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in liver disease
fibrosis mRNA
Anti-viral effect
Anti-tumor effects
Conclusion
This study suggest that GL inhibit HCV full length viral particles
and HCV core gene expression or function in a dose dependent
manner and had synergistic effect with interferon.
Given the complexity of the interactions between tumor cells and their
environment, the effect of a combination therapy of GA, administered in
conjunction with sorafenib or rapamycin, is worthy for further study.
In summary, this study further supports the theory that HSCs have an
inhibitory effect on immune responses via their regulation of T cells in the
development of HCC.
This interaction identifies the therapeutic target for GA, which provides
convincing evidence for GA as an anticancer drug.
This study shows that GL, via its activate metabolite GA,
could decrease MCD diet-induced NASH, as revealed by
improved hepatic steatosis, inflammation, and fibrosis.