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Mehwish ayaz(87-E-14)
PHARMACY DEPARTMENT BAHAUDDIN ZAKARIYA UNIVERSITY, MULTAN
Group No: 07 (Evening)
Assigned Drug: lansoprazole
Abstract:
Introduction
Same method was used but sampling was done at fixed time interval of 5 mins for
30mins. The concentration was determined by finding the absorbance using the
UV-Spectrophotometer and referring to the linearity curve that was plotted previously.
Absorbance of Lansoprazole from intestine of Rabbit: Fill the drug solution in the
intestine of rabbit and held in the buffer of PH 7.4 and took the sample at different time
interval and calculated the concentration through absorbance.
Table 1
Figure I
Time Absorbance %age conc.
30 min 1.3
Time (X-axis)
Similarity Index (f2) = 30.9%
Linearity curve data shown in Table I shows that this drug obeys Beer-Lambert Law upto
25ppm after it shows deviation.
Multiple Point dissolution data showsn in Table 2 shows that lancet and Slan are similar
The results of bioequilance shows that two brands are similar
References:
1- LEON SHARGEL BIOPHARMACEUTICS AND PHARMACOKINETICS
2- Drugbank.com
3- United state pharmacopoeia (USP)
4- BNF
5- Basic Pharmacokinetics by Sunil S Jambhekar and Philip J Breen.