Research Topic Learnings

A novel solubilization technique for

poorly soluble drugs through the
integration of nanocrystal and
cocrystal technologies

A novel solubilization technique for

poorly soluble drugs through the
PRAYAS ACHARYA integration of nanocrystal and
cocrystal technologies.
 A novel solubilization technique for
poorly soluble drugs through the
PRAYAS ACHARYA integration of nanocrystal and
cocrystal technologies.
 Research Methodo
Primary literature

1.The solubility of the poorly soluble

drugs can be increased by nano-cocrystal
technologies

1)N. Blagden, M. de Matas, P.T. Gavan, P.

York, Crystal engineering of active
pharmaceutical ingredients to improve
solubility and dissolution rates, Adv.
Drug Deliv. Rev. 59 (2007) 617–630
2.The optimal selection of cocrystals and
concentration of stabilizers are key
factors in the design of nano-cocrystal
formulations.

2)S. Basavoju, D. Boström, S.P. Velaga,

Indomethacin–saccharin cocrystal: design,
synthesis and preliminary pharmaceutical
characterization, Pharm. Res. 25
(2008) 530–541
3.Nano-cocrystal formulations have
higher dissolution rates and saturation
concentrations compared to the pure
nanocrystals and cocrystals.

3)L. De Smet, L. Saerens, T. De Beer, R.

Carleer, P. Adriaensens, J. Van Bocxlaer, C.
Vervaet, J.P. Remon, Formulation of
itraconazole nanococrystals and
evaluation of their bioavailability in dogs, Eur.
J. Pharm. Biopharm. 87
(2014) 107–113.
4. The dissolution profiles of furosemide
nanocrystal suspension and furosemide-
caffeine nano-cocrystal suspension

4)N.H. Chun, I.C. Wang, M.J. Lee, Y.T. Jung,

S. Lee, W.S. Kim, G.J. Choi,
Characteristics of indomethacin–saccharin
(IMC–SAC) co-crystals prepared
by an anti-solvent crystallization process,
Eur. J. Pharm. Biopharm. 85 (2013)
854–861.
5.In stability study,the nano-cocrystal
suspensions are physically and
chemically stable for atleast one month at
room temperature

5)E. Baka, J.E. Comer, K. Takács-Novák,

Study of equilibrium solubility
measurement by saturation shake-flask
method using hydrochlorothiazide
as model compound, J. Pharm. Biomed.
Anal. 46 (2) (2008) 335–341.
6)M. George, I. Ghosh, Identifying the
correlation between drug/stabilizer
properties and critical quality attributes
(CQAs) of nanosuspension
formulation prepared by wet media milling
technology, Eur. J. Pharm. Sci. 48
(2013) 142–152
ch Methodology
References

Primary literature

1) S. Di Maio, R.L. Carrier,

Gastrointestinal contents in fasted state
and post-lipid
ingestion: in vivo measurements and in
vitro models for studying oral drug
delivery, J. Control. Release 151 (2011)
110–122
2) C. Brough, R.O. Williams III,
Amorphous solid dispersions and nano-
crystal
technologies for poorly water-soluble drug
delivery, Int. J. Pharm. 453 (2013)
157–166
3) N. Shan, M.J. Zaworotko, The role of
cocrystals in pharmaceutical science,
Drug
Discov. Today 13 (2008) 440–446
ogy
References

Secondary literature

Roop K. Khar, SP Vyas, Farhan J Ahmad, Gaurav K Jain,

Lachman/Lieberman's Industrial Pharmacy, Fourth edition 2015
 Assignment-I

Tertiary literature