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Surgery Illustrated

SURGERY ILLUSTRATED
LE and SEGURA

Surgical Atlas
a

Ureterorenoscopy
CARTER Q. LE and JOSEPH W. SEGURA
Department of Urology, Mayo Clinic, Rochester, Minnesota, USA
b 1 2 3 4

ILLUSTRATIONS by STEPHAN SPITZER, www.spitzer-illustration.com

b INTRODUCTION PATIENT SELECTION


c

In 1978, a paediatric cystoscope was used to There are several treatments for urolithiasis,
d
examine a dilated distal ureter in a female [1]. including observation, medical expulsive
This procedure inaugurated an era where therapies [2], shock-wave lithotripsy, and
accessing the upper urinary tract has percutaneous nephrolithotripsy. Each
progressed at an ever increasing pace. The treatment should be considered with regard
a
development of smaller calibre, longer, and to the clinical scenario. Failure of conservative
more nimble ureteroscopes has driven this therapy or other considerations, such as
revolutionary advance. This progress has occupational requirements (e.g. airline pilots),
resulted in a revolution in the management renal insufficiency, or coexisting infections,
b
of urolithiasis and an ever-increasing role can hasten surgical intervention.
in oncology treatment. In this article we
present our current technique of Patients presenting with ‘high-spiking’ fever
performing ureterorenoscopy which we and rigors, mental status changes, or other
think maximises the chances of success, signs of serious infection, would better
while minimizing the risks of failure and benefit from a percutaneous nephrostomy.
complications. Irrigating pressures within the ureter during
endoscopy can be such that pyelovenous and/
or pyelolymphatic back-flow can occur,
placing the patient at risk. Nephrostomy tubes
PLANNING AND PREPARATION can be placed quickly, under light sedation,
and would permit larger calibre drainage of
INDICATIONS the urinary system.
a

The indications for ureteroscopy fall into two


b c

categories, diagnostic and therapeutic. SPECIFIC EQUIPMENT/MATERIALS


Diagnostic indications include evaluating a
patient with a radiological filling defect, In endoscopically manipulating the upper
haematuria, or positive cytology of the upper urinary tract, the surgeon should be
tract, or surveillance of patients with upper intimately familiar with the equipment. The
tract malignancies that have been treated capabilities, idiosyncrasies and characteristics
endoscopically. Therapeutic indications (good or bad) of each piece must be appraised
include removing upper tract stones or other before use and there is no substitute for
foreign bodies, treating upper tract personal experience. The following list details
malignancies, or treating strictures or areas of the authors’ preferred equipment and
a b c
obstruction. materials for ureterorenoscopy.

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• Endoscopic table with fluoroscopy review of 1000 consecutive cases. Submitted). count with differential. Analysis and culture
(or C-arm). The calibre is generally 7.5 F to 8.6 F, and the of the urine should reveal no active infection;
• Ureteroscopes, rigid/flexible. working chambers will accommodate 3 F otherwise, a course of antibiotics should
• Guidewires (a variety). instruments; however, these instruments will precede intervention. Any abnormalities in the
• 8 F Acorn-tipped ureteric catheter. adversely affect the deflection of the tip. patient’s history should be cleared by the
• Contrast medium. Nevertheless, with these scopes we can appropriate medical services.
• Ureteric access sheath. visualize virtually any area of the upper
• Holmium :YAG laser (with laser fibre, 365 or collecting system, most notably the renal In deciding on anaesthetic options, we
200 µm). pelvis and its various calyces. Furthermore, routinely use general anaesthesia with muscle
• Stone baskets (a variety). some flexible ureteroscopes on the market paralysis. This strategy avoids possible
• Biopsy forceps or brush (if needed). can be used to actively ‘double deflect’ the tip, ureteric injuries resulting from sudden patient
• Ureteroscopes. allowing access into the most difficult of movement, such as coughing, and has not
anatomical areas, but these come at a high been a factor in any decision concerning
Rigid ureteroscopes range from 4 F to 13.5 F price in durability [3]. In the uncomplicated admission of a patient after ureteroscopy [4].
at the tip and use channels for instruments proximal stone or diagnostic procedure, we Cephalexin (500 mg i.v.) or levofloxacin
and/or irrigation ranging from 2.3 F to 5.4 F. use the 6.9 F flexible DUR-8 ureteroscope by (250 mg i.v.) is given before anaesthesia.
Advantages of the rigid scope include the ACMI. If the stone cannot be seen with this Appropriate preoperative radiological studies
large working channel, greater durability, and scope, the Dur-8 Elite or Storz Flex-X scope should be accessible in the operating room for
excellent visualization. The disadvantages may be necessary to find it. rapid reference.
include its rigidity and size, which become
apparent while trying to traverse the ureter SPECIFIC PATIENT PREPARATION Discussions with the patient should avoid
over the pelvic brim. We prefer the semi-rigid unnecessarily high expectations of success
6 F ureteroscope (Wolf, Germany) in the distal The preoperative evaluation includes a and explain the risks of ureteroscopy. These
ureter, or mid-ureter if accessible. focused history and physical examination, risks include ureteric injury (i.e. perforation,
with particular attention to coagulation stricture, false passage, or avulsion), bleeding,
In our practice, flexible ureteroscopes are used disorders and current medications. Laboratory and sepsis, although these complications have
for ≈39% of procedures (Krambeck et al. evaluation includes serum creatinine and diminished with the advent of smaller
Contemporary trends in ureteroscopy: a electrolyte levels, as well as a white blood cell ureteroscopes [5].

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Figure 1

SPECIFIC PATIENT POSITIONING

The patient is placed in a dorsal lithotomy


position and all pressure points are padded. If
possible, arrange the legs in position before
anaesthesia induction, to give the patient the
opportunity to voice any discomfort. Raising
the contralateral leg might provide more
room for manoeuvring a ureteroscope if
necessary.

URETERIC ACCESS

The ureteric access sheath has recently


assumed a greater role in accessing the upper
urinary tract, allowing repeated passage of a
the flexible ureteroscope. It is valuable in
minimizing distal ureteric trauma, wear on
the ureteroscope, and the operative time of
the procedure. There is a reported 1.7%
stricture rate with the access sheath [6],
although our experience does not support
this.

MANIPULATION

The lithotripsy devices that are most


effectively used through the ureteroscope are
the electrohydraulic lithotripter and the laser.
We prefer the holmium:YAG laser, with its
ability to thermally drill through even the
most difficult stones. Disadvantages are the
relatively brittle laser fibres, potential for
damage or wear on the ureteroscope, and
expense. We typically use the 365 µm fibre for
the rigid, and the 200 µm fibre for the flexible
ureteroscope.

There are many and various stone-retrieval


devices; the baskets that we most commonly b 1 2 3 4
use are the flat-wire basket and the NitinolTM
tip-less basket, although we use other baskets
as the situation dictates. Along with spiral and
multiwire baskets, the flat-wire baskets have a
tip protruding beyond the cage and are used
primarily in the ureter. While working in the although we most often use a stone-retrieval therapeutic procedures. The following steps
renal calyces, tip-less baskets and graspers basket for tissue sampling. can be used for either type of procedure, and
can avoid trauma to the renal papillae. We differences will be highlighted.
have found these instruments particularly
useful in moving stones from less accessible SURGICAL STEPS There are three main steps in ureteroscopy: (1)
calyces and repositioning them into the renal accessing the ureter; (2) instrumentation of
pelvis before definitively treating them. Instrumentation of the ureter can be the ureter with or without manipulation; and
categorized into either diagnostic or (3) withdrawing from the ureter.
For retrieval of tissue, grasping forceps, cold-
cup and alligator-toothed biopsy forceps, and
retractable biopsy brushes are available,

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LE and SEGURA

Figure 2

STEP 1: ACCESSING THE URETER

A full cysto-urethroscopy is performed


initially. If there is any concern for cancer,
fluid for cytology or biopsies can be taken. An
acorn-tipped catheter is used to intubate the
ureteric orifice and a retrograde uretero-
pyelogram is taken with contrast medium
diluted to a half or a third. The anatomy of the
ureter is thus accurately defined before
manipulation.

If the procedure is not purely diagnostic, a


guidewire is passed into the collecting system
under fluoroscopy. Balloon dilatation of the
a ureteric orifice is done over a non-hydrophilic
guidewire. Care is taken to avoid over-
inflation beyond the pressure limit of the
balloon.

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Figure 3

Identifying and accessing the ureteric orifice


can be particularly challenging in cases of
previous surgery, detrusor hypertrophy,
or ectopic ureters. After ureteric re-
implantation, the orifice can be far removed
from its usual position. A flexible cystoscope
through which a 5 F open-ended catheter
with a hydrophilic angle-tipped ‘glidewire’
has been fed can be very useful. The catheter
lends stiffness to the wire if necessary, and is
used to inject contrast medium to confirm
correct placement. Once a glidewire has been
properly placed into the collecting system, the
catheter is also used to exchange the
glidewire for a PTFE-coated guidewire.
However, in many cases access into these a
ectopic orifices will be impossible in a
retrograde fashion, and the surgeon might
need to resort to an antegrade percutaneous
approach.

A ‘needlescopic’ (4.5 F) ureteroscope can be


useful in the patient with detrusor
hypertrophy with a tortuous intramural
ureter. The needlescope can be advanced into
the orifice, the lumen identified, and a
hydrophilic glidewire placed under direct
vision. Once fluoroscopy confirms the correct
position, the glidewire can be exchanged for a
PTFE guidewire through an open-ended
catheter.

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Figure 4

At times, the initial passage of the guidewire


for ureteral access may in fact have created a
false passage or perforation through which
the wire is now positioned. Clues to this
occurrence include difficulty passing
catheters or the ureteroscope over the
wire, passage of the wire outside of the
remaining contrast following the initial
ureteropyelogram, or failure of the wire to coil
in the renal pelvis. At this point, passage of
the ureteroscope under direct vision over the
guidewire can locate the spot of the injury.
The guidewire is then withdrawn into the
scope, and under direct vision, passed into the
true lumen. The procedure can then continue
and a stent may be left in place for 3-6 weeks
post-operatively.

STEP 2: INSTRUMENTATION

This section describes the completion of the


main objectives of the procedure. The bladder
should be drained before starting a lengthy
procedure. Afterwards, the contralateral
ureter should also be evaluated if indicated.

DIAGNOSTIC INSTRUMENTATION

For diagnostic procedures (such as evaluating


filling defects or positive cytology), the semi-
rigid ureteroscope is used to gain access and
examine the intramural ureter without using
a guidewire. The area is then balloon-dilated if
no suspicious lesions are found, and the scope
is passed under direct vision up the ureter. If
needed, a guidewire is placed, also under
direct vision, and the flexible scope and/or
access sheath passed for complete renoscopy.
In this way, the collecting system can be
examined without the trauma of blindly
passing a guidewire, which could lead to
iatrogenic lesions or areas of suspicion. This
can result in a biopsy of otherwise normal
tissue or worse, inadvertent dismissal of
clinically significant lesions.

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Figure 5

THERAPEUTIC INTERVENTIONS

If a stone or ureteric lesion is distal to the


pelvic brim, balloon dilatation of the ureteric
orifice is used after placing a guidewire. A
semi-rigid ureteroscope can then be passed to
the area of interest. Along the ureter there
can be narrow sections that might not allow
easy passage; advancing the scope in this
situation can result in telescoping of the
ureter and subsequent damage. At this point,
advancing a second guidewire through the
working channel into the proximal ureter and
then advancing the scope between the wires
might allow advancement past the narrowing.

For a proximal ureteric lesion, a ureteric


access sheath is placed. With a guidewire in
place, a dual-lumen catheter is passed
coaxially over the wire and a second a
guidewire is placed. The dual-lumen catheter
is removed, and the access sheath is passed
over the new wire. Care is taken to advance
the sheath beyond the iliac vessels and near
the area of interest under fluoroscopy. This
leaves the original guidewire as a safety wire
outside of the access sheath. The flexible
ureteroscope can then be passed up through
the sheath.
b c
At this point, renoscopy can proceed under
direct visualization and fluoroscopic control,
and the objectives of the procedure can be
completed. Dilute contrast medium can be
injected gently to further define the renal
pelvic anatomy and ensure adequate
visualization of all calyces.

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Figure 6

OTHER MANIPULATIONS

For urothelial cancers, the objective is to


obtain tissue for diagnosis without
perforation or removal of the full-thickness of
the ureteric wall. Gravity irrigation is
preferred after access into the ureter,
ensuring that the pressure in the collecting
system is kept to a minimum. Although there
is no particularly good trans-ureteric biopsy
instrument, we have had success with the
following technique. A flat-wire basket is
passed superior to the lesion. The cage is
opened and carefully withdrawn inferiorly.
Once the lesion is within the cage, the basket
is closed and the ureteroscope and specimen
are removed in its entirety. Care should be
taken not to crush the specimen, which is
often very friable. The scope is then replaced
into the ureter and the base of the lesion
cauterized. Several specimens can be taken.
The ball electrode or the holmium:YAG laser is
used to fulgurate the area. An indwelling
ureteric stent is placed for 7–10 days.

a b c

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STONE-BASKETING AccusizeTM balloon may be used to treat a PUJ procedure that goes smoothly. Provided that
stricture or distal ureteric stricture. It should there is guidewire access, there is no single
The size of the stone, especially the size not be used elsewhere in the ureter because ‘point of no return’ as with many other
relative to the ureter, should be carefully of the risk of injury to vasculature adjacent to procedures. If a guidewire has not been
assessed. Extraction should never be the ureter. At the PUJ the incision should be placed, a percutaneous nephrostomy can
attempted unless it is absolutely certain that made laterally; in the ureter below the iliac provide temporary drainage.
the stone is extractable, keeping in mind that vessels, the incision should be medial and
a 6-mm stone requires an 18 F tract for intact anterior. Laser incisions can be used anywhere We advocate routine balloon dilatation of the
removal. An impacted stone should be else in the ureter, carefully under direct vision, intramural ureter and the ureteric orifice as
drained with either an indwelling stent or a and are made through the full thickness of the initial instrumentation. Certain exceptions
percutaneous nephrostomy; once the acute the ureteric wall. The surrounding wispy to this might include cases where a ureteric
situation has stabilized, definitive treatment retroperitoneal fat should be seen through stent had been left in place. There have been
can be considered. the incision. An 8 F indwelling ureteric stent is several reports questioning routine balloon
placed for 4–6 weeks. dilatation [8,9]. However, we think that
With the ureteroscope in place, the basket is balloon dilatation allows for easier and more
passed superior to the stone under direct STEP 3: CONCLUDING THE PROCEDURE rapid access through the intramural ureter,
vision. Care is taken to avoid creating a false facilitating repeated passes of the
passage, particularly if there is no visible The ureteroscope should be withdrawn under ureteroscope and removal of calculi.
lumen around the stone. Rotating the scope direct vision to inspect the mid- and distal Furthermore, larger and more capable
can position the wire optimally due to the ureter on the way out. The ureteric sheath, if instruments can be passed. Our evidence has
offset working port. Care should be taken with present, can be withdrawn simultaneously. shown that balloon dilatation has minimal
the irrigation pressure to avoid blowing the The access wire should remain in place with long-term disadvantages, as confirmed by our
stone up into the renal pelvis, converting a the tip in the renal pelvis. 0.5% stricture rate [4,10].
relatively simple stone basketing into a more
complicated procedure. Placing the patient in At this point, a JJ indwelling stent with the
a reverse Trendelenburg position can also ‘tail’ is placed over the remaining guidewire. POSTOPERATIVE CARE
help. Under direct vision, the rigid cystoscope is
back-loaded onto the wire and replaced into In the recovery room, diet is advanced as
With the basket engaged, the ureteroscope the bladder. The stent with the tail is passed tolerated. If the patient is able to urinate on
and stone are removed together, keeping the under direct vision until the distal tip of the his or her own, discharge to home is ordered.
stone in view at all times to monitor for stent is 1 or 2 cm outside the orifice, and the A typical stay in our outpatient recovery room
intussusception of the ureter or lodging of the wire is removed. is 3–4 h. Pain after discharge is managed with
stone. Particular attention is paid to the oxycodone/acetaminophen (5 mg/325 mg),
ureteric wall relative to the stone. The Alternatively, the stent can be placed under one or two tablets by mouth every 4 h if
appearance should be similar to watching fluoroscopic guidance without the needed, as well as a stool softener such as
from the back of a subway car with the cystoscope. The stent with the dangle is docusate sodium. Urgency is managed with
‘tunnel’ walls moving freely around the loaded onto the wire, and under dynamic oxybutynin, either 10 mg every 8 h, or 10 mg
basketed stone and away from the observer. If fluoroscopy, the radio-opaque tip of the of the extended release form each day.
the wall is not moving relative to the stone, it pusher is advanced to the top of the pubic Dysuria is managed with phenazopyridine,
is possible that the ureteric wall is entrapped symphysis. The wire is removed and 200 mg every 8 h with meals, for 48 h.
with the stone within the basket. At this point, placement confirmed with fluoroscopy. If the
the basket can be opened further, the ureter stent has been pushed too far into the ureter Our practice is to routinely leave a JJ ureteric
freed, and the basket re-closed. (no curl is visible in the bladder), tension is stent with a tail taped to the patient’s skin. We
applied to the tail to advance the tip distally. inform our patients that they should expect a
After removal, the scope is then replaced into This method can save 2–3 min of operative mild amount of gross haematuria, passage of
the ureter and the collecting system inspected time [7]. blood clots, urgency, frequency, ipsilateral
for residual stones and/or lesions. To facilitate flank discomfort while voiding, and dysuria
this, further contrast dye can be placed in the that will improve. When the stent is removed
collecting system and will aid in later stent HIGHLIGHTS after 48 h the symptoms will further improve
placement. dramatically. With proper preoperative
One of the main differences between education, we have found that nearly all of
For treating strictures, the ureteroscope (rigid ureteroscopy and other procedures our patients will tolerate the stent until
or flexible) is passed alongside the guidewire (particularly open procedures) is that, if removal.
up to the level of the obstruction. The wire problems are encountered, a JJ stent can be
should be directly visualized passing through placed, the procedure concluded, and the For those who have had an uncomplicated or
the true lumen of the stricture. It might be objectives accomplished at another time. routine procedure, no further follow-up,
necessary to pass a ureteric catheter superior ‘When the going gets tough, the tough put up including radiographic studies, is necessary.
to the stricture and inject contrast medium to a JJ stent and quit.’ The patient is seldom However, if there has been a complicated case
confirm placement into the renal pelvis. The worse, and the result is often an easier second or the procedure was not routine, follow-up

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LE and SEGURA

with IVU or ultrasonography might be overlying the sacroiliac joint, and the patient attached to a bar of soap. Often, after
indicated. opted for endoscopic management. Despite overnight tension, the stone and basket will
several efforts, we were never able to access be in the bed in the morning. Otherwise,
the ureter adequately or visualize the stone repeat ureteroscopy after a day or two will
FROM SURGEON TO SURGEON with the ureteroscope. We are limited to the often permit stone destruction.
Dornier HM-3 lithotripter at this institution,
PREDICTORS OF DIFFICULT CASES and the patient was offered a referral to A basket with a broken wire might be
another facility with other lithotripter intentional or inadvertent, but presents two
Lower-pole renal calculi (particularly those options, but he declined. Extracorporeal dilemmas: (i) the misshapen basket, and (ii)
with narrow infundibulopelvic angles), lithotripsy proceeded, but his symptoms the stone. The resulting shape of the distal
anomalous anatomy, and calyceal diverticulae persisted. He finally underwent an open end of the basket can cause significant
present the most challenging cases to the ureteric exploration and a significant amount ureteric trauma. For tip-less Nitinol baskets,
endoscopic urologist. Previous reconstructive of debris was encountered within his ureter an open-ended catheter (7 F) or access sheath
urinary tract surgery can alter the location of which was cleared as much as possible. We may be advanced co-axially over the basket
the ureteric orifice, the lie of the intramural could never definitively declare that he was and the basket withdrawn [13]. For other
ureter, and the angle into which the ureter stone-free; meanwhile his symptoms baskets, the cage can be withdrawn under
enters the bladder. The surgeon must be gradually improved. It was a long, convoluted, direct vision with the distal broken wire
prepared to seek another option if access to and invasive way to manage a relatively small grasped with forceps to protect the ureteric
the ureter cannot be obtained in a retrograde stone, with a less than satisfying conclusion. wall. Alternatively, it might be necessary to
fashion, such as percutaneous access. The transect the remaining wires, remove the
same might be true when encountering HIGHS: SINGLE MOST HELPFUL ASPECT proximal basket, and advance the distal
atypical upper tract anatomy, such as a portion into the renal pelvis, where forceps
horseshoe or pelvic kidney. Open surgery is For one reason or another, a stent might are used to turn it around; it can then be
almost never a primary intervention at this already be in place before the procedure. removed with the tip first [14].
time [11]. Although we do not advocate routinely
placing JJ stents before surgery, a stent in the REFERENCES
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