A RETROSPECTIVE STUDY OF GEN K-RAS EXPRESSIO IN METHASTATIC

COLORECTAL CANCER PERIOD OF JANUARY-DECEMBER 2016 IN DR.

MOEWARDI HOSPITAL

saqibnahdi*, idabagusbudhi**
*PPDS IlmuBedah FK UniversitasSebelasMaret, Surakarta Indonesia
**Sub BagianBedahDigestif FK-UNS/RSUD Dr.Moewardi, Surakarta Indonesia

ABSTRACT

Background: K-RAS is one of the mutations commonly encountered in colorectal cancer tissue.
85% of cases of colorectal cancer are caused by mutations in the sporadic K-RAS genes. One of
the metastasis therapy of colorectal cancer is the monoclonal antibody used to target the EGFR
(Epidermal Growth Factor Receptor) gene. Where the therapy showed a positive response to
patients who did not have mutations in the genes K-RAS.

Methods: Descriptive retrospective study by taking medical record data of anatomic pathology
of immunohistochemical examination in colorectal cancer metastasis patients in RS Dr.
Moewardi Period from January to December 2016.

Results: Number of patients with colorectal cancer metastasis examined by Gen K-Ras in
RSUD. Dr. Moewardi between January and December 2016 recorded as many as 10 patients. By
comparison sex of man and woman 40 %: 60 %. The mean age of the patients was 56,75 years,
the age distribution most prevalent in the age range >50 years. Distributed according to where
RCC tumor originates: LCRC: Rectum 1: 2 : 2. Of a total of 10 patients, there were 2 patient
whose KRAS gene expression mutated from the origin of RCC and LCRC Tumor. And no one
has mutated on NRAS gene expression.

Conclusion: In research at RSUD Dr. Moewardi can be concluded by patients with metastatic
colorectal cancer resulted from mutation of KRAS gene expression unrelated to age, sex, tumor
location, depth of tumor invasion, lymph node metastasis, distant metastasis, tumor level, tumor
size, or angiolymphatic invasion.

Keyword : KRAS, NRAS, Colorectal Cancer.