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Radiographic manifestations of
periapical inflammatory lesions
How new radiological techniques may improve endodontic
diagnosis and treatment planning
HANS-GÖRAN GRÖNDAHL & SISKO HUUMONEN
Diagnosis, treatment planning, and treatment monitoring in endodontics depend to a very large extent on results
from radiographic examinations. The often complex anatomy in respect to the teeth themselves as well as their
surrounding structures may render those tasks difficult. New tomographic techniques hold promises for
improvements in all those areas, in particular techniques that can display the object in all its three dimensions and
remove disturbing anatomical structures to make it possible to evaluate each root and its closest surroundings in
detail. They also provide images, taken at different points in time, that are similar in geometry and contrast making
it possible to evaluate differences occurring in the fourth dimension – time. Image-processing techniques applied to
digital images obtained with conventional periapical radiography can be of some help towards improved diagnosis
provided that optimal irradiation geometry has been used during image acquisition. When conventional
radiographs are used and conventional means employed for their evaluation, one should take radiographs from
more than one direction to ensure that at least some three-dimensional information will be obtained. When
evaluating images over time they must be compared side by side to provide best possibilities of subjectively
detecting changes occurring over time.
The radiological examination is an integral and technique to ensure not only more accurate diagnoses
essential part of endodontic management, from the but also better possibilities for root-length measure-
initial diagnostic work-up to the monitoring of ments. However, for a multi-rooted tooth in which the
treatment results. Unfortunately, it is not infallible roots diverge in the bucco-lingual no single radiograph
because of many, quite different, reasons. We believe allow all roots to be imaged according to the bisecting-
the most important is the limitations of conventional angle rule. As a consequence, significant image
radiological examinations to fully describe the three- distortions can result. Nevertheless, from images with
dimensional (3D) anatomy of the teeth and their all these inbuilt restrictions the observer must try to
surrounding structures. Those techniques make all visually recreate the underlying three dimensions, a far
structures in the anatomical 3D space become com- from easy feat in many cases.
pressed into a two-dimensional image (Fig. 1). There- It is possible to overcome at least some of the
fore, not only do they display limited aspects of the limitations of conventional radiology by using at least
anatomy, but because of the complexity of the anatomy two radiographs obtained from different, usually
itself and the characteristics of the central perspective horizontal, directions. In our normal daily life, we
irradiation geometry, geometric dimensions as seen in would never be content with a single view if, for
the radiographs can be very different from the actual example, asked to describe a mug as that in Fig. 2. We
ones. The so-called paralleling technique is usually, and would, probably without even thinking of it, look at it
rightfully, recommended over the bisecting-angle from different angles maybe by rotating it. It is,
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Gro¨ndahl & Huumonen
therefore, always amazing to see how many dentists that that are perpendicular to each other, a technique that
are content with single radiographic views for describing for most medical applications is common. Instead we
the anatomy of teeth and surrounding bone and, based have to rely on radiographs taken with different
on that, make a diagnosis and a treatment plan. angulations in the same plane. In some cases, as when
An important principle in radiological imaging is to clinical signs and symptoms strongly suggest a condi-
perform the examinations so that diagnostically neces- tion that ought to be radiologically evident but not
sary 3D information is obtained. As regards teeth it is seen in the radiographs already taken, one may have to
usually meaningless to take radiographs in directions take more radiographs from different perspectives.
However, there is a limit to how much information that
can be obtained by means of conventional radiographs
regardless of how many.
Another important principle in radiology is that
structures of diagnostic interest should be displayed
onto as homogeneous a background as possible.
However, teeth are surrounded by jawbone and other
facial bones, some at a distance from the roots and
apices of the teeth and therefore unlikely to contain
information of endodontic, diagnostic interest, e.g. the
bone in the chin and the zygomatic bone (Fig. 3). Not
Fig. 1. In central perspective images, structures in the infrequently, however, these structures become super-
three-dimensional (3D) domain become compressed into
imposed onto the anatomic features of diagnostic
a two-dimensional (2D) representation making the
images of the structures become distorted and super- interest, sometimes to the extent that the latter become
imposed on each other. From the 2D image, observers concealed. Irrelevant information, in this case as a result
must try to mentally recreate the 3D reality. Reproduced of anatomical noise (anatomic structures concealing
with permission from (1).
structures of interest) has thus been sampled during the
radiological process. The most common reason is that
non-optimal irradiation geometry has been used. In
cases of multi-rooted teeth, especially when the roots
are situated close to each other, it can be difficult or
impossible to radiographically separate them from each
other by means of conventional methods.
Fig. 2. To best describe a three-dimensional object one From the above, it is evident that conventional
must look at it from different directions, sometimes many. radiological examinations often suffer from limitations
Fig. 3. In the left image, some roots and apices are obscured by anatomical noise (the zygomatic bone and arch). In the
right image, as a result of better irradiation geometry (paralleling technique and orthoradial projection) the roots and
apices are seen against a more homogeneous background (the maxillary sinus).
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Periapical inflammatory lesions
as regards the 3D depiction of the examined region and plates (Fig. 4). In those cases, the difficulties described
in the possibilities of displaying the structures of can be real (Fig. 5) and a possibility of producing cross-
interest against a homogeneous background, that is, sectional radiographic slices should be particularly
one free from disturbing image features because of valuable.
neighboring anatomical structures. Particularly when It should be needless to say that when radiographs
examining multi-rooted teeth multiple projections will have been taken at different points in time they must be
increase the rate of detection of periapical lesions. This carefully compared, but experience tells this is not
can be explained by the higher probability of less always the case. It cannot be said too often that there is
anatomical noise affecting the images of the different no better way to detect differences occurring over a
roots, an effect similar to that described for chest time interval than to compare serially obtained radio-
radiography (2). With multiple projections, stereo- graphs placed side by side (Fig. 6).
scopic viewing can be used. This has been described as Ideally, it should be possible radiologically to examine
improving the signal-to-noise ratio and resulting in any dentate region of the jaws so that individual roots
better visualization of anatomical details (3). could be assessed without the disturbance caused by
Equally important as taking account of the three superimposed structures. Likewise, it should be possi-
dimensions in the spatial domain, both when performing ble to evaluate the bony areas surrounding each root
a radiological examination and, not least, when inter-
preting its information, is to take the fourth dimension –
time – into consideration. This requires radiographs to
be compared over some time interval to be as similar as
possible in respect to geometry as well as density and
contrast. Otherwise, the information gleaned from
comparisons of serial radiographs might consist more
of irrelevant information (noise) – that can be quite
misleading – than actual subject-related temporal
differences reflecting true biological change. Also, the
density in a summation image resulting from conven-
tional radiography is caused both by the lesion itself and
the anatomical structures on either side in the direction
of the X-rays. This means that lesions surrounded by
thick or dense bone over time must increase or decrease
more in size than a lesion surrounded by thinner or less Fig. 4. Cross-sectional view of mandible before (left) and
dense bone to give rise to the same observable gray-level after removal of bone around the distal apex of the molar.
difference in the radiograph.
When Bender & Seltzer (4, 5), Schwartz & Foster (6)
described the difficulties in detecting lesions in
trabecular jaw bone that had not encroached upon
the surrounding cortical bone, endodontists might
have started to wonder about the value of radiography
in endodontic diagnosis. However, it has been specu-
lated that when lesions affected the lamina dura (as
endodontic lesions do) the area of rarefication becomes
more apparent when the trabeculae are resorbed at the
junction of cancellous and cortical bone. Also, most
root apices are close to the cortical bone, which is
therefore quickly affected by apical inflammatory
lesions (5). However, for some teeth, particularly the
lower premolars and molars, the apices sometimes are
found between the buccal and lingual cortical bone Fig. 5. Radiographs before and after bone was removed.
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Gro¨ndahl & Huumonen
Fig. 6. In a patient presenting with pain in the upper right molar region a dentist believed he found the reason for it in a
periapical lesion that he saw in the left one of these images and initiated endodontic treatment. A comparison with a
previously taken radiograph (right image) might have made him perceive the absence of the lower border of the maxillary
sinus and the presence of soft tissue within it indicating a different cause of the patient’s problem than an inflammatory
periapical lesion. Eventually it was found that the patient suffered from a malignant lymphoma.
and, in the presence of one or more periapical lesions, it make other types of radiographs necessary such as those
should be possible to assess each separate lesion in primarily aimed for examinations of the maxillary sinus
respect to its borders and its relation to surrounding (Fig. 7).
anatomical structures. It should be possible to make
reliable (accurate and precise) measurements of any
desired distance and to obtain accurate information
Conventional tomography
from comparisons of images from different points
in time. In conventional tomography, structures on either side
Advances in computer science both as regards of a selected object layer are blurred because of a
hardware (cheaper, faster and with more memory) synchronized motion of X-ray source and detector, so
and not least software (image-processing algorithms) that structures inside the layer of interest appear sharply
have enabled a development of radiographic machinery depicted. In the resulting tomograms, the blurred
moving us towards the ideal situation as far as structures may be seen as homogeneous, low-contrast
radiological examinations of endodontic problems are shadows or, if the blurring is sufficiently effective, not at
concerned. In this chapter, we will describe some all. The tomographic motion pattern and the amplitude
techniques that can be of value for the endodontist, in of the motion affect the quality of the tomographic
particular when the conventional intraoral radiological images. Spiral tomography, in which the X-ray tube and
examination does not suffice in providing diagnostic the detector move in a spiral pattern is an effective type
information that can aid in the selection of a manage- of motion particularly well suited for the production of
ment that can best help both dentist and patient. The tomograms within anatomically complex regions such
latter is the ultimate goal of any diagnostic procedure. as the facial skeleton.
For radiography of the facial skeleton, so-called
Radiographic examinations multi-modality units have been developed that permit
complementing intraoral different imaging modes and principles to be used.
They include a spiral tomographic imaging mode with
radiography
which e.g. dento-alveolar structures can be visualized
In all types of radiological diagnosis, there is a need to free from disturbing, surrounding structures (Fig. 8). It
see the borders of the lesion and at least some of its has been demonstrated that the visualization of
surroundings. When a lesion has reached a size that periapical bone lesions, particularly in the premolar
makes it impossible to capture by intraoral radiographs and molar regions, is better than that achieved with
other means must be used. In the lower jaw, panoramic intraoral periapical radiography (7). Not surprisingly,
radiography can then be useful. This can also be used in differences between those techniques were smaller for
the upper jaw but its more complex anatomy often lesions in the anterior jaw regions.
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Periapical inflammatory lesions
Fig. 7. In this 12-year-old girl presenting with pain in the upper left molar region intraoral radiographs did not describe
a suspected lesion in its entirety. The absence of a clear anterior and lower border of the maxillary sinus and the
homogeneous density of the region of the sinus indicate the presence of an extensive lesion. A lateral sinus scanogram
(left lower radiograph) and an anterior sinus scanogram (lower right radiograph) demonstrate the presence of a large
cystic lesion that, as a result of being infected, had a lower lateral border that had become resorbed. Lower two
radiographs were obtained with a Scanora multimodality unit (Soredex Co., Helsinki, Finland).
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Gro¨ndahl & Huumonen
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Periapical inflammatory lesions
measurement tool. Regions, or teeth, to be compared significantly increase the possibilities of reliably mon-
over time need not be radiographed in exactly the same itoring treatment effects.
way, as the case is in conventional radiography. It does happen that fractures occur in roots with root-
Similarity between images can namely be achieved post canal posts. In many cases it is only the development, at
hoc both in terms of geometry and contrast. The the root surface at a level of the tip of the post, of an
elimination of overlying structures will therefore inflammatory lesion with or without communication to
the marginal bone crest that indirectly signals the presence
of a fracture. The fracture itself is often not seen until a
dislocation of a fracture fragment has occurred and
sometimes the inflammatory lesion is situated in a
position that makes its detection in ordinary intraoral
radiographs difficult or even impossible. In such cases the
limited cone-beam CT might be helpful (Fig. 13).
In cone beam CT, artifacts from metallic objects and,
to some extent, root canal fillings can be quite
disturbing. For that reason, internal root resorption
and root canal perforations cannot always be diag-
nosed. Therefore, a combination of periapical radio-
graphy and cone beam CT occasionally might be
necessary.
The cone beam CT technology is also used in X-ray
machines that acquire data from a large volume (16).
Fig. 11. In this patient, the upper left second premolar Such a technique has been used for the planning of
showed a large periapical lesion with a breakdown of part minimal invasive endodontic surgery via the vestibular
of its buccal border and of that expanding into the approach (17). Information derived from cone beam
maxillary sinus in which there is an extensive soft-tissue
reaction. Note also, in the axial view, that the tooth had no
CT was considered essential in the surgical procedure
less than three roots. In the periapical radiograph, little of and particularly useful for selecting direction of the
all this information was obtained. surgical approach and length of instruments. It was
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Gro¨ndahl & Huumonen
always best to have as good images as possible in the Color coding has been proposed as a mean of
front end of the diagnostic process, another reason why detecting differences between sequential images by
it is usually better to view the object from different means of image addition to detect bone changes (33).
angulations to start with (Fig. 20). Assigning a color to a range of gray creates colorized
images, but the process discards information (Fig. 21).
Color coding can be used to help to find possible
lesions; in diagnosis, however, a gray-scale image was
preferable (34).
Densitometric image analysis and subtraction have
been applied to enhance the detection of small osseous
changes over time. The purpose of subtraction is to
eliminate all unchanged structures from a pair of
radiographs, displaying only the area of change stand-
ing out against a neutral gray background. The
technique requires a high degree of similarity both in
irradiation geometry and contrast that can be difficult
to achieve during clinical conditions. Image-processing
techniques have been developed that can correct for
errors due to projection differences that occur when
the sensor translates or rotates relative to the object or
when the object rotates around its z-axis relative to the
X-ray source (35–37). Errors caused by vertical or
horizontal rotation of the object relative to the source
cannot be corrected for. Several methods for contrast
correction have been proposed in the past (38).
Follow-up studies of the healing of periapical lesions
after endodontic treatment have shown that subtrac-
Fig. 16. The human eye’s response to brightness tion may be a useful tool to evaluate the healing
differences is logarithmic. Therefore, the same physical process. Significantly better agreement between ob-
brightness difference is differently perceived if it occurs
servers have been demonstrated when subtraction
against a light background than a dark one. A lesion can
therefore be easier to detect when a radiograph is made images are used than when conventional are employed
darker. for this type of evaluation (39, 40).
Fig. 17. As this radiograph gradually gets darker, the lesions at the apices of the first molar become more visible.
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Periapical inflammatory lesions
Fig. 18. Increasing contrast only in a radiograph that is too light to start with usually does not improve its diagnostic
value.
Fig. 19. By first decreasing image brightness slightly and then carefully increasing contrast, an image of better diagnostic
value can be achieved.
Fig. 20. In the premolar image, a lesion at the apex of the premolar can be seen that is not visible in the image of the
cuspid area because of the different irradiation geometry. Lower image brightness and higher contrast (right image pair)
does little or nothing to improve lesion visibility when the primary conditions are suboptimal.
Fig. 21. Color coding of radiographs presents the information in a different way that is not always logical as the gray-
scale image is (properly exposed and processed). A color algorithm, sometimes called Fire (the two images to the right)
provides colors going from black, through red and yellow to white, as if a piece of iron was heated so that its temperature
gradually rose. This is a logic resembling that of the gray-scale image.
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