TUGAS PENGANTAR KIMIA FARMASI

TITRASI ASAM BASA

NAMA : NISA AYU AMALIA

NPM : 260110160012

1. A 0,467 g sample containing sodium bicarbonate (a monoacidic base) and

titrated with a standard solution of HCl, requairing 40,72 ml. The
hydrocloric acid was standarized by titrating 0,1876 g sodium carbonate,
wich required 37,86 ml. Calculate the percent sodium bicarbonate in the
sample.
Diketahui:
Massa NaHCO3= 0.467 gram
V1 HCl = 40.72 ml
V2 HCl : 37.86 ml
Massa Na2CO3 = 0.1876 gram
BM Na2CO3 = 106
Ditanyakan : % kadar NaHCO3?

Jawab:
mg Na2CO3
 V2 HCl x N HCl = BE Na2CO3
187.6
37.86 N HCl = 53

N HCl = 0,093 N
V1HCL ×N HCL ×BE NaHCO3
 % NaHCO3 = 𝑥 100%
mg NaHCO3
40.72 ×0.093 ×84
% NaHCO3 = 𝑥 100%
467

NaHCO3 = 68.11 %
2. How many millimiters of concentrated sulfuric acid 94% (g/100g solution)
density 1.843 g/cm3 are required to prepare 1 L of 0,100M solution.
Diketahui :
M2 = 0,100
𝜌 = 1.843 g/cm3
𝑘𝑎𝑑𝑎𝑟 = 94%
Ditanyakan : V1
Jawab :

ρ × %kadar ×1000
M= BM

1.843 × 94/100 ×1000

M= = 17,68 M
98

M1 × V1 = M2 × V2

17,69 M × V1 = 0,1M × 1 L

V1 = 0,0056 L = 5,6 ml

3. Calculate the grams of each substance required to prepare 250 mL of

0.100 M KOH
Diketahui :
V KOH= 250ml
BM KOH = 56
M KOH = 0,1 M
Ditanyakan : gram setiap zat
Jawab:
gram KOH
MKOH x VKOH = BM KOH
gram KOH
0,1 M × 250 ml = 56

Gram KOH = 1400 mg = 1,4 gram.

4. How many milliliters of concentrated hydrochloric acid,38%(wt/wt),
specific gravity 1.19, are required to prepare 1L of a 0.100 M solution
Diketahui :
HCl 38,0%
ρ = 1,19 g/cm3 = 1.19 g/mL
V2 = 1 L
BE HCl = 36,45 g/mol
Ditanyakan : V HCl terkonsentrasi
Jawab :
𝑚𝑜𝑙
a. M = 𝑉
massa
 ρ= 𝑉

Massa = 1,19 gram/mL × 1000 mL

Massa = 1190 gram
 Massa HCl = 1190 × 38.0 %
Massa HCl = 452,2 gram
452,2 gram
 Mol HCl = gram = 12,401 mol
36,45
mol

𝑚𝑜𝑙 12.406
 M= = = 12,406 M
𝑉 1𝐿

 M1 V1 = M2 .V2
12,406 × V1 = 0.1 × 1 L
V1 = 0,00806 L = 8,06 ml

BJ×10×%
b. M= Mr
1,19 x 10 x 38
M HCl = = 12,389 M
36,5

 M1 V1 = M2 V2
12,389 .V1 = 0,1 .1 L
V1 = 0,00807 L = 8,07 mL
5. How many milliliters of 0.10 M of H2SO4 must be added to 50 mL of 0.1
M NaOH to give a solution that is 0.050 M in H2SO4? Assumes volumes
are additive
Diketahui :
 N H2SO4 = M H2SO4 × e
N H2SO4= 0,1 × 2
N H2SO4 = 0,2 N

 N NaOH = M NaOH × e
N NaOH = 0,1 × 1
N NaOH = 0,1 N

 V NaOH= 50 ml

Dit: V H2SO4
Jawab:
V H2SO4 × N H2SO4 = V NaOH × N NaOH
50 ml ×0.1 N
V H2SO4 = 0.2N

V H2SO4 = 25 ml

 Jadi volume total cairan adalah 75 ml.

 Volume H2SO4 yang dibuat untuk menghasilkan konsentrasi
sebesar 0,05 M :
M1 .V1 = M2. V2
0,1 × V = 0,05 × (75+V)
0,1V = 3,75 + 0,05V
0,05V = 3,75
V = 75 ml
 Jadi volume 0.1 M H2SO4 yang dibutuhkan untuk menghasilkan
0.05 M H2SO4 adalah 75 ml
6. A preparation of soda ash is known to contain 98.6% Na2CO3. If a 0.678
g sample requires 36.8 ml of sulfuric acid to complete neutralization, what
is the molarity of the sulfuric acid solution?
Diketahui :
Mg sampel = 0,678 g
BE = 53,258
VH2SO4 = 36,8 ml
Ditanyakan : molaritas H2SO4
Jawab :
mg
N1 x V1 = BE
mg
(M×e)H2SO4 × V H2SO4 = BE
678
M × 2 × 36,8 = 53,258

M = 0,1714 M

7. A sample of USP grade citric acid (H3C6O7, three titratable protons) is

analyzed by titrating with 0.1087 M NaOH. If a 0.2678 g sample requires
38.31 ml for titration, what is the purity of the preparation? (USP requires
99.5%)
Diketahui :
M NaOH = 0.1087 M
Massa Sampel = 0.2678 g
Vtitrasi = 38.31 ml
USP = 99.5%
Ditanyakan : % kemurnian
Jawab:
MNaOH ×Vtitrasi ×BE
% kemurnian = Massa sampel
0.1087 ×38.31 ×62.33
% kemurnian = 267.8

% kemurnian = 96.9%
8. A solution is prepared by dissolving 7.82 g NaOH and 9.26 g Ba(OH)2 in
water and diluting to 500 ml. What is the normality of the solution as a
base?
Diketahui :
Massa NaOH = 7,82 gram
Massa Ba(OH)2 = 9,26 gram
BE NaOH = 40
BE Ba(OH)2 = 85,67
V = 500 mL
Ditanyakan : Normalitas (N)
Jawab : 7,82 g NaOH + 9,26 g Ba(OH)2 → 500 mL
gr 1
𝑁 = BE x V(L)
gr
𝑁.𝑉 = BE × 1
7,82
 𝑁.𝑉 𝑁𝑎𝑂𝐻 = = 0,1955
40
9,26
 𝑁.𝑉 𝐵𝑎(𝑂𝐻)2 = 171,34 = 0,108
⁄2

V1 .[OH−]+ V2 .[OH−]
 [𝑂𝐻−] = 𝑉1+𝑉2
V1 . N1 + V2 . N2
𝑁= V1 + V2
0,1955 + 0,108
𝑁= 0,5 N

N = 0,607 N

9. A 25 ml solution of 0.5 M NaOH is titrated until neutralized into a 50 ml

sample of HCl. What was the concentration of the HCl
Diketahui :
M1 = 0,5
V1 = 25 ml
V2 = 50 ml
 Ditanyakan : M2
Jawab :
M1 V1 = M2 V2
0,5 M × 25 ml = M2 × 50 ml
M2 = 0.25 M

10. 10.00 mL sample of concentrated HCl was diluted to mark in 250 mL

volumetric flask. To titrate 25.0 mL sample of diluted solution 43.56 mL
of 0.1023 M NaOH was needed. What was the original concentration of
hydrochloric acid?
Diketahui :
V sample awal = 10 ml
V pengenceran = 250 ml
V titrat HCl = 25ml
V NaOH = 43,56 ml
M NaOH = 0,1023

Ditanyakan : M HCl mula-mula?

Jawab :
 M akhir HCl
V HCl x M HCl = V NaOH x M NaOH
25 ml x M HCl = 43,56 ml x 0,1023
M HCl = 0,178 M

 M awal HCl
V awal x M awal = V akhir x M akhir
10 ml x M awal = 250 ml x 0,178 M
M awal = 4,45 M
Jadi Molaritas HCl mula mula = 4,45 M