8/2/2018 Attenuation of Cisplatin Ototoxicity by Otoprotective Effects of Nanoencapsulated Curcumin and Dexamethasone in a Guinea Pig Model

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Otology & Neurotology. 35(7):1131–1139, AUG 2014

DOI: 10.1097/MAO.0000000000000403,  PMID: 24841915
Issn Print: 1531-7129
Publication Date: 2014/08/01

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Attenuation of Cisplatin Ototoxicity by

Otoprotective Effects of
Nanoencapsulated Curcumin and
Dexamethasone in a Guinea Pig Model
Pezhman Salehi; Olubunmi Victoria Akinpelu; Sofia Waissbluth; Emilia Peleva; Brian Meehan;
Janusz Rak; Sam J. Daniel

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Abstract
Objectives
Cisplatin, one of the most effective and widely used chemotherapeutic agents in the treatment
of head and neck malignancies, has severe dose-limiting side effects including ototoxicity. This
study evaluates the effectiveness of nanoencapsulated curcumin and dexamethasone in
preventing degenerative changes in inner ear cells caused by cisplatin.
Study Design
Prospective study, animal experiment.
Methods
Cultured auditory cells [House Ear Institute Organ of Corti-1 (HEI-OC1)] and a guinea pig model
were used for in vitro and in vivo experiments, respectively. Cell viability assays were
conducted to compare the direct toxicity of cisplatin against auditory cells in the presence or
absence of pretreatment with nanoencapsulated curcumin and dexamethasone. To
recapitulate these effects in vivo, 68 guinea pigs received cisplatin either alone, or along with
dexamethasone, nanoencapsulated curcumin, or the combination of both products. Outcome
measures included auditory brainstem response, cochlear morphology under both light and
scanning electron microscopy, and antioxidant enzyme assays.
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8/2/2018 Attenuation of Cisplatin Ototoxicity by Otoprotective Effects of Nanoencapsulated Curcumin and Dexamethasone in a Guinea Pig Model

Results
Pretreatment of auditory cells with naonoencapsulated curcumin and dexamethasone resulted
in significant attenuation of cisplatin toxicity. Similarly, in the corresponding animal model
(guinea pig), cisplatin caused an average hearing loss of 50 dB, which was attenuated by
nanoencapsulated curcumin and dexamethasone across all of the hearing frequencies. There
was also greater preservation of histologic structures in this group. Superoxide dismutase and
catalase activities were increased in cisplatin-treated animals, whereas the nanoencapsulated
curcumin with dexamethasone led to a diminution of this effect.
Conclusion
Nanoencapsulated curcumin administered in combination with dexamethasone provides a
partial but marked protection against cisplatin-induced hearing loss, likely because of reduced
toxic damage to auditory cells.

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Related Topics
 Neuro-otology

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