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Acidosis
National Kidney and Urologic Diseases Information Clearinghouse
Type 4 RTA occurs when blood levels of the • Without proper treatment, chronic
hormone aldosterone are low or when the kid acidity of the blood leads to growth
neys do not respond to it. Aldosterone directs retardation, kidney stones, bone
the kidneys to regulate the levels of sodium, disease, chronic kidney disease, and
potassium, and chloride in the blood. Type 4 possibly total kidney failure.
RTA also occurs when the tubule transport • If RTA is suspected, additional
of electrolytes such as sodium, chloride, and information about the sodium,
potassium is impaired due to an inherited dis potassium, and chloride levels in the
order or the use of certain drugs. urine and the potassium level in the
Drugs that may cause type 4 RTA include blood will help identify which type of
RTA a person has.
• diuretics used to treat congestive
heart failure such as spironolactone or • In all cases, the first goal of therapy
eplerenone is to neutralize acid in the blood, but
different treatments may be needed
• blood pressure drugs called angiotensin- to address the different underlying
converting enzyme (ACE) inhibitors and causes of acidosis.
angiotensin receptor blockers (ARBs)
• the antibiotic trimethoprim
• the antibiotic pentamidine, which is used genetic basis for their body’s resistance to the
to treat pneumonia hormone. To treat type 4 RTA successfully,
• an agent called heparin that keeps blood patients may require alkaline agents to correct
from clotting acidosis and medication to lower the potas
sium in their blood.
• a class of painkillers called nonsteroidal
anti-inflammatory drugs (NSAIDs) If treated early, most people with any type
of RTA will not develop permanent kidney
• some immunosuppressive drugs used to failure. Therefore, the goal is early recogni
prevent rejection tion and adequate therapy, which will need to
Type 4 RTA may also result from diseases be maintained and monitored throughout the
that alter kidney structure and function such person’s lifetime.
as diabetic nephropathy, HIV/AIDS, Addi
son’s disease, sickle cell disease, urinary tract Hope through Research
obstruction, lupus, amyloidosis, removal or
The National Institute of Diabetes and Diges
destruction of both adrenal glands, and kidney
tive and Kidney Diseases (NIDDK) conducts
transplant rejection.
and supports research into many kinds of kid
For people who produce aldosterone but ney disease, including renal tubular acidosis.
cannot use it, researchers have identified the NIDDK-supported researchers are exploring