Professional Documents
Culture Documents
Product Training
Agenda
Water Contaminants
Water Requirements
Purification Technology Overview
Millipore Lab Water System
DI water Aquadest Aquademin
Analytical Method
Conductivity :
F Ci Zi µi
=
Conductivity Mobility
Concentration of Valence
(µSiemens/cm) V-1.cm2.s-1
each ionic species
(moles/mL)
Faraday
R = 1/ Resistivity
(MOhm.cm)
Pure Water Resistivity = f (T°C)
Theoretically pure water ions = only H+ + OH- (
water dissociation) :
Resistivity [ H+ ] = [ OH- ] = 10-7 mol / L
100
(M.cm)
90 ⇒ high electric resistance
80
30
An electric current can go through water because
20 18.18
of contaminant ions (mainly).
10
0
0 10 20 30 40 50 60 70 80 90 100
Temperature (°C)
Why test for TOC ?
Water Contaminants
Water Requirements
Purification Technology Overview
Millipore Lab Water System
Standard Requirements
Standard specifications
Explicit set of requirements for an item, material, component, system or service
Guidelines
Framework of common industry practices and recipes
– ISPE (International Society for Pharmaceutical Engineering)
– PIC/S pharmaceutical inspection convention/cooperation scheme
– CLSI - Clinical and laboratory Standard Institute
US and European Pharmacopoeia
CLSI* water quality specifications
Water Contaminants
Water Requirements
Purification Technology Overview
Millipore Lab Water System
Contaminant Removal Efficiency
Lab Water Purification Technologies
“Ultrapure” Type 1
Synergy & Simplicity
Reverse Osmosis
Tap UV185/254nm
UV254nm
water
Pure
water Ultrapure
water
Water Contaminants
Water Requirements
Purification Technology Overview
Millipore Lab Water System
Water
Types
Tap
Type 3
Type 2
Type 1
1
Simplicity
5
RiOs 3
RiOs-Di 3
Milli-DI
Milli-Di
Direct-Q 3
Direct-Q 5
Synergy
25
RiOs 5 -16
Elix 3 - 15
Milli-Q Integral 3 - 15
250
RiOs Large
Millipore Lab Water System Panorama
Elix Large
Super-Q
Volume in L / day
Water Purification Systems
Tap Water to Tipe 2 & Tipe 3
Launch
25 RiOs Essential | May 2012
Water Purification Systems
Ultrapure Water Systems – Pure Water Feed
Pure Water Feed Tipe 2/3 to Ultrapure Tipe 1
Ideal for current bottled water Synergy with remote Dispenser Simplicity
users.
Ultrapure Water Quality
Simplicity : Applications
Titrators, Buffers, pH
solutions, Standards
Chromatography:
HPLC, ILC, LC
Simplicity
Simfilter
Cell Culture
Molecular Biology
(PCR, DNA
sequence, Blotting)
Simplicity UV BioPak
Water Purification Systems
Ultrapure Water Systems
Pure Water Feed Tipe 2/3 to Ultrapure Tipe 1
Milli-Q Reference
Milli-Q Reference
Direct-Q 3/5/8
Sale 33
s
Water Purification Systems
Tap to ultrapure water Tipe 1 & Tipe 3
Milli-Q
Integral A10
3/5/10/15
POD paks
PAK: MilliPak 40 BioPak LC - Pak VOC - Pak EDS - Pak
Biological Contaminants
Particulate removal and Removal; RNase,
Removal of Trace Organic Removal of Volatile Removal of Endocrine
Purpose: Bacteria removal DNase, Pyrogens,
Compounds Organic Compounds Disrupters
(LRV > 7) Proteases, Viruses and
Bacteria
Endocrine Disrupter
General laboratory Cell Culture, Trace organics analysis by
Research, Endocrine
Application: applications, Analytical Biochemistry, Molecular HPLC, UPLC, LC-MS, LC- Water Analysis by GC
Disrupter Screening and
applications Biology MS/MS
Testing