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system.
Physical chemist:
Thermodynamically unstable mixture.
Product development technologist:
Intimate mixture of two immiscible liquid that
exhibit an acceptable shelf life near room
temperature.
Definition
Short shelf-life.
Unstable:- soluble phase separate
slowly
Handling
Storage.
Classification
a. According to emulsifying agent
containing:
Natural product: polysaccharides, cellulose.
Sterol/soap substances.
Saponins.
Starch.
Natural wax.
Surface active agent.
• Anionic surfactants
• Non-ionic surfactant
Classification
DROPLET STABILIZATION
1. Reduction in Interfacial Tension:
Thermodynamically stabilization
1. Formation of Interfacial Rigid Film:
Mechanical barrier to coalescence
1. Formation of Electrical Double
Layer:
Electrical barrier to approach of particles.
Theory of emulsification
Interfacial Tension:
tension exist at interface of two
immiscible liquid
stronger attractive forces for a molecule
at the interface.
Surfactants are added to reduce
interfacial tension.
Surfactant are absorbed at surface of
liquid and diminishes attractive force.
Theory of emulsification
Interfacial film formation (oriented-wedge
theory micelle formation):
Emulsifying agent surrounding the droplet
of internal phase form a thin film adsorbed
at surface of droplet.
Ampihillic EA: Hydrophilic (polar) end
absorbed in water phase and
hydrophobic/lipophilic (non-polar) in oil
phase.
This prevent the coalescence of droplets.
Theory of emulsification
Oriented-wedge theory:
There are three type of films formed:
Monomolecular: Surface active agent,
anionic emulsifying agent, soaps.
Multimolecular: Non ionic emulsifier,
polysaccharide (gums).
Solid particle film: Inorganic emulsifying
agent
Theory of emulsification
Electrical Repulsion:
Electrically charged group oriented on the
surface of emulsified globule produce
repulsive electrical forces between
approaching droplet due to electrical double
layers.
This prevent the coalescence of globules.
Ex. o/w emulsion stabilized by sodium soap.
(C17H35COO--Na+)
Theory of emulsification
Zeta potential:
Zeta Potential is the electrical
potential that exists at the
"shear plane" of a particle,
which is small distance from its
surface.
Zeta Potential is derived from
measuring the mobility
(velocity of particle/electric
field unit) distribution of a
dispersion of charged particles
as they are subjected to an
electric field.
High zeta potential confer
Formulation of emulsion
A.Emulsifying agent:
B.Preservative:
C.Antioxidants:
D.Flavoring agent:
Emulsifying agent
Qualities required for good Emulsifying agent:
1. It should reduce surface tension below 10
dynes/cm.
2. It should be absorbed quickly on surface of
dispersed medium.
3. It should form coherent (non-adherent)
film.
4. It should be effective in low concentration.
5. It should increase viscosity and maintain
consistency.
Classification of emulsifying
agents
1. Natural:
a. Vegetable source: Gum acacia, tragacanth, agar,
starch, pectin, iris moss.
b. Animal source: wool fat, egg yolk, gelatin.
2. Semi synthetic: Methyl cellulose, Na CMC
3. Synthetic:
a. Anionic: Sodium Lauryl Sulphate
b. Cationic: Cetrimide, benzalkonium chloride.
c. Non-ionic: Glyceryl ester- glyceryl monoesters etc.
4. Inorganic: Milk of magnesia, Mg oxide, Mg trioxide etc.
5. Alcohols (polyoles): Carbowax, cholesterol and lecithin.
Natural emulsifying agents
a. Vegetable source:
i. Acacia:
Emulsion is attractive, palatable and stable in ph 2-
5.
Preferred in o/w type of emulsion.
Low viscosity and form multimoleculer film around
globules
i. Tragacanth:
Produce coarse, thick emulsion so rarely used.
Improve viscosity so used in combination with
acacia.
i. Agar:
It is not a good emulsifying agent.
Natural emulsifying agents
a. Vegetable source:
iv. Pectin:
1% mucilage in water used as EA.
It is incompatible with alkalis, strong alcohol, tannic
acid and salicylic acid.
iv. Starch:
It is rarely used as it form coarse emulsion.
It is used in preparation of enemas.
iv. Iris moss (chondrus):
Thickening agent.
Used in combination with acacia in cod-liver oil
emulsion.
Concentration of 3% used as EA.
Natural emulsifying agents
b. Animal source:
i. Wool fat:
Prepare external use emulsion, absorb 50% of
water.
Produce o/w type of emulsion.
i. Egg yolk:
Prepare internal use emulsion.
Preservation in refrigerator.
It used concentration of 12 to 15%
i. Gelatin:
Used for emulsification of liquid paraffin emulsion.
It produce white and agreeable taste emulsion.
Concentration 1%, require preservation.
Semi-Synthetic Emulsifying
agent
a. Methyl cellulose:
It is synthetic derivative of cellulose.
It is used as suspending/thickening agent.
Concentration of 2%.
It form precipitate with electrolytes.
attach.
Unsaturated oils become rancid on
Almond oil
Arachis oil
Cod-liver oil
Cinnamon oil
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