Professional Documents
Culture Documents
known teratogens?
phenytoin**
thalidomide**
trimethoprim
valproic acid
warfarin
A third of Australian women take medication while pregnant . ...
the last menstrual period , medication does not change the
woman's baseline ... The following medicines should be avoided ,
particularly during the first trimester:.--->>What period of
pregnancy should medication be avoided if possible?-1st
trimester - organogenesis-brain development
In general, salicylates, which are very similar to aspirin ,
should be avoided during pregnancy . Aspirin is probably the
most ... Aspirin absolutely should never be used during the
last three months of pregnancy . The only exception is when
low Absolutely avoid products containing: • Retinol or Retin A.
• Accutane. ... Salicylic acid is a potential problem because
it is related to aspirin ....->>>When should aspirin absolutely
be avoid during pregnancy?
3rd trimester
increased risk for hemorrhage
inhibition of prostaglandin synthesis - construction of ductus
arteriosus, decrease blood flow to primary organs
========================
Because most cases of new diagnoses have been in the third
trimester , most of these pregnancies result in live-born ...
NSAIDs should be discontinued after 30 weeks' gestation because
of the risk of premature closure of the ductus arteriosus.----
>>>NSAIDs--3rd trimester - premature closing of ductus
arteriosis, jaundice, brain damaage (fetus), and bleeding in
mother during delivery
First-trimester exposure to paroxetine was compared between
cases and controls by calculating adjusted odds ratios (AOR).
We included 678 cases with isolated heart defects and 615
controls. The first trimester exposure rate was 1.5% for ...-
>>>Paroxetine-congenital heart defects - ventricular septal
defects--most other SSRIs cat C --sertraline B
Statins are contraindicated in pregnancy; however, as women
delay pregnancy and statin use increases the risk of statin
exposure in pregnancy is likely to rise. In contrast to some
early reports that statins are teratogenic, more recent
observational studies have called into question the teratogenic
risk of statins. Therefore, whether statins are associated with
congenital anomalies or other pregnancy complications remains
an important clinical question.