port and then stops.
To roatate and remove dirt from the mixing rod, click Move five to ten times.
(If you continuously keep clicking this button, it will generate an error. Click
the button when the mix rod stops rotating.)
⑪ Perform the same operations for 52.MIX2 to remove dirt from MIX2.
⑫ Perform INITIALIZE to move the analyzer to READY mode.
⑬ Perform WASH3 to rinse off the detergent.

4-17
4 MAINTENANCE

4.4.18 Disk defragmentation for PC with WindowsXP


When you use a workstation PC for long period of time, files on the hard disk of the PC
become fragmented, causing in slow PC processing and in the worst case, errors such as
“2618 or 2633 and 2644 Acquisition error: Sample Information cannot be acquired” may
occur.
To prevent such problems, perform disk defragmentation regularaly according to the steps
described below to optimize fragmented files.
① Exit the system software (see P 1-17) and click Cancel in the Biomajesty
Startup window to close the startup window.

② Click Start at the bottom left of the screen, then select Programs, Accesso-
ries, System Tools and Disk Defragmenter. (If the Disk Defragmenter icon
is displayed on the desktop, double-click it.)

③ The Disk Defragmenter window appears.


Click (C:) in the volume to select. (When selected, the line is highlighted in blue.)
Click Defragment to perform disk defragmentation. (You can click Pause or Stop
during defragmentation.)

4-18
4 MAINTENANCE

④ When the disk defragmentation completion window appears, close all the
windows.
⑤ Click Start at the bottom left of the screen and select Shutdown to restart in
order to complete the defragmentation.

4.4.19 Cleaning ISE waste drain nozzle


For information on how to clean the ISE waste drain nozzle, see 55.5.Washing ISE Waste
Drain Nozzle on P5-10 of Chapter 5 ISE Unit (ISE09).

4.4.20 Cleaning RTT, CTT and STT trays


RTT, CTT and STT need cleaning due to serum on STT and condensation on CTT and
RTT.
Remove and clean the RTT and STT (CTT) as required.
① Remove the STT, CTT and RTTs covers.
② The STT and CTT trays have two latches (black buttons) on each of them.
Pull up these latches and remove the trays by lifting it up gently by the han-
dles.
CTT latch STT latch

CTT handles (outside) STT handles

③ Wipe off the condensation inside the CTT and clean the trays.
(Check that the tube holders are in good condition with no defect.)

4-19
4 MAINTENANCE

④ To clean RTT1 and 2 trays, turn the handle in the center to remove the trays
and wipe off any condensation.
⑤ To replace an RTT tray, place the tray over the pin with a triangular mark so
that the pin fits into the hole of the tray.
Turn the screw of the center handle until it is tightly fastened.
Turn the trays manually with your hand to check they are securely fixed in the
correct position and the movement of the trays is smooth and flat.

Triangular mark

Turn and loosen the upper handle

Hold the lower part to remove

⑥ Replace the STT, CTT and RTTs covers.

4.4.21 Cleaning filter for cooling part of the chiller


① Open the front panel and pull out the chiller filter from the left side. Pull the
filter upward to remove it.

The side of the Chiller

② Remove particles and dirt on the filter by a vacuum cleaner. Put back the filter
to its original position.

4.4.22 Cleaning the cuvette wash solution bottle and cuvette condi-
tioner bottle
Remove the bottle sensor and the aspiration tube to wash inside the bottle.
(Do not clean the Reaction bath oil bottle.)

4-20
4 MAINTENANCE

4.4.23 Cleaning line filter for consumable bottles


Clean the filter inside the tip of the aspiration tube by using a tool such as a toothbrush.

4.4.24 Cleaning Detergent Lines (WUD)


Reaction Cuvette Wash Mechanism
The blue-marked nozzles drain the waste fluid from the cuvettes first when cuvette wash
starts.
Then the red-marked nozzles discharge the wash solution in the cuvettes for washing.
The yellow-marked nozzlles aspirate the solution discharged into the cuvettes from the
upper part of the cuvettes in order to prevent overflow.
Over a long period of time, serum or reagent crystals may build up in the lines, which can
cause insufficient draining. When this happens, the liquid level may reach up to the
edge of the cuvettes. To avoid such problems, clean the drain lines regularaly.
If a waste fluid nozzle is clogged after suctioning dirt or foreign matter from a cu-
vette, it can also cause insufficent draining. Use a cleaning wire for nozzles and
remove clot by following the instructions in 4.6.36 Unclogging the WUD nozzles in
Maintenance in the instruction manual.

Seventh portSixth port Fifth port Fourth port Third port Second port First port
I C3 B3H5G F H4C2 B2H3E D H2C1 B1H1A

赤1
Red 1

Yellow3 Yellow2 Yellow1


・Blue marked nozzle: aspiration
Blue3 3 Blue 2 Blue1
・Yellow-marked nozzle: overflow
・Red-marked nozzle: water or detergent

4-21
4 MAINTENANCE

How to clean the cuvette wash line (WUD)


① Check that the analyzer is in READY mode. Place a towel and plastic sheet
under the WUD.
② Loosen the fixing screw with a 4-mm Allen wrench to remove the WUD.
③ Check the inside of all the nozzles for clogging or dirt.
④ Attach a silicon tube at the tip of nozzle for each blue or yellow line you want
to wash.

Fixing screw

⑤ Put the silicon tubes in a container that is filled with 150 ml of 50% hypochlo-
rite solution or 1N - NaOH aqueous solution. (Important: Do to use foaming
detergent. Do not pour more than 150 ml.)
You can place the nozzles directly into the container. When you do so, do not put
the WV nozzle in the container. Do not soak the WUD deeper than nozzles in the
solution.

WV nozzle
Do not soak
nozzles deeper
than this level.

4-22
4 MAINTENANCE

⑥ In the Menu window, select Maint., then select User Maintenance to open
the User Maintenance window.

⑦ Click WASH Start in Cuvette Detergent Aspirate Line Wash, and then se-
lect Yes in the window as shown below. The nozzles start aspirating the so-
lution for one minute for washing.

⑧ The following message appears when the wash is completed. Leave the
lines for a few minutes. Replace the silicon tubes in a container filled with
150 ml pure water. Click OK in the dialog box below. The nozzles start as-
pirating the pure water.

⑨ When aspiration of water is completed, the following dialog box appears.


Click OK to close the window.

4-23
4 MAINTENANCE

⑩ Wipe the tip of each nozzle that you washed, remove the towel and the plastic
sheet and return the WUD to the original position. Observe the WUD from the
side to see if the tips of the nozzles are in the correct positions and then
tightly fasten the fixing screw.
⑪ Perform INITIALIZE.
⑫ Check the positions of the nozzles.
In the Menu window, select Maint. and then Manual Operation. Dou-
ble-click 23.WUD to open the window shown below. Click Move to
lower the WUD. Lower the nozzles carefully. Check that the wash nozzles
are correctly positioned in the center of the cuvettes. Click the Init. Button
to move up the WUD to the original position. Click Exit to close the Manual
Operation window.

⑬ Exit the Manual Operation window. After performing INITIALIZE,check that


there is no leak from the tube connections.
⑭ Perform WASH3 and check that wash is completed without any problems.

4.4.25 Cleaning fans


Use a vacuum cleaner to remove dust from the fans installed on the right and rear sides of
the analyzer.

4-24
4 MAINTENANCE

4.5 REGULAR PARTS REPLACEMENT


4.5.26 Replacing Lamp
If you have not replaced the lamp for three or more months or the result data seems to
show fluctuation due to the lamp, you may need to replace the lamp. Follow the instruc-
tions below to replace the lamp.
① Lift the top cover of the analyzer and check how much lamp coolant is left.
If the liquid level of the lamp coolant is low or there is no coolant at all, it may
be the cause of data fluctuation. Refill LAMP COOLANT-C in the tank.
② Exit the system software applications to display the BioMajesty Startup win-
dow and turn off the analyzer power by turning to the right of the Power
Panel on the analyzer.
③ Remove the lamp.
The lamp housing may be very hot. To avoid burns, allow it to cool down be-
fore touching any components.
Loosen the lamp cable screw bolts to remove the cables. Unfasten the lamp fixing
screws to remove the halogen lamp from the lamp housing. (You cannot remove
the fixing screws from the plate.)

Lamp holder hole

Cables Lamp fixing screws

④ Install a new lamp in the lamp housing and securely fasten the fixing screws
and cable screw bolts.
Do not touch the glass portion of the lamp.
⑤ Turn on the analyzer by setting to PC CONTROL. Perform INITIALIZE,
then check that the analyzer is in READY mode.
⑥ Wait for 30 to 40 minutes for the lamp to stabilize. In the Menu window, se-
lect Maint. and then Lamp Energy Monitor to check the lamp energy.
Select Maint., then User Maintenance
to start the cuvette blank measurement.

4.5.27 Replacing ISE Electrodes


See 5.5.8. Replacing ISE Electrodes on P 5-13 of Chapter 5 ISE Unit (ELA09).

4-25
4 MAINTENANCE

4.5.28 Replacing Reaction Cuvettes (this should be done when the


power is off)
① Shutdown the system software to display the BioMajesty Startup window
and turn off the analyzer by turning to the right on the Power Panel.
② Remove all the reaction cuvettes installed on the analyzer.
③ Carefully install all of the 11 new reaction cuvettes by following the instruc-
tions below.
1. Do not remove or install reaction cuvettes in front of the detector lens (where
the light path of the lamp goes through.). The space between the detector and
reaction cuvettes is very narrow and there is a risk of damaging the cuvettes
when replacing.
2. Be careful not to drop the cuvette fixing screws into the reaction bath or in-
side the analyzer.
3. Make sure not to drop reaction bath oil into the cuvettes. If reaction bath oil
drops into a cuvette, shake the cuvette well to remove the oil and dry the cuvette
overnight.
4. Do not touch or wipe the cuvettes.

④ Turn on the analyzer by setting the power switch to PC CONTROL on the


Power Panel. Perform INITIALIZE and check that the analyzer is in READY
mode.
⑤ Set REAGENT PROBE WASH-S (5%) and pure water on RTT and CTT as
indicated below, then select WASH2. (This is the same as WASH2 described
for a weekly wash in Daily and Weekly Wash on P 4-8.)
• No 44 on RTT1 and RTT2: 5% REAGENT PROBE WASH-S (Wash with deter-
gent)
• No 45 on RTT1 and RTT2: Pure water (Wash with pure water)
⑥ In the Menu window, select Maint. and Lamp Energy Monitor to check the
lamp energy. Select Maint. and User Maintenance to start the cuvette
blank measurement.

4-26
4 MAINTENANCE

4.6 OTHER MAINTENANCE


4.6.29 When the pure water tank is empty
If an analysis is performed without sufficient water supplied from the Purified water pro-
duction system, a warning is issued for lack of water in the purified water tank. If you
continue the analysis without replenishing water, air bubbles are generated in the pump
that supplies pure water to the components. This can result in a failure to sufficiently
clean the reaction cuvettes, probes, and mixing rods.
1. When a warning is reported for lack of pure water in the purified water tank,
open the faucet or turn on the Purified water production system switch. Select
STOP on the workstation to stop sampling and wait until the status of the ana-
lyzer changes to READY. If the error mentioned in (2) is not reported, the
problem is solved. In the Menu window, select Maint. to open the Manual
Operation window. Select 71: LWP to turn it to ON and check the LWP pres-
sure gauge. If the displayed pressure is around the range of 70 to 72 kpa, and
there are no air bubbles; then you can continue the analysis.
2. If there is absolutely no pure water left in the pure water tank and air bubbles
are generated in the pump supplying pure water to components, the “9002
LWP gauge sensor abnormal” alarm sounds. In the event of the alarm sound-
ing, press the SYSTEM STOP button on the power panel to change the mode
to WAIT. If an error message is reported, click ALARM. The message disap-
pears. (Do not select and perform INITIALIZE.)

If you experience what is described in (2), remove the air bubbles by following the steps
below.
Aspirate cuvette
セル洗浄水 VP真空
wash water
セル洗浄
Cuvette wash line 吸引 To VP vacuum pump
ポンプへ
Wash SPP and RPP
SPP,RPPを洗浄 (water supply)
ライン
LWPに空気が入った時、
(給水) Wh
LWP圧力 このマニュアルコックを開け、
this manual cock
ゲージ
LWP pressure gauge
LWP Flowrate
Adjustment valve valve and
LWPに水を満たす
LWP with water.
en
LWP流量調整弁
70~72 kPa
76kPa
SRWP (LWP.W.V)
Probe
ピペット

Mixing
攪拌棒 rod

GE

Water
ミニクリアsupply
LWPライン Equipment
LWP line filter
フィルタ Analyzer
本体
純水分岐ジョイ
Pure water branching
ント(J4)
joint (J4 Manifold)

LWP 70 ~72Pure
kpa water bottle WEV
純水タンク

Overview of the LWP line

4-27
4 MAINTENANCE

When the pure water tank is empty


① In the Menu window, select Maint. to open the Manual Operation window.
② If the Purified water production system is not functioning correctly, fix it so that
the equipment returns to the normal status.
Check that 72.WEV on Manual Operation is OFF when the pure water tank
of the analyzer unit becomes full.
③ To remove air bubbles in LWP.
a. Loosen or remove the screw of the manual cock valve cover so that the cock
valve can move.
b. Double-click 59.VP in the Manual Operation window so that ON is dis-
played.
c. Double-click 61.VDP so that ON is displayed.
d. Open the manual cock valve for three seconds only and then close it imme-
diately. Put back the manual cock valve cover.
Never open the cock valve for longer than three seconds.

Manual Cock valve

Manual Cock Valve

Closed Open
(Normal Status)

e. Double-click 61.VDP in the Manual Operation window so that OFF is dis-


played.
f. Double-click 59.VP so that OFF is displayed.
④ Adjust the LWP flow rate.
a. In the Manual Operation window, double-click 71.LWP so that ON is dis-
played.
b. Turn the LWP Flowrate Adjustment valve fully counterclockwise to open it
and leave in that position for approximately 30 seconds.
Click BUZZAR to stop the “LWP gauge abnormality” alarm.

LWP Pressure gauge


LWP Flowrate
Adjustment valve

c. Turn the LWP Flowrate Adjustment valve fully clockwise to fasten it.

4-28
4 MAINTENANCE

d. Check the LWP pressure gauge. If 100kPa (---) or greater is shown, it indi-
cates air bubbles have been removed.
If the pressure does not rise up to this level, turn the LWP Flowrate Adjustment
valve counterclockwise to open it and keep it at that position for 10 to 20 sec-
onds. Fasten the valve and check if the pressure rises. If the pressure does not
rise, even after you repeat this operation several times, start the operation again
from 3. Remove air bubbles in LWP
If your analyzer unit has been used for a long time, this operation can wash the
line contamination into the filter. This may lead to difficulties in increasing
pressure. If this is suspected, double-click 71.LWP to set it to OFF, clean the
LWP line filter (see P 4-15), and then double-click 71.LWP to set it to ON and
check the pressure.
e. Turn the LWP Flowrate valve counterclockwise to open it and adjust the
pressure to approximately 70 to 72 kPa.
⑤ Remove air bubbles from the probe and mixing rod tubes.
a. Check that the pressure that the LWP pressure gauge shows the range
around 70 to 72 kPa.
b. Cover SPP V-blocks with gauze. (There are two SPP V-blocks.)

c. Double-click 21.SPEV2 for the magnetic valve in Manual Operation.


ON is displayed for SPEV2 and pure water is supplied to the wash port. At
this time if there are air bubbles in the line, water may splatter and make
noise as the air bubbles are discharged. Wipe away any splattering.
d. When pure water is evenly supplied as usual, double-click 21.SPEV2 to dis-
play OFF and stop the pure water supply.
e. Perform the steps mentioned above for the other probes and mixing rods.
The table below displays the units:
Probe Unit Mixing rod Unit

SPP 21.SPEV2 MIX1 46.MWEV1

RPP1 42.RPEV2-1 MIX2 58.MWEV2

RPP2 54.RPEV2-2

f. When air bubbles are removed from all the V-block tubes, close the Manual
Operation window, click INITIALIZE on the workstation and check READY
is displayed for the analyzer.
g. Check that there is no leakage in the analyzer unit.

4-29
4 MAINTENANCE

⑥ After the above steps, set all lines to 10 times for PRIME 2 or 3 to remove air
bubbles from probes and cuvette wash lines.
⑦ Perform WASH3 to remove small air bubbles.

4.6.30 Removing air from cuvette wash solution line and cuvette
conditioner line
Perform the following steps when the lines are completely empty.
① Check that the filter of the aspiration nozzle is not contaminated.
② Check that the pipe joint installed on the tank lid is not loose.
③ In the Menu window, select Maint. to open the Manual Operation window.
④ Double-click 59.VP so that ON is displayed.
⑤ For the cuvette wash solution line, double-click 24.AEV1 and 62.VEV1 so that
ON is displayed for both. For the cuvette conditioner line, double-click
34.DCEV1 and 63.VEV2 so that ON is displayed for both.
⑥ Wait for 10 seconds, and then double-click 62.VEV1 for the cuvette wash so-
lution line and 63.VEV2 for the cuvette conditioner line to display OFF.
⑦ Close the Manual Operation window, click INITIALIZE in the workstation,
and check if the mode is READY.
⑧ Select WASH3 and check that there is no leak from the WUD (R2 for the cu-
vette wash solution and R4 for cuvette conditioner) and that there is no inclu-
sion of air from the tank lid joint.

4.6.31 Replacing the SPP probe


Replace the probe if it is damaged, deformed, or clogs cannot be removed.
• The SPP is equipped with a liquid level sensor and a crash sensor.
• This task is performed without powering off the analyzer.
• All screws are just loosened but not removed.
How to replace the probe
① If the probe arm is not in the READY position, manually lift the shaft of the
probe arm to the uppermost level and move it to the position that makes re-
placement easy.
② Cover the reaction cuvettes and the wash port with gauze or something simi-
lar to prevent screws from falling out.
③ Loosen (but do not remove) the two screws that support the probe arm cover
so you can lift the cover.

4-30
4 MAINTENANCE

Pipe fitting Square shape joint Terminal fixing screw1 Post Terminal 1

Terminal 2
Terminal fixing screw2 Sensor board

Spring

④ Loosen terminal fixing screws 1 and 2 by using a Phillips screwdriver to re-


move the terminals 1 and 2. (Do not remove the terminal fixing screws.) If the
post under the screws moves when you loosen the screws, hold the post with
needle nose pliers.

⑤ While pressing the square shape joint with your fingers, turn the pipe fitting
counterclockwise with needle nose pliers and then loosen it manually to re-
move it. If you experience any leaks from the probe as you do this task, wipe
the leaking material with gauze or something similar.

4-31
4 MAINTENANCE

⑥ Hold and lift the end of spring with needle nose pliers to remove it from the
probe.
⑦ Rotate and remove the sensor board while using your fingers to lift the
washer with the U slot under the sensor board.

Sensor board

Washer

⑧ Place a flat bladed screwdriver under the square shape joint to lift it.

Square shape joint

Guide

Pipe fitting Holder

⑨ Hold the probe with your hand, and lift and remove it.
⑩ Insert a new probe in the holder and push the square shape joint vertically
into the guide.
⑪ Lift the washer and rotate and fix the sensor board. (See the illustration for (7)
mentioned above.)
⑫ Hold and lift the end of the spring with needle nose pliers to fix it to the probe.
(See the illustration for (6) mentioned above.)
⑬ While holding the square shape joint with your fingers, turn the pipe fitting
clockwise a few times and fasten it tightly. Fasten it for another 30 degrees by
using the square shape joint. Be careful not to damage the thread of the pipe
fitting.
⑭ Replace terminals 1 and 2 and fasten the terminal fixing screws 1 and 2 with
a Phillips screwdriver. As you fasten screws, hold the post under the screws
with needle nose pliers so that it will not move. (See the illustration for (4)
mentioned above.)

4-32
4 MAINTENANCE

How to check the operation of the probe after replacement


⑮ Remove gauze placed under the probe, lift the probe arm shaft manually to
the uppermost level, and carefully turn it to check that the tip of the probe
travels over the center of the V-block. Small displacements can be fixed by
bending the probe. If the displacement is large, check the probe installation.
⑯ Click INITIALIZE on the workstation to check probe operations are performed
correctly and that there is no leak from the joint.
⑰ In the Menu window, select Maint.
and User Maintenance. Click
Start in Position Probes for Rou-
tine Cleaning. After a while, all
probes move over the RRV cu-
vettes and then lower a little to
stop.

⑱ Check if the tip of the probe is positioned at the center of a reaction cuvette.
To fix small displacements, hold and raise the probe arm shaft to the upper-
most level and adjust the probe by bending it. If the displacement is large, the
probe tube may have been installed incorrectly. Check the installation. (If you
reinstall the probe, click INITIALIZE in the workstation and then click Start
again in Position Probes for Routine Cleaning as mentioned in (17).)
⑲ Click INITIALIZE in the workstation to check READY is displayed for the ana-
lyzer.
⑳ Select WASH3 and check for a short period of time that the probe operates
correctly without splattering.
Note: Tighten the splash cover screws before starting WASH 3 so that they
will not fall out.
21 Stop the analyzer and when READY mode is displayed, install the probe arm
cover.

4.6.32 Replacing RPP1 and RPP2 probes


Replace the probe if it is damaged, deformed, or clogs cannot be removed.
• RPP1 and 2 are equipped with a liquid level sensor.
• This task is performed without powering off the analyzer.
• All screws are just loosened but not removed.
How to replace the probe
① If the probe arm is not in the READY position, manually lift the shaft of the
probe arm to the uppermost level and move it to the position that makes re-
placement easy.
② Cover the reaction cuvettes and the wash port with gauze or something simi-
lar to prevent screws from falling out.
③ Loosen (but do not remove) the two screws that support the probe arm cover
so you can lift and remove the cover.

4-33
4 MAINTENANCE

Squrare shape joint


Pipefitting

Guide

Terminal
ターミナル2 2

Terminal 1
ターミナル1
Fixed screw D

Fixed screw C

Fixed screw B

Fixed screw A

Holder

Probe
サンプルチューブ

④ While pressing the square shape joint with your fingers, turn the pipe fitting
counterclockwise with the needle nose pliers and then loosen it manually to
remove it. If you experience any leaks as you do this task, wipe the leaking
material with the gauze or something similar.
⑤ Loosen the fixed screws A, B, and C and the square shape joint with a Phil-
lips screw driver. (Do not remove them.)
⑥ Hold the probe with your hand and
lift and remove it. A part Terminal 1
⑦ Insert a new probe in the terminal 1, Stopper
holder, and terminal 2.
⑧ Push the stopper of the probe and
Terminal 1 firmly from the top to
make sure there is no space be- Screw A
tween them, and securely tighten Tight fit
screw A with a Phillips screw driver.
Lift the A part of the probe above the No space between the
stopper to check that it does not stopper and Terminal 1.
move.
⑨ While holding the probe with your hand, tighten the probe screws B and C
and the square shape joint fixing screw with a Phillips screw driver. Do not
tighten the square shape joint fixing screw too hard so you do not damage the
guide.
⑩ While holding the square shape joint with your fingers, turn the pipe fitting
lightly clockwise a few times and fasten it tightly. Fasten it another 30 degrees
with needle nose pliers. Be careful not to damage the thread of the pipe fit-
ting.
How to check the operation of probe after replacement See the procedures from
P 4-33 (15).

4-34
4 MAINTENANCE

4.6.33 Replacing L-Ring set (1 mm) of sample pump(SP)


Remove the pump
① Stop the system and power off the analyzer unit and in the BioMajesty
Startup window.
② Open the front door of the analyzer.
③ Cover the joints located at the upper
part and the front of the cylinder of
the pump to be replaced with gauze
or something similar before loosen-
ing and removing the joints. Wipe
off any pure water leaking from the
pump onto the tip of the probe.

SP SRWP RP1 RP2

④ Remove the two fixing screws of the pump base.


⑤ Pull the pump forward slightly and remove the two electrical wiring connectors
attached to the pump. (Press the center of the raised part of the connector so
that the connector can be easily pulled out.)
⑥ Remove the pump unit from the analyzer, put the unit on the table, and re-
place the L-Ring set (seal).
Replace the seeling material (L-Ring set)
① Remove the cover protecting the piston.
② Press the drive lever down. (This will prevent the piston from being bent when
the cylinder is removed.)
③ Remove the two screw bolts from the cylinder and then carefully remove the
washer, cylinder and holder in sequence.

Do not remove these screws

Screw bolt Washer Cylinder Holder Piston

L-Ring Set (one unit) Block Drive Lever

④ Remove the L-Ring set (seal) installed at the upper part of the holder.

4-35
4 MAINTENANCE

⑤ Use the L-Ring fitting jig, to install a new L-Ring Set (seal) to the upper part of
the holder.
⑥ Adjust the screw holes of the washer and the cylinder so that they match and
then attach them with screw bolts.
⑦ Slowly move the drive lever up and down to see if it moves smoothly.
⑧ Install the cover.
Install the pump
① Put the pump in front of the base and install the two connectors.
② Set the pump on the base and secure it with Philips-head screws.
③ Manually tighten the joints at the upper part and the front of the cylinder and
then tighten another 45 degrees using long-nose pliers.
④ Set the main switch of the analyzer power panel to PC CONTROL.
⑤ Select Re-Start in the BioMajesty Startup window and click INITIALIZE to
display READY mode.
⑥ Set all line times to 10 for PRIME2 and then select PRIME2.
⑦ Select WASH3.
⑧ Check that there is no leaking from the joints and the pump sealing and that
no air has entered the cylinder and then close the door.

4.6.34 Replacing L-ring sets (5mm) of RP1 and RP2, and


OMNISEAL (14mm) for SRWP
These pumps have a dual set of sealing material. Change both of the sealing.

Tab

Connector (SP-2)

Tab
RP1 RP2

Connector (SP-1)

Remove the pumps


① Stop the system and power off the analyzer unit in the BioMajesty Startup
window
② Open the front door of the analyzer.
③ Cover the joints located at the upper part and the front of the cylinder of the
pump to be replaced by gauze or something similar before loosening and re-
moving the joints. Wipe off any pure water leaking from the pump onto the tip
of the probe.

4-36
4 MAINTENANCE

④ Remove the two fixing screws of the pump base.


⑤ Pull the pump forward slightly and remove the two electrical wiring connectors
attached to the pump. (Press the center of the raised part of the connector so
that the connector can be easily pulled out.)
⑥ Remove the pump unit from the analyzer, put the unit on the table, and re-
place the sealing material.
Replace the sealing material
RP1 and RP2 (L-Ring set)
① Prepare two pieces of pump sealing material for one pump.
Remove the two cylinder block screw bolts.
Marking the front-facing side of each part (cylinder, holder, and spacer) will make
re-assembly easier.
Cylinder block
Screw bolt

Cylinder block

Holder
Spacer Cylinder Remove

② Remove the cylinder block by gently pulling in the direction of the arrow.
(Pull the cylinder block only as the pump piston cannot be removed.)
Note: The white 5 radius piston is made of ceramic and can be damaged
easily. Handle with care.

L-Ring Set
Spacer

Cylinder

Piston
Piston

RP (5mm radius) Holder

Cylinder block
Cylinder fixing bolt

③ Remove the three cylinder screw bolts attached to the cylinder block. The
cylinder block can be disassembled into the spacer, the holder with L-Ring
sets (seal) and the cylinder.
④ Using the removing tool, remove the two L-Ring (seal) sets without damaging
the holder.
⑤ Use pure water to clean the spacer, holder, cylinder, and piston you removed.
Wipe the pump unit if wet.
⑥ Apply silicon grease lightly inside the holder where the L-Ring sets (seal)
touch.

4-37
4 MAINTENANCE

⑦ Using the L-Ring fitting jig, set a L-Ring set (seal) on each side of the holder
without twisting the new L-Ring set.
⑧ Assemble the spacer, holder, and cylinder by adjusting the marks. Push the
spacer evenly from the top and loosely fasten the three cylinder screw bolts.
Next, insert the L-Ring fitting jig of the same diameter and evenly tighten the
three cylinder screw bolts evenly and then remove the jig.
⑨ Attach the cylinder block to the pump unit and push it straight.
⑩ Attach the two cylinder block screw bolts and fasten tightly.

SRWP (OMNISEAL)
① Prepare two pieces of pump seal (14mm OMNISEAL set) for one pump.
② Mark the joint fixing hole (front facing) on the Nut and the ring to align their
positions when they are reassembled.

Joint fixing hole

Turn right

Nut

③ Turn the nut fixing the Nut and the spacer to the right. When the nut is re-
moved, the cylinder block can be disassembled as shown in Figure 1.

Nut
OMNISEAL
<b>
<a>

Holder Spacer Ring Cylinder

④ Use the removing tool to remove the two OMNISEAL sets from the Spacer
and the cylinder.
a. Insert the L-Ring removal jig 5mm into the OMNISEAL
b. Tilt the L-Ring removal jig slightly.
c. While maintaining the tilted position, remove the OMNISEAL.

4-38
4 MAINTENANCE

Removing an OMNISEAL using the jig

Jig

OMNISEA
Cylinder Spacer

⑤ Insert a new omni seal set into the Spacer and the cylinder by using the fitting
jig.
Attaching an OMNISEAL with the jig

Cylinder OMNISEAL

Spacer

Jig

⑥ Match the spacer pin with the holder fitting hole, and the Spacer pin with the
cylinder fitting hole to fix them.

<a> Pin
Spacer

Holder
Fitting hole

<b> Fitting hole


Pin

Spacer
Cylinder

⑦ Lastly, turn the nut to the left and fasten tightly (in the order shown in Figure
1) until the mark on the cylinder meets the mark on the nut.

4-39
4 MAINTENANCE

Install the pumps


① Put the pump in front of the base and install the two connectors.
② Set the pump on the base and attach it with Philips-head screws.
③ Manually tighten the joints at the upper part and the front of the cylinder and
then tighten another 45 degrees by using long-nose pliers.
④ Set the main switch of the analyzer power panel to PC CONTROL.
⑤ Select Re-Start in the BioMajesty Startup window, click INITIALIZE to dis-
play READY mode.
⑥ Set all line times to 10 for PRIME2 and then select PRIME2.
⑦ Select WASH3.
⑧ Check that there is no leakage from the joints and the pump sealing and that
no air has entered the cylinder, and then close the door.

4.6.35 Replacing mixing rod


If the mixing rod is bent, follow the steps below to replace it.
Do not power off the analyzer to replace the mixing rod.
① Cover the cuvettes with gauze or something similar to prevent dust or small
parts falling into them.
② Rotate the housing for the mixing rod in the direction of the arrow (clockwise
when viewed from above) and then lower and pull it out to remove it. Attach a
new mixing rod by inserting the top end of the silicon tube into the shaft of the
motor located above.

③ Push the mixing rod straight up from the bottom and then rotate in direction of
the arrow to fix (counterclockwise when viewed from above, the opposite of
(2)).
④ Check the mixing rod is firmly attached and then clean it with the gauze or
something similar. Remove the gauze or similar material that is covering the
cuvettes.
⑤ Select INITIALIZE and check that the system is in READY mode.

4-40
4 MAINTENANCE

Check behavior
① Select Maint. and Manual Operation.
② Double-click 44. MUD-1 to open the window to check MIX1. Double-click
56.MUD-2 to open the window to check MIX 2.
③ In the opened window, click Init. to return the mixing rod to the wash port.
When you slowly click Move twice after the mixing rod has returned to the
wash port, the mixing rod enters a cuvette.
④ Close the 44. MUD-1 or 56.MUD-2 window.
⑤ Double-click 45. MIX-1 or 57. MIX-2 to open the corresponding window.
⑥ Click Move in the window. The mixing rod moves back and forth in the cuvette
and stops after a short period of time. Check that the mixing rod does not hit
the cuvette while in motion.
⑦ Close the 45. MIX-1 or 57. MIX-2 window.
⑧ Double-click 40.MIXR-1 or 52.MIXR-2 to open the corresponding window.
⑨ Click Move in the window. The mixing rod starts to rotate in the cuvette and
then stops after a short period of time. Check that the mixing rod does not hit
the cuvette while it is rotating.
⑩ Close the 40.MIXR-1 or 52.MIXR-2 window.
⑪ Close the Manual Operation window and then select INITIALIZE.
⑫ Select WASH3 and check that the mixing rod does not scrape the cuvette.

4.6.36 Removing clot in WUD


When blue-mark nozzles for disposing liquid in cuvettes and yellow-mark nozzles for
overflow aspirate dust and waste or are clogged, liquid rises up to the top end of the cu-
vette and may overflow. In this case, remove clot from the nozzles.
The red-marked lines dispense water or detergent. Do not clean them unless there is
a leak problem.
① Check that the analyzer is in READY mode. Cover the RRV with gauze or
something similar to protect the cuvettes from dust, and then remove the
WUD. (For information on how to remove the WUD, see P 4-22 ②.)
② Hold the nozzles and remove the blue-marked and yellow-marked silicon
tubes. If you are using the type of nozzle that is connected by a joint, hold the
rectangular metal part of the nozzle with long-nose pliers and remove the
upper joint by rotating it.

• Silicon tube attached type

Remove a silicon
tube from a nozzle

4-41
4 MAINTENANCE

Joint connection

While holding the metal


part of the nozzle, rotate
the joint to remove it.

③ Insert a wire into the nozzle from the top to remove the clot.

④ Wash the inside of the nozzle with pure water by using an injector or some-
thing similar.
⑤ Wipe the exterior of the nozzle and firmly attach the silicon tube.

Replace when silicon tubes become loose.


- Yellow-marked nozzle: internal diameter 1mm x external diameter 3mm
- Blue-marked nozzle: internal diameter 1.5mm x external diameter 3mm
Note that the blue and the yellow silicon tubes have different diameters.

⑥ Return the WUD to its original position on the analyzer and check the opera-
tion. (see P 4-24 ⑫).

4-42
4 MAINTENANCE

4.6.37 Backing up system file to DVD


The analyzer unit program runs on Windows XP. The software consists of a program that
runs the analyzer, handles data and customized specifications. Make a backup when you
change your specifications since the specifications differ from one analyzer to another (It
is recommended that a backup should be saved in two locations.)

4.6.37a How to perform a backup


Use a DVD+RW or DVD+R as a back up DVD to save data. Typically when a DVD
backup is made, a folder for the date in which specifications are copied is created. When-
ever a backup is created, a folder with a date is added. While you cannot delete data on a
DVD+R, data on a DVD+RW can be deleted. Use the BioMajesty Startup window to
make a backup.
① Prepare a DVD and insert it into the DVD drive. Wait for a short time and then
click Back-up located at the lower right of the BioMajesty Startup window.

② In the Backup TOOL window, select Make a Backup Copy and System
Files omly (click to clear the Data Files check box),and check that the figure
in Total size is smaller than the figure in Space Available. Use a new DVD if
there is not enough free capacity.

4-43
4 MAINTENANCE

③ When you click Execute, the message “Do you want to make a backup copy
to D:¥ ~ ?” (if DVD is D:¥)appears. Click OK to start the backup. A folder
named with the current date,in which the specifications are copied, is created
in the DVD (D:¥) (20090627 for the window shown above).
④ When backup is completed, a message informing you of the completion ap-
pears. When you click OK to close the message, you will return to the
Backup TOOL window. Click Exit to return to the BioMajesty Startup win-
dow.
⑤ Eject the DVD from the drive, write down the date and version and store it.
Make sure to make a backup after performing an upgrade. If you have multiple ana-
lyzers, make a backup for each analyzer.

4.6.37b Restoring data from a backup disk


If a failure occurs in your computer software or the software does not work prop-
erly,contact your JEOL service office. The JEOL service office may ask you to perform
the following operations. The specification and configuration of the analyzer can be re-
stored by using what you saved on the backup disk as described in the previous section.
Before you start the restoration, check if the version of the workstation’s software is the
same as the version of the backup.
① Insert the backup DVD into the DVD drive. The system will detect the DVD.
② Wait a short time and then click Back-up located at the far right of the Bio-
Majesty Startup window to open the backup window.
③ Select Restore a Backup Copy in the Backup TOOL window. Click Browse
in the Source Folder in the DVD (in this example, D:) and select the dated
file that you want to restore by highlighting it in blue, and then clicking OK.

④ The file name is shown in Destination Folder.Click Execute to start restoring


the data.
⑤ When the restoration is complete, click OK to return to the Backup TOOL
window. Click Exit to return to the BioMajesty Startup window.
⑥ Eject the DVD from the drive.

4-44
4 MAINTENANCE

⑦ Select New Start in the BioMajesty Startup window to start the analyzer unit
software. Check the specifications and configuration. Modify if necessary be-
fore you start using the system.
Cuvette blank and calibration data are not saved.

4.6.38 Recovering from a power failure and computer maintenance


When a power failure occurs, check that the main breaker and switch located in the rear
of the analyzer unit are ON.
4.6.38a Recovery from an unexpected power failure
① If power has not returned:
Power off the workstation (PC rack). Restert in regular mode after power re-
turns. Select INITIALIZE, check that READY mode is displayed, and then
check the measurement data.
② If power has returned:
If the BioMajesty Startup window appears, click Shutdown and restart in
regular mode. Power off the workstation (PC rack), wait for about ten seconds,
and then restart in regular mode. Click INITIALIZE, check that READY mode
is displayed, and the check the measured data.
③ If the startup in “(1) or (2)” fails:
If you cannot perform initialization or if READY mode is not displayed, termi-
nate the software,select New Start and click OK in the BioMajesty Startup
window. Click INITIALIZE so that the system enters READY mode. (The data
for that day will be deleted when selecting NewStart.)
④ If the startup still fails after performing (3), follow the instructions in the next
section.
4.6.38b Checking the behavior of the workstation
① WindowsXp is running successfully if the BioMajesty Startup window ap-
pears after the workstation is powered on.
② The BioMajesty system is running successfully if the Menu window and the
Operation Panel window are displayed after you have selected New Start or
Re Start and clicked OK. If this is not the case, the program may be cor-
rupted.
Contact your JEOL service office if you feel the program may be corrupted.
4.6.38c Workstation problems
① When the screen hangs:
a. While pressing the Ctrl and Alt keys together, press the DEL key. Which will
open the following screen.

4-45
4 MAINTENANCE

Click Task Manager to open the Windows Task Manager window, where a
list of the software programs currently running is displayed. Click the task
with the “Not Responding” status to highlight it in blue and click End Task.

After a short time, the window shown above at the right appears. Click End
Now.
b. If the problem persists even after performing the procedure described in
Step 1, shut down and restart the system. If you cannot shutdown the sys-
tem, click Start located in the corner of the bottom left of the monitor and
select Shut Down to quit Windows and power off the workstation. Follow the
procedure described in 1. “Recovery from an unexpected power failure.”
② When the screen is frozen:
a. While pressing Ctrl and Alt keys together, press the DEL key twice to force
the program to end. (This will reset the computer.)
b. If you still cannot perform keyboard operations even after performing the
procedure described in Step 1, power off the computer by pressing the
power button for 10 seconds. The analyzer unit will also power off. Wait for
10 seconds and then follow the procedure described in 1. “Recovery from an
unexpected power failure.”
In this situation or any similar situation, the customized specifications (for example,
analysis parameters) may be erased because of corruption of the database file. To
avoid this kind of situation, make sure to back up data to a DVD when an analysis
parameter has been changed or a test has been added.
4.6.38d Using the manual for the JCA-BM6010/C Automatic Analyzer
① Click Start located at the bottom left corner on the monitor and select “Manual
for the JCA-BM6010/C Automatic Analyzer” at the top of the Start menu to
open the instruction manual. Select the title of the instruction manual you
want to read. The instruction manuals are provided in PDF format.
② You can navigate to the section you want to read by clicking the section in
the table of contents. Use this function as required.

4-46
4 MAINTENANCE

4.6.38e Others
① Up to 10 BM6010/c windows can be opened at a time. The following message
appears if you attempt to open an extra window. Click OK to slose this dialog
box. Close one of the windows that is already open and then open a new
window.

② The names of the open windows appear when you move the mouse pointer to
the bottom of the screen. The window appears in the foreground when you-
click a window name.
③ If you cannot close a window because it is overlapped by the Menu window
and the Operation Panel window, follow the steps below.
a. Select System(S) in the Operation Panel window and click Top Display
once to cancel the settings of the topmost window.
b. Click a part of the overlapped window to display it in the upper right fore-
ground.Close that window.
c. Select System(S) in the Operation Panel window again and click Top Dis-
play to restore the settings.

4.6.39 Before a long period of nonuse


Perform the following tasks before and after a long period (approximately four or more
days) of nonuse because the detergent lines of the WUD may dry and clogged. For infor-
mation on the ISE module, see P5-14.
Before the period of nonuse
① Perform WASH2 to complete washing when the routine operations are over.
② Pull out the aspiration tubes of the cuvette conditioner bottle and the cuvette
wash solution (CUVETTE WASH SOLUTION-3 or 5) bottle in the detergent
container, rinse them with pure water and then put them in a beaker or some-
thing similar filled with 500ml of pure water. If liquid is left in any of the tanks,
cover them to keep out dust.
Leave incubation bath oil (ACUR30) as it is. (*Important note)
③ Perform WASH3 (washing only by water).
④ When WASH3 is over, replace the aspiration tubes in the tanks that they were
originally installed.
⑤ Cover the top of detergent and reagent bottles in reagent trays (RTTs) with
plastic film, Parafilm®. (Make sure to remove the film when you restart the
analyzer.)
⑥ Dispose detergent in the refrigerated sample tray (CTT).
⑦ Perform shutdown.
Do not perform Auto Startup.

4-47
4 MAINTENANCE

After the period of non use


① Check that there are no crystals at the tip of WUD metal nozzles.
The second port (red 2); cuvette wash solution, the fourth port (red 4); cuvette
conditioner.
If there appears to be crystals or clogging, remove the WUD unit (by one Allen
screw) and remove crystals or clogging by feeding a wire through the nozzle
tips from the bottom of the nozzles. (Do not remove the connection joint. For
more information, see P4-41.
② Perform the startup.
③ Set the detergent in the CTT.
④ Remove the plastic film covering the top of the detergent and reagent bottles
in reagent trays (RTTs).
⑤ Perform PRIME1.
⑥ Perform WASH3. When WASH is started, observe behavior of the WUD for a
short time to check that the upper end silicon tube dose not come off or has
leak.
⑦ Perform regular analyses.

4-48
5
ISE UNIT
5.1 OVERVIEW ....................................................................................................... 5-1
5.2 ANALISYS OPERATION ................................................................................ 5-1
5.3 ROUTINE OPERATION AND CALIBRATION .............................................. 5-1
5.3.1 Start-up ....................................................................................................... 5-1
5.3.2 Calibration .................................................................................................. 5-1
5.3.2a Measurement ....................................................................................... 5-1
5.3.2b Data (Request — RealTime Monitor) ................................................... 5-2
5.3.3 Control, Sample Measurement ................................................................... 5-5
5.3.4 Single operation of ISE module ................................................................. 5-5
5.3.5 End Operation ............................................................................................ 5-5
5.4 SETTINGS ......................................................................................................... 5-5
5.4.1 Basic Setting............................................................................................... 5-5
5.4.2 User Setting ................................................................................................ 5-6
5.5 MAINTENANCE............................................................................................... 5-8
5.5.1 Checking ISE Buffer Level ........................................................................ 5-9
5.5.2 Checking Internal Standard Level.............................................................. 5-9
5.5.3 Washing Electrode and End Operation....................................................... 5-9
5.5.4 Cleaning ISE Dilution Bowl..................................................................... 5-10
5.5.5 Washing ISE Waste Drain Nozzle ............................................................ 5-10
5.5.6 Washing the ISE Line (Use Dummy electrode, ISE detergent
solution, probe)......................................................................................... 5-11
5.5.7 Conditioning Electrode (Electrode Na,K only) ....................................... 5-12
5.5.8 Replacing ISE Electrodes ......................................................................... 5-13
5.5.9 Storing Electrodes .................................................................................... 5-14
5.5.10 Long-term Storage of ISE module ........................................................... 5-14
5.6 ISE UNIT LAYOUT ......................................................................................... 5-15
5.7 ISE MODULE SCHEMATIC DIAGRAM....................................................... 5-15
5 ISE UNIT

5.1 OVERVIEW
Favorable data can be obtained with high-speed response, high selectivity, and high sta-
bility as a crown ether membrane is utilized for the sodium electrode (Na) and potassium
electrode (K) and a newly developed molecular-oriented membrane is utilized for the
chloride electrode (Cl). Calibration can be started simultaneously with other chemical
tests using the dedicated ISE serum and the urine standards (Low and High). After that,
you can perform control and sample analysis similar to other chemical tests.

5.2 ANALISYS OPERATION


① Pre-washing operation
Pre-washing operation is performed if time has passed more than 15 seconds since
the last measurement (After measuring leading base potential)
② Leading base potential measurement
③ Sample potential measurement
④ Washing operation
Washing is performed to prevent sample from carry-over
⑤ Trailing base potential measurement
Operation finishes after measuring trailing base if no other sample is left.
Base potential is determined by striking an average of leading base potential and
traling base potential in order to use measured base potential to calculate concentara-
tion of sample.

5.3 ROUTINE OPERATION AND CALIBRATION


5.3.1 Start-up
Since the ISE unit operates in conjunction with the chemical analyze unit, start the system.
Prime is performed in synchronization with the INITIALIZE operation of the analyzer
unit. You can start analysis when the status changes to READY.

5.3.2 Calibration
Measure calibration every day before measuring a sample. Also, measure calibration after
replacing the ISE buffer solution, Internal standard solution, or electrode, and after main-
tenance.
5.3.2a Measurement
① Pour approximately 500 μl of serum ISE Standard of Low-STD and serum ISE
Standard of High-STD (urine Low-STD and urine High-STD in the case of
urine analysis) into sample cups and set them at the STD position of CTT.
Note: The STD positions and the container types are set in the Setup — ISE
Parameters Setting window. (See P 5-7). Examples at delivery are C-11, 12,
13, and 14.
② You can similarly perform the START operation simultaneously with the cali-
bration of the chemical tests. The ISE analysis is performed in the order of
serum High-STD and then, Low-STD (if urine analysis is to be made, urine
High-Low follows after that). Each STD is measured at least three times

5-1
5 ISE UNIT

continuously, and the number of measurement times increases one by one up


to eight times until the difference between the last two data falls within
Calib.clear.
Calib.clear is a value set in the Setup - ISE Setting window, and the default
value is 1 for blood serum and within 2 for urine.
You can perform Electrolyte calibration separately in the Maint.– ISE Opera-
tion window (see P 5-7 to 9).
③ If the electrolyte calibration is completed without an error, perform the calibra-
tion of chemical tests. (If multi-point calibration tests are performed at the
same time, perform measurements in the order of Multi-pnt. → ISE →
One-pnt.STD test.)

5.3.2b Data (Request — RealTime Monitor)


Serum(S) or Urine(U)
H-STD(H) or L-STD(L) Thermistor 1 potential when the
Number of the day’s analysis sample potential is measured
Number of measure corresponding to this analysis
Thermistor 1 potential when
Measurement result (value of sample potential minus buffer potential) Buffer potential is measured
Data alarm flags

Base

Base

Base

Base

Base

Base

5-2
5 ISE UNIT

Base L-STD Base Slope Dilute

Flagged:
Slope alarm flag (l.h) Ref electrode If a Slope is out side the
Abnormal slope (H,L) control value of Ref If a dilution factor is
range from 38 to 65,it is outside the range from
Abnormal Dilution factor electrode :Flagged “d” abnormal 25 to 60, it is abnormal
abnormal (d) when this value becomes
Abnorma bial abnormal (NG) 350 or less

The above display appears when the RealTime Monitor display is in the Standard
setting. For the Conc. setting, only S-B potential difference and ISE calibration
result appear.
① Averages of the last two data of High-STD and Low-STD are each stored as
results.
② Temperature of measured solution is always measured by thermistor and
measurement result is displayed as TH. The very last measured value of
H-STD and L-STD will be saved.
③ Slope and Dil.factor are calculated from the results of High-STD and
Low-STD.
④ The results appear in the Maint. — ISE Monitor window. You can check them
with the previous ones.

Base Base

Base Base

Base

5-3
5 ISE UNIT

⑤ Calibration data error


In the case of a calibration error of electrolytes, an alarm goes off and the analyzer
enters the STOP mode. In this mode the subsequent measurements are not per-
formed. (If the calibration of the chemical tests were started simultaneously,
one-point calibration is not measured.) Be sure to solve the error before you perform
the calibration again.
1. Calibration error
a. Calibration Low-STD (or High-STD) error
If either of the STDs does not fall within Calib.clear in eight measurements, 4268
ISE Calibration HIGH STD Imprecision (or LOW STD) is shown. The data
may be unstable and vary.
(Calib.clear is a value set in the ISE Parameter window, and the default value is 1
for blood serum and within 2 for urine.)
b. Calibration range error
If the potential difference in measurement (sample potential – buffer potential) does
not fall within the set range, it becomes a calibration range error. This error might be
caused by incorrect placement of a standard solution, deterioration of the standard
solution, or deterioration of the electrode.
In the case of this error, the previous calibration result remains in the ISE
Monitor window.
If you perform the CV check using a sample before re-calibration to solve an
error, click Data transf. in the ISE Monitor window and select either Serum
or Urine to execute. Then, you can perform analysis using the previous cali-
bration results. After that, be sure to perform re-calibration before sample
analysis.
2. Slope abnormality/Dil.factor abnormality/Bias abnormality/Ref Electrode
abnormality
• Slope : Slope abnormality is caused if the range of 65 to 38 is missed.The slope
gradually drops as the analysis progresses. If the value begins to fall below
45, it is time to replace the electrode.
• Dil.factor…This is a Dil.factor value of a sample calculated from the calibration
data using ISE buffer solution. If the range of 25 to 60 is missed, “d” is
printed. This indicates an error. It might be caused by deterioration of
the standard solution or the buffer solution, or insufficient washing.
• Ref.Electrode…This is a control value of Electrode Ref. If the value falls below
500, the d flag is given.
In the case of this error, the calibration value in the ISE Monitor window has
been updated, but this is an error value and cannot be used for analysis as is.
If you perform START for re-calibration after this error, an alarm goes off
again and the message, 4247 ISE analysis command was rejected, appears.
However, since calibration is continued during the re-calibration, ignore it and
click the ALARM button to cancel the message. (This is only a message indi-
cating that the previous calibration has not been obtained.)
If you perform the CV check using a sample before re-calibration to solve the
error, click the Monitor search button in the ISE Monitor window, and select
a past date of measurement to display the calibration data on that day in the
window. Next, click the Data trasf. button and select Serum or Urine to exe-

5-4
5 ISE UNIT

cute so that analysis can be performed using the calibration result. After that,
be sure to perform re-calibration before sample analysis.

5.3.3 Control, Sample Measurement


Perform the operation in the same way as the analyzer unit operation. If there are both
chemical tests and analysis for the same sample, dispense to ISE unit, and then proceed to
the analysis of chemistry tests.

5.3.4 Single operation of ISE module


If the analyzer unit is in READY mode, you can perform a single calibration of the elec-
trolyte or other operations by Maint. – ISE Operation.

5.3.5 End Operation


① Pour approximately 100 μl of ISE Detergent Solution into a sample cup and
set it in CTT.
The CTT position and the Container type are set in the ISE Operation win-
dow. (C-15 at delivery)
If this is set with a thick container such as a test tube, pour approximately 200
to 300 μl inside.
② Perform the end processing to the analyzer unit. (Electrode washing is per-
formed in conjunction with WASH2.)
If you wash only the ISE unit, execute Wash Electrode in the ISE Operation
window.

In order to shut down BioMajesty, fill the ISE Dil.Bowl with pure water before
shutting it down. This prevents the electrodes from drying out. Execute the Final
operation in the Maint. – ISE Operation window, or pour 1 ml of pure water into
the ISE Dil.Bowl with a dropper. In order to automatically end the analyzer unit, you
can set the End ISE operation in Shutdown. (See P1-20)
If the analyzer unit is powered on and the analyzer is used even if only temporarily
after the ISE end operation, water in the Dil.Bowl is drained.
Be sure to refill pure water in Dil.Bowl after that.

5.4 SETTINGS
5.4.1 Basic Setting
① System Specifications Set (initial setting)
ISE Module, Avail.
② ISE Parameters setting (initial setting)

5-5
5 ISE UNIT

• Basic setting of analysis conditions.


• Setting of the CTT positions and the Container type of each standard solution
when you perform the calibration in START mode of the analyzer unit.
• Setting for executing electrode washing during execution of WASH2 of the ana-
lyzer unit. Or, setting of a detergent position (CTT position) and the Container
type required in the operation.
③ System Monitor (Maint.)
Set ISE to Operate in Chemistry of Pre-operation set.
④ ISE Operation (Maint.)
This window is used for the separate operation of the ISE Module. Setting of the
CTT position and the Container type.
⑤ Ctrl/Cal Sample Setup (Setup).
Enter the container and comments at the STD calibration position and the electrode
washing position of CTT.

5.4.2 User Setting


① ISE Parameter Settings (Setup)
Change standard solutions, detergent positions, pure water position, Container type,
and other information as necessary.
② Process Sequence (Setup)
Enter the position of Entry Order and Print Monitor Order.
③ QC Sample Definition (QC)
Check each required control sample.
If you measure the control sample by a urine calibration result, set the sample type
of the control to Urine.
④ Test Select (Request, Calib., or QC)
Check the required measurement. Usually, check 1.Routine/Interrp./STAT
samp.meas., 2.Ordinary control samp.meas., and 5.6 Ordinary calibration meas.

5-6
5 ISE UNIT

⑤ Sample Select (Calib. or QC)


Check the position of standard solution on the CTT.
⑥ Others
1. Cancell electrolyte analysis
Click Maint. – System Monitor and set ISE to Cancel in Pre-operation set to
execute the INITIALIZE operation. Electrolytes are then ignored and only photo-
metric analysis is performed. (Execute the INITIALIZE operation as well, when
changing to Operate.)
2. Management of calibration data
You can check the past calibration results in Maint. – ISE Monitor. Click Monitor
search and select the past date of measurement to execute. After that, the data on
that day appears. Then, if you use the result for the CV check or other operations,
click Data transf. and select either Serum or Urine to execute. (Never execute De-
lete All ISE Data. It will erase the past calibration results.)

3. Operation of ISE module


You can perform singular calibration analysis of electrolytes, CV check, washing,
and end operation in the Maint. – ISE Operation window, if the unit is READY.
This window is used during maintenance.
The setting of the CTT position and container type in this window is not linked with
the setting in the ISE Parameters Setting window, so be careful when you change
the settings.

5-7
5 ISE UNIT

5.5 MAINTENANCE
■ Regular maintenance and washing
Every Every 3 Every Every 2 One Irregu-
No Item Remarks
day days week weeks month larly
Addition of ISE Buffer is
1 Checking Buffer level ○
only once
Internal Standard Do not add internal
2 ○
level standard
3 Washing Electrodes ○
Washing ISE Anytime if crystals are
4 ☆ ○
Dil.Bowl found
Anytime if crystals are
5 Washing ISE WB ○ ○
found
Number of processed di-
alysis samples
Note 1: 500 sam-
ples/month or more
Note 2: 100 sam-
○ ○ ○ ○ ples/month or more
6 Washing ISE line
Note 1 Note2 Note 3 Note 4 Note 3: 100 sam-
ples/month or less
Note 4: 1 to 3 months
without any dialysis
samples
■ Other operations
When replaced with a new Elec-
7 Electrode aging ○
trode
In the case of Slope failure or
8 Electrode replacement ○
Selectivity
Maintenance for
9 ○ When stopped for 3 days or more
long-term storage
10 Notes for long-term stop ○ When stopped for 3 days or more
☆:See P 5-9 section5.5.4

For maintenance, open the top cover and the cover at the electrolyte sample dispens-
ing position, and perform the operations mainly in the Main – ISE Operation win-
dow.
• For maintenance, click ISE-WASH-ON in the Operation Panel Window, and per-
form maintenance with the display set to ISE-WASH-OFF. After the maintenance is
complete, execute INITIALIZE on the unit or Execute of Initialize on ISE Opera-
tion so as to return to ISE-WASH-ON.
• If water or ISE buffer solution is spilled, clean it up immediately.

5-8
5 ISE UNIT

5.5.1 Checking ISE Buffer Level


Check the ISE buffer level of the Buffer bottle. If it is low, do not add solution; instead,
replace the bottle with a new bottle. After that, set prime to 15 times in ISE Operation
and Execute, and then perform calibration.
Any buffer remaining in the bottle should be stored with the lid firmly closed. When sev-
eral bottles accumulate, mix them together well before using, and dispose them when they
are empty.

5.5.2 Checking Internal Standard Level


Check the remining of internal standard at ISE Operation window before measurement.
Do not add internal standerd but replace the bottle with new one by following next pro-
cedure.
Make sure that BM instrument is READY or WAIT mode before exchanging bot-
tles.
① Press IS remaining quantity Change in ISE Operation window. Window ap-
pears. No.ISE Wash is performed.
Window will be appeared to warn you the instrument is in preparation when the
instrument is performing ISE wash and is unable to replace internal standard.
Please wait until the instrument becomes ready to exchange bottles.
② Remove bottle of internal standard. Then remove connector of bottle.
③ Install bottle connector into a new bottle of internal standard, and place the
bottle of internal standard in analyzer.
④ Press Setting button. Remaining quantity of IS is reset int ISE Operation
window.
⑤ Execute IS line prime by setting Number of time to 10 times in ISE Operation
window.
⑥ Execute INITIALAZE of ISE module.
⑦ Perform the calibration before sample measurement.

5.5.3 Washing Electrode and End Operation


1. Wash the electrode after the operation is complete. Place the ISE Detergent
Solution on the CTT and perform WASH2 to the analyzer unit. Electrode
washing starts in conjunction with WASH2. (Check the position of the ISE
Detergent Solution and the type of container in Setup — ISE Parameter Set-
ting.) If you perform electrode washing separately, execute it in Wash Elec-
trode in the Maint. — ISE Operation window.
2. If the analyzer unit is to be shut down and will not be used for a while, fill the
ISE Dil.Bowl with pure water and execute Final Operation so that the Elec-
trode does not dry up. If the analyer unit is to be shut down automatically, set
to System Startup/Shutdown Setting so that pure water is filled automati-
cally in the Dil.Bowl. If you execute the ISE module separately, execute Final
Operation in the Maint. — ISE Operation window, or fill with pure water using
a dropper.

5-9
5 ISE UNIT

If the analyzer unit is powered on and analyzer unit is used even if only temporarily
after the end operation of the ISE unit, the pure water in the Dil.Bowl is drained.
Execute Final Operation in Maint. – ISE Operation, or pour 1 ml of pure water
into the Dil.Bowl using a dropper.

5.5.4 Cleaning ISE Dilution Bowl


Check stains on the Dil.Bowl
every day. If it is stained
with crystals or other materi-
als, wipe them off with gauze
cotton stick
or a cotton stick soaked with
Liquid-supply
pure water. Also, clean the Nozzle
給液ノズル
Bowl once a week according
to the following procedure.

① Set to ISE-WASH-OFF.
② Open the cover at the sample dispensing position, loosen and slide the screw
found on the stainless cover at the upper part of the ISE unit to the front; then
remove the cover.

③ Fill several mL of pure water in the Dil.Bowl and the tray using a dropper.
④ Leave it for about 5
minutes.
⑤ Set 5 in Times in
Dropper
Dil.Bowl Drain in
the ISE Operation
window, and click
Execute to drain
water.

⑥ Wipe off the remaining water or stains around a liquid supply with gauze or a
cotton stick or other similar materials.
⑦ Slide the upper-part of the stainless cover of the ISE unit to mount, and fix it
by tightening the screw. Be careful not to damage the tube or the Dil.Bowl
when sliding the cover. Also, check that the cover fits in the groove and is not
loose.
⑧ Mount the cover at the sample dispensing position.
⑨ Set 2 to 3 in Times of prime in the ISE Operation window, and click Exe-
cute.
⑩ Execute INITIALIZE of ISE module and return to ISE-WASH-ON.

5.5.5 Washing ISE Waste Drain Nozzle


① Set to ISE-WASH-OFF.

5-10
5 ISE UNIT

② Open the cover at the sample dispensing position, loosen the screw on the
stainless cover at the upper part of the ISE unit, slide it to the front, and re-
move it. (See 3. Cleaning ISE Dil.Bowl,(2).)
③ Remove the thumb-screw and then remove the Waste Drain Nozzle with the
pipes attached.
④ Remove the adhering crystals with paper or similar material, and wash the
nozzle with pure water.
⑤ Return the waste fluid nozzle to the wash bottle (paying attention not to break
the tube) and secure it with the thumb-screw.
⑥ Set 4 or 5 in prime in the ISE Operation window, and execute it. Check that
the fluid is not accumulated in the wash bottle at this time.
⑦ Mount the stainless cover and the cover at the sample dispensing position
(see 3. Washing ISE Dil.Bowl, (7), (8)).
⑧ Return to ISE-WASH-ON.
thumb-screw

5.5.6 Washing the ISE Line (Use Dummy electrode, ISE detergent
solution, probe)
① Set to ISE-WASH-OFF.
② Open the cover at the sample dispensing position, and loosen the screw on
the stainless cover at the upper part of the ISE unit. Slide it to the front and
remove it. (See 3. Washing ISE Dil.Bowl, (2).)
③ Remove Electrodes Na, K, Cl, Ref. (See Replacing Electrodes.)
④ Mount the Dummy electrode instead of the Electrode Na, K, Cl, Ref.
⑤ Remove the cap of the Dummy electrode.
⑥ Use a dropper to pour approximately 5 ml of ISE detergent solution into the
Dummy electrode.
⑦ Securely tighten the cap of the Dummy electrode. ropper

5-11
5 ISE UNIT

⑧ Click Execute(STEP-1) in ISE line wash in the ISE Operation window, and
perform washing. The washing will end in about 16 minutes.
⑨ After the washing is complete, return the Dummy Electrode to the Electrode
Na, K, Cl, Ref. At this time, make sure to check that a small black O-ring is
mounted on each Electrode. (This may result in leakage if it is missing.)
⑩ Click Execute(STEP-2) in ISE line wash in the ISE Operation window to
perform washing. Buffer prime will be performed 10 times.
⑪ Mount the stainless cover and the cover at the sample dispensing position
(see 3.Washing ISE Dil.Bowl, (7), (8)).
⑫ Return to ISE-WASH-ON.
⑬ Perform the calibration before sample measurement.

5.5.7 Conditioning Electrode (Electrode Na,K only)


It takes time for a new Electrode to get stable, and calibration might result in an error.
Thus, it is recommended that Electrode is aged according to the following procedure the
day before starting use.
① Take out the Electrode from the case and
remove the sponge inside the case.
② Place the Electrode to be aged in a plastic case.
(If the terminal has a cap, age both of them as they
are.)
③ Pour 0.5 ml of fresh serum that does not have
have any dangers of infectious desease into
the line of the Electrode. Press the dropper into
the hole so that the serum goes through the line.
Ensure that you can see that the serum went through the line from the bottom
of the Electrode.
Be sure to use the serum that is not antigenenic to avoid the chance of viral in-
fection. However, avoid using the control serum as additives may adversely af-
fect the Electrode.
④ Add ISE buffer solution until the entire Electrode is soaked.
⑤ Leave the Electrode for one night to perform aging on it.
(Do not perform aging for more than 24 hours.)
⑥ To use the aged electrode from the case, wash it with water, wipe it well (wipe
the terminal portion well), and then install the Electrode according to the pro-
cedure in step 7 below.
⑦ After you perform washing to the electrode in ISE Operation, set the CV
check to N=20 and execute it.
⑧ Perform calibration.
Electrode Ref and Electrode Cl do not need aging. Wash them with pure wa-
ter and carefully wipe their terminals before use.

5-12
5 ISE UNIT

5.5.8 Replacing ISE Electrodes


① Set to ISE-WASH-OFF.
② Open the cover at the sample dispensing position and loosen the screw on
the stainless cover at the upper part of the ISE unit. Slide it to the front and
remove it. (See 3. Washing ISE Dil.Bowl, (2).)
③ Remove the Electrode.
a. Remove the connector from the Electrode.
b. Remove the thumb-screw, incline the plate retaining the electrode, and take
out the Electrode to be replaced.

Thumb-screw Plate retaining the electrode

④ Mount the electrode.


(Use the aged electrode.)
a. Wash Electrodes to be mounted
with water and wipe them thoroughly
(particularly, thoroughly wipe the
joint portion with the terminal), and set
them in the correct order.
Check that the black O-ring is fitted on
the one side (the right side of each
Electrode as seen in the photo on the
right) of each Electrode at mounting. If the O-ring is missing, it can result in leak-
age.
b. Press Electrode with the retaining plate and move Electrode to the right
and left to make sure that there is no gap. (If there is a gap between Elec-
trodes, you cannot close the retaining plate.) Secure it by tightening the
thumb-screw.
c. Connect the terminal to the electrode.
⑤ Execute Initialize in ISE Operation window and return to ISE-WASH-ON. At
this time, make sure that the fluid is draining smoothly from Dil.Bowl and there
is no leakage.
⑥ Mount the stainless cover and the cover at the sample dispensing position.
(See 3. Washing ISE Dil.Bowl, (7), (8).)
⑦ Set the CV check to N=20 in CV check and execute it.
⑧ Perform the calibration.

5-13
5 ISE UNIT

5.5.9 Storing Electrodes


Store the new electrodes that are kept in the attache case in a dark place at a
room temperature.

If you are finished using the electrode, store it after washing it.
(If the electrode has a lid for the terminal end, store it with the lid closed as be-
low.)
① Cl, Na, and K・・・Store them in a refrigerator in a case containing ISE buffer
solution.
If you use the electrode again, take it out of the refrigerator at least 6 hours be-
fore and let it return to room temperature before using it.
② Ref・・・ Dampen the sponge in the case with pure water, place the Electrode
Ref on it, close the lid, and store it at room temperature.
Store it in a moisturized condition but do not store it in water.)

5.5.10 Long-term Storage of ISE module


If you stop the analyzer for 3 days or less, power it off, and then use a dropper to
fill the ISE Dil.Bowl with pure water (in order to prevent the Electrode from drying
out).
If you stop the analyzer for 4 days to one month, execute Wash electrode, and
then replace the Electrode with the Dummy electrode. After that, fill with pure wa-
ter using a dropper, execute Dil.bowl drain in the ISE Operation window, and fill
the waste fluid line with pure water.
Store the Electrode as described in 8. Storing ISE Electrodes.
If you stop the analyzer for one month or more, execute Wash electrode, and then
replace the Electrode with the Dummy electrode. After that, remove the buffer bot-
tle and replace it with a bottle containing pure water. Set Bufferprime to 50 times
and execute it, and replace all the lines with pure water. Store the electrode as
described in 8. Storing ISE Electrodes.

5-14
5 ISE UNIT

5.6 ISE UNIT LAYOUT

Electrode 电极 Dilution Bowl


(MIXER) 混匀稀释杯

排空电磁阀 缓冲液电磁阀

脱气罐
Degasser 内标液电磁阀

废液瓶
Wash Bottle

Sylinge 注射器:排空、内标液、缓冲液

5.7 ISE MODULE SCHEMATIC DIAGRAM

Degasser

Electrode
Degasser

Drain

5-15
USER INTERFACE
6
6.1 SYSTEM ............................................................................................................ 6-1
6.1.1 BioMajesty Startup window ....................................................................... 6-1
6.1.2 Menu window/Operation Panel window .................................................... 6-2
6.2 OPERATION PANEL WINDOW ...................................................................... 6-3
6.2.1 Start Conditions window ............................................................................ 6-3
6.2.2 STAT Port ................................................................................................... 6-5
6.2.3 PRIME........................................................................................................ 6-7
6.2.4 WASH......................................................................................................... 6-7
6.2.5 Other buttons .............................................................................................. 6-8
6.3 MENU WINDOW.............................................................................................. 6-9
6.3.1 REQUEST .................................................................................................. 6-9
6.3.1a Order Entry ......................................................................................... 6-9
6.3.1b Test Result Monitor ........................................................................... 6-11
6.3.1c 3Review/Edit..................................................................................... 6-13
6.3.1d Reaction Monitor............................................................................... 6-14
6.3.1e Print Report ....................................................................................... 6-15
6.3.1f Statistics ............................................................................................ 6-16
6.3.1g Test Select.......................................................................................... 6-16
6.3.1h Sample Log* ..................................................................................... 6-18
6.3.1i RealTime Monitor ............................................................................. 6-18
6.3.1j Cup/Tube Assign* ............................................................................. 6-19
6.3.1k STAT Order Setup* ........................................................................... 6-20
6.3.1l Correlation* ...................................................................................... 6-21
6.3.2 CALIBRATION ....................................................................................... 6-22
6.3.2a View Calibration Curve .................................................................... 6-22
6.3.2b Test Select.......................................................................................... 6-16
6.3.2c Sample Select .................................................................................... 6-24
6.3.2d Calibration Setup*............................................................................. 6-24
6.3.3 QUALITY CONTROL............................................................................. 6-27
6.3.3a Daily Precision Control..................................................................... 6-27
6.3.3b QC Cumulative.................................................................................. 6-29
6.3.3c Real-Time QC.................................................................................... 6-30
6.3.3d Control Data Registration .................................................................. 6-31
6.3.3e QC Sample Definition* ..................................................................... 6-32
6.3.3f Test Select .......................................................................................... 6-16
6.3.3g Sample Select .................................................................................... 6-24
6.3.4 REAGENT................................................................................................ 6-33
6.3.4a Reagent Test Monitor......................................................................... 6-33
6.3.4b CTT Monitor ..................................................................................... 6-35
6.3.4c Reagent Container Settings ............................................................... 6-35
6.3.5 MAINTENANCE ..................................................................................... 6-37
6.3.5a System Startup/Shutdown Setting ..................................................... 1-22
6.3.5b System Monitor ................................................................................. 6-37
6.3.5c Lamp Energy Monitor ....................................................................... 4-10
6.3.5d User Maintenance.............................................................................. 6-38
6.3.5e Manual Operation.............................................................................. 6-39
6.3.5f System Maintenance Monitor............................................................ 6-42
6.3.5g ISE Operation ...................................................................................... 5-7
6.3.5h ISE Monitor......................................................................................... 5-3
6.3.5i Communication Monitor ................................................................... 6-43
6.3.5j Error Report....................................................................................... 6-43
6.3.5k Liquid Level Sensor Monitor* .......................................................... 6-44
6.3.5l Clot Monitor* .................................................................................... 6-45
6.3.6 SETUP ...................................................................................................... 6-46
6.3.6a System Specification Settings ........................................................... 6-46
6.3.6b Analytical Parameters (Chemistry).................................................... 6-47
6.3.6c System Test List................................................................................. 6-49
6.3.6d Process Sequence............................................................................... 6-49
6.3.6e Analytical Parameters (Serum).......................................................... 6-50
6.3.6f Ratio Parameters................................................................................ 6-51
6.3.6g ISE Parameter Settings ........................................................................ 5-6
6.3.6h Blank Reagent Settings...................................................................... 6-52
6.3.6i Reflex Test Settings ........................................................................... 6-53
6.3.6j Contamination Settings ..................................................................... 6-53
6.3.6k Print Form Settings............................................................................ 6-58
6.3.6l Online Settings .................................................................................. 6-59
6.3.6m Ctrl/Cal Sample Setup ....................................................................... 6-59
6.3.6n Alarm Buzzer Set .............................................................................. 6-60
6.3.6o Setting System Parameters ................................................................ 6-61
6.3.6p Reaction Check Logic ....................................................................... 6-61
6.3.6q Carryover Setting .............................................................................. 6-62
6.3.6r User Code Settings ............................................................................ 6-62
6.3.6s New Test Registration........................................................................ 6-63
6 USER INTERFACE

6.1 SYSTEM
6.1.1 BioMajesty Startup window

Startup
User Name, Password Enter the user name and the password you set in the User Code Set
window.
SN Displays the serial number of the analyzer
Ver No. Displays the version number of the software.
System Date Displays the date when you start the system.
New Start To clear all data and start the system, select this option.
Re-Start To start the system while keeping the data active, select this option.
OK To start the system, click this button.
Shutdown To shutdown Window, click this button.
Back-up Click this button to back-up the system data
Movement Click this button to temporarily transfer specifications, except the ana-
lyzer-specific parameters, from one analyzer to another. Ask service
person for instructions.

6-1
6 USER INTERFACE

6.1.2 Menu window/Operation Panel window


■ System (BioMajesty)

Menu window Operation Panel window

Operation status display

Password Use this dialog box to set a password if necessary (See Chapter 3 Settings,
P3-1.)
User Name: Enter manager to dis-
play the Setup menu window.
Setup menu will not be displayed
when logged in as user.

Password: Enter a password only if


you have set it. No password is set
at the time of delivery.
Change Password Use this dialog box to change the password.
Top display Click Top display to keep Menu Window and Operation Panel
Window displayed on top of other windows.
Version Info. You can check the version of the software.

Version Information

Screen Print Click this button to output a hard copy of the screen.
Change User Click this button to change the user name set for starting the sys-
tem.
Exit Click this button to shutdown the system (see Chapter 1 Basic Op-
eration, P 1-17, System Exit).

6-2
6 USER INTERFACE

6.2 OPERATION PANEL WINDOW

Operation Panel

6.2.1 Start Conditions window


Select appropriate Analyze check boxes in Calibration (Multipnt.smp, One-pnt.smp),
Control, and Patient sample sections, and click START to start the analysis.

Start Conditions

Calibration
Multipnt.smp. Select this Analyze check box when analyzing a multi-
point calibration test. Then, select 98 or 99 for TTNo.
Since the routine sample is analyzed on STT, you can-
not analyze the routine sample and multipoint calibra-
tions at the same time.
Singlepnt.smp Select this Analyze check box when analyzing a single
point calibration test.
Ordinary calib./Special calib. Select the appropriate radio button and click Temp.test
select to change the tests for each calibration
Temp.test select Click this button to temporarily change the tests for
calibration measurement (BLK, STD) and control
measurement.
Temp.sample select Click this button to temporarily change the samples for
calibration measurement.

6-3
6 USER INTERFACE

Control
Control smp. Select this Analyze check box when measuring control sam-
ples.
Temp.test select Same as above.
Temp.sample select Click this button to temporarily change the samples for con-
trol measurement.
Patient sample
Analysis mode Select Barcode for analysis of barcoded samples.
Select Cup posi. for analysis of samples by their cup posi-
tions on the sample tray. (Prior registration of workorder is
required for Cup posi. analysis.)
Tray No. If you select Cup posi. for Analyze mode, enter the STT
number from 1 to 97. It is the STT number you selected
when registering the workorder to the analyzer.
Routine smp. Select this check box to analyze routine samples. Enter the
range of sample positions on STT between 1 and 84.
Temp.cup/tube select You can temporarily change the status, the container and the
Priority of an analysis for each position on STT.
status/container You can temporarily change the container type for each of the
position numbers on STT.
“I” Click Priority to analyze a sample with priority.
Start Click this button to start analysis under the conditions you
have set.
Cancel Analysis will not start if you click this button. However, if
you cancel analysis while the analyzer is in PAUSE mode,
the analyzer will return to START mode.
The same Temp.test select window appears when you click the Temp.test select
button in the Calibration or Control section.

Sample Confirmation window (see P 1-9 — 10)


A barcode number scanned for each STT position appears if you select Barcode for Pa-
tient sample in the Start Conditions window. You can modify the incorrect sample ID
numbers here. Check the box to the left of the position number to prioritize the sample
and the analyzer will run the samples in the order of priority.

Sample Confirmation

6-4
6 USER INTERFACE

OK Click this button to start dispensing the sample.


Cancel Click this button to cancel analysis of the sample whose bar-
code has been scanned. However, if you cancel analysis while
the analyzer is in PAUSE mode, the analyzer will return to
START mode.
Retry Click this button to retry scanning the barcode of a sample.
Timer off You can set the timer to off when setting the time to scan
the sample barcode. The status of a sample appears in the
Sample Conditions window.

Colors of the Sample ID field When the analyzer reads the barcode, the scanned
sample ID number appears in colored field, indicating the sample
status.
Sample ID field color Sample status
Red The sample is not analyzed yet.
Pink The sample is being dispensed or analyzed for the first time
Blue The sample completed the initial run or rerun.
Light blue Rerun is in process.
Green A sample before analysis (registered).
Gray The analyzer could not read the barcode.
The sample is not registered, or the sample of this barcode
White
number is being analyzed now.
Unavailable The sample cannot be removed.
The colors are different from those in the Test Result Monitor dialog box.

Icons The barcode box turns gray when a barcode error arises, or an icon
is displayed with the barcode number to prompt cautions.
Icon Name Sample status
Caution (yellow) This icon appears mainly when the barcode cannot be read.
Warning (red) This icon appears when the barcode number is different from the
one that should present at the cup (dispensing) position. This
warns you about the possibility of dispensing a wrong sample.

6.2.2 STAT Port


The STAT Port window
The STAT Port window appears if you set a sample on the STAT port and push in the
lever while the analyzer is in the START, READY, STOP, or PAUSE mode. However,
you cannot use this window in the R-PAUSE or WAIT mode. This window automati-
cally closes when the dispensing of a sample on the STAT port is completed.

6-5
6 USER INTERFACE

STAT Port

STAT Set Specification No setting is necessary if you measure a barcode


sample. If you click STAT Set Specification after the barcode
is scanned, the Sample No. will automatically increase incre-
mentally from S01 to S100. (see P3-2 STAT Oder Setup)
Comment Enter the name of the STAT set, or make temporary changes
here.

Temporary Change Use this dialog box to temporarily change the tests that are regis-
tered for each set.
Selection Release Click this button to cancel STAT Set Specification
Timer Off Click this button to cancel automatic start.

Page switch button Temporary change

6-6
6 USER INTERFACE

6.2.3 PRIME
In the PRIME Set window, you can configure settings for PRIME and execute it so that air
bubbles are removed from the pure water lines. Click EXECUTE to start the pumps of each
linr and they will operate the number of times you have specified to remove air bubbles. Exe-
cute PRIME 1 in the morning and prime is performed 5 times per line. If you wish to prime
each line for times other than 5, select PRIME 2 or 3 and specify the number of times.

PRIME Set Select You can select PRIME 1, 2, or 3.


Times Type the number of times to prime each line.
Normally, specify five times if you have to remove the air bubbles produced par-
tially in the lines. Specify 10 times if the lines are entirely filled with air.
Execute Click this button to start PRIME.

PRIME Set

Save Click this button to save the settings that you have changed.
Cancel Click this button to terminate the function without executing it.

6.2.4 WASH
In the WASH Set window, you can wash the analyzer. Select WASH1, 2 or 3, place liquids in
the designated positions on the RTT1 and 2 trays and click EXECUTE. Normally, for washing
in the morning, select WASH 3 and rinse the analyzer. For washing in the evening, select
WASH 2, to wash the analyzer with a detergent and rinse. To rinse the analyzer, set pure water
in the RTT1 and 2 trays. To wash it with a detergent, set pure water and the alkali detergent
(REAGENT PROBE WASH-K) in the RTT1 and 2 trays.
Replace a liquid in the detergent position with REAGENT PROBE WASH-K (5%)
and wash the analyzer with it at least once a week (see p 1-4).

6-7
6 USER INTERFACE

WASH Set
WASH 1 Select this button to wash all the probe lines (the initial wash takes approxi-
mately 14 minutes, plus an extra 20 minutes per additional wash).
WASH 2,3 Select this button to wash all probe lines and all reaction containers. (The ini-
tial wash takes approximately 27 minutes, plus an extra 12 minutes per addi-
tional wash.)
WASH 2 and WASH 3 are run the same way.
Cycle Select the number of washes.
CTT cup position, Container type Currently not available.
RTT1 bottle posi.0, Container Type Displays the position on the RTT1 tray
where you place the liquid for WASH and
the container type.
RTT2 bottle posi., Container Type Displays the position on the RTT2 tray where you
set the liquid for WASH and the container type.
Execute Click this button to start washing.
Save Click this button to only save the setting and terminate the function.
Cancel Click this button to terminate the function without changing the setting.

6.2.5 Other buttons


HOST ON Click this button to switch between online and offline connections to the
host computer.
ISE-WASH-ON Click this button to switch between ON and OFF for the regular wash of
the ISE Unit.
ALARM Clicking this button displays the Error Report window. If a message
appears in any window, you can check its details in this window (see
Chapter 7 P7-10, Alarm Tables).
BUZZER Clicking this button stops the alarm.

6-8
6 USER INTERFACE

6.3 MENU WINDOW


6.3.1 REQUEST

* *These are displayed if


* * you enter manager in
the password window.

Request

6.3.1a Order Entry

Order Entry

Sample Workorder Information


Sample Workorder Information Registered or No Regist is displayed as the request status
of the order number currently displayed.
Workorder Displays the number of the currently registered samples.
Order Entry
Type Specify the priority of an analysis as Routine or Priority.
A sample specified as Priority. is given priority when
analyzing samples simultaneously.

6-9
6 USER INTERFACE

Order no. Specify the order number of a sample. The number of


samples that can be registered depends on the number of
the tests ordered.
posi.no. Enter the STT tray number from 1 to 97 in the box to the
left. Enter the 4-digit rack number when using a rack. En-
ter the position number corresponding to STT (or the rack
holder) in the box to the right.
posi.type Select 1: TT or 2: RACK.
Samp.no. Enter a barcode number when analyzing a barcode (up to
13 digits).
You need to enter a sample number even if an order entry uses a position number
(cup position analyses). Any sample number can be used. Note that you cannot in-
crease a sample number to a value that exceeds the number of digits set in Sequen-
tial.
You cannot use the same sample number for Order no., Posi.no., and Samp.no on
the same day. Note that the registered information will be overwritten.
Test tbl no. If you want to change the amount of a sample (dilution
conditions) to measure the sample, enter the value in this
box.
Multi Dil. Select the dilution conditions to be set for each tests to be
rerun from D1-D4. You can measure a sample under the
multiple dilution conditions from the initial run.
System Dilution Mode Select from M Cond., D1 Cond., D2 Cond., D3 Cond.,
or D4 Cond. ( initial condition/rerun condition ) . For
samples that had confirmed high or low concentrations at
the initial test, you can specify the analyses conducted
under each of the D1-D4 rerun conditions for each test.
To set this, click the test so the test number is displayed
in the Test-tbl no. box. Then, change the sample value
to D1, D2, D3, or D4 condition, so the M condition of
the test in the Request tests list on the right hand side is
changed to D1, D2, D3, or D4. After this procedure, the
condition of the next test returns to the M condition.
You need to set dilution conditions for M, D1, D2, D3, or D4 in the Reanalysis Con-
ditions Set dialog box that appears by clicking the Rerun conditions set button in
the Analytical Parameters (Chemistry) window. (see P2-4)
Container type Specify the type of a container used for analysis. Select
from 1-9 in Sample Container Specifications in Sys-
tem Specifications Set.
Samp.type Select the sample to be analyzed from Serum or Urine.
Dil.factor Type in the dilution factor of a sample. The measured
value is multiplied with this factor.
Comment 1,2 Enter two comments. You can use them for the searches
performed in the Review/Edit window.
Sex Select M for male, or F for female.
Age Enter the age.
Blood collection date Enter the date when the blood was collected. Use this to
check the order status.
Up , Down Click these buttons to increase or decrease the number in
the Order no. box. Use them to check the registered sam-
ples.

6-10
6 USER INTERFACE

New Click this button to move Order no. to the first of No


Regist. numbers. If there are two or more groups of un-
registered numbers, the order number changes to the
first number in each group, every time you click the but-
ton.
Enter Click this button to register the order settings.
Profiles Clicking the group name selects all the tests
you have set at once. To make this available, spec-
ify the profile using Create Profile.
Batch entry
Use this button to register samples consecutively if they have the same order test and the
same container type (see P 1-21).
Batch func.
Use this button to delete the same tests consecutively from and enter the same tests at
once into the Order no. which has already been entered.
Create profile
You can set the profile from 1 to 150 types of group sets.
View worksheet
Displays the registered samples as a list. You can check the sample volume that has been
used.
Host request
Click this button to transfer the order settings of a sample number in the host computer to
the analyzer.
Normally, the sample number is transferred to the host computer as soon as the sample
barcode is scanned at the start of analysis; then the order settings included in the sample
number are transferred to the analyzer online.

6.3.1b Test Result Monitor


The Test Result Monitor window displays the current status of analyzing samples and the latest
measurement result in real time.
Double-clicking the sample position displays the amount of time until the measurement of a sam-
ple is completed or the time when the measurement will be finished.
System Status Displays the current status of the analyzer.
Sample Information Displays the sample number and the sample position of
the next sample in Samp.No. and Samp.Posi., respec-
tively.
Sample Information History Select Registerd or Newest.
TT No. You can check the current status of a sample by selecting
the Tray number of the sample after analysis is completed.
Also, you can check the status of the multi-standard sam-
ple. The status of the calibration samples, including the
electrolyte samples, and the status of the control samples
is displayed at each CTT position.
Test Result Information Displays the latest information about the data to be ana-
lyzed.

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6 USER INTERFACE

Test Result Monitor


Sample search
Clicking this button will record the order number, the position number, and the sample
number of a sample and display the amount of time it takes to analyze the sample.
Analyzing Sample Info.
Clicking this button will display the amount of time it takes to analyze the sample in
process using a rack and a LAS.
Do not take out sample : Samples with a high possibility of an error in dispensing.

Status display of Do not Status Reason


take out sample
(Red) Untested Dispensing starts shortly after.
(Pink+Black) Dispensing Currently dispensing.
Rerun may be performed.
(Pink) In Process (When STT retest is specified.)

(Yellow) Pending Rerun dispensing starts shortly after.


Rerun (When STT retest is specified.)

(Light blue+Black)
Rerun Currently dispensing.(When STT retest
Dispensing is specified.)

Pending Rerun (Do not take out sample), Rerun In process, or Complete (Rerun)
is displayed when you set auto rerun.

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6.3.1c 3Review/Edit
You can check the measurement result in the Review/Edit window.

Review/Edit
Checking the measurement result
Routine smp. You can check the data of a routine sample and a STAT sample.
Today You can check the data for one week including the present day. As for
the data of the present day, do not forget to click the Save button for
each sample if you change the contents which can be overwritten. If
you do not click the button, the overwritten contents will not be saved.
・Glay Untested.
・Blue All assigned tests completed, including reruns.
・Yellow Analysis completed, including rerun tests (ticked in the R column
on the left list).
・Light blue Analysis completed with some untested tests.
・Pink In analysis.
Clicking the Order no. header displays an order test and its data on the right. For
the samples specified to be reanalyzed, an asterisk is placed in the R column and
sample volume (reanalysis conditions) is selected depending on the setting of the
analysis conditions. You can order reruns of samples that are not specified to be
reanalyzed by checking the R and the dispensing volume boxes of the sample listed
on the right hand of the headers by saving the settings.
R Displays an asterisk if the sample is specified to be reanalyzed.
Flag Data are flagged H, L, u, d, and with other flags.
Rerun val. Displays the data of the rerun value.
Prev val. Displays the previous values sent from the host computer system.
Dil.cond. Select the rerun condition.
・M An initial condition where a rerun is conducted based on the reaction
sample volume and the dilution condition set in the Analysis test condi-
tion setting section of the Analysis Parameters (Chemistry) window.

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6 USER INTERFACE

・D1-D4 Conduct a rerun based on the reaction sample volume and the redilution
condition set in the Reanalysis condition section of the Analysis Pa-
rameters (Chemistry) window.
Save
Click this button to save the changes to the data, the rerun order, and the dispensing vol-
ume of a sample for a rerun.
Update
Displays the latest information while the Review/Edit window is open. Data are not
shown in real time.
Disp search cond
Enter the details of a sample to be displayed on the display list on the left side.
Display conditions Tick Pending, Complete, Rerun Complete, Incomplete, and/or In
Process.
Samp.type Select Serum + Urine, Serum, or Urine.
Search conditions Includes Sample #, Comment1, and Comment2.
Correction Calc.
You can specify the range of a sample and make corrections on the measurement results
for each test in batch.
Print Report
Click this button to print data in the format you created in the Print Form Settings window
that was opened from the Setup window.
Host Transfer
Transfers the measurement results to the host computer in batch.

6.3.1d Reaction Monitor


This window displays the reaction process and the details of data analyzed over the past week
including the present day.

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Date Displays the date of the past week including the present day.
Sample type Select a type from Routine smp., STAT.sample, Control smp.,
STD.sample (including reagent blank), Water Blank, or Detect.RV
chk.
Sample list Set Order no., Posi.no., or Sample.no of a sample to display tests ana-
lyzed in the sample in the Test name list window.
To display the reaction process of a control sample, select Control. smp. under
Sample type, and enter 001 or 201 in the Order no. box or PA001 or PB001 in the
Samp.no box. To display the reaction process of a standard sample, select STD
sample under Sample type and enter C0101 or M980101 in the Samp.no box.
UP, DOWN Displays the previous and the following samples to the test you
selected.
React.proc.data information Displays the details of data (see P 2-10)
Calc.results Displays the reaction process of measurements calculated in
main and subsidiary wavelengths.
M/S-WL Displays blue for the reaction process of a main wavelength
and red for that of a sub wavelength.
Aprox.curve Photometric points used in data calculation are displayed in
the reaction process.
Data List
Displays the absorbance of each photometric point.
Cuvette Blank
Displays the cuvette blank of a cuvette used in the reaction before and after it.
Scale change
Changes a scale of the X-axis and the Y-axis of the reaction process.
Create data file
Absorbance of each photometric point of the wavelength you selected is saved in the me-
dia.
Data Print
Prints the absorbance of each photometric point.
14WL monitor
Displays the reaction process of the fourteen wavelengths between 340 and 884nm.

6.3.1e Print Report


In the Print Report window, the
data set is printed in the format
you created previously in the
Print Form Settings window
that was opened from the Setup
window.

Print Report

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6.3.1f Statistics
Perform the statistic calculation for the data analyzed.

Statistics and Print


Smp.type Select a type from routine smp. or STAT smp.
Filename Select a date from the past 7 days including the present day.
Setting tests to print
Select test to print Enter the number of the Test table number in the box or click the
number from the Test table.
Print type
・Statistics Prints the average (Ave), maximum (Max), minimum (Min),
diffusion (Diff), SD, and CV of ABS-R, ABS, ABS1, ABS2,
E1, and E2.
・Test data Prints the Ave, Max, Min, Diff, SD, and CV of the concentra-
tion data.
・Details of test data Prints the concentration data, and the Ave, Max, Min, Diff, SD,
and CV of the concentration data.
Print
Enter the range of a sample and click Execute.

6.3.1g Test Select

Test Select
1. Routine/Priority/STAT samp.meas. To analyze routine samples, select this test.
2. Ordinary control samp. meas To analyze ordinary control samples, select this
test. Before selecting Temp.test at the start of an
analysis, select this test.

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3. Auto control samp.meas. To analyze control samples automatically, select this


test. Auto control can be set by selecting QC – QC
Sample Definition.
4. Auto control means. after calib. To analyze control samples automatically after auto-
matically measuring calibration, select this test.
5. Ordinary calibration meas.(BLK) To analyze blank samples with the normal calibration,
select this test. Before temporary changes are made,
select this test.
6. Ordinary calibration meas.(STD) To analyze standard samples with the normal calibra-
tion, select this test. Before temporary changes are
made, select this test.

Test Select

7. Auto calibration meas.(BLK) To analyze blank samples with the automatic


calibration, select this test. When executing, enter the
settings in Calib. – Calibration Setup – Auto Cali-
bration Setting.
8. Auto calibration meas.(STD) To analyze standard samples with the automatic
calibration, specify this test. When executing, enter
the settings in Calib. – Calibration Setup – Auto
Calibration Setting.
9. Special calibration meas.(BLK) This function is similar to ordinary calibration meas-
urement (BLK). You can use this to change the cali-
bration tests on different dates.
10. Special calibration meas.(STD) This function is similar to ordinary calibration meas-
urement. You can use this to change the calibration
tests on different dates.

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6.3.1h Sample Log*


The Sample Log lists all the samples absorbed from STT, CTT, Rack, or LAS. The default num-
ber of logs you can save is 3000.
Switching display Click All, Routine/Ctl, or Routine Only
Search You can search a sample by entering search conditions in the
Samp.no, Asp.Date, and Asp.Time boxes.
Print Log Summary You can specify the range in Asp.Date or Asp.Time and print
the sample log summary in that range.
Clear Select a sample ID and click this button to delete the log of se-
lected sample
All Clear Click this button to clear all the sample logs.
Update Displays the latest information.
Export You can export the sample log by selecting File–Export.

Sample Log

6.3.1i RealTime Monitor


This window displays the results for measuring routine samples, control samples, and standard
samples in real time. Also, it displays the measurement result of a sample you select from the
left-hand list. You can select the display format from Standard or Conc. in the System Moni-
tor window. Data will be kept for the next 7 days.
Print Clicking this button prints data in the same way as batch printing in
the User Maintenance window.
P is flagged to the right of the sample number you have printed.
Monitor PAUSE Pauses to update the monitor screen to real time information.
Word size You can select the size of characters to be displayed from Small or
Big.

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Rial Time Moniter

6.3.1j Cup/Tube Assign*


Specify the container type and the priority request for each of the STT positions. This setting
has priority over the setting specified in the Order Entry dialog box (see P 3-1 ).
Status/Container Select the Container Type for each of the STT position num-
bers. The settings specified in the Order Entry window are ac-
tive for 0:Priority requested.
Interrupt If you click the “I” box, analyzing the sample at this position
will have priority.

Cup/Tube Assign

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6.3.1k STAT Order Setup*


Configure the emergency settings in the STAT Order Setup window in advance if you conduct
an interruptive analysis of a sample without a barcode using STAT port (see P 3-2). See P 1-13
for how to use STAT.

STAT Order Setup


STAT set You can select the sample set from the 10 types (0 to 9).
Comment1,2 Comment 1 appears in the selection screen when analyzing (the
set name).
Dil.factor, Samp.type, Container You can change the test name immediately before
analyzing.

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6.3.1l Correlation*
The Correlation window creates the correlation diagram of two different data or of measured
data and data you entered manually in the window.

Correlation
* Follow the instructions below when creating a new correlation diagram.
Register a name of the data in the Data regist. window, and select the file number you have
just registered from the top right of the Data search menu. Enter necessary data in the List
disp. window, click Save, and then click Return to create a correlation diagram.
You can create up to 100 correlation diagrams. A correlation diagram is printed as a hard copy
of the screen.
Data regist.
Registration list Displays a list of the correlation diagrams already created (en-
try numbers and registration names).
Entry no. Type a numerical value in the range from 1 to 100. Avoid any
numbers used in Registration list. (The registration number
refers to the numbers in the Registration list. in this win-
dow.)
Correlation range Specify the Order no. in the Order Entry list. You can select
up to 1000 pieces of data.

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6.3.2 CALIBRATION

* This is displayed if you


* enter manager in the
password window

Calibration
6.3.2a View Calibration Curve
Displays the most recent calibration results.
You cannot save or edit except for in READY or WAIT mode.

View Calibration Curve


(Point 0) on the calibration curve Y-axis is a reagent blank. This is set as the base point
for the Y-axis STD OD value (ABS-RB) with the blank reagent subtracted and for the
X-axis concentration. The B mark on the Y-axis base (point 0) when set as the cuvette
blank, shows the concentration of the reagent blank.
Calib. curve info.
• Test name...When selecting the test that you want to display, the Calc. Mthd, Axis
conv., Multipoint formula, # cal, Statistical data, and Calibration curve information
appears.
Statistical data
After performing calibration, results are updated in real time. They can be rewritten.
• FV...Measurement concentration.
• MEAN...The average for the data excluding the upper and lower value from the total
number of measurements.
(The STD results are displayed with the BLANK’s MEAN subtracted).

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6 USER INTERFACE

• F...Concentration value when the OD is at 1.


When you change this value, the value of the standard’s mean will also change.
Reapproxim.
Use this button to perform recalculation when changing MEAN (ABS) of BLANK, FV
value of STD, and MEAN (MEAN of ABS-BLANK) from the statistical data column.
(Refer to P 3-7.)
Calib. History
Click to display statistics and graphs (most recent display to the left) for each test for the
last 60 calibration (STD-OD, BLK-OD) results.

Slider Bar
View Calibration Curve and Calibration Trace (Calibration History)
Calib.summary
Displays the calibration values used for the current operation.
When clicking the test name, the test calibration values appear in the column on the right.

Calib.summary
Multi-point calibration curve results cannot be printed. Perform Screen print to re-
tain the results.

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6 USER INTERFACE

6.3.2b Test Select


(Refer to P 6-16.)

6.3.2c Sample Select


Select the standard and control sample positions. You can change them when starting analysis.
・Select the analysis sample CTT/STT98/STT99.

Sample Select

6.3.2d Calibration Setup*


You can enter the position to place the standard and the type of container in accordance with the
settings in the calculation method set in Analysis Parameters (Chemistry). (See P 3-6.)
• BLK posi....Set the position to place the reagent blank on the CTT.
• STD posi....Set the position to place the standard on the CTT.
• Coeff(FV)...Enter the factor value and the standard concentration value.
* You can use the blank position and the STD position as a simple calibration for
multi-point standard items.
* The sample dilution when calibrating is performed to the same conditions as the
Analytical Parameters (Chemistry) test conditions.

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6 USER INTERFACE

・MSTD...The Setting button displays Multi-STD Setting tests done from the Analytical Parame-
ter. You can enter the position to place the standard for configured tests as a
multi-point calibration curve (MSTD) from Calc.mthd in the Analytical Parame-
ter (Chemistry) window. (See P 3-6.)

Tray Number...Set the standard multi-point item in the STT. This is the number.
* The final concentration becomes approximately a straight line.
CTT set
Specify each CTT position (Cup/Tube Type) and enter Reps and Comment.
STT set
Specify the TT No.98, 99 containers for calibration (multi-standard) and enter Meas.times and
comment.

Calibration Setup and Multi Standard Setup


Auto calib.set
Configure for each test to make the analyzer perform calibration when there are set time intervals
or when there is an automatic replacement of reagent bottles.
See the operation manual for automatic calibration.

Auto Calibration Setting


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6 USER INTERFACE

• Test...Set the test number to perform the automatic calibration.


• Sample select, Blank, Standard...Set the measurement calibrator (blank and
standard).
• Control select...Set the control sample after automatic calibration and set its
type (A~Z).
• Bottle enforcement...Conduct calibration when replacing the reagent bottle.
• Time enforcement...Set an initialization time to conduct calibration.
• Interval time(min.)...Set the interval time in minutes to conduct scheduled cali-
bration.
• Count start...Initialize the countdown time from the Reset button.
• All reset...Initialize the configured countdown time for all tests.
Save...Save the setting and start the count.
Clear...Clear all settings.
Remain time...Displays the remaining time until conducting the next scheduled calibration.

When using auto calibration it is necessary to set the 7.Auto Calibration meas.
(BLK) and 8.Auto Calibration meas. (STD) (also 4.Auto control meas. after calib)
from Calib.-Test Select. (see P6-16)

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6.3.3 QUALITY CONTROL


*: Displayed in Manager

QC
6.3.3a Daily Precision Control
■ X Chart
Each control of the data analysis appears as a graph for each test.
A graph appears in blue. If one of the data plots for a graph is out by +/-3SD, it appears in red.
Save...Click Save after omit (delete) operation is selected for each data. It can be used only in
READY or WAIT mode.

Daily Precision Control


Delete...Delete all the displayed control sample data for each test.
Save control...The mean and fluctuation width for the measured control samples are forwarded as
QC Cumulative processed data. If this operation is not performed, the data for
the day cannot be recorded as QC Cumulative. (The data can be recorded when
the window is closed.)

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6 USER INTERFACE

Save control data...The displayed control sample’s statistical data for the day (mean and fluctua-
tion width displayed in the QC List) is recorded in Daily QC in the
Control Data Registration window. (See P 3-10~11.)
Display order test...The display order for the X Chart.
Settings(S)–Setting of the order of display...Sets the display number of the X Chart. *When
you close this window, the same window as QC Cumulative appears. Click Yes in the Add
Daily to QC Cumulative data? window that appears. Next, click OK in the QC Cumulative
Calculation window that appears and record this data in QC Cumulative. (See P 1-7~8.)
■ QC List
When changing the X Chart to the QC List display, each control sample and the acquired data
for each test appear. (Ave. and SD can be saved as control values. See P 3-11.)

QC List

■ Control Data
When changing the X Chart to the Control Data, each control sample and the acquired data
for each test appear.
Specified test’s statistical data X Chart

Control Data
Data Display Section
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6 USER INTERFACE

• Test...Displays the data for each test. Statistical information also appears.
• Omit...The data cannot be changed, however, when you click Omit the data appear in
red and after clicking Save the data are no longer reflected in the cumulative calcula-
tions.
• Overlap...Displays the graph for the checked controls.

6.3.3b QC Cumulative
Similar to the Daily Precision Control window.
■ X Chart
Displays in blue each control and each test for the last month including the current day in a graph. If
one of the data plots for a graph is out by ±4SD, it appears in red.

QC Cumulative

System–Specification at date...Changing the display data range.


* When confirming past data, change the data display period in System–Specification at
date. The X-R chart, Control data, and QC List are displayed for this configured pe-
riod.
■ Control Data
Controls, tests, and dates of acquired data appear.
■ QC List
The statistics appear for each test’s acquired data for each control sample’s data display range.

When confirming past data, change the data display period in Sys-
tem—Specification at date. The X-R chart, Control data, and QC List are displayed
for this configured period.

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6 USER INTERFACE

6.3.3c Real-Time QC
Two types of random control data are displayed for each analysis in the same graph.
■ X Chart
Decide on the number of graphs to be displayed in one window in Setting–Chart setting.

Real-Time QC
■ Twin-Plot
When changing from X Chart to Twin-Plot display, a maximum of 200 data plots are displayed.
Registration list edit
When unedited, decide on two control types and tests and decide on the display order in the
Real-Time QC window display order.
① Select the controls from A to Z to measure as Control 1 and Control 2. The
two control type’s common measured test appears in Test List.
② Click the test to highlight in blue, and then click Regist to add it to the Regist
Test. Real-Time QC Registration List
③ Shift the graph display order
UP or DOWN and click OK to
decide and create the graph.
Control 1, Control 2...Select two
control samples to perform
Twin-Plot.
Test List...Select the Twin-Plot test
to perform.
Regist Test...List of the Twin-Plot
display tests.

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6 USER INTERFACE

6.3.3d Control Data Registration


The Real-Time QC and the Daily Precision Control graphs appear based on Daily QC mean and
SD. The QC Cumulative graph appears based on the QC Cumulative mean and SD. The dis-
played 2SD and 3SD are the SD values 2x and 3x.
When measuring the control sample, use this value and perform the below flag evaluation. Based
on this Daily QC, add a flag to print the data. (See P 2-11.)
Add (l) (h) flag: 2x SD ≤|(acquired data) — mean |≤3x SD

Add (L) (H) flag: 3x SD <|( acquired data) — mean|

Control Data Registration


Copy
Copying data between Daily QC and QC Cumulative.
• Copy performs all controls at the same time.
• Statistics (X, SD) from the Daily QC and QC Cumulative windows can be reflected in
the Control Data Registration window. Click Save control data in the Daily QC and
QC Cumulative windows. (See P 3-11.)

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6 USER INTERFACE

6.3.3e QC Sample Definition*


From A to Z, specify a maximum of 26 types of control sample analysis tests.
Set each control sample’s established CTT position, Sample type, Container type, Replicates and
Comments. (See P 3-8.)
• Ctrl.ID...Able to set 26 types of control from A to Z.
• CTT Posi.no....The CTT position when measuring the control.
• Comment 1...Display (print) Comment 1 as control information.
• Dil.factor, Samp.type, Container
• Replicates...Able to set from 1 to 5

QC Sample Definition
CTT Set
Specify each CTT position’s container and enter Replicatets and Comments.
AUTO Control
During the measurement of a routine sample, the control sample set in the CTT is automati-
cally measured at the configured test intervals.
Select and set from Auto Control (TOTAL TEST) or Auto Control (TEST). (Change the
settings in Setup–Setting System Parameters.)
*See the auto control measurement operation manual.

6.3.3f Test Select (See P 6-16.)

6.3.3g Sample Select (See P 6-24.)

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6.3.4 REAGENT

Reagent
6.3.4a Reagent Test Monitor
Displays the Remain Vol. (mL) and test times for R1, R2e, and R2 for each separate test. (See
Reagent P 3-3.)
• The remaining volume displayed in the window renews every 5 seconds.

Reagent Test Monitor


Reagent Position
You can confirm the position for the reagent in RTT1/2 for each separate test.
Reagent Scan
Confirms the installed RTT1 and RTT2 reagent’s barcode and remaining volume.
A check is added and displayed for the specified empty bottle’s position. After this, check
the position that you want to confirm and select Barcode scan/Bottle scan or Bottle scan
and then Start to perform a bottle scan after performing the barcode scan. The results will
appear in the reagent remaining volume monitor after it finishes.
For barcode specified bottles, be sure to enter a check and perform the scan even if
resetting the bottle to the same position.

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6 USER INTERFACE

Reagent Bottle Scan

Reset
The specified range for the remaining volume of a reagent resets when you click reset in
the event the reagent has become empty. You can continue to do analysis without hav-
ing to perform a remaining volume scan. (During the measurement, when the RPP re-
agent for the test has aspirated, the reagent’s remaining volume is newly displayed.)
Remain test
When the number of the tests remaining lowers the configured test number, the graph
display changes from green to yellow as well as test names. The initial setting is for 100.
This can be changed for each test. When the reagent becomes empty, its name appears
in red with the E symbol.
Reagent Moniter
Displays the reagent bottle’s liquid surface height in (cm) and the reagent’s remaining
volume (mL) for each RTT position.
When you click the name of each test, the position of the reagent for the test and
the number of tests remaining for each reagent appear.

Reagent Position

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6 USER INTERFACE

6.3.4b CTT Monitor


The remaining quantities for the standard and control samples and detergents that are set on the
CTT are displayed.
For the remaining volumes that are displayed, you can confirm in the System Specifications Set-
ting’s sample container that the entries are correct by comparing to the actual remaining volume.

CTT Monitor
The sample container’s remainder and the reagent’s remaining volume (mL) for each position in
the CTT.

6.3.4c Reagent Container Settings


Each test name for the reagent’s position in RTT1 and RTT2 appear. Set the identification for the
container.

Reagent Container Set

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6 USER INTERFACE

RTT Select・・・RTT1 or RTT2.


• Posi., Test name・・・The set position is automatically displayed. When barcodes are
used, the barcode appears after it is read.
• Barcode・・・Only displayed once it has been read.
• Container・・・Select from 7, 20, 40 mL. Displayed automatically when the barcode has
been read.
• Cancel・・・ Add a checkflag if not using to measure.
• Exp.Date・・・Displayed when the barcode has been read.
• R-Type・・・R1 is RTT1, R2e or R2 is RTT2. Automatically appears when the barcode is
read.
Barcode scan・・・When clicking the reagent bottle’s barcode specifications, the reagent’s bot-
tle position is read. The results that were read appear in the Barcode col-
umn. It is necessary to enter the code number for each test in
Setup–System Test List in advance.
(See 6. Change of Reagent Bottle Size on P 3-5.)

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6.3.5 MAINTENANCE

*: Displayed in manager
* *

Maintenance

6.3.5a System Startup/Shutdown Setting (See P 1-22.)

6.3.5b System Monitor


Operating Conditions...OK indicates normal operations (except for RRV Bath Circ.Rate).
When there is an abnormality, an X appears and an alarm is sounded.

System Monitor
During-operation system set
• Realtime monitor
Routine analysis/STAT analysis...Select the display and reprint for the Realtime
Monitor. (Normally, Standard or Conc. is used.) (See P 3-12.)

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6 USER INTERFACE

Variance value display...Select the variation value for the response process ab-
normality check. The variation value appears only for those
samples with a check flag that was added when selecting Dis-
play when there is a flag.
On-line...On-line selection. Select Do or Not do.
Pre-operation set
Chemistry...Specifies whether to cancel analysis (Operate/Cancel).
The ISE module only operates when canceling the analyzer.
ISE...Specifies whether to cancel the ISE module (Operate/Cancel)
Labo.Auto.Sys....Specifies whether to cancel the Rack Handler (option)
(Operate/Cancel)
Rack Handler...Specifies whether to detach the LAS (Laboratory Automation Sys-
tem) (Operate/Detach).
Clot Detect
Clot Detect...Avail./N.A. (SPP clot detection).

6.3.5c Lamp Energy Monitor (See P 4-10.)

6.3.5d User Maintenance


Perform Cuvette blank meas. check (reaction cuvette check, acquires evaluation data for
evaluating normal cuvettes), Batch print, Archive of Test Results, Save of Text File (change
the text format and save the file), Position Probes for Routine Cleaning.
Cuvette blank meas. check
Use once a week when you start cuvette blank measurement. (See P 4-12 for acquisition
method.)

User
Maintenance

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6 USER INTERFACE

Water blank measurement


For JEOL service personnel
Position Probes for Routine Cleaning
The operation button to confirm the probe’s positioning and adjustments. (Use after re-
placing the probes.)
See P 4-30 for probe replacement.
When executing Start, all probes move to the RVV cuvette and then the probes and
WUD lower slightly and stop. The analyzer enters WAIT mode. In this mode, the
porbe’s tip positioning and the centering of the cuvette’s position is confirmed and
adjusted. Perform the initialization operation after adjusting.
Cuvette Detergent Aspirate Line Wash
The operation button to wash the WUD aspirate line. (See P 4-21 for maintenance check.)
Batch print
Use when printing acquired data in a batch. (See P 3-13.)
Enter the control sample: PA001, PB001…etc
Enter the standard sample: C0101, M980101…etc
Cuvette Blank Batch Print
Print the cuvette blank results (See P 4-12.)
Save of Text File
Use when creating the measurement data in the text format. (See P 3-13.)
Refer to the operation manual for the text file creation program.
When entering an external memory device, specify the Sample type, Date, Output
Form, Save Range, and when clicking Save, the device’s directory appears. Enter
the file name and then click Save. If there is no device entered when saving, you
will be asked for a save location so click Cancel and redo.
Archive of Test Results
Use when saving measured data to an external memory device in the system file format.
(You can confirm the saved data by opening the Review/Edit file.)
When entering the device, select Sample type and Date and when clicking Save,
the devices directory appears. Click Save to save. If there is no device entered when
saving, you will be asked for a save location so click Cancel and specify the save
location to save. Additionally, the selected date appears as the file name – do not
change this file name. (You will no longer be able to seek the file in Review/Edit, so,
in addition, do not change the file type as well.)

6.3.5e Manual Operation


This is a window for operating each unit within the analyzer. You can operate when the ana-
lyzer’s mode is set to READY or WAIT. Operate the units with caution so as not to cause injury
or damage to the analyzer.
See System Overview in the operation manual chapter and Manual Operation in
User Interface in regards to unit abbreviations.
• No.... Enter the unit number to operate and click Execute to start the unit operation.
You can also operate by double-clicking the left mouse button on the abbreviated unit’s
position.

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• Execute...The button to execute the unit operation according to the entered No.

Manual Operation

44.MUD1
45.MIX1
40.MIXR1
23.WUD
SPP
46.MWEV1
ELA07 16.SPPLR
MIX1 56.MUD2
17.SPPUD
57.MIX2
21.SPEV2
22.RRV 52.MIXR2
58.MWEV2

RPP2
RPP1 MIX2
2.STT/CTT 49.RPPLR2
37.RPPLR1
50.RPPUD2
38.RPPUD1
54.RPEV2-2
42.RPEV2-1

STAT

48.RTT2
47.RBC2 36.RTT1
35.RBC1

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Manual Operation

Vacuum pump

Analyzer’s back compartment Analyzer’s front compartment


BIEV
WVT FP
RVT

41.RPEV1-1

61.VDP

20.SPEV1 53.RPEV1-2

1 Liquid Waste 2

71.LWP

(Back) Conditioner
19.SRWP 51.RP2
(Front) Cuvette wash

69. 33. 26. 30. 29. 63. 24.


18.SP 39.RP1
CDEV2 CWEV CEV1 CEV5 CEV4 VEV2 AEV1
68. 70. 60. 28. 27. 62. 34.
DEV1 CDEV3 VIEV CEV3 CEV2 VEV1 DCEV

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* Example: 17:SPPUD
・ Init....The button to arrange initialization for independent units. (SPP is on the ISE mod-
ule.)
・ Move...The button to order operations for units. A one step operation (A B, B C, C A) is
continuously executed. (For example: to stop the sample tube at the upper end in System
Specification Settings–Sample Container Specifications for SPPUD.)
・ Position...Specify the cuvette position and cup position number for the specified operation
of a related tray.
・ Unit...Specify the distance of movement (mm) for the probe related operation.
・ LLS-Action...According to the sample tube
number settings entered for specifying the opera-
tion of the probe that has the attached liquid sen-
sor, the probe lowers to the liquid surface and
stops. (System Specification Settings–Sample
Container Specifications) If there is no liquid in
the container, the probe lowers to the bottom of
the container and stops.

SPPUD

6.3.5f System Maintenance Monitor


This is a window to control maintenance on the analyzer. Enter the maintenance test no. and
maintenance part when you record the Type, Period, and Replaced date (conducted date). The next
schedule day/elapsed time appears.

System Maintenance Monitor


No....Able to enter up to 200 tests.
Maintenance part...Enter the maintenance title. This can be changed.
Type...Select from No setting, Monthly, Weekly, Daily, Current time, Working time.
Period...Enter the maintenance period.
Replaced...Enter the day when last conducted. (Up to 8 digits beginning with the year.)
Schedule day/Elapsed time...The next schedule day or the elapsed time appears.
Start...Brings the above stated configured elapsed time into effect.
Maintenance monitor...Displays the elapsed time in a graph.

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6.3.5g ISE Operation (See P 5-7)

6.3.5h ISE Monitor (See P 5-3)

6.3.5i Communication Monitor


This is a window to monitor online information. You can confirm such data as sent data from the
analyzer unit, received data and control signals from the host computer for a maximum of 7 days.
(For details, refer to the operation manual.)

Communication Monitor

6.3.5j Error Report


You can confirm the date and time of occurrence, place of occurrence, analyzer mode, and
Safe.no. In the event any trouble occurs, details such as Samp.no and Test name will be concluded
in the Error Report. You can also display historical data. (For details, see P 7-1 (Alarm display).)
Even if you click ALARM in the Operation Panel Window, the window appears.
When you want to confirm the details, double-click on the content and the Error
Report appears.
Safety clear…Clears the details of the Error Report.
Latest info. …Refresh the display details. (This window is not displayed in real time.)
Print…The specified range of the print details.
Disp.switch…Standard/Extend. The normal setting is Standard. When you want to con-
firm the content in detail, set to Extend.
Scope…The normal display is on that day only. You can use the All display when in the
READY or WAIT mode.
Measure column...A number indicates normal processing, WARNING indicates a warning
message and STOP indicates STOP mode.

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• STOP+R‐Enters STOP mode and an alarm sounds. Once data output is finished, it
stops in the READY mode.
• STOP+W‐Enters STOP mode and an alarm sounds. Once data output is finished, it
stops in the WAIT mode.
• Emergency Stop ‐ Everything is suspended.
When you want to confirm the details, double-click on the content and the Error Report De-
tails appear.

Error Report

6.3.5k Liquid Level Sensor Monitor*


The monitor displays the detected waveforms from the liquid level sensor for each probe. Level
detection starts each time the probe is lowered and creates a graph by sensing the level.
When you select Samp.no, Test name, Test type, or Division, the results and liquid level sensor
waveforms are displayed. (For details see the operation manual.)

Start
f

Liquid Level Sensor Monitor


It is normal for the graph to show no dips until detection has completed.

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6.3.5l Clot Monitor*


You can gain information about SPP clot situations. The A flag will be added to the test when a
clot occurs. When you select the Sample ID and Date/Time, the clot waveform appears. (See the
operation manual for details.)

Waveform monitor Clot Monitor


• C…When washing the inside of the probe in the wash port. Checks if the sensor is
functioning correctly or not.
• A…When finishing the washing inside the probe and restoring the atmospheric pres-
sure conditions. Checks if there is a clot occurring from the previous measurement.
Sampling stops after an error occurs.
• B…Before sample aspiration. Checks if the sensor is functioning correctly or not.
• D…After sample aspiration. Checks for clots within the sample. After an error occurs,
the wash port exhausts the sample and measurement is not performed on the sample.

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6.3.6 SETUP

Log on as ‘manager’ to access


window under the Setup list.

Setup
6.3.6a System Specification Settings
Use this window to enter the basic settings which will take effect after the next New Start. Sam-
ple Container Specifications and Reagent Bottle Specifications will take effect through the
INITIALIZE operation after saving the settings.

System Specifications Set


System Basic Configuration
Select availability of ISE Module, Sample delivery (RACK/External), On-line, Barcode,
Conc. Waste Bottle, and others.
Basic System Operation Mode
• Auto.retest・・・N.A./STT retest
• Rerun Flag・・・Rerun tests/Incomplete tests/All tests

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Various system operation spec.


• Serum indices・・・request. test range/Compulsory test analysis/Not handled
Smart PAUSE
• STT Cover・・・N.A. / Avail.
Transition from Smart PAUSE to START is possible by opening or closing the STT
cover while analyzing barcoded samples. In order to make this operation possible,
select Avail. here. Also, select Avail. for Sample barcode, and Rerun tests or In-
complete tests for Rerun Flag. (See P 1-12 for details.)
Auto Reagent PAUSE…N.A. / Avail.
• When you select Avail., the Auto Reagent PAUSE function becomes available.
Auto Reagent PAUSE is a function to automatically enter the R-PAUSE mode when
a reagent shortage is detected during analysis. (For starting operation after R-PAUSE,
see P 3-3.)
Sample Container Specifications D1
• Type・・・Select from Container1 to Container9.
• Container name・・・Enter the name by the type.
• D1,D2,D3・・・Diameters of the sample tube.
• h1,h2,h3・・・Heights of the sample tube. D2
• LLS.sensitivity・・・Low/Mid./High
(Usually set to Low). h1
h2
Reagent Bottle Specifications h3
Pre-set when the analyzer is delivered. D3
• Container name・・・Name by the type
• Bottle section area・・・Section area of the reagent bottle
• LLS.sensitivity・・・Low/Mid./High (Usually set to Low)

6.3.6b Analytical Parameters (Chemistry)


Up to 100 analytical conditions can be entered.
Analytical Parameters (Chemistry)

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Analytical condition
Enter Reagent volume, Reagent diluent volume, Sample volume, stir (strong or weak),
Reaction Time and other settings.
For three-part reagent, concentrated reagent setting, urine setting, and reaction time
extension, see APPLICATIONS THREE PART REAGENT,” USING
CONCENTRATED REAGENTS, MEASURING URINE and PROLONGING
ROUND in the user’s guide.
• Analysis test condition setting・・・Conditions for sample dilution can be set for each
sample type.
Sub pram.#・・・1 - 3
Sub pram# 2 and 3 are used when extracting data from the same reaction with different
analytical conditions.
Sub analysis conditions
Enter the data in Name, Digits, M-wave.L., S-wave.L., Analy.mthd, Calc.mthd,
Qualit.judge, and other settings. The selection of Calc.mthd determines the availability
of the standard position of calibration and multi-standard. (See the user’s guide for de-
tails.)
• Real-time correct.form.・・・Apply calculated data into this formula to quickly correct
data.
• Reanalysis conditions・・・When reanalysis of data is specified, serum will be diluted by
this condition for reanalysis. Four dilution conditions can be specified in D1 to D4 for
each test. When you specify 2 or more conditions, enter the dilution ratios in ascending
order from D1 so that the lowest ratio is in D1. (See P 2-4 and pages following.)
• Rerun conditions set・・・Dilution conditions M and D1 to D4 can be selected for each
flag attached to data. (See P 2-4.).
• Flag setting・・・Whether to print flags or not.
• Normal value setting・・・Set normal values.
• Abnormal value setting・・・Set the limit H and L for abnormal values. (See P 2-3.)
Standards setting
Enter FV, BLK H / L, and STD H / L.
• Multi-STD setting・・・Sets the multipoint calibration curve.
• Error judge rate (vs.previous data)・・・If data are more than this setting (%) away
from the previous calibrated value, the data will be flagged with (Z). Do or Not do has
to be selected in Maint. – System Monitor – Error judge rate
(vs.previous data). (See P 2-11.)
Calculation method setting
Enter measurement detection points, Limit value, Variance (for linearity flag (*) judg-
ment), and the necessary settings for RRA and EPA, such as Blank(u)(d), Sample(u)(d)
(for RRA), Reabsorb(u)(d) (for EPA), Prozone setting, and others. (See P 2-7 to 2-9.)
CTT Set
Enter the CTT settings such as Replicates of calibrators, dedicated diluents, and control
samples, Cup/Tube type, and Comments.
Copy
Use this button to copy other Analytical Parameters.

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Use it when you want to replace all the settings for the Analysis condition number cur-
rently displayed with the settings for other Analysis condition numbers.
Parameter Check
Use this button to check whether there is any errors or inconsistencies in the settings.

6.3.6c System Test List


You can set up analysis order and reagent positions. (See P 3-6 and P 3-18.)

System Test List

• Anal.cond # & test name・・・Displayed in the order entered in the Analytical Parameter
(Chemistry) window.
• System test #・・・Analysis will be performed in this order.
• R-Code・・・Enter the code number when reagents are barcoded.
• Position・・・Enter the position of R1 (RTT1), R2e or R2 (RTT2).
Analysis order
Use this button when you want to change the analysis order later in System test #.

6.3.6d Process Sequence


Use this window to set up the displaying order and printing order of the tests in the Entry Order
window. Do not change Processing test order without a specific reason as it will affect Online
Settings, Serum indices, Ratio, Q C, and others.
• Seq.No.・・・This number is used in the Order Entry and other windows. This will be
the processing number of the test. When adding a new test, be sure to assign a vacant
number. (See P 3-18.)

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• Cond.no.・・・If you enter a number here, the Test name appears automatically. You can
edit the Test name here.
• <SP and DEL buttons・・・Do not use these buttons because they will change the Proc-
essing test order.
• Processing test Order・・・Displays the test list.
• Print Monitor Order・・・The order of the tests for RealTime Monitor and Batch print.
The order can be changed using the Up and Down buttons.

Process Sequence

6.3.6e Analytical Parameters (Serum)


Use this window to select whether to use Qualitative judge, and to set up the tests to be used for
serum indices measurement. (See P 3-14 and pages following.)
• Analy Cond.No・・・Condition No.121 is used for Lct (chyle), No.122 for Hem (hemoly-
sis) and No.123 for Lip (icterus).
• Test name・・・Enter the test name for serum indices.
• Digits・・・Number of digits after the decimal point (up to 4 digits).
• Quali.judg.・・・Not do/Do (Qualit.set will appear in the window when you select Do.)
• Quali.judg.type・・・Qualitative/Critical
• Qualitative Judgment Set
Characters・・・Characters to display within the range specified in Border values.
If Critical is selected, only the characters displayed in the left-end and
right-end boxes will be utilized.
Border values・・・Judgment border values for Qualitative and Critical settings.
In limit judgment, only the values in the left-end and right-end boxes will
be utilized.

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Analytical Parameters (Serum)


• Test No.・・・Enter the number of the test to obtain serum indices.
The test entered in the area 1 will correspond with the specification of compulsory test
analysis.
• Test Name・・・Enter the Test no. and the name of the test for obtaining the serum index
will be displayed.
• Factor a to f・・・Enter the factors for calculating serum indices.

6.3.6f Ratio Parameters


Calculations are performed for each test using its measurement data, and the result is entered here
for a newly created test. If an order request is made for the new test, a request for the original test
is also made automatically. (See P 3-21.)
Analysis condition
• Analy.cond.no.・・・20 tests can be set from 101 to 120.
• Test name・・・Enter the test name.
Real-time Calculation Ratio Parameters
• Test #・・・Enter Seq.no. of the tests necessary for calculation in S to Z.
• Factor・・・Enter the factors a to f when using them.
• Formula・・・Use +, -, * (multiplication), / (division), and parentheses to define the cal-
culation formula.
• Simulation・・・Click Simulation, enter the concentration in the formula in the displayed
window and perform the calculation to validate the formula.

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Ratio Parameters

6.3.6g ISE Parameter Settings (See P 5-6)

6.3.6h Blank Reagent Settings


(See the user’s guide for details.)
The following setting is for when using the D-Bil standard value for T-Bil.

Blank Reagent Set

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6.3.6i Reflex Test Settings

Reflex Testing Setup


When the measurement values for the tests in Process Test Number satisfy the values and the
judgment conditions specified, a request for the test in Reflex Process Test Number(s) is auto-
matically made, and the value is measured in the reanalysis.
• Setup no.・・・Up to 30 logics can be set.
• Process Test Number・・・Up to 3 tests can be specified per logic. Reanalysis request for
Reflex Process Test Number(s) is made when all the conditions are met.
• Assay Judgment Value (Conc.)・・・Set the judgment value.
• Judgment Decision・・・Select Above or equal to or Below or equal to for the judgment
value.
• Reflex Process Test Number(s)・・・Up to 3 tests can be specified to request reflex test.

6.3.6j Contamination Settings


Use this window to set the tests that might cause contamination and the detergents for contamina-
tion avoidance. Enter the settings for both Setting condition for avoiding reagent probe con-
tamination. and Setting condition for avoiding RRV cuvette contamination.
(See the user’s guide for details.)
Detergent Set
Enter the detergent settings for avoiding
contamination as shown on the right.
• RTT1 (901 – 905),RTT2 (906 – 910)
・・・Detergent number
• Posi.・・・Enter position number 47 for 901
and 906, 48 for 902 and 907, and 50 for
903 and 908.
• Comment・・・Detergent name
• Detergent vol. and Diluent vol.・・・
Liquid volume to use for avoiding contamination. Detergent Set

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■ Setting condition for avoiding reagent pipette contamination.

How to avoid reagent probe contamination


The basic purpose of changing the analysis order for contamination avoidance is to main-
tain the analysis speed. If A contaminates B, the analysis order changes and a few unre-
lated tests are run between A and B to avoid contamination. The number of tests needed
to be run between A and B is called the Influence effect. If the number of tests that are
run between A and B is less than the Influence effect, or if the analysis order cannot be
changed, probe wash using detergent for contamination avoidance is performed. It is
also possible to select probe wash from the beginning so that the analysis order is not
changed.

A. Reagent probe contamination

ex.) Contamination pair ALT -> LDH


Influence effect: 2
Preventive detergent: REAGENT PROBE WASH-1

Analysis order

1. ALT → LDH → TP → ALB → ALP ALT immediately followed by LDH



Bad data
2. ALT → TP → LDH → ALB → ALP ALT followed by LDH after 1cycle

Bad data
3. ALT → TP → ALB → LDH → ALP ALT followed by LDH after 2 cycles

2 cycles Good data
4. ALT → REAGENT → LDH → ALB → … ALT followed by probe washing with
PROBE WASH1 ↓ REGENT PROBE WASH-1 before LDH
washing Good data

*1) Analysis order is changed to avoid contamination.


When the analysis order cannot be changed, wash the reagent probes 1 and 2
with preventive detergent after ALT before using themfor LDH.

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Settings for avoiding reagent probe contamination


① Settings for avoiding contamination must be configured for each R1 and R2
(Even when an test in Substance contaminating or Substance contami-
nated is one-part reagent, both R1 and R2 have to be set. If both are one-part
reagents, then only R1 has to be set.)
② Use Pure water, REAGENT PROBE WASH-1, REAGENT PROBE WASH-2
as the preventive detergents in this priority order (When any detergent can
avoid contamination, use Pure water. If pure water cannot avoid contamina-
tion but REAGENT PROBE WASH-1 or 2 can, then use REAGENT PROBE
WASH-1. If only REAGENT PROBE WASH-2 can avoid contamination, then
use REAGENT PROBE WASH-2.)
③ For a pair where pure water can avoid contamination, enter “1” for Influence
effect and “Pure water” for Preventive detergent (see 1 and 2 in the follow-
ing table).
④ For a pair where REAGENT PROBE WASH-1 or 2 can avoid contamination,
enter the number you checked in avoiding probe contamination for Influence
effect and select REAGENT PROBE WASH-1 or 2 for Preventive detergent
if the analysis order cannot be changed (see 3 and 4 in the table).
⑤ When Influence effect cannot be determined (contamination cannot be
avoided by changing the analysis order), set “999” for Influence effect and
select REAGENT PROBE WASH-1 or 2 for Preventive detergent (see 5 and
6 in the table).
⑥ You also have to set up the effect of REAGENT PROBE WASH (see 7 and 9
in the table).
When R2e (optional) is available and is affected by preventive detergent
(REAGENT PROBE WASH-2), R2e of RPP2 also has to be set up in addition to R1
and R2 (see 8 in the table). If this option is used when starting analysis from the
READY mode, reagent probes are washed with (Clean1) and (Clean2) before the
analysis. Here, you have to add No.8 in the following table because RTT2 is washed
at the timing of R2e. The analysis order cannot be changed in this case, so “999” is
specified for the timing of R2e.
⑦ You can also insert 2 or more washing processes between the tests (see 10
to 13 in the above table).
For example, when you repeat the washing process twice using the same detergent, 904
(detergent 4) and 905 (detergent 5) are available at RTT1, and 909 (detergent 4) and
910 (detergent 5) are available at RTT2, so you can configure and use the new deter-
gent settings.

Contaminating Contaminated
No. Probe Reagent Reagent Inf.effect Detergent no.
Test Test
1 RPP1 LAP R1 CRP R1 1 (903) Pure water
2 RPP2 LAP R2 CRP R2 1 (908)Pure water
(901) REAGENT
3 RPP1 GPT R1 LDH R1 12
PROBE WASH 1
(906) REAGENT
4 RPP2 GPT R2 R2e 12
LDH PROBE WASH 1
(902) REAGENT
5 RPP1 TCHO R1 FCHO R1 999
PROBE WASH 2
(907) REAGENT
6 RPP2 TCHO R2 FCHO R2 999
PROBE WASH 2
(902) REAGENT
7 RPP1 R1 Fe R1 999 (903) Pure water
PROBE WASH 2

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(907) REAGENT
8 RPP2 R2e Fe R2 999 (908) Pure water
PROBE WASH 2
(907) REAGENT
9 RPP2 R2 Fe R2 999 (908) Pure water
PROBE WASH 2
(902) REAGENT
10 RPP1 A R1 B R1 999
PROBE WASH 2
(907) REAGENT
11 RPP2 A R2e B R2e 999
PROBE WASH 2
(902) REAGENT (904) REAGENT
12 RPP1 R1 B R1 999
PROBE WASH 2 PROBE WASH 2
(907) REAGENT (909) REAGENT
13 RPP2 R2e B R2e 999
PROBE WASH 2 PROBE WASH 2

■ Setting condition for avoiding RRV cuvette contamination

How to avoid RRV cuvette contamination


Examine the previous test in a cuvette to decide whether to change the analysis order or to
wash the cuvette with preventive detergent. When pure water can avoid contamination, spec-
ify the contaminated test as the contaminating test, and select Pure water for Preventive
detergent. If Pure water cannot avoid contamination, specify All test (900) for the contami-
nated test and be sure to insert the washing process. (Even if you enter a specific test for the
contaminated test, the data will have no problems because the analysis order can be changed.
The contaminated test, however, can be in the cuvette that measured the contaminating test
in the next cycle.) If the analyzer ends the operation after analyzing the contaminated test,
the cuvette has to be washed with preventive detergent before entering READY mode.

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B. RRV cuvette contamination

ex.) Contamination pair ALT → LDH


preventive detergent: Pure water

reaction cuvette
… TP ALPCREALT AST … Previous test

… CREALP TP … Current test

1. LDHALB ………… Using a cuvette previously used for ALT


↑ for LDH causes contamination.
Bad data
2. ALBLDH………… Use the cuvette previously used for ALT for another test,
↑ and use a different cuvette for LDH to avoid contamination.
Good data
3. WASH LDHALB …… Wash the cuvette that was previously used for ALT with preventive
↑ detergent, and use a different cuvette for LDH
Good data to avoid contamination.

*1 ) Change the analysis order to avoid contamination.


When the analysis order cannot be changed, wash the cuvette
with preventive detergent after ALT before using it for LDH.
*2 ) Analysis order will not be changed and washing is always inserted in some settings.
*3 ) When prevetive detergent other than pure water is used, do not change the analysis order and always
insert washing process.

Settings for avoiding RRV cuvette contamination


① Use pure water, REAGENT PROBE WASH-1, REAGENT PROBE WASH-2
as preventive detergent in this priority order (when any detergent can avoid
contamination, use pure water. If pure water cannot avoid contamination but
REAGENT PROBE WASH-1 or 2 can, use REAGENT PROBE WASH-1. If
only REAGENT PROBE WAHS-2 can avoid contamination but pure water
and REAGENT PROBE WASH-1 cannot, then use REAGENT PROBE
WASH-2).
② For a pair where Pure water can avoid contamination, enter the contaminating
and contaminated tests and make other settings (see 1 in the following table).
③ For a pair where pure water cannot avoid contamination, specify All test(900)
for the contaminated test.
④ When there are more than one contaminated tests for a contaminating test
(such as A→B and A→C), confirm that B and C can be avoided with the same
detergent and enter All test(900) for the contaminated test.

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⑤ Also set the REAGENT PROBE WASH effect (the REAGENT PROBE WASH
effect can be avoided with pure water. Specify the contaminated test).

Detergent no.
No. Contaminating test Contaminated test
RPP1 RPP2
1 LAP CRP (903) Pure water (908) Pure water
(901) REAGENT (906) REAGENT
2 GPT (900)All test
PROBE WASH 1 PROBE WASH 1
(902) REAGENT (907) REAGENT
3 TCHO (900)All test
PROBE WASH 2 PROBE WASH 2
4 Detergent Fe (903) Pure water (908) Pure water

6.3.6k Print Form Settings


You can print out simplified reports from the workstation.
Use this window to set up the size of the reports, and the layout of sample attributes, test data and
other tests.
See the user’s guide for details.

Print Form Set

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6.3.6l Online Settings


Use this window to set up the conditions for communication with a host computer (see the user’s
guide for details).

On-Line Set
Set Test
Enter Batch, Real, Qual, and Code numbers for each test.
Loop back test
This setting is for service personnel.
Data Clean Set
Data Clean check is a function to detect abnormal data and the mix-up of samples before
transmitting the data to the inspection system (host computer). It compares the obtained
results with the previous values sent from the host computer to analyzer unit, and only the
correct results are sent to the host computer.
In Data Clean Set, you can perform 5 checks per sample for each combination of sample
type (serum or urine) and method (real-time online or batch online). The actual check
takes place when data are transmitted online to the host computer. The check result is
saved by Request – Review/Edit – Transfer Result. If a sample is determined to have
errors in the check, it can be suspended from transmission to the host computer (tempo-
rary retention).

6.3.6m Ctrl/Cal Sample Setup


You can view and modify the settings on CTT, STT-98, and STT-99 (standard sample, control
sample and others).
• Position・・・Position on each tray.
• Usage・・Displays the usage if it is already set.
• # of replicates・・・Measurement times.
• Container type・・・Select the container type.
• Comment・・・Enter the names of the tests to be placed there.
• Contents・・・Displays the tests that are already placed.

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Con/Cal Sample Setup

6.3.6n Alarm Buzzer Set


Use this window to configure the alarm buzzer sounds for analyzer unit. You can make the ini-
tial settings in the following window. If you want to modify or add to these settings, please
contact your JEOL service office.
See the user’s guide for details.

Alarm Buzzer Set

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6 USER INTERFACE

6.3.6o Setting System Parameters


Use this window to set up the parameters related to the analyzer operation and data process.
Note: You can configure any settings as necessary, but do so with caution since incorrect settings
may affect the operation and the measurement data. (The settings will take effect after the
INITIALIZE operation is completed.)
Note: See the user’s guide for details.

Setting System Parameters


6.3.6p Reaction Check Logic
When the measurement values of the tests in Assay Number satisfy the values and the judgment
conditions specified, the test in Assay to be flagged is flagged with J to execute reanalysis.

Reaction Check Logic

6-61
6 USER INTERFACE

• Setup No.・・・Up to 30 logics can be set.


• Assay Number・・・Specify the test to be performed together regardless of whether it is
requested or not in order to evaluate the judgment value for the test in Assay to be
flagged.
• Cut-off Value・・・Enter the threshold value for the judgment.
• Judgment Decision・・・Select Above or equal to or Below or equal to for the judgment
value.
• Assay to be flagged・・・ Up to 3 tests can be specified. If any one of the tests here is
requested, the measurement of Process Test Number is performed automatically.

6.3.6q Carryover Setting


If the measurement value for the test in Carryover test satisfies the condition in Assay Judg-
ment Value (Conc.) and Judgment Decision, and if the value is measured in the sample imme-
diately after that sample, the test is flagged with O to warn of sample carryover.

Carryover Setting
• Setup No.・・・Up to 10 logics can be set.
• Carryover test・・・Specify the test that needs a carryover check.
• Assay Judgment Value (Conc.)・・・Enter the threshold value for the judgment.
• Judgment Decision・・・Select Above or equal to or Below or equal to for Assay Judg-
ment Value.

6.3.6r User Code Settings


This is for service personnel.

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6 USER INTERFACE

6.3.6s New Test Registration


This window shows the procedures for New Test Registration, Calibration Setup, QC Sample
Definition, and Sample Container Setup, and opens the respective windows when clicking each
of the buttons. (See P 3-17 .)

New Test Registration

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OTHERS MATERIALS
7
7.1 HbA1c................................................................................................................. 7-1
7.1.1 General ....................................................................................................... 7-1
7.1.2 Measuring Method ..................................................................................... 7-1
7.1.3 Specifications ............................................................................................. 7-1
7.1.4 Analysis ...................................................................................................... 7-2
7.1.5 Setting......................................................................................................... 7-2
7.1.5a HbA1c Setting..................................................................................... 7-2
7.1.5b Setting Dilution Conditions................................................................. 7-3
7.1.5c Hb Setting ........................................................................................... 7-4
7.1.5d Sampling Position Setting ................................................................... 7-4
7.1.5e HbA1c% Setting............................................................................... 7-5
7.1.6 Maintenance ............................................................................................... 7-6
7.2 NEW SAMPLE CONTAINER SETTING ......................................................... 7-7
7.2.1 Measure the shape of the sample container. ............................................... 7-7
7.2.2 Set the shape of the measured sample container. ....................................... 7-7
7.2.3 Execute INITIALIZE. ................................................................................ 7-8
7.2.4 Check the shape of the container................................................................ 7-8
7.3 ALARM TABLES ............................................................................................ 7-10
7.3.1 When an alarm sounds ............................................................................. 7-10
7.3.2 Explanation of the Error Report window ................................................. 7-11
7.3.3 General method of reading alarm descriptions......................................... 7-11
7.3.4 Safety No. Table ....................................................................................... 7-12
7.4 DETERGENT DESCRIPTION........................................................................ 7-26
7 OTHERS MATERIALS

7.1 HbA1c
7.1.1 General
JCA-BM6010/C enables you to analyze for a blood cell component (HbA1c) and for plasma
components (such as Glu or 1.5AG) simultaneously by setting the sampling positions for each
test .

7.1.2 Measuring Method


Place a blood sample in a sample tube with anticoagulant, centrifuge it, uncap it, and set it in the
analyzer.
Analysis Procedure

Measure Glu, 1.5AG


Cen-
tri-fugin Dispense to reaction CV

Aspirate the plasma component

Measure HbA1c

Dispense to reaction CV Dispense to reaction CV


Dilution, hemolysis
Aspirate the
Use pure water or dedicated
blood cell component
diluent

7.1.3 Specifications
Cleaning the SPP probe:
Aspiration from [Top]: 15 mm away from the tip of the probe
Aspiration from [Bottom]: 60 mm away from the tip of the probe

Sample aspiration order:


Test specified in [Top] Test specified in [Bottom]

Capacity:
Max. 800 tests/hour
Analysis of blood cell components requires the use of a hemolysis sample that was created
with the reaction cuvette mounted to the analyzer. This hemolysis sample requires the op-
eration time for one test. Analysis of one test for the blood cell component requires the op-
eration time for two tests. Therefore, operation of the analyzer for only the analysis of blood
cell components enables 400 tests per hour. If, for example, the plasma component analysis

7-1
7 OTHERS MATERIALS

(with no hemolysis reaction) and blood cell component analysis (with hemolysis reaction)
are respectively regarded as one test per sample, operation with this combination enables
533 tests per hour (Analysis for the two tests will take place in the operation time for three
tests).

7.1.4 Analysis
The basic operation is the same as for BM6010/C.
When you perform measurement for a test (such as HbA1c) whose Sampling
position setting is set to Bottom, keep the liquid height of the sample in the
container no higher than 60 mm. For cleansing the SPP probe in the wash port, the
cleansing height must reach up to 60 mm above the tip.
7.1.5 Setting
Click Setup – Analytical Parameters (Chemistry) for the sample dilution condition set-
ting or the sampling position setting. (manager)

Following HbA1c parameters are preliminary.

7.1.5a HbA1c Setting


Set the HbA1c parameters as follows.

Also ,set the Diluent position on RTT1.Placethe Diluent on the position.

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7 OTHERS MATERIALS

7.1.5b Setting Dilution Conditions


① Analysis of HbA1c (blood cell component)
requires dilution of samples.
In the Analysis Test Condition Setting
(M) dialog box, enter data for Dilution
method, Undiluted sample volume, and
Diluent volume.

② For instance, in the case of a sample that


has already had diluted hemolysis per-
formed in an HbA1c test, dilution by the
analyzer needs to be removed. In that
case, you can conduct analysis by speci-
fying STAT/Cut in as Sample type and
No dilution as Dilution method as
shown in the window on the right.

③ Set the dilution condition for the control


material contained in the HbA1c Kit.

Note:
• Dilution specification-
Not do: Conducts measurement with the analysis conditions in Serum.
Do: Conducts measurement with analysis condition other than that set in Serum.
• Undiluted sample volume: Enter the amount of the sample to be used for analy-
sis.
• Dilution method: Choose No dilution or With dilution. With dilution refers to the
dilution method using RRV cuvettes.You need to set Undiluted sample volume,
Diluent volume, Diluent position, and Diluent volume from RPP.

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7 OTHERS MATERIALS

7.1.5c Hb Setting
Change Sub Param. for HbA1c to 2 ,and set Sub-analy.conditions to Hb.

HbA1c

7.1.5d Sampling Position Setting


Choose the sampling position from Top and Bottom for each test and for each sample
type. In the initial setting Top is set for samples to aspirate from the solution surface.
Sampling positions for the tests analyzing blood cells such as HbA1c require the position to
be changed to be aspirated from the lower part of a sample (Bottom setting).

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7 OTHERS MATERIALS

As for Standards and Controls ,set to Top. Ordinary samples that have already had diluted
hemolysis performed are registered as STAT, and Top is specified as the sampling position
so that dilution by the analyzer will not be performed. See (2) in Setting Dilution condi-
tions above.)
* In the Sampling Position Setting window, under Gen/STAT/Priority and Con-
trol(A-M/N-Z), before slash “/” is the setting for the upper row and after slash “/” is the
setting for the lower row.
Height Setting
Specify the distance from the bottom of the container when Bottom is specified as
Sampling position.

As for other parameters setting ,refer to P3-17

7.1.5e HbA1c% Setting


Click Setup - Ratio Parameters. Set Parameters as follows. (See P3-21)

7-5
7 OTHERS MATERIALS

7.1.6 Maintenance
Cleaning a probe and Checking a location
After finishing the HbA1c analysis each day, move the probe of SPP to a position where you
can easily wipe it, and then use pure water to wipe the probe.
1. Move the SPP probe to a location where you can easily wipe it, and carefully wipe the out-
side of the probe upward using gauze or similar materials soaked with pure water.
2. Click INITIALIZE so that the analyzer will enter the READY state.Observe the DPP’s
wash port from above, and make sure that the probe does not touch the wash port or the
washing water retaining plate when the probe moves downward.
3. Double-clicking 17.SPPUD in the Maint. – Manual Operation window opens the win-
dow for instructing the SPPUD operations.
When you click the Move button,SPP moves downward at the wash port. At this time
check that SPP lowers to the bottom without touching the wash port or the washing water
retaining plate. Clicking the Move button again will raise SPP. (This check is required be-
cause the SPP’s probe moves up and down at the wash port when SPP is being washed.)
4. Click Init. in this SPPUD window to raise it to the original position.
(See 2. Inspecting and cleaning the tip of probes on page P 4-4.)

7-6
7 OTHERS MATERIALS

7.2 NEW SAMPLE CONTAINER SETTING


7.2.1 Measure the shape of the sample container.
Place the sample container in STT or CTT properly, and measure each dimension indi-
cated in Fig. 1.
- h1: Height from the base of STT D1
(CTT) to the top of sample container.
- h2: Height up to the top of the lower
cone shaped portion.
- h3: Height up to the bottom of the
container (in some cases, higher settings D2
may be used in consideration of the serum h1
separators and other materials. Include
an allowance of approximately 2 mm.) h2
- D1: Inside diameter at top of h1 h3
- D2: Inside diameter at top of h2 D3
- D3: Inside diameter at top of h3
Reference point: Top sur- Fig. 1
face of the aluminum plate
placed at the bottom of
STT

7.2.2 Set the shape of the measured sample container.


Click Setup and then System Specification Setups (password: manager) to open the Sys-
tem Specification Setups window.

① Enter the data in Sample Container Specifications.


Up to 9 types of sample container settings are allowed.
Select a container from Container1 to Container9 in Type, and make the settings for
Container name and others.
- Container name: Enter the name of the container.
- D1,D2,D3/h1,h2,h3: Dimensions measured in step 1 above.
- LLS Sensitivity: Low/Mid./High (ordinarily Low, when there is little serum, Mid.)
- Liq.volume judge: N.A./Avail. (ordinarily Avail. )
When the Order Request is registered, the settings in Container1 appear preferen-
tially.
When there is no container specification available online, use Container1 for meas-
urement.
② After entering data, click Save.

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7 OTHERS MATERIALS

7.2.3 Execute INITIALIZE.


Executing INITIALIZE reflects the change.

7.2.4 Check the shape of the container.


① Remove the sample container at the STT position 1.
② Click Maint. — Manual Operation to open the window.
* Take care not to place anything on STT or CTT as SPP is manually oper-
ated.

③ Double-click 16.SPPLR to open


the window.

④ Click Init. SPP moves to an RRV cuvette and then stops.


⑤ Click Move slowly 3 times. Each time you click the button, SPP moves to the
position 1 of STT.
⑥ Click Exit to close the SPPLR window.
⑦ Double-click 17.SPPUD to open the window.

(8)
(9)

Move moves SPP up to the top


end of the container.
LLS-Action moves SPP to the
(11)
bottom when the container is
empty.

⑧ Enter the registration number for the new sample container in the boxes to the
right of Move and LLS-Action.
⑨ Confirm that the sample container is not in position 1 of STT, and then click
Move. SPP lowers to the top position according to the Sample Container

7-8
7 OTHERS MATERIALS

Specifications (h1 setting). Place the sample container to check in position 2


of STT, manually rotate STT. Confirm that the tip of the SPP probe is almost
above the sample container set to position 2.
⑩ Click Init. to raise SPP to the top.
If the height is incorrect, close all the windows, measure the dimensions (h1 to
h3) of the sample container again, and register them in Sample container
specifications. Then, execute INITIALIZE, and repeat the same steps from
(3) to recheck the shape of the container.

⑪ Manually rotate STT so that SPP moves to right above position 1 of STT.
Confirm that there is no sample container there. Check the box to the right of
LLS-Action to see that the registration number for the new sample container
is entered, and then click LLS-Action. SPP lowers to the bottom of the Sam-
ple container setting (h3 setting). Confirm that SPP does not touch the bottom
of the container during the operation.
⑫ Click Init. to raise SPP to the top.
⑬ Manually operating STT, check that SPP is almost above the sample con-
tainer set to position 2, and then click LLS-Action. SPP lowers to the bottom
of the Sample container setting (h3 setting).
⑭ Then, manually raise the sample container set to position 2 and confirm that
there is a little room.
⑮ Click Init. to raise SPP to the top.
⑯ Click Exit to close the Manual Operation window.
⑰ Execute INITIALIZE to confirm that the analyzer enters the READY state.

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7 OTHERS MATERIALS

7.3 ALARM TABLES


7.3.1 When an alarm sounds
① The alarm buzzer sounds, the ALARM lamp at the top right of the analyzer is
lit, and the alarm message appears in the window.

MAIN switch

ALARM

② When you click ALARM, the Error Report window appears, and the alarm
message disappears.

[Screen print]button

When the mouse is double-clicked, details are displayed.

③ Description of the device status is displayed in the Contents column. The lat-
est information is given at the top.
When WARNING appears in the Measures column, the alarm buzzer sounds. Check
the details of the alarm.

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7 OTHERS MATERIALS

If an analysis has been performed, check Samp.ID and Test Name that are displayed.
④ Double-clicking the content of an alarm message opens the Error Report De-
tails window to check the details.
* Several lines of errors may appear at the same time. In that case, if the time is the
same, usually the one displayed at the bottom refers to the first cause of the error.
Check the content.
⑤ Check the following content and, if necessary, contact your JEOL service
center.
(You can print by clicking Screen print in System(S) at top left of the window.)
a. Date/time of the alarm and what was taking place at the time of the alarm.
b. Safe.No (described later)
c. Check the content and details
d. Identify the failed unit (not displayed in some cases).

7.3.2 Explanation of the Error Report window


Safety clear button: Erase all content. (NEVER EXECUTE THIS BUTTON.)

Latest info.: This window is not a Realtime Monitor, so close the window and open it
again. Alternatively, click Latest info.

Print: Prints the content in the specified number range. (Or Screen print)

Disp.swich: Standard/Extend (Extend displays more detailed processing description.)


Scope: Today/All (All displays all of the previous contents when the analyzer is in the
READY state.

Measures: Number - Ordinary processing; WARNING - Alarm only


• STOP: System enters the STOP state.
• STOP+R: System enters the STOP state and an alarm sounds. (After the output of
data is finished, the analyzer stops in the READY state.)
• STOP+W: System enters the STOP state and an alarm sounds. (After the output of
data is finished, the analyzer stops in the WAIT state.)
• Emergency Stop: All operations will stop immediately.

7.3.3 General method of reading alarm descriptions


■ Example 1: 5010 STT during starting and SPPLR is encoders pos6 and
SPPUD is IN0 OFF.
When an attempt was made to rotate SPP from the STT position (ENC.Pos6 position),
SPP had not been raised to the top.
Cause: Because the vertical (SPPUD) operation of the dilution probe was not smooth,
SPP had not been raised to the top. (IN0 OFF)
* If you double click the error message, a more detailed content and the analyzer in ques-
tion appear.
* Pos #: Position (position of inspection)
* ENC #: Encoder (This measures the angle or length of the correct movement.)
* IN #: Position (position of inspection)

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7 OTHERS MATERIALS

■ Example 2: 6173 SPP sensed ISE Buffer height error

SPP lowered and stopped at a positon that was too high or too low.
Cause: The volume of ISE Dil.bowl in WARNING is abnormal.
Upon double-clicking, "Buffer Height:HIGH" appears which indicates that the volume is
too high.
As a result of this problem, after the transition to STOP due to "Remaining fluid in ISE
bowl error," SPP stopped its operation.
Consequently a unit operation timeover occurred, thereby the analyzer stopped in the
WAIT state.

7.3.4 Safety No. Table


■ 0001 to 1930 Workstation
1583 to 1585 STT cover SW (switch) In the present mode, STT cover switch operation is invalid.
1901 to 1930 Communication error There is no communication between the workstation and
the analyzer unit.
Terminate the system, and turn off the PC and the analyzer
unit. After one minute, restart.

■ 2000 to 2999 Entry & data processing part


2000 to 2220 Errors related to analy- Check the analysis conditions and the applicable location
sis conditions or to for the request.
sample or request in-
formation
2400 to 2428 Calculation errors Calculation error of analyzer. Check the related settings.
2600 to 2651 Acquisition errors Check the applicable location for the correct setting and
check the conditions.
2800 to 2834 System errors Perform the same operation again. If the same error occurs
again, contact your JEOL service center.

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7 OTHERS MATERIALS

■ 3000 to 3999 Online-related Online communication errors


Host online timeout Online information from the host computer was not transferred within
3001 the management time.
Check whether another task is being performed on the host computer
side.
Click Maint.–Communication Monitor to check the timeout related
settings.
3002, Receiving frame Format error occurred in the online information from the host.
3003 format errors
3004 Online reception The host computer is not in a state that enables reception of the mes-
error sage sent by BM.
Check the text message sent from BM (to see the state of the host
computer which cannot receive data) by clicking
Maint.–Communication Monitor, and restart.
3005 Online reception The text message sent from the host computer is defective, and BM
error has made a retransmission request beyond the specified number of
times.
Check by clicking Maint.–Communication Monitor, and restart.
3006 Online format error Error in sample division for the text message sent from the host com-
in receiving time puter
Sample division N: Routine sample; I: Emergency sample (Never
use others.)
3007 LIS received data, Error in sample ID in the text message sent from the host computer
Sample ID error Up to 13 digits for alphanumerics. Maximum sequential analysis is 9
digits in the case where LAS is attached.
Check by clicking Maint.–Communication Monitor.
3008 System error online Check the reception state of the host computer and restart.
communications
3009 Batch request regis- For all the sample numbers BM requested to the host, the location in-
tration error formation beyond the possible sample set location range was received.
Check by clicking Maint.–Communication Monitor.
3010 Batch request regis- For all the sample numbers BM requested to the host, the location in-
tration error formation beyond the possible sample set location range was received.
Check by clicking Maint.–Communication Monitor.
3011 Reception error oc- Error in the text message sent from the host. Unexpected character or
to curred code was received.
3013 Check by clicking Maint.–Communication Monitor.
3040 No problem in par-
ticular
3041 Online format error Check by clicking Maint.–Communication Monitor in all cases.
to
3049
・3041 and 3046 Information other than “M,” “F,” “Male,” or “Female” was sent.
・3042 and 3047 Information other than "0.1" to "99.9" was sent as the dilution factor.
・3043 and 3048 Information other than "1," "2," "Serum," or "Urine" was sent as the
sample type.
・3044 and 3049 Information other than "1" to "9" was sent as the container type.
3051 LIS workorder con- The test number from the host is incorrect.

7-13
7 OTHERS MATERIALS

tains invalid test no. Check the test number displayed in the error report details.
3061, No problem in par- Check the settings by clicking Maint. –Communication Monitor.
3062 ticular
3503 Error in the text message from the host. Check by clicking
to Maint.–Communication Monitor.
3516

■ 4000 to 4499 ISE-related ISE-operation or data error


4041 BP ISE BP (buffer pump) does not operate, or it is not smooth, or oper-
to ate poorly.
4047 INITIALIZE and retry. If the same error occurs again, the unit is de-
fective.
ISE07

Inside the unit


ISE Dil.Bowl

ISE MIX-1
MIX
M IXE
室温恒温

SPP 室
Reaction

Reaction 温
carousel 恒
MIX-2 BPEV
B PE
STT 温 WB DPEV
D PE

脱 気 ユニッ
Air removal unit

RPP-2 RPP-1 脱

STATport ユ DBP
P BP
DP
RTT-2 RTT-1 ニ

4079 Restart, and if recovery fails, contact your JEOL service center.
to
4081
4082 ISE thermistor error Thermistor (temperature element) disconnected wire, defect, or re-
moved connector. Refix it.
4083 Same as for 4079
4091 ISE Calibration Slope value is outside the range of 38 to 65.
slope error
4092 ISE Calibration Sample-buffer value is abnormal.
range error
4093 Calibration High Variation of sample-buffer value is too large. Failed to fall into the
STD error range even after 8 measurements.
4094 Calibration Low Variation of sample-buffer value is too large. Failed to fall into the
STD error range even after 8 measurements.
In the case of the above 4 errors, use a new standard solution to per-

7-14
7 OTHERS MATERIALS

form calibration again.


Or, before recalibration, execute the CV check.
(When the CV check is executed after a calibration error, Data
transf. is required in ISE Monitor.)
If the electrode is old, replace it.
4096 ISE No sample No sample is placed in the CTT/STT tray or the sample is empty.
Check if the cup is improperly placed or if the amount of the sample
is insufficient.
4097 Remaining fluid in SPP has detected that the amount of solution in the ISE bowl is ab-
ISE bowl error normal.
(Check height with Check if the electrode is set correctly and check for solution leakage
6173) around the electrode.
Also, check that the inside of the electrode is not clogged.
4141 BP Same as for 4041 to 4047.
to
4146
4182 See 4082 to 4097.
to
4197
4199 ISE cannot accept The calibration data may have a problem.
command Execute INITIALIZE and then execute calibration again.
4201 ISE communication Terminate the system, turn off the power, and then restart.
to error
4203
4207 ISE buffer reagent isCheck the remaining amount of the buffer bottle solution and, if it is
low small, replace the bottle while the system is in the READY mode.
4208 ISE periodical wash Execute INITIALIZE to check that the system enters the READY
error state.
If the same error occurs again, contact your JEOL service center.
4209 Unit- or opera- Execute INITIALIZE. If the same error occurs again, contact your
to tion-related errors JEOL service center.
4235
4236 ISE electrode-wash No detergent solution for ISE
no sample error Check if the cup is placed incorrectly or if the amount of the detergent
is insufficient.
4237 Execute INITIALIZE. If the same error occurs again, contact your
to JEOL service center.
4242
4242 Incorrect ISE cali- Error issued after a calibration fails
bration slope value For recalibration, the calibration goes on.
At the sample measurement, processing terminates without electrolyte
analysis.
(Correct calibration is required for sample analysis.)
4243 Cannot operate due ISE module is not in the operable state (READY).
to ISE NOT Execute INITIALIZE so that the system enters the READY state.
READY error
4244, Execute INITIALIZE. If the same error occurs again, contact your
4245 JEOL service center.

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7 OTHERS MATERIALS

4246 No ISE calibration Analysis started with no electrolyte calibration performed or with data
data erased.
Execute calibration.
4252 ISE no sample No sample is placed. Or the sample is empty.
(Sample analysis) Check if the cup is placed incorrectly or if the amount of the sample is
insufficient.
4253 ISE no calibration Standard solution is not placed, or the cup is empty.
sample (calibration) Check if the cup is placed incorrectly or if the amount of the standard
solution is insufficient.
4254 ISE buffer height See 4097.
error
4255 Execute INITIALIZE. If the same error occurs, contact your JEOL
to service center.
4256
4257 ISE calibration See 4092.
range error
4258 Execute INITIALIZE. If the same error occurs again, contact your
to JEOL service center.
4265
4266 See 4091 to 4097.
to
4270
4271 ISE calibration cor- Calibration error. Execute calibration again.
to rection data are in- If the electrode is old, replace it.
4272 correct
4273 ISE calibration dilu-
Dilution factor in the calibration result is abnormal.
tion factor error After performing maintenance, perform the CV check, and then repeat
calibration.
4274 Transmitted ISE Check the applicable columns above.
to calibration contain
4277 data error

■ 5000 to 5999 Unit-safety-related (improper operation)


Unit operation is improper. Refer to the message details, and identify and check the de-
fective unit.
If you find it difficult to solve the problem, contact your JEOL service center.
You can identify the defective unit in the following way:

Example: 5034 RRV INIT during starting and SPPUD is IN0 OFF.
Explanation: When RRV attempted to perform the INITIALIZE operation, the ver-
tical operation of SPP was poor, resulting in an error.
Action: Lubricate the shaft with oil for the smooth vertical operation of SPP.
If the situation is not improved, contact your JEOL service center.
If the error explanation ends with one of the following, the operation of the unit
just described is improper.
① In xxxx, IN # OFF for MUD1 => The vertical operation of MIX1 is improper.

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7 OTHERS MATERIALS

② In xxxx, ENC pos undefined for RPPLR 1 => The horizontal operation of
RPP1 is improper.
③ In xxxx, NOT ENC (or Internal) pos # for STT => The STT operation is im-
proper.
④ In xxxx, MIXR2 is under operation or in xxxx, RPEV1_2 is OFF =>
MIX2 rotation improper. RPEV1-2 (electromagnetic valve) operation improper

Top view of the main unit


ISE WUD MIX1

RPP2 SPP
RPP1 RRV
WUD
MIX2
SPP STT/CTT

RPP2 RPP1

STT/CTT STAT RTT1 RTT2 RTT1


RTT2
RRV

Identify the unit in question.


① If the probe operation is improper, lubricate the shaft with oil (see Fig. below),
and perform INITIALIZE.

[Probe] [Mixer Rod]


Horizontal
movement Rotation
Vertical  SPPLR  MIXR1
movement  RPPLR1  MIXR2
 SPPUD  RPPLR2
 RPPUD1
 RPPUD2

Vertical
Apply oil movement
onto shaft  MUD1
 MUD2

② If the pump (SRWP, RP1, RP2) operation is improper, perform the shutdown
operation once, remove the pump fixing screw, and pull the pump a little to-
ward you. Rotate the motor shaft in the direction of the arrow (see Fig. below)
to move the plunger, and restore the unit to the original position. Then restart
and perform INITIALIZE.

7-17
7 OTHERS MATERIALS

[Pump]

[Electro-magnetic valve] SPEV1 RPEV1‐1 RPEV1‐2

③ For units other than the above, perform the shutdown operation once, and re-
start and perform INITIALIZE.

■ 6000 to 6099 Unit-related errors


6115 System error Unit operation is poor. (Double-click to identify the defective
unit.)
6116 Task not completed in Time Unit operation is poor. (Double-click to identify the defective
unit.)
6117 Deviced fail to operate Unit operation is poor. (Double-click to identify the defective
unit.)
6118 Out of range Command send Unit operation is poor. (Double-click to identify the defective
to device unit.)
6122 SPP LLS status error Cleansing for the probe is insufficient or the mounting of the
probe is loosened.
6123 Probe LLS transition alarm If no problem arises after reanalysis, there is no need to worry.
6138 SPP detected sample above The setting for the sample container is incorrect,or the mount-
container ing of the probe is loosened.
6139 SPP full stroke error No sample is placed in the CTT/STT tray, or the sample is
empty.
When a Liquid Level Sensor error occurs for a probe, check the following three
comments:
① Contamination at the probe tip (cleanse it)
② The screw within the probe cover is loosened (retighten it)
SPP RPP stopper Terminal 1

Tight fit

Caution
There shall be no gap between
stopper and terminal 1

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7 OTHERS MATERIALS

connector
③ Improper contact with the LLS connector in the
probe cover (remove/insert the connector)

6140 Diluent LOW The special diluent (within CTT) has nearly run out.
6141 Diluent EMPTY The special diluent (within CTT) has run out.
6142 RPP1 probe detected re- The mounting of the probe is loosened.
agent above wedge
6143 RPP1 reagent EMPTY The reagent has run out.
6144 RPP1 sensor full stroke Reagent has been left unattended or has run out.
error
6145 RPP1 Detergent LOW REAGENT PROBE WASH, water, and detergent have nearly
run out. (RTT1)
6146 RPP1 Detergent EMPTY REAGENT PROBE WASH, water, and detergent have run out.
(RTT1)
6147 RPP2 probe detected re- The mounting of the probe is loosened.
agent above wedge
6148 RPP2 Detergent EMPTY Reagent has run out.
6149 RPP2 probe detected no Reagent has been left unattended or has run out.
reagent
6150 RTT2 Detergent LOW REAGENT PROBE WASH, water, and detergent have nearly
run out. (RTT2)
6151 RTT2 Detergent EMPTY REAGENT PROBE WASH, water, and detergent have run out.
(RTT2)
6173 SPP sensed ISE buffer The volume of the ISE bowl is abnormal (too high or too low).
height error Check the remaining amount of the buffer bottle and check for
solution leakage around the electrode.
6177 System error The state of the sensor is poor when the probe is not touching
(LLS status error) anything.
The probe is dirty, or the connector has poor contact, or the
sensor is defective.
Check if detergent has been supplied properly.
6178 Probe did not detect wa- Cleansing of the probe tip at the wash port
ter at wash port is insufficient.
Check in the same way as above.

6202 System error REAGENT PROBE WASH, water, and detergent have run out.
(RPP1 sensor full stroke (RTT1)
error)
6203 System error REAGENT PROBE WASH, water, and detergent have run out.
(RPP2 sensor full stroke (RTT2)
error)
6204 No rack sample The sample has not reached the dispense position.

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7 OTHERS MATERIALS

6205 LAS/URH Sample ID The sample has not reached the dispense position.
communication error
6207 DWUD nozzle sensor WV Nozzle of DWUD hit the cuvette and did not come down.
error
6208 WUD nozzle sensor error WV Nozzle of WUD hit the cuvette and did not come down.
6222 Probe clash detected The probe hit the bottom of the sample container.
6227 LAS/URH Sample ID Communication text message error between BM and LAS
communication error
6230 Arrival Sample ID Information about the dispense sample ID was abnormal when
pointer abnormal dispensing the rack sample.
6238 The rotational speed is The number of back-forth mixing operations of the MIX1 unit
abnormal of MIX1 was outside the specified value range.
6239 The rotational speed is The number of rotational mixing operations of the MIX1 unit
abnormal of MIXR1 was outside the specified value range.
9240 The rotational speed is The number of back-forth mixing operations of the MIX2 unit
abnormal of MIX2 was outside the specified value range.
6241 The rotational speed is The number of rotational mixing operations of the MIX2 unit
abnormal of MIX2R was outside the specified value range.
* For the above errors of the MIX unit, contact your JEOL service center.
6242 Internal Special function A conflict occurred in the internal program that operates the
abnormal unit.
6247 RPP1 liquid surface veri- Sample tube has come off the solution surface even though R1
fication error (liquid sur- is being aspirated.
face separation)
6250 RPP2 liquid surface veri- Sample tube has come off the solution surface even though R2e
fication error (liquid sur- is being aspirated.
face separation)
6251 RPP2 liquid surface veri- When the probe stopped on the solution surface, its sensitivity
fication error (liquid level did not reach the level sufficient to recognize the solution sur-
sensor signal did not face.
reach
6252
6255 Clot Parameter error This is a sensor that checks the pressure inside SPP and detects
to clogging.
6289 ・Related to clot-A Check whether the pressure has returned to the atmospheric
pressure in the wash port when probe cleansing (proble wash-
ing) is finished.
* Possibility of clogging is high. Replace the SPP probe.
・Related to clot-B Check the pressure immediately before sample aspiration.
・Related to clot-C Check the pressure at probe cleansing (probe washing).
・Related to clot-E Checks whether the sensor functions immediately after starting
from READY.
* In the case of B, C, or E above, the sensor may be defective.
Contact your JEOL service center.
・Related to clot-D Check the pressure to see if a foreign matter was aspirated after
sample aspiration.
* It is possible that fibrin has been educed in the sample.
Check the sample and the measurement data.

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7 OTHERS MATERIALS

* If no clot error occurs in the next sample even though this er-
ror appears, clogging has been deleted with reverse cleansing
(probe washing).
* For other clot-related errors, contact your JEOL service center.
6300 SPP liquid surface veri-
to fication error
6302
6301 (liquid surface separa- Sample tube has come off the solution surface even while a
tion) sample is being aspirated.
6302 (liquid level sensor signal When the probe stopped on the solution surface, its sensitivity
did not reach the thresh- did not reach the level sufficient to recognize the solution sur-
old) face.
6303 Diluent Bottle will be
changed.
6304 0 time of the second
processing did not end in
regulated time.
6304 STAT-related
to
6322
6323
to
6329
6331 Sample carryover wash-
ing - SPP sensor upper
limit error
6332 Sample carryover deter-
gent shortage
6333 The sample carryover
detergent emptied
6334 Sample carryover wash-
ing - SPP full stroke error

■ 6400 to 6499 Parameter-acquisition-related errors


■ 6500 to 6599 LAS-control-related errors
6528 LAS abnormal Communication with LAS is abnormal. DPP communication
related to LAS is abnormal. Check if the rack is on the belt.

■ 6900 to 6999 Other errors


■ 7000 to 8199 Controller-processing-related
■ 8200 to 8499 Manual-operation-related
■ 8500 to 8879 Controller-related, computation-related
8759 Continuous cuvette skip Check the light intensity to see if there is no lamp varia-
generation tion.
Remeasure the cuvette blank again and analyze.
8760 RRV Cuvette (#1) skipped Same as above
- bad cuvette blank

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7 OTHERS MATERIALS

8761 to 8766 Insufficient sample


8770 Automatic-time-out-pilot
timing occurred.
8771 to 8775 Cannot start run due to Abnormal parameter
parameter error
8776,8777 STT Sample skipped - no No information about test selection for the analysis sam-
tests to run ple
8780 to 8792 LAS xxxx LAS communication is abnormal.
8794,8795 Rack xxxx Rack communication is abnormal.

■ 8880 to 8899 Analysis-condition- or entry-related


■ 8900 to 8999 Controller-processing-, calculation-, or communica-
tion-related
■ 9000 to 9299 Alarm-specification-, standby-check-specification-related er-
rors
9001
9002 LWP gauge sensor abnor- Air may be inside the pure water circulation line.
mal Check the LWP pressure gauge when executing
INITIALIZE. If the result is 76 kpa or less, remove air
bubbles from the line. (Refer to the course material.)
Check the tap water faucet and the Purified water pro-
duction system for defects.
9003 VP gauge sensor abnormal Pressure of the vacuum pump is abnormal. Check the
pressure and promptly rearrange the vacuum pump.

No.9080
Vacuum gause Pressure gause
For ISE LWP filter For LWP

Vacuum gause LWP pressure adjustment valve


9007,9061
For VP

9004 to Detergent, Cuvette condi- Check the amount remaining in detergent bottle and add
9006 tioner, ACUR, bottle in- detergent.
sufficient
9007 Pump chassis lower Leak The liqiud leakage sensor at the rear of the pump de-
tected leakage.
Check the location of the liquid leakage and take action.
For leakage, see No.9025.
9008 B1200 electric board 24V
power failure
9009 Abnormal of temperature

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7 OTHERS MATERIALS

of B1200 chassis
9010 RRB liquid surface level Level of incubation bath oil under reaction cuvettes de-
LOW creased or increased.
9011 RRB liquid surface level Check the detergent volume of the incubation bath oil
HIGH (for refill) tank within the detergent container.
9012 Logic is the RRB liquid There is a conflict between the two sensors above.
surface sensor abnormal.

Bath oil level sensor (High & Low)

STT/CTT Tray

9013 RTT cover open


9014 RTT1 loader none The RTT1 tray has come off.
9015 RTT2 cover open
9016 RTT2 loader none The RTT2 tray has come off.
9017 Pure water tank float sensor The pure water tank is running short of water. Check
LOW the tap water faucet and the Purified water production
system for detects.
9020 Waste fluid tank fullness The optional waste bottle, if mounted, has become
9021 Strong-waste fluid tank full- full.
ness
9022 RPP1 WASHPORT overflow Check if detergent has been collected in the RPP1
wash port.
Overflow: The sensor detecting the collection of liquid in the wash port of each unit
has detected an overflow.
Normally, there is no fluid collected. If fluid is collected, clogging in the waste
tube may be causing this.
Dirt in the sensor may also result in the same reaction. (Cleanse the sensor.)
9023 RPP2 WASHPORT overflow
9024 SPP WASHPORT overflow

Probe Mixer Rod

Wash port

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7 OTHERS MATERIALS

9025 SPP washing port lower case Leak


Leakage: When the fluid-leackage detection sensor mounted within the analyzer detects
fluid leakage, appears. (Leak sensor: )

9045
ISE WUD MIX1
<Rear view>

9048,9076 9027,9047
SPP ,9045
RRV
9025
MIX2
STT/CTT

RPP2 9026
RPP1 Incubation
bath
STATport tem-prema
RTT2 RTT1 ture

Leakage sensor position

VDP

9026 RPP1,2 washing port lower case


Leak
9027 Leak under RPEV2-2
9028 S chassis upper row VDP horizontal
side Leak
9029 S chassis inside steps Leak
9030 Set electromagnetic valve lower case
Leak
9031 Waste fluid trap sensor alarm RVTS The liquid level sensor inside the waste fluid trap is
9032 Waste fluid trap sensor alarm WVTS activated.
Waste fluid is collected in the tank.
9034 Alarm of temperature of heater Incubation bath oil temperature is abnormal.
9035 Heater thermostat abnormal
9036 Lamp thermostat abnormal Light source temperature is abnormal (too high).
Check the lamp cooling water.
9039 RRV electric board 24V power fail- Interface error. Contact your JEOL service office.
ure
9040 Alarm of temperature of RRV chassis
9041 MIX electric board 24V power fail-
ure
9042 Alarm of temperature of MIX chassis
9043 MIX1 WASHPORT overflow See 9022.
9044 MIX2 WASHPORT overflow See 9022.
9045 Right horizontal case Leak in device Fluid leakage may have occurred.
upper row Check for leakage.
9046 Case Leak after the right of device (Refer to the "Leakage sensor position" diagram.)
upper row

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7 OTHERS MATERIALS

9047 Leak under MIX2


9048 J4 water trap lower side case Leak
9049 SGL electric board 24V power failure
9050 Alarm of temperature of SGL chassis
9052 Oil bath bottle liquid insufficiency See 9004 to 9006.
9053 CTT cover open
9055 RTT Abnormal HIGH temperature Reagent Tray temperature is abnormal
9056 RTT Abnormal LOW temperature
9058 CTT loader none
9059 SPP WASHPORT overflow See 9022.
9060 DISTRI chassis upper row Leak
9061 Pump chassis lower Leak See 9007.
9062 SPP washing port 2 lower case Leak See "Leakage
sensor position"
diagram.
9064 Leak for ISE unit Same as above
9065 SPP washing port 2 overflow See 9022.
9066 Leak for ISE unit 3 See "Leakage sensor position" diagram.
9069 RRB temperature monitor abnormal
9070 Buffer bottle liquid insufficiency
9071 Pure tank sensor abnormal Check the tap water faucet and the Purified water
9073 Pure tank supply Time Over-1 alarm production system for defects. If no defect is found,
9074 Pure tank supply Time Over-2 alarm contact your JEOL service center.
9075 Pure tank liquid insufficiency
9076 Lamp cooling water tank lower case Fluid leakage may have occurred. Check for the
Leak leakage. See "Leakage sensor position "diagram.
9077 System temperature adjustment lower
case Leak
9078 MIX driver abnormal detection
9079 STT cover open
9080 ISE GE sensor Abnormal Abnormal vacuum pressure in electrolyte unit

9101 to 9281 Standby check (abnormality detected at the time of start)


9101 to 9181 refer to the same contents as for 9001 to 9081.

■ 9300 to 9306 RRB temperature monitor abnormal


■ 9500 to 9599 System-activation-management-related errors
■ 9600 to 9699 System-activation-management-related errors
■ 9700 to 9799 Parameter-loading-related errors
■ 9780 to 9799 Parameter authorization system errors
■ 9800 to 9899 Analyzer-side operation log
■ 9900 to 10001 to 11001 9999 Analyzer mode transition
Normal operation
■ 10001 to 11001 EOL RACK HANDLER alarms

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7 OTHERS

7.4 Detergent Description


■ For Routine Use Detregent and Reagent 1
No Part Name Part Number Picture Description

①Set Place is : Detergent Bottle(CW) in instrument the lower


1 Cuvette Wash Solution7 7806 08917 ②Adjustment is : Ready to use
③Material is : Alkali and Surfactant detergent

①Set Place is : Detergent Bottle(CCON) in instrument the lower


2 Cuvette Conditioner EX 7806 08925 ②Adjustment is : Ready to use
③Material is : Surfactant detergent

①Set Place is : ISE Buffer Bottle in instrument the lower


To be
3 ISE Buffer(ELA-IS)
determined Not Avail ②Adjustment is : Ready to use
③Material is : Buffer
①Set Place is : Internal Standard in instrument the lower
MID STANDARD To be
4
(Inetnal Standard) determined Not Avail ②Adjustment is : Ready to use
③Material is : MID Standard

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7 OTHERS

■ For Routine Use Detregent and Reagent 2


No Part Name Part Number Picture Description

①Set Place is : Set position is No42 in RTT1 and 2


4 Reagent Probe Wash1 7806 54072 ②Adjustment is : Ready to use
③Material is : Alkali Detergent

①Set Place is : Set position is No43 in RTT1 and 2


5 Reagent Probe Wash2 7806 54081 ②Adjustment is : Ready to use
③Material is : Acid Dtergent

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7 OTHERS

■ For Wash Detregent


No Part Name Part Number Picture Description

①Use for : Daily WASH2


②Set Place is : Set position is No44 in RTT1 and 2 for WASH2
1 Reagent Probe Wash K 7806 54056
③Adjustment is : Dilutes to 20% for Use
④Material is : Alkali and Surfactant detergent

①Use for : Weekly WASH2


②Set Place is : Set position is No44 in RTT1 and 2 for WASH2
2 Reagent Probe Wash S 7806 08909 ③Adjustment is : Dilutes to 5% for Use !!!Prepare before use!!!
④Material is : Sodium Hypochlorite detergent
⑤Warning : Remove after use

①Use for : Daily WASH2


②Set Place is : Set position is No15* * in CTT for WASH2
3 ISE Detergent Solution 7806 54099
③Adjustment is : Ready to Use
④Material is : Sodium Hypochlorite detergent

*
Default Setting(ISE Setting):User can change

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7 OTHERS

■ For ISE Calibration


No Part Name Part Number Picture Description
①Use for : Daily measurement ISE Serum Calibration
1 ISE Serum Standard Set 7806 54111 Not Avail ②Set Place is : Set position is No11(Low),No12(High)* in CTT
③Adjustment is : Ready to use
①Use for : Daily measurement ISE Urine Calibration
2 ISE Urine Standard set 7806 54129 Not Avail ②Set Place is : Set position is No13(Low),No14(High) * in CTT
③Adjustment is : Ready to use

■ OTHER
No Part Name Part Number Picture Description

①Use for : Refill as required


1 Lamp Coolant C 7806 56661 ②Set Place is : CLP Tank
③Adjustment is : Ready to use

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