% disuelto de Ketoprofeno

referencia
5 28.51 35.38 27.54 27.1 29.6 34.35 29.31
10 39.76 44.34 41 32.79 35.81 46.42 37.1
15 56.34 66.41 57.86 48.82 53.82 68.85 54.9
20 68.98 78.66 70.7 59.72 67.99 83.69 68.92
25 69.45 83.7 79.14 67.12 76.74 92.37 78.55
30 69.27 86.05 83.31 73.03 80.2 92.73 85.01
35 92.2 87.07 86.76 78.17 81.33 91.98 87.43
40 90.88 88.09 86.67 78.19 80.24 91.57 87.74
45 89.56 85.29 85 79.74 81.61 91.68 88.88
50 88.93 85.69 86.13 81.17 81.01 91.49 88.51
55 90.59 84.48 86.96 81.64 81.95 92.89 87.23
60 88.03 84.48 85.86 82.73 82.55 93.27 87.25

generico A
5 31.9 29.64 28.6 24.54 30.47 36.15 34.05
10 34.99 32.37 32.71 28.38 31.86 37.85 33.38
15 45.58 43.85 41.83 38.91 41.29 45.89 43.22
20 52.69 52.42 48.49 48.29 50.1 52.5 49.43
25 57.59 59.29 54.94 53.54 55.47 57.87 55.55
30 62.63 64.54 59.53 60.41 61.53 63.43 59.04
35 71.08 69.03 64.03 67.98 65.32 68.5 62.37
40 77.34 71.71 67.05 72.71 69.71 71.46 65.56
45 81.13 74.39 69.6 77.86 72.28 74.93 65.9
50 85.05 75.72 72.66 79.39 75.08 77.28 68.35
55 88.25 78.25 75.92 81.41 77.86 80.09 72.21
60 89.04 79.05 77.11 83.81 79.57 81.99 78.44

generico B
5 0.584 0.667 0.216 0.69231 0.571 0 1.164
10 7.89 3.82 2.35 4.61 8.57 0 14.66
15 28.79 25.95 24.68 26.28 31.76 26.49 35.67
20 47.87 40.12 44.59 42.05 56.68 49.27 51.2
25 66.72 53.59 63.19 55.04 69.55 66.97 66.97
30 77.59 67.86 73.83 67.27 76.59 77.26 77
35 84.36 72.47 79.28 75.64 81.04 84.33 84.15
40 86.76 76.81 83.87 80.51 83.07 87.09 88.98
45 86.07 81.18 85.95 83.88 84.74 87.76 90.38
50 86.05 83.23 84.94 82.28 84.12 87.45 91.29
55 86.44 82.32 85.59 83.7 85.44 87.2 90.24
60 85.17 82.73 86.48 83.52 84.02 85.89 91.21

generico C
T5 29.49 41.61 34.78 32.44 38.16 33.65 42.52
 10 57.46 79.95 68.09 64.43 73.5 65.41 49.85
15 78.51 88.74 87.73 85.71 88.41 88.66 71.11
20 84.85 89.86 93.16 94.9 91.61 95.81 79.65
25 85.11 89.83 90.06 94.98 92.02 94.44 80.67
30 84.56 88.74 92.28 94.71 91.48 95.09 81.37
35 84.71 90.14 91.8 94.51 92.17 94.24 79.9
40 84.47 89.64 92.15 94.13 90.62 94.72 80.59
45 84.26 90.21 90.88 95.49 92.02 96.08 80.6
50 83.8 90.22 91.59 92.52 91.48 93.03 81.65
55 82.89 87.88 91.59 91.81 90.93 92.58 80.17
60 82.92 88.38 91.78 94.69 91.62 92.47 79.51

generico D
T5 18.39 19.28 25.24 20.32 18.96 15.24 16.28
10 31.51 27.22 33.56 30.03 28.93 21.94 34.25
15 48.39 42.58 51.71 47.19 46.32 37.89 50.14
20 61.44 52.86 65.05 62.04 59.1 46.96 65
25 71.41 61.58 71.47 70.31 68.09 54.73 68.96
30 74.57 69.17 76.8 77.35 74.4 50.75 74.48
35 78.07 71.4 79.14 83.14 81.27 65.09 82.57
40 81.21 74.17 83.38 84.67 87.68 67.41 87.21
45 82.3 75.91 85.77 85.16 88.52 69.48 89.54
50 82.98 76.67 85.58 83.79 88.78 70.67 88.86
55 81.65 75.53 85.31 84.87 89.01 71.65 89.05
60 81.96 77.03 84.53 84.09 88.89 72.12 89.57

generico E
T5 29.53 30.25 30.03 32.33 32.29 26.12 22.77
10 35.43 33.28 35.09 35.64 34.28 31.07 28.52
15 49.66 47.54 50.42 50.37 48.47 44.92 39.22
20 61.62 59.89 64.53 61.88 61.62 57.43 43.84
25 70.56 68.34 75.34 69.73 74.94 67.3 53.22
30 77.25 78.71 81.19 77.65 83.73 72.96 61.11
35 80.63 84.36 87.9 82.81 89.43 81.08 67.42
40 84.5 87.93 90.01 86.61 91.54 82.86 73.63
45 90.25 94.67 91.66 89.14 94.69 85.55 79.97
50 90.2 94.52 93.31 91.01 93.79 89.39 83.17
55 89.49 93.29 92.57 90.93 93.26 91.29 82.71
60 89.36 93.83 91.85 92.33 92.12 90.41 82.42
 42.19 28.85 25.57 36.11 27.27
54.03 36.34 32.01 43.23 33.74
76.33 52.31 47.87 61.25 51.17
89.66 65.68 61.1 75.77 64.61
92 76.16 73.73 86.08 77.37
91.47 83.23 78.48 89 85.3
90.42 88.71 83.02 89.18 90.06
88.69 89.51 82.41 91.35 92.03
90.99 89.43 83.33 90.27 91.96
91.9 87.82 83.56 90.87 91.26
90.2 88.01 82.64 89.97 91.43
90.66 88.38 84.28 89.55 92.2

26.62 25.21 26.67 24.24 24.82

26.72 23.45 27.12 23.42 31.5
37.59 34.98 38.18 33.36 42.27
45.14 43.25 45.89 43.66 50.19
51.26 47.72 52 50.44 56.41
56.21 51.47 59.05 57.09 62.13
63.17 55.58 63.34 63.75 66.95
67.11 60.43 66.93 66.46 70.19
69.89 63.36 69.32 75.02 77.72
73.28 67.3 74.18 78.33 82.12
74.64 70.22 74.48 80.33 84.55
77.43 72.72 75.49 81.23 84.7

0.1202 0 1.75 0.487 1.11

13.09 6.15 2.35 3.425 9.93
31.1 20.84 15.35 20.39 29.11
49.75 34.04 39.03 39.72 45.94
66.39 51.16 58.65 55.75 58.79
79.09 69.6 72.29 68.93 70.82
82.29 80.86 80.32 78.64 79.22
86.76 85.66 85.79 85.07 86.03
87.87 89.34 87.47 88.66 91.54
87.97 92.03 91.69 91.92 91.78
88.97 94.14 92.82 91.76 93.78
90.58 92.14 93.3 92.48 95.47

47.89 35.78 37.45 43.14 45.01

 59.3 30.16 53.03 53.49 61.15
73.34 64.22 75.59 71.6 81.7
79.29 78.2 80.59 78.26 84.81
81.69 82.41 83.76 81.92 83.51
82.53 81.11 82.98 82.16 84.96
83.87 82.68 82.27 82.5 84.96
82.88 82.19 82.74 83.52 84.54
82.74 82.85 84.29 82.42 84.03
82.42 82.71 80.97 80.42 84.38
83.27 82.13 82.85 81.84 84.33
80.79 82.03 82.07 82.88 83.76

11.98 10.6 11.64 13.22 14.64

27.66 24.84 27.67 32.59 31.46
41.19 33.96 39.9 44.86 42.29
55.28 51.88 50.83 60.87 60.29
64.77 61.9 60.07 72.39 70.97
66.96 69.88 66.31 76.36 79.44
73.91 80.63 70.87 84.56 84.99
80.91 89.68 72.97 88.09 87.36
84.98 92.62 77.17 92.13 89.34
86.34 93.14 78.26 93.24 93.7
86.98 94.47 78.8 95.34 91.75
84.93 92.74 80.52 95.37 90.82

20.66 27.89 28.15 29.27 26.74

25.4 31.55 30.13 31.41 31.59
37.19 44.29 43.34 42.02 45.61
46.98 54.8 52.83 55.8 58.99
54.22 62.17 63.22 64.5 66.57
58.19 68.86 71.51 70.25 71.44
63.76 72.91 76.03 75.94 74.42
66.94 77.35 80.63 79.55 75.88
67.98 77.69 84.75 82.74 78.09
69.6 81.18 84.23 82.79 78.25
67.77 78.74 84.28 82.47 78.73
68.55 76.25 85.32 82.367 80.41
DDSolver 1.0 Dissolution Data Modeling of First-order Model

Time Unit min Analyst lapcy

Model First-order Date 2018-10-16
Equation F=100*[1-Exp(-k1*t)] Time 18:52:41

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7

(min) F(%) F(%) F(%) F(%) F(%) F(%) F(%)
5 18.39 19.28 25.24 20.32 18.96 15.24 16.28
10 31.51 27.22 33.56 30.03 28.93 21.94 34.25
15 48.39 42.58 51.71 47.19 46.32 37.89 50.14
20 61.44 52.86 65.05 62.04 59.10 46.96 65.00
25 71.41 61.58 71.47 70.31 68.09 54.73 68.96
30 74.57 69.17 76.80 77.35 74.40 50.75 74.48
35 78.07 71.40 79.14 83.14 81.27 65.09 82.57
40 81.21 74.17 83.38 84.67 87.68 67.41 87.21
45 82.30 75.91 85.77 85.16 88.52 69.48 89.54
50 82.98 76.67 85.58 83.79 88.78 70.67 88.86
55 81.65 75.53 85.31 84.87 89.01 71.65 89.05
60 81.96 77.03 84.53 84.09 88.89 72.12 89.57

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7

(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
5 18.80 15.46 20.41 19.70 19.78 12.53 20.76
10 34.07 28.53 36.65 35.52 35.64 23.49 37.21
15 46.46 39.58 49.57 48.22 48.37 33.07 50.24
20 56.53 48.92 59.86 58.42 58.58 41.46 60.57
25 64.70 56.82 68.05 66.61 66.77 48.79 68.76
30 71.34 63.49 74.57 73.19 73.34 55.21 75.24
35 76.73 69.14 79.76 78.47 78.61 60.82 80.38
40 81.10 73.91 83.89 82.71 82.84 65.73 84.46
45 84.65 77.94 87.18 86.12 86.24 70.02 87.68
50 87.54 81.35 89.79 88.85 88.96 73.78 90.24
55 89.88 84.24 91.88 91.05 91.14 77.06 92.27
60 91.78 86.67 93.53 92.81 92.89 79.94 93.87

Best-fit Values
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
k1 0.042 0.034 0.046 0.044 0.044 0.027 0.047

Secondary Parameter
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
T25 6.907 8.565 6.303 6.556 6.528 10.745 6.182
T50 16.641 20.636 15.186 15.796 15.729 25.890 14.895
T75 33.283 41.272 30.372 31.592 31.458 51.780 29.790
T80 38.640 47.916 35.261 36.677 36.522 60.115 34.585
T90 55.281 68.552 50.447 52.473 52.251 86.005 49.480

Goodness of Fit
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
N_observed 12 12 12 12 12 12 12
DF 11 11 11 11 11 11 11
R_obs-pre 0.9785 0.9796 0.9858 0.9806 0.9930 0.9804 0.9932
Rsqr 0.9469 0.9352 0.9542 0.9588 0.9840 0.9444 0.9854
Rsqr_adj 0.9469 0.9352 0.9542 0.9588 0.9840 0.9444 0.9854
MSE 25.6780 26.8865 20.5078 22.0069 9.9365 21.7970 8.6927
MSE_root 5.0673 5.1852 4.5286 4.6912 3.1522 4.6687 2.9483
Weighting 1 1 1 1 1 1 1
SS 282.4576 295.7513 225.5863 242.0760 109.3018 239.7669 95.6195
WSS 282.4576 295.7513 225.5863 242.0760 109.3018 239.7669 95.6195
AIC 69.7223 70.2742 67.0244 67.8710 58.3294 67.7560 56.7245
MSC 2.7691 2.5701 2.9168 3.0217 3.9660 2.7222 4.0588

No.1
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.2
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.3
100

90 Observed
80
Predicted
 No.3
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.4
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.5
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10
 60

Fraction dissolve
50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.6
90

80 Observed
Predicted
70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.7
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.8
100

90 Observed
80
Predicted

70
)
 No.8
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.9
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.10
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
Fraction dissol
50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.11
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.12
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

Mean
100

90 Observed
80
Predicted

70
(%)
 Mean
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

Predicted Data
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
0 0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.2 4.88 3.95 5.33 5.13 5.15 3.16 5.43
2.4 9.51 7.75 10.38 10.00 10.04 6.22 10.57
3.6 13.92 11.39 15.15 14.61 14.67 9.19 15.42
4.8 18.12 14.89 19.68 18.99 19.07 12.06 20.02
6 22.11 18.25 23.96 23.15 23.23 14.84 24.36
7.2 25.91 21.48 28.01 27.09 27.19 17.53 28.47
8.4 29.52 24.58 31.85 30.83 30.94 20.14 32.36
9.6 32.96 27.56 35.48 34.38 34.50 22.66 36.03
10.8 36.23 30.42 38.92 37.74 37.87 25.11 39.50
12 39.34 33.17 42.17 40.94 41.07 27.48 42.79
13.2 42.29 35.81 45.26 43.97 44.11 29.77 45.90
14.4 45.11 38.35 48.17 46.84 46.98 31.99 48.84
15.6 47.78 40.78 50.94 49.57 49.71 34.14 51.61
16.8 50.33 43.12 53.55 52.15 52.30 36.22 54.24
18 52.75 45.37 56.03 54.61 54.76 38.24 56.73
19.2 55.05 47.53 58.37 56.94 57.09 40.19 59.08
20.4 57.25 49.60 60.59 59.15 59.30 42.08 61.30
21.6 59.33 51.59 62.69 61.24 61.40 43.91 63.40
22.8 61.31 53.51 64.68 63.23 63.39 45.69 65.39
24 63.20 55.34 66.56 65.12 65.27 47.40 67.27
25.2 64.99 57.11 68.34 66.91 67.06 49.07 69.05
26.4 66.70 58.80 70.03 68.60 68.76 50.68 70.73
27.6 68.32 60.43 71.63 70.21 70.37 52.24 72.32
28.8 69.87 61.99 73.14 71.74 71.89 53.75 73.82
30 71.34 63.49 74.57 73.19 73.34 55.21 75.24
31.2 72.73 64.94 75.93 74.57 74.71 56.63 76.59
32.4 74.06 66.32 77.21 75.87 76.02 58.00 77.86
33.6 75.33 67.65 78.43 77.11 77.25 59.33 79.06
34.8 76.53 68.93 79.58 78.28 78.42 60.61 80.20
36 77.68 70.16 80.66 79.40 79.53 61.86 81.27
37.2 78.76 71.34 81.69 80.45 80.59 63.06 82.29
38.4 79.80 72.47 82.67 81.46 81.59 64.23 83.25
39.6 80.78 73.56 83.59 82.41 82.54 65.36 84.16
40.8 81.72 74.60 84.47 83.31 83.44 66.46 85.02
42 82.61 75.60 85.30 84.17 84.29 67.52 85.84
43.2 83.46 76.57 86.08 84.98 85.10 68.54 86.61
44.4 84.27 77.49 86.82 85.75 85.87 69.54 87.33
45.6 85.03 78.38 87.52 86.48 86.59 70.50 88.02
46.8 85.76 79.24 88.19 87.17 87.28 71.43 88.67
48 86.46 80.06 88.82 87.83 87.94 72.34 89.29
49.2 87.12 80.84 89.41 88.46 88.56 73.21 89.87
50.4 87.75 81.60 89.98 89.05 89.15 74.06 90.42
51.6 88.34 82.33 90.51 89.61 89.71 74.88 90.94
52.8 88.91 83.03 91.02 90.14 90.24 75.67 91.43
54 89.45 83.70 91.50 90.65 90.74 76.44 91.90
55.2 89.97 84.34 91.95 91.13 91.22 77.19 92.34
56.4 90.46 84.96 92.38 91.58 91.67 77.91 92.75
57.6 90.92 85.55 92.79 92.01 92.10 78.61 93.15
58.8 91.36 86.12 93.17 92.42 92.51 79.28 93.52
60 91.78 86.67 93.53 92.81 92.89 79.94 93.87
 No.8 No.9 No.10 No.11 No.12
F(%) F(%) F(%) F(%) F(%) Mean SD RSD(%)
11.98 10.60 11.64 13.22 14.64 16.32 4.29 26.31
27.66 24.84 27.67 32.59 31.46 29.31 3.66 12.49
41.19 33.96 39.90 44.86 42.29 43.87 5.22 11.91
55.28 51.88 50.83 60.87 60.29 57.63 5.91 10.26
64.77 61.90 60.07 72.39 70.97 66.39 5.68 8.55
66.96 69.88 66.31 76.36 79.44 71.37 7.76 10.87
73.91 80.63 70.87 84.56 84.99 77.97 6.29 8.07
80.91 89.68 72.97 88.09 87.36 82.06 7.08 8.62
84.98 92.62 77.17 92.13 89.34 84.41 7.07 8.37
86.34 93.14 78.26 93.24 93.70 85.17 7.18 8.43
86.98 94.47 78.80 95.34 91.75 85.37 7.35 8.61
84.93 92.74 80.52 95.37 90.82 85.21 6.72 7.88

No.8 No.9 No.10 No.11 No.12

F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
17.32 18.48 15.22 21.16 20.67 18.36 2.70 14.73
31.64 33.55 28.13 37.84 37.06 33.28 4.48 13.47
43.48 45.83 39.07 50.99 50.07 45.41 5.57 12.27
53.26 55.84 48.34 61.36 60.39 55.29 6.17 11.15
61.36 64.00 56.20 69.53 68.57 63.35 6.40 10.11
68.05 70.66 62.87 75.98 75.07 69.92 6.39 9.14
73.58 76.08 68.52 81.06 80.22 75.28 6.20 8.24
78.16 80.50 73.31 85.07 84.31 79.67 5.91 7.41
81.94 84.10 77.38 88.23 87.55 83.25 5.54 6.65
85.07 87.04 80.82 90.72 90.12 86.19 5.14 5.96
87.65 89.44 83.74 92.68 92.17 88.60 4.72 5.33
89.79 91.39 86.21 94.23 93.78 90.58 4.30 4.75

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)

0.038 0.041 0.033 0.048 0.046 0.041 0.007 16.070

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)

7.564 7.039 8.711 6.051 6.213 7.280 1.410 19.374
18.225 16.960 20.988 14.579 14.970 17.541 3.398 19.374
36.450 33.921 41.977 29.158 29.940 35.083 6.797 19.374
42.317 39.381 48.733 33.852 34.759 40.730 7.891 19.374
60.542 56.341 69.722 48.431 49.729 58.271 11.289 19.374

No.8 No.9 No.10 No.11 No.12

12 12 12 12 12
11 11 11 11 11
0.9939 0.9924 0.9903 0.9980 0.9929
 0.9842 0.9446 0.9793 0.9772 0.9733
0.9842 0.9446 0.9793 0.9772 0.9733 0.9639
9.9139 49.2184 10.5214 17.0879 19.0964
3.1486 7.0156 3.2437 4.1338 4.3699
1 1 1 1 1
109.0527 541.4028 115.7355 187.9674 210.0609
109.0527 541.4028 115.7355 187.9674 210.0609
58.3020 77.5300 59.0157 64.8352 66.1688 65.2961
3.9839 2.7257 3.7123 3.6130 3.4567
 No.8 No.9 No.10 No.11 No.12
F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
0.00 0.00 0.00 0.00 0.00 0.00 0.00
4.46 4.79 3.89 5.55 5.40 4.76 0.75 15.74
8.72 9.34 7.62 10.78 10.52 9.29 1.43 15.42
12.80 13.68 11.21 15.73 15.35 13.59 2.05 15.10
16.69 17.81 14.66 20.40 19.93 17.69 2.62 14.78
20.40 21.75 17.98 24.82 24.26 21.59 3.12 14.47
23.95 25.49 21.16 28.99 28.35 25.30 3.58 14.17
27.35 29.06 24.23 32.93 32.22 28.83 4.00 13.86
30.59 32.45 27.17 36.65 35.89 32.19 4.37 13.56
33.69 35.69 30.00 40.16 39.35 35.39 4.70 13.27
36.64 38.76 32.72 43.48 42.63 38.43 4.99 12.98
39.47 41.69 35.33 46.61 45.73 41.33 5.25 12.69
42.17 44.48 37.85 49.57 48.66 44.08 5.47 12.41
44.75 47.14 40.26 52.37 51.44 46.71 5.67 12.13
47.22 49.67 42.58 55.01 54.06 49.21 5.84 11.86
49.57 52.08 44.81 57.51 56.54 51.58 5.98 11.59
51.82 54.37 46.96 59.86 58.89 53.85 6.10 11.33
53.97 56.56 49.02 62.09 61.12 56.00 6.20 11.07
56.02 58.64 51.00 64.19 63.22 58.05 6.28 10.81
57.99 60.62 52.90 66.18 65.20 60.01 6.34 10.56
59.86 62.50 54.73 68.05 67.09 61.87 6.38 10.31
61.65 64.30 56.49 69.82 68.86 63.64 6.41 10.07
63.36 66.00 58.18 71.50 70.55 65.32 6.42 9.83
65.00 67.63 59.81 73.08 72.14 66.93 6.42 9.59
66.56 69.18 61.37 74.57 73.64 68.46 6.41 9.36
68.05 70.66 62.87 75.98 75.07 69.92 6.39 9.14
69.48 72.06 64.31 77.31 76.42 71.31 6.36 8.92
70.84 73.40 65.70 78.57 77.69 72.63 6.32 8.70
72.14 74.67 67.03 79.76 78.90 73.89 6.27 8.48
73.38 75.88 68.31 80.88 80.04 75.09 6.21 8.27
74.57 77.04 69.54 81.94 81.12 76.23 6.15 8.07
75.70 78.14 70.73 82.94 82.14 77.32 6.08 7.87
76.79 79.18 71.87 83.89 83.10 78.36 6.01 7.67
77.82 80.18 72.96 84.78 84.02 79.35 5.93 7.48
78.81 81.13 74.01 85.63 84.88 80.29 5.85 7.29
79.76 82.03 75.02 86.42 85.70 81.19 5.77 7.10
80.66 82.89 75.99 87.18 86.47 82.04 5.68 6.92
81.52 83.71 76.92 87.89 87.20 82.86 5.59 6.74
82.35 84.49 77.82 88.56 87.89 83.64 5.49 6.57
83.14 85.23 78.68 89.19 88.55 84.38 5.40 6.40
83.89 85.94 79.51 89.79 89.17 85.09 5.30 6.23
84.61 86.61 80.31 90.36 89.75 85.76 5.20 6.07
85.29 87.25 81.07 90.89 90.31 86.40 5.10 5.91
85.95 87.86 81.81 91.40 90.83 87.01 5.00 5.75
86.58 88.44 82.51 91.88 91.33 87.60 4.90 5.60
87.18 89.00 83.19 92.33 91.79 88.15 4.80 5.45
87.75 89.52 83.85 92.75 92.24 88.69 4.70 5.30
88.29 90.02 84.47 93.15 92.66 89.19 4.60 5.16
88.82 90.50 85.08 93.53 93.05 89.68 4.50 5.02
89.32 90.96 85.66 93.89 93.43 90.14 4.40 4.88
89.79 91.39 86.21 94.23 93.78 90.58 4.30 4.75
DDSolver 1.0 Dissolution Data Modeling of Higuchi Model

Time Unit min Analyst lapcy

Model Higuchi Date 2018-10-16
Equation F=kH*t^0.5 Time 18:58:31

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7

(min) F(%) F(%) F(%) F(%) F(%) F(%) F(%)
5 18.39 19.28 25.24 20.32 18.96 15.24 16.28
10 31.51 27.22 33.56 30.03 28.93 21.94 34.25
15 48.39 42.58 51.71 47.19 46.32 37.89 50.14
20 61.44 52.86 65.05 62.04 59.10 46.96 65.00
25 71.41 61.58 71.47 70.31 68.09 54.73 68.96
30 74.57 69.17 76.80 77.35 74.40 50.75 74.48
35 78.07 71.40 79.14 83.14 81.27 65.09 82.57
40 81.21 74.17 83.38 84.67 87.68 67.41 87.21
45 82.30 75.91 85.77 85.16 88.52 69.48 89.54
50 82.98 76.67 85.58 83.79 88.78 70.67 88.86
55 81.65 75.53 85.31 84.87 89.01 71.65 89.05
60 81.96 77.03 84.53 84.09 88.89 72.12 89.57

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7

(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
5 27.08 24.75 28.07 27.79 28.27 22.24 28.70
10 38.30 35.00 39.69 39.31 39.98 31.45 40.59
15 46.90 42.87 48.61 48.14 48.97 38.52 49.71
20 54.16 49.50 56.13 55.59 56.55 44.48 57.40
25 60.55 55.35 62.76 62.15 63.22 49.73 64.17
30 66.33 60.63 68.75 68.08 69.25 54.48 70.30
35 71.65 65.49 74.26 73.54 74.80 58.84 75.93
40 76.59 70.01 79.39 78.61 79.97 62.91 81.17
45 81.24 74.25 84.20 83.38 84.82 66.72 86.10
50 85.64 78.27 88.76 87.89 89.41 70.33 90.76
55 89.81 82.09 93.09 92.18 93.77 73.76 95.19
60 93.81 85.74 97.23 96.28 97.94 77.04 99.42

Best-fit Values
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
kH 12.111 11.069 12.552 12.430 12.644 9.946 12.835

Secondary Parameter
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
T25 4.261 5.101 3.967 4.045 3.909 6.318 3.794
T50 17.045 20.404 15.868 16.181 15.638 25.271 15.176
T75 38.352 45.909 35.703 36.406 35.185 56.859 34.146
T80 43.636 52.235 40.622 41.422 40.033 64.693 38.851
T90 55.227 66.109 51.412 52.425 50.667 81.877 49.170

Goodness of Fit
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
N_observed 12 12 12 12 12 12 12
DF 11 11 11 11 11 11 11
R_obs-pre 0.9382 0.9563 0.9471 0.9396 0.9668 0.9719 0.9601
Rsqr 0.8797 0.9145 0.8885 0.8828 0.9277 0.9349 0.9200
Rsqr_adj 0.8797 0.9145 0.8885 0.8828 0.9277 0.9349 0.9200
MSE 58.2080 35.4769 49.9454 62.5423 44.7838 25.5160 47.5736
MSE_root 7.6294 5.9562 7.0672 7.9084 6.6921 5.0513 6.8974
Weighting 1 1 1 1 1 1 1
SS 640.2880 390.2454 549.3989 687.9648 492.6219 280.6762 523.3097
WSS 640.2880 390.2454 549.3989 687.9648 492.6219 280.6762 523.3097
AIC 79.5430 73.6013 77.7059 80.4049 76.3969 69.6464 77.1221
MSC 1.9507 2.2929 2.0267 1.9772 2.4604 2.5646 2.3590

No.1
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.2
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.3
120

Observed
100 Predicted
 No.3
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.4
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.5
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20
Fraction dissolve
60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.6
90

80 Observed
Predicted
70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.7
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.8
100

90 Observed
80
Predicted

70
)
 No.8
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.9
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.10
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
Fraction dissol
50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.11
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.12
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

Mean
100

90 Observed
80
Predicted

70
(%)
 Mean
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

Predicted Data
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
0 0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.2 13.27 12.13 13.75 13.62 13.85 10.90 14.06
2.4 18.76 17.15 19.45 19.26 19.59 15.41 19.88
3.6 22.98 21.00 23.82 23.58 23.99 18.87 24.35
4.8 26.53 24.25 27.50 27.23 27.70 21.79 28.12
6 29.66 27.11 30.75 30.45 30.97 24.36 31.44
7.2 32.50 29.70 33.68 33.35 33.93 26.69 34.44
8.4 35.10 32.08 36.38 36.03 36.65 28.83 37.20
9.6 37.52 34.30 38.89 38.51 39.18 30.82 39.77
10.8 39.80 36.38 41.25 40.85 41.55 32.69 42.18
12 41.95 38.34 43.48 43.06 43.80 34.46 44.46
13.2 44.00 40.22 45.60 45.16 45.94 36.14 46.63
14.4 45.96 42.00 47.63 47.17 47.98 37.74 48.70
15.6 47.83 43.72 49.58 49.09 49.94 39.28 50.69
16.8 49.64 45.37 51.45 50.95 51.82 40.77 52.61
18 51.38 46.96 53.25 52.74 53.64 42.20 54.45
19.2 53.07 48.50 55.00 54.47 55.40 43.58 56.24
20.4 54.70 49.99 56.69 56.14 57.11 44.92 57.97
21.6 56.29 51.44 58.34 57.77 58.76 46.23 59.65
22.8 57.83 52.85 59.93 59.35 60.37 47.49 61.29
24 59.33 54.23 61.49 60.89 61.94 48.73 62.88
25.2 60.79 55.57 63.01 62.40 63.47 49.93 64.43
26.4 62.23 56.87 64.49 63.87 64.97 51.11 65.95
27.6 63.62 58.15 65.94 65.30 66.43 52.25 67.43
28.8 64.99 59.40 67.36 66.71 67.85 53.38 68.88
30 66.33 60.63 68.75 68.08 69.25 54.48 70.30
31.2 67.65 61.83 70.11 69.43 70.62 55.56 71.69
32.4 68.94 63.01 71.45 70.75 71.97 56.62 73.06
33.6 70.20 64.16 72.76 72.05 73.29 57.65 74.40
34.8 71.44 65.30 74.05 73.33 74.59 58.67 75.71
36 72.66 66.41 75.31 74.58 75.86 59.68 77.01
37.2 73.87 67.51 76.56 75.81 77.12 60.66 78.28
38.4 75.05 68.59 77.78 77.03 78.35 61.64 79.53
39.6 76.21 69.66 78.99 78.22 79.57 62.59 80.77
40.8 77.36 70.70 80.18 79.40 80.76 63.53 81.98
42 78.49 71.74 81.35 80.56 81.94 64.46 83.18
43.2 79.60 72.75 82.50 81.70 83.10 65.37 84.36
44.4 80.70 73.76 83.64 82.83 84.25 66.28 85.52
45.6 81.78 74.75 84.76 83.94 85.38 67.17 86.67
46.8 82.85 75.72 85.87 85.03 86.50 68.04 87.80
48 83.91 76.69 86.96 86.12 87.60 68.91 88.92
49.2 84.95 77.64 88.04 87.19 88.69 69.77 90.03
50.4 85.98 78.58 89.11 88.24 89.76 70.61 91.12
51.6 86.99 79.51 90.16 89.29 90.82 71.45 92.20
52.8 88.00 80.43 91.21 90.32 91.87 72.27 93.26
54 88.99 81.34 92.24 91.34 92.91 73.09 94.32
55.2 89.98 82.24 93.26 92.35 93.94 73.90 95.36
56.4 90.95 83.13 94.26 93.35 94.96 74.70 96.39
57.6 91.91 84.01 95.26 94.34 95.96 75.49 97.41
58.8 92.87 84.88 96.25 95.32 96.95 76.27 98.42
60 93.81 85.74 97.23 96.28 97.94 77.04 99.42
 No.8 No.9 No.10 No.11 No.12
F(%) F(%) F(%) F(%) F(%) Mean SD RSD(%)
11.98 10.60 11.64 13.22 14.64 16.32 4.29 26.31
27.66 24.84 27.67 32.59 31.46 29.31 3.66 12.49
41.19 33.96 39.90 44.86 42.29 43.87 5.22 11.91
55.28 51.88 50.83 60.87 60.29 57.63 5.91 10.26
64.77 61.90 60.07 72.39 70.97 66.39 5.68 8.55
66.96 69.88 66.31 76.36 79.44 71.37 7.76 10.87
73.91 80.63 70.87 84.56 84.99 77.97 6.29 8.07
80.91 89.68 72.97 88.09 87.36 82.06 7.08 8.62
84.98 92.62 77.17 92.13 89.34 84.41 7.07 8.37
86.34 93.14 78.26 93.24 93.70 85.17 7.18 8.43
86.98 94.47 78.80 95.34 91.75 85.37 7.35 8.61
84.93 92.74 80.52 95.37 90.82 85.21 6.72 7.88

No.8 No.9 No.10 No.11 No.12

F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
26.63 28.10 24.76 29.47 28.99 27.07 2.14 7.90
37.66 39.74 35.02 41.67 41.00 38.28 3.03 7.90
46.12 48.67 42.89 51.04 50.22 46.89 3.71 7.90
53.25 56.20 49.52 58.93 57.99 54.14 4.28 7.90
59.54 62.83 55.37 65.89 64.83 60.53 4.78 7.90
65.22 68.83 60.65 72.18 71.02 66.31 5.24 7.90
70.45 74.35 65.51 77.96 76.71 71.62 5.66 7.90
75.31 79.48 70.04 83.34 82.00 76.57 6.05 7.90
79.88 84.30 74.29 88.40 86.98 81.21 6.42 7.90
84.20 88.86 78.30 93.18 91.68 85.61 6.77 7.90
88.31 93.20 82.13 97.73 96.16 89.78 7.10 7.90
92.24 97.34 85.78 102.07 100.43 93.78 7.41 7.90

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)

11.908 12.567 11.074 13.178 12.966 12.107 0.957 7.903

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)

4.408 3.957 5.097 3.599 3.718 4.348 0.790 18.169
17.631 15.830 20.386 14.397 14.871 17.391 3.160 18.169
39.669 35.617 45.869 32.393 33.459 39.131 7.110 18.169
45.134 40.525 52.188 36.856 38.069 44.522 8.089 18.169
57.123 51.289 66.051 46.645 48.181 56.348 10.238 18.169

No.8 No.9 No.10 No.11 No.12

12 12 12 12 12
11 11 11 11 11
0.9751 0.9801 0.9736 0.9742 0.9627
 0.9274 0.8956 0.9330 0.9297 0.9120
0.9274 0.8956 0.9330 0.9297 0.9120 0.9121
45.6647 92.6518 34.1117 52.6139 62.9661
6.7576 9.6256 5.8405 7.2535 7.9351
1 1 1 1 1
502.3116 1019.1701 375.2291 578.7527 692.6274
502.3116 1019.1701 375.2291 578.7527 692.6274
76.6306 85.1209 73.1304 78.3305 80.4859 77.3432
2.4565 2.0932 2.5361 2.4884 2.2636
 No.8 No.9 No.10 No.11 No.12
F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
0.00 0.00 0.00 0.00 0.00 0.00 0.00
13.04 13.77 12.13 14.44 14.20 13.26 1.05 7.90
18.45 19.47 17.16 20.41 20.09 18.76 1.48 7.90
22.59 23.84 21.01 25.00 24.60 22.97 1.82 7.90
26.09 27.53 24.26 28.87 28.41 26.52 2.10 7.90
29.17 30.78 27.13 32.28 31.76 29.65 2.34 7.90
31.95 33.72 29.71 35.36 34.79 32.49 2.57 7.90
34.51 36.42 32.10 38.19 37.58 35.09 2.77 7.90
36.90 38.94 34.31 40.83 40.17 37.51 2.96 7.90
39.13 41.30 36.39 43.31 42.61 39.79 3.14 7.90
41.25 43.53 38.36 45.65 44.92 41.94 3.31 7.90
43.26 45.66 40.23 47.88 47.11 43.99 3.48 7.90
45.19 47.69 42.02 50.01 49.20 45.94 3.63 7.90
47.03 49.64 43.74 52.05 51.21 47.82 3.78 7.90
48.81 51.51 45.39 54.01 53.14 49.62 3.92 7.90
50.52 53.32 46.98 55.91 55.01 51.36 4.06 7.90
52.18 55.07 48.52 57.74 56.81 53.05 4.19 7.90
53.78 56.76 50.02 59.52 58.56 54.68 4.32 7.90
55.34 58.41 51.47 61.24 60.26 56.27 4.45 7.90
56.86 60.01 52.88 62.92 61.91 57.81 4.57 7.90
58.34 61.57 54.25 64.56 63.52 59.31 4.69 7.90
59.78 63.09 55.59 66.15 65.09 60.77 4.80 7.90
61.18 64.57 56.90 67.71 66.62 62.20 4.92 7.90
62.56 66.02 58.18 69.23 68.12 63.60 5.03 7.90
63.90 67.44 59.43 70.72 69.58 64.97 5.13 7.90
65.22 68.83 60.65 72.18 71.02 66.31 5.24 7.90
66.51 70.20 61.86 73.61 72.42 67.62 5.34 7.90
67.78 71.53 63.03 75.01 73.80 68.91 5.45 7.90
69.02 72.85 64.19 76.39 75.16 70.18 5.55 7.90
70.25 74.13 65.33 77.74 76.49 71.42 5.64 7.90
71.45 75.40 66.44 79.07 77.80 72.64 5.74 7.90
72.63 76.65 67.54 80.37 79.08 73.84 5.84 7.90
73.79 77.87 68.62 81.66 80.35 75.02 5.93 7.90
74.93 79.08 69.69 82.93 81.59 76.19 6.02 7.90
76.06 80.27 70.73 84.17 82.82 77.33 6.11 7.90
77.17 81.44 71.77 85.40 84.03 78.46 6.20 7.90
78.27 82.60 72.79 86.61 85.22 79.57 6.29 7.90
79.35 83.74 73.79 87.81 86.40 80.67 6.38 7.90
80.41 84.86 74.78 88.99 87.56 81.75 6.46 7.90
81.46 85.97 75.76 90.15 88.70 82.82 6.55 7.90
82.50 87.07 76.72 91.30 89.83 83.88 6.63 7.90
83.53 88.15 77.68 92.43 90.95 84.92 6.71 7.90
84.54 89.22 78.62 93.55 92.05 85.95 6.79 7.90
85.54 90.27 79.55 94.66 93.14 86.97 6.87 7.90
86.53 91.32 80.47 95.75 94.22 87.97 6.95 7.90
87.51 92.35 81.38 96.84 95.28 88.96 7.03 7.90
88.47 93.37 82.28 97.91 96.33 89.95 7.11 7.90
89.43 94.38 83.17 98.96 97.37 90.92 7.19 7.90
90.37 95.38 84.05 100.01 98.40 91.88 7.26 7.90
91.31 96.37 84.92 101.05 99.42 92.83 7.34 7.90
92.24 97.34 85.78 102.07 100.43 93.78 7.41 7.90
DDSolver 1.0 Dissolution Data Modeling of Korsmeyer-Peppas Model

Time Unit min Analyst lapcy

Model Korsmeyer-Peppas Date 2018-10-16
Equation F=kKP*t^n Time 19:02:32

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7

(min) F(%) F(%) F(%) F(%) F(%) F(%) F(%)
5 18.39 19.28 25.24 20.32 18.96 15.24 16.28
10 31.51 27.22 33.56 30.03 28.93 21.94 34.25
15 48.39 42.58 51.71 47.19 46.32 37.89 50.14
20 61.44 52.86 65.05 62.04 59.10 46.96 65.00
25 71.41 61.58 71.47 70.31 68.09 54.73 68.96
30 74.57 69.17 76.80 77.35 74.40 50.75 74.48
35 78.07 71.40 79.14 83.14 81.27 65.09 82.57
40 81.21 74.17 83.38 84.67 87.68 67.41 87.21
45 82.30 75.91 85.77 85.16 88.52 69.48 89.54
50 82.98 76.67 85.58 83.79 88.78 70.67 88.86
55 81.65 75.53 85.31 84.87 89.01 71.65 89.05
60 81.96 77.03 84.53 84.09 88.89 72.12 89.57

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7

(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
5 29.80 25.94 32.65 29.69 26.90 20.45 29.07
10 40.79 36.11 43.84 41.05 38.69 29.76 40.93
15 49.00 43.81 52.09 49.62 47.86 37.06 50.00
20 55.82 50.25 58.86 56.76 55.66 43.31 57.63
25 61.75 55.89 64.72 63.00 62.57 48.87 64.34
30 67.06 60.96 69.94 68.60 68.85 53.94 70.40
35 71.91 65.61 74.67 73.73 74.65 58.63 75.97
40 76.39 69.92 79.04 78.47 80.06 63.02 81.15
45 80.57 73.96 83.10 82.92 85.17 67.17 86.00
50 84.51 77.77 86.90 87.10 90.01 71.12 90.60
55 88.23 81.39 90.50 91.07 94.62 74.88 94.96
60 91.78 84.83 93.91 94.85 99.04 78.50 99.13

Best-fit Values
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
kKP 14.385 12.045 16.468 13.995 11.562 8.554 13.130
n 0.453 0.477 0.425 0.467 0.525 0.541 0.494

Secondary Parameter
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
T25 3.391 4.626 2.669 3.460 4.350 7.249 3.685
T50 15.682 19.796 13.626 15.248 16.304 26.082 15.002
T75 38.410 46.335 35.360 36.306 35.316 55.158 34.103
T80 44.296 53.052 41.155 41.682 39.939 62.141 38.865
T90 57.462 67.919 54.292 53.629 49.993 77.244 49.335

Goodness of Fit
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
N_observed 12 12 12 12 12 12 12
DF 10 10 10 10 10 10 10
R_obs-pre 0.9431 0.9582 0.9538 0.9427 0.9651 0.9696 0.9607
Rsqr 0.8864 0.9160 0.9078 0.8858 0.9291 0.9387 0.9201
Rsqr_adj 0.8751 0.9076 0.8986 0.8744 0.9220 0.9325 0.9121
MSE 60.4211 38.3324 45.4128 67.0275 48.2900 26.4345 52.2621
MSE_root 7.7731 6.1913 6.7389 8.1870 6.9491 5.1415 7.2293
Weighting 1 1 1 1 1 1 1
SS 604.2110 383.3239 454.1284 670.2751 482.9003 264.3455 522.6209
WSS 604.2110 383.3239 454.1284 670.2751 482.9003 264.3455 522.6209
AIC 80.8471 75.3866 77.4206 82.0923 78.1577 70.9271 79.1063
MSC 1.8420 2.1441 2.0504 1.8366 2.3136 2.4579 2.1936

No.1
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.2
90

80 Observed
Predicted
70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.3
100

90 Observed
Predicted
 No.3
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.4
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.5
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20
 80

Fraction dissolved (
60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.6
90

80 Observed
Predicted
70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.7
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.8
120

Observed
100 Predicted
 No.8
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.9
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.10
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10
 60

Fraction dissolve
50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.11
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.12
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

Mean
100

90 Observed
80
Predicted

70
)
 Mean
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

Predicted Data
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
0 0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.2 15.62 13.14 17.80 15.24 12.72 9.44 14.37
2.4 21.38 18.28 23.90 21.07 18.30 13.74 20.23
3.6 25.69 22.18 28.39 25.47 22.64 17.11 24.71
4.8 29.26 25.44 32.09 29.13 26.33 20.00 28.49
6 32.37 28.30 35.28 32.33 29.60 22.57 31.80
7.2 35.15 30.87 38.12 35.21 32.57 24.91 34.80
8.4 37.69 33.23 40.70 37.84 35.31 27.08 37.55
9.6 40.04 35.41 43.08 40.28 37.87 29.11 40.11
10.8 42.23 37.46 45.30 42.56 40.28 31.02 42.51
12 44.30 39.38 47.37 44.70 42.57 32.84 44.78
13.2 46.25 41.22 49.33 46.74 44.76 34.58 46.94
14.4 48.11 42.96 51.19 48.68 46.85 36.25 49.00
15.6 49.88 44.63 52.96 50.54 48.86 37.85 50.97
16.8 51.58 46.24 54.66 52.32 50.79 39.40 52.87
18 53.22 47.78 56.28 54.03 52.66 40.90 54.71
19.2 54.80 49.28 57.85 55.69 54.48 42.36 56.48
20.4 56.32 50.72 59.36 57.29 56.24 43.77 58.19
21.6 57.80 52.12 60.82 58.84 57.95 45.15 59.86
22.8 59.23 53.48 62.23 60.34 59.62 46.49 61.48
24 60.62 54.81 63.61 61.81 61.24 47.80 63.06
25.2 61.97 56.10 64.94 63.23 62.83 49.08 64.59
26.4 63.29 57.36 66.24 64.62 64.38 50.33 66.09
27.6 64.58 58.59 67.50 65.98 65.90 51.55 67.56
28.8 65.84 59.79 68.73 67.31 67.39 52.76 69.00
30 67.06 60.96 69.94 68.60 68.85 53.94 70.40
31.2 68.26 62.11 71.11 69.87 70.28 55.09 71.78
32.4 69.44 63.24 72.26 71.11 71.69 56.23 73.13
33.6 70.59 64.35 73.39 72.33 73.07 57.35 74.45
34.8 71.72 65.43 74.49 73.53 74.42 58.45 75.75
36 72.83 66.50 75.57 74.70 75.76 59.53 77.03
37.2 73.92 67.54 76.64 75.86 77.07 60.60 78.29
38.4 74.99 68.58 77.68 76.99 78.37 61.65 79.53
39.6 76.04 69.59 78.70 78.11 79.64 62.68 80.74
40.8 77.08 70.59 79.71 79.20 80.90 63.70 81.94
42 78.10 71.57 80.69 80.28 82.14 64.71 83.12
43.2 79.10 72.54 81.67 81.35 83.36 65.71 84.29
44.4 80.08 73.49 82.62 82.40 84.57 66.69 85.44
45.6 81.06 74.43 83.57 83.43 85.76 67.66 86.57
46.8 82.02 75.36 84.49 84.45 86.94 68.62 87.69
48 82.96 76.27 85.41 85.45 88.10 69.56 88.79
49.2 83.89 77.18 86.31 86.45 89.25 70.50 89.88
50.4 84.81 78.07 87.20 87.43 90.38 71.43 90.95
51.6 85.72 78.95 88.08 88.39 91.51 72.34 92.02
52.8 86.62 79.82 88.94 89.35 92.62 73.25 93.07
54 87.50 80.68 89.79 90.29 93.71 74.14 94.11
55.2 88.38 81.53 90.64 91.22 94.80 75.03 95.13
56.4 89.24 82.37 91.47 92.14 95.88 75.91 96.15
57.6 90.10 83.20 92.29 93.06 96.94 76.78 97.15
58.8 90.94 84.02 93.11 93.96 98.00 77.64 98.15
60 91.78 84.83 93.91 94.85 99.04 78.50 99.13
 No.8 No.9 No.10 No.11 No.12
F(%) F(%) F(%) F(%) F(%) Mean SD RSD(%)
11.98 10.60 11.64 13.22 14.64 16.32 4.29 26.31
27.66 24.84 27.67 32.59 31.46 29.31 3.66 12.49
41.19 33.96 39.90 44.86 42.29 43.87 5.22 11.91
55.28 51.88 50.83 60.87 60.29 57.63 5.91 10.26
64.77 61.90 60.07 72.39 70.97 66.39 5.68 8.55
66.96 69.88 66.31 76.36 79.44 71.37 7.76 10.87
73.91 80.63 70.87 84.56 84.99 77.97 6.29 8.07
80.91 89.68 72.97 88.09 87.36 82.06 7.08 8.62
84.98 92.62 77.17 92.13 89.34 84.41 7.07 8.37
86.34 93.14 78.26 93.24 93.70 85.17 7.18 8.43
86.98 94.47 78.80 95.34 91.75 85.37 7.35 8.61
84.93 92.74 80.52 95.37 90.82 85.21 6.72 7.88

No.8 No.9 No.10 No.11 No.12

F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
22.91 19.56 22.44 25.98 26.37 25.98 4.01 15.45
34.10 31.27 32.82 38.35 38.52 37.18 4.38 11.79
43.03 41.15 40.99 48.16 48.08 45.90 4.57 9.95
50.75 50.00 48.00 56.61 56.26 53.33 4.75 8.90
57.69 58.16 54.24 64.18 63.56 59.91 4.98 8.31
64.05 65.80 59.95 71.10 70.22 65.91 5.27 8.00
69.97 73.04 65.23 77.53 76.39 71.44 5.64 7.89
75.55 79.95 70.19 83.58 82.17 76.62 6.06 7.91
80.83 86.59 74.87 89.29 87.64 81.51 6.54 8.02
85.87 92.99 79.33 94.74 92.83 86.15 7.05 8.18
90.69 99.19 83.58 99.95 97.80 90.57 7.60 8.39
95.34 105.21 87.67 104.96 102.56 94.81 8.17 8.62

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)

9.095 6.579 9.285 10.515 10.943 11.380 2.810 24.697
0.574 0.677 0.548 0.562 0.547 0.524 0.067 12.859

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)

5.823 7.184 6.088 4.670 4.534 4.811 1.485 30.877
19.487 19.998 21.549 16.034 16.117 17.910 3.550 19.820
39.498 36.397 45.140 32.991 33.843 39.071 6.610 16.919
44.200 40.037 50.778 37.006 38.085 44.270 7.460 16.851
54.269 47.645 62.945 45.635 47.244 55.634 9.478 17.036

No.8 No.9 No.10 No.11 No.12

12 12 12 12 12
10 10 10 10 10
 0.9701 0.9716 0.9700 0.9698 0.9590
0.9383 0.9412 0.9381 0.9376 0.9166
0.9321 0.9353 0.9319 0.9314 0.9083 0.9135
42.7183 57.3989 34.6722 51.3405 65.6043
6.5359 7.5762 5.8883 7.1652 8.0997
1 1 1 1 1
427.1833 573.9887 346.7222 513.4050 656.0434
427.1833 573.9887 346.7222 513.4050 656.0434
76.6866 80.2313 74.1823 78.8928 81.8347 77.9804
2.4518 2.5006 2.4485 2.4415 2.1512
 No.8 No.9 No.10 No.11 No.12
F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
0.00 0.00 0.00 0.00 0.00 0.00 0.00
10.10 7.44 10.26 11.65 12.09 12.49 2.95 23.63
15.03 11.90 15.01 17.20 17.66 17.81 3.49 19.61
18.97 15.66 18.74 21.60 22.04 21.93 3.79 17.29
22.38 19.03 21.95 25.39 25.79 25.44 3.99 15.67
25.43 22.13 24.80 28.78 29.14 28.54 4.12 14.45
28.24 25.04 27.41 31.88 32.19 31.37 4.23 13.47
30.85 27.79 29.83 34.77 35.02 33.97 4.30 12.67
33.31 30.42 32.09 37.48 37.67 36.41 4.37 11.99
35.64 32.95 34.23 40.04 40.17 38.70 4.42 11.42
37.86 35.38 36.27 42.49 42.56 40.88 4.47 10.92
39.98 37.74 38.22 44.82 44.83 42.95 4.51 10.50
42.03 40.03 40.08 47.07 47.01 44.94 4.55 10.12
44.01 42.26 41.88 49.24 49.12 46.85 4.59 9.79
45.92 44.44 43.62 51.33 51.15 48.69 4.63 9.51
47.77 46.56 45.30 53.36 53.11 50.48 4.67 9.26
49.58 48.64 46.93 55.33 55.02 52.20 4.72 9.04
51.33 50.68 48.52 57.25 56.87 53.88 4.76 8.84
53.04 52.68 50.06 59.12 58.68 55.51 4.81 8.67
54.72 54.64 51.57 60.94 60.44 57.10 4.87 8.53
56.35 56.57 53.04 62.72 62.16 58.65 4.93 8.40
57.95 58.47 54.48 64.46 63.84 60.16 4.99 8.29
59.52 60.34 55.89 66.17 65.48 61.64 5.05 8.20
61.06 62.19 57.27 67.85 67.09 63.09 5.12 8.12
62.57 64.01 58.62 69.49 68.67 64.51 5.20 8.06
64.05 65.80 59.95 71.10 70.22 65.91 5.27 8.00
65.51 67.57 61.25 72.68 71.74 67.27 5.36 7.96
66.94 69.32 62.53 74.24 73.24 68.61 5.44 7.93
68.35 71.05 63.79 75.78 74.71 69.93 5.53 7.91
69.74 72.76 65.03 77.28 76.15 71.23 5.62 7.89
71.11 74.45 66.25 78.77 77.58 72.51 5.72 7.89
72.46 76.12 67.45 80.24 78.98 73.76 5.82 7.89
73.80 77.77 68.64 81.68 80.36 75.00 5.92 7.89
75.11 79.41 69.80 83.10 81.72 76.22 6.03 7.91
76.41 81.03 70.96 84.51 83.07 77.42 6.13 7.92
77.69 82.63 72.09 85.90 84.40 78.61 6.25 7.95
78.96 84.23 73.22 87.27 85.70 79.78 6.36 7.97
80.21 85.80 74.32 88.62 87.00 80.94 6.48 8.00
81.44 87.37 75.42 89.96 88.28 82.08 6.60 8.04
82.67 88.92 76.50 91.28 89.54 83.21 6.72 8.07
83.88 90.45 77.57 92.59 90.78 84.32 6.84 8.11
85.07 91.98 78.63 93.89 92.02 85.42 6.97 8.16
86.26 93.49 79.67 95.17 93.24 86.51 7.09 8.20
87.43 94.99 80.71 96.43 94.45 87.58 7.22 8.25
88.59 96.48 81.73 97.69 95.64 88.65 7.35 8.30
89.74 97.96 82.75 98.93 96.82 89.70 7.49 8.35
90.88 99.43 83.75 100.16 97.99 90.75 7.62 8.40
92.01 100.89 84.74 101.38 99.15 91.78 7.76 8.45
93.13 102.34 85.73 102.58 100.30 92.80 7.89 8.51
94.24 103.78 86.70 103.78 101.43 93.81 8.03 8.56
95.34 105.21 87.67 104.96 102.56 94.81 8.17 8.62
DDSolver 1.0 Dissolution Data Modeling of Hixson-Crowell Model

Time Unit min Analyst lapcy

Model Hixson-Crowell Date 2018-10-16
Equation F=100*[1-(1-kHC*t)^3] Time 19:05:54

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7

(min) F(%) F(%) F(%) F(%) F(%) F(%) F(%)
5 18.39 19.28 25.24 20.32 18.96 15.24 16.28
10 31.51 27.22 33.56 30.03 28.93 21.94 34.25
15 48.39 42.58 51.71 47.19 46.32 37.89 50.14
20 61.44 52.86 65.05 62.04 59.10 46.96 65.00
25 71.41 61.58 71.47 70.31 68.09 54.73 68.96
30 74.57 69.17 76.80 77.35 74.40 50.75 74.48
35 78.07 71.40 79.14 83.14 81.27 65.09 82.57
40 81.21 74.17 83.38 84.67 87.68 67.41 87.21
45 82.30 75.91 85.77 85.16 88.52 69.48 89.54
50 82.98 76.67 85.58 83.79 88.78 70.67 88.86
55 81.65 75.53 85.31 84.87 89.01 71.65 89.05
60 81.96 77.03 84.53 84.09 88.89 72.12 89.57

Time No.1 No.2 No.3 No.4 No.5 No.6 No.7

(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
5 15.84 13.08 17.20 16.69 16.76 10.81 17.56
10 29.91 24.96 32.30 31.40 31.53 20.81 32.94
15 42.32 35.71 45.44 44.28 44.44 30.03 46.28
20 53.17 45.38 56.76 55.43 55.62 38.51 57.72
25 62.56 54.03 66.40 64.98 65.19 46.27 67.40
30 70.61 61.72 74.49 73.07 73.27 53.35 75.49
35 77.41 68.49 81.16 79.80 79.99 59.78 82.11
40 83.07 74.42 86.55 85.30 85.48 65.59 87.41
45 87.70 79.55 90.80 89.70 89.86 70.81 91.55
50 91.40 83.94 94.05 93.12 93.26 75.48 94.67
55 94.27 87.66 96.42 95.69 95.80 79.61 96.90
60 96.41 90.75 98.06 97.52 97.60 83.26 98.41

Best-fit Values
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
kHC 0.011 0.009 0.012 0.012 0.012 0.007 0.012

Secondary Parameter
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
T25 8.186 10.016 7.500 7.745 7.710 12.223 7.332
T50 18.468 22.597 16.921 17.473 17.394 27.576 16.542
T75 33.126 40.532 30.352 31.342 31.199 49.463 29.671
T80 37.168 45.479 34.056 35.166 35.006 55.499 33.292
T90 47.968 58.693 43.951 45.385 45.178 71.626 42.966

Goodness of Fit
Parameter No.1 No.2 No.3 No.4 No.5 No.6 No.7
N_observed 12 12 12 12 12 12 12
DF 11 11 11 11 11 11 11
R_obs-pre 0.9667 0.9681 0.9794 0.9732 0.9904 0.9722 0.9880
Rsqr 0.8721 0.8534 0.8735 0.9096 0.9725 0.8894 0.9614
Rsqr_adj 0.8721 0.8534 0.8735 0.9096 0.9725 0.8894 0.9614
MSE 61.8581 60.8310 56.6581 48.2533 17.0267 43.3151 22.9544
MSE_root 7.8650 7.7994 7.5272 6.9465 4.1263 6.5814 4.7911
Weighting 1 1 1 1 1 1 1
SS 680.4389 669.1413 623.2394 530.7861 187.2932 476.4656 252.4986
WSS 680.4389 669.1413 623.2394 530.7861 187.2932 476.4656 252.4986
AIC 80.2729 80.0719 79.2192 77.2923 64.7921 75.9967 68.3769
MSC 1.8899 1.7537 1.9005 2.2366 3.4274 2.0354 3.0877

No.1
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.2
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.3
120

Observed
100 Predicted
 No.3
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.4
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.5
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20
Fraction dissolve
60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.6
90

80 Observed
Predicted
70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.7
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.8
100

90 Observed
80
Predicted

70
)
 No.8
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.9
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.10
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
Fraction dissol
50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

No.11
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

No.12
120

Observed
100 Predicted
Fraction dissolved (%)

80

60

40

20

0
0 10 20 30 40 50 60 70
Time (min)

Mean
100

90 Observed
80
Predicted

70
(%)
 Mean
100

90 Observed
80
Predicted

70
Fraction dissolved (%)

60

50

40

30

20

10

0
0 10 20 30 40 50 60 70
Time (min)

Predicted Data
Time No.1 No.2 No.3 No.4 No.5 No.6 No.7
(min) F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre
0 0.00 0.00 0.00 0.00 0.00 0.00 0.00
1.2 3.97 3.25 4.33 4.19 4.21 2.67 4.42
2.4 7.83 6.43 8.52 8.26 8.30 5.29 8.71
3.6 11.59 9.54 12.60 12.22 12.27 7.86 12.87
4.8 15.24 12.58 16.55 16.06 16.13 10.39 16.91
6 18.79 15.55 20.38 19.78 19.87 12.87 20.81
7.2 22.24 18.45 24.09 23.40 23.49 15.30 24.59
8.4 25.59 21.29 27.68 26.90 27.01 17.69 28.25
9.6 28.84 24.06 31.16 30.29 30.42 20.04 31.79
10.8 32.00 26.76 34.53 33.58 33.72 22.33 35.21
12 35.06 29.40 37.78 36.77 36.91 24.59 38.51
13.2 38.03 31.97 40.93 39.85 40.00 26.80 41.70
14.4 40.91 34.48 43.96 42.82 42.98 28.96 44.78
15.6 43.70 36.93 46.89 45.70 45.87 31.08 47.75
16.8 46.40 39.32 49.72 48.48 48.66 33.16 50.61
18 49.01 41.64 52.44 51.17 51.35 35.20 53.36
19.2 51.53 43.91 55.07 53.76 53.94 37.20 56.01
20.4 53.97 46.11 57.59 56.25 56.44 39.15 58.55
21.6 56.33 48.26 60.02 58.65 58.85 41.07 61.00
22.8 58.60 50.35 62.36 60.97 61.17 42.94 63.35
24 60.79 52.38 64.60 63.20 63.39 44.77 65.60
25.2 62.91 54.36 66.75 65.34 65.54 46.56 67.76
26.4 64.95 56.28 68.81 67.39 67.59 48.32 69.82
27.6 66.91 58.14 70.79 69.36 69.57 50.03 71.80
28.8 68.79 59.96 72.68 71.25 71.46 51.71 73.68
30 70.61 61.72 74.49 73.07 73.27 53.35 75.49
31.2 72.35 63.42 76.21 74.80 75.00 54.95 77.20
32.4 74.02 65.08 77.86 76.46 76.66 56.51 78.84
33.6 75.63 66.68 79.42 78.04 78.24 58.04 80.39
34.8 77.16 68.24 80.92 79.55 79.75 59.53 81.87
36 78.63 69.74 82.33 80.99 81.18 60.99 83.27
37.2 80.04 71.20 83.68 82.36 82.55 62.41 84.60
38.4 81.38 72.61 84.96 83.67 83.85 63.80 85.85
39.6 82.66 73.97 86.16 84.90 85.09 65.15 87.03
40.8 83.88 75.29 87.31 86.08 86.25 66.46 88.15
42 85.04 76.56 88.38 87.19 87.36 67.75 89.20
43.2 86.15 77.79 89.40 88.24 88.41 69.00 90.19
44.4 87.20 78.97 90.35 89.23 89.39 70.21 91.11
45.6 88.19 80.11 91.24 90.16 90.32 71.40 91.98
46.8 89.13 81.21 92.08 91.04 91.19 72.55 92.78
48 90.02 82.27 92.86 91.87 92.01 73.67 93.53
49.2 90.86 83.29 93.59 92.64 92.78 74.76 94.23
50.4 91.65 84.26 94.27 93.36 93.49 75.83 94.88
51.6 92.40 85.20 94.90 94.03 94.16 76.86 95.47
52.8 93.10 86.10 95.48 94.66 94.78 77.86 96.02
54 93.75 86.97 96.01 95.24 95.35 78.83 96.52
55.2 94.37 87.79 96.50 95.78 95.88 79.77 96.98
56.4 94.94 88.58 96.95 96.27 96.37 80.68 97.39
57.6 95.47 89.34 97.36 96.73 96.82 81.57 97.77
58.8 95.96 90.06 97.73 97.14 97.23 82.43 98.10
60 96.41 90.75 98.06 97.52 97.60 83.26 98.41
 No.8 No.9 No.10 No.11 No.12
F(%) F(%) F(%) F(%) F(%) Mean SD RSD(%)
11.98 10.60 11.64 13.22 14.64 16.32 4.29 26.31
27.66 24.84 27.67 32.59 31.46 29.31 3.66 12.49
41.19 33.96 39.90 44.86 42.29 43.87 5.22 11.91
55.28 51.88 50.83 60.87 60.29 57.63 5.91 10.26
64.77 61.90 60.07 72.39 70.97 66.39 5.68 8.55
66.96 69.88 66.31 76.36 79.44 71.37 7.76 10.87
73.91 80.63 70.87 84.56 84.99 77.97 6.29 8.07
80.91 89.68 72.97 88.09 87.36 82.06 7.08 8.62
84.98 92.62 77.17 92.13 89.34 84.41 7.07 8.37
86.34 93.14 78.26 93.24 93.70 85.17 7.18 8.43
86.98 94.47 78.80 95.34 91.75 85.37 7.35 8.61
84.93 92.74 80.52 95.37 90.82 85.21 6.72 7.88

No.8 No.9 No.10 No.11 No.12

F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
14.71 15.80 12.95 17.93 17.58 15.57 2.25 14.42
27.89 29.84 24.74 33.58 32.96 29.41 4.02 13.67
39.65 42.23 35.41 47.10 46.31 41.60 5.36 12.88
50.05 53.07 45.02 58.65 57.75 52.26 6.31 12.07
59.18 62.46 53.63 68.39 67.44 61.49 6.90 11.23
67.12 70.50 61.28 76.46 75.52 69.41 7.19 10.36
73.97 77.30 68.05 83.02 82.14 76.10 7.21 9.47
79.78 82.97 73.98 88.24 87.44 81.69 7.00 8.57
84.66 87.61 79.12 92.26 91.58 86.27 6.60 7.65
88.69 91.32 83.54 95.24 94.69 89.95 6.05 6.73
91.94 94.20 87.28 97.33 96.92 92.84 5.40 5.81
94.50 96.36 90.41 98.70 98.42 95.03 4.68 4.92

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)

0.010 0.011 0.009 0.013 0.012 0.011 0.002 15.145

No.8 No.9 No.10 No.11 No.12 Mean SD RSD(%)

8.854 8.206 10.117 7.171 7.326 8.532 1.531 17.939
19.976 18.513 22.824 16.179 16.529 19.249 3.453 17.939
35.830 33.207 40.940 29.021 29.648 34.528 6.194 17.939
40.203 37.259 45.936 32.562 33.267 38.741 6.950 17.939
51.884 48.085 59.283 42.024 42.933 49.998 8.969 17.939

No.8 No.9 No.10 No.11 No.12

12 12 12 12 12
11 11 11 11 11
0.9883 0.9938 0.9808 0.9961 0.9906
 0.9723 0.9774 0.9390 0.9914 0.9797
0.9723 0.9774 0.9390 0.9914 0.9797 0.9327
17.4128 20.0234 31.0470 6.4244 14.5314
4.1729 4.4748 5.5720 2.5346 3.8120
1 1 1 1 1
191.5411 220.2575 341.5165 70.6684 159.8451
191.5411 220.2575 341.5165 70.6684 159.8451
65.0612 66.7376 72.0008 53.0960 62.8905 70.4840
3.4206 3.6251 2.6303 4.5912 3.7299
 No.8 No.9 No.10 No.11 No.12
F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre F(%)_Pre Mean SD RSD(%)
0.00 0.00 0.00 0.00 0.00 0.00 0.00
3.67 3.96 3.22 4.52 4.43 3.90 0.58 14.97
7.25 7.81 6.37 8.90 8.72 7.70 1.14 14.80
10.74 11.56 9.45 13.15 12.88 11.39 1.67 14.63
14.15 15.20 12.46 17.26 16.92 14.99 2.17 14.45
17.46 18.75 15.40 21.24 20.83 18.48 2.64 14.27
20.69 22.19 18.28 25.09 24.61 21.87 3.08 14.09
23.83 25.54 21.09 28.81 28.27 25.16 3.50 13.91
26.89 28.78 23.84 32.41 31.81 28.36 3.89 13.73
29.87 31.93 26.52 35.88 35.23 31.46 4.26 13.54
32.76 34.99 29.14 39.24 38.54 34.47 4.60 13.36
35.58 37.96 31.69 42.47 41.73 37.39 4.92 13.17
38.31 40.83 34.19 45.59 44.81 40.22 5.22 12.98
40.96 43.61 36.62 48.59 47.78 42.96 5.49 12.79
43.54 46.31 38.99 51.48 50.64 45.61 5.74 12.59
46.04 48.91 41.30 54.26 53.39 48.17 5.97 12.40
48.47 51.43 43.55 56.93 56.04 50.65 6.18 12.20
50.82 53.87 45.74 59.50 58.59 53.05 6.37 12.00
53.10 56.22 47.88 61.96 61.03 55.36 6.53 11.80
55.31 58.50 49.96 64.32 63.38 57.60 6.68 11.60
57.45 60.69 51.98 66.58 65.63 59.76 6.81 11.40
59.52 62.80 53.95 68.74 67.79 61.83 6.92 11.19
61.52 64.84 55.86 70.81 69.86 63.84 7.01 10.99
63.45 66.80 57.72 72.78 71.83 65.77 7.09 10.78
65.32 68.69 59.53 74.66 73.72 67.62 7.15 10.57
67.12 70.50 61.28 76.46 75.52 69.41 7.19 10.36
68.86 72.24 62.99 78.16 77.24 71.12 7.22 10.15
70.54 73.91 64.64 79.79 78.87 72.76 7.23 9.94
72.16 75.52 66.24 81.33 80.42 74.34 7.23 9.72
73.71 77.05 67.79 82.79 81.90 75.86 7.21 9.51
75.21 78.53 69.30 84.17 83.30 77.30 7.18 9.29
76.65 79.93 70.76 85.47 84.63 78.69 7.14 9.08
78.03 81.28 72.17 86.71 85.88 80.01 7.09 8.86
79.35 82.56 73.53 87.87 87.06 81.28 7.02 8.64
80.63 83.78 74.85 88.96 88.18 82.48 6.95 8.42
81.84 84.95 76.12 89.98 89.23 83.63 6.86 8.20
83.01 86.05 77.35 90.94 90.21 84.73 6.76 7.98
84.13 87.10 78.54 91.83 91.14 85.77 6.65 7.76
85.19 88.10 79.69 92.67 92.00 86.75 6.54 7.54
86.21 89.05 80.79 93.44 92.81 87.69 6.42 7.32
87.18 89.94 81.85 94.16 93.56 88.58 6.28 7.10
88.10 90.78 82.88 94.82 94.25 89.42 6.15 6.87
88.98 91.58 83.86 95.44 94.90 90.21 6.00 6.65
89.81 92.32 84.81 96.00 95.49 90.95 5.85 6.43
90.60 93.03 85.71 96.51 96.03 91.66 5.70 6.21
91.35 93.68 86.59 96.98 96.53 92.32 5.53 5.99
92.05 94.30 87.42 97.40 96.99 92.94 5.37 5.78
92.72 94.87 88.22 97.78 97.40 93.52 5.20 5.56
93.35 95.41 88.98 98.13 97.78 94.06 5.03 5.35
93.94 95.90 89.72 98.43 98.12 94.56 4.85 5.13
94.50 96.36 90.41 98.70 98.42 95.03 4.68 4.92
tiempo generico D
5 18.39 19.28 25.24 20.32 18.96 15.24
10 31.51 27.22 33.56 30.03 28.93 21.94
15 48.39 42.58 51.71 47.19 46.32 37.89
20 61.44 52.86 65.05 62.04 59.1 46.96
25 71.41 61.58 71.47 70.31 68.09 54.73
30 74.57 69.17 76.8 77.35 74.4 50.75
35 78.07 71.4 79.14 83.14 81.27 65.09
40 81.21 74.17 83.38 84.67 87.68 67.41
45 82.3 75.91 85.77 85.16 88.52 69.48
50 82.98 76.67 85.58 83.79 88.78 70.67
55 81.65 75.53 85.31 84.87 89.01 71.65
60 81.96 77.03 84.53 84.09 88.89 72.12
16.28 11.98 10.6 11.64 13.22 14.64
34.25 27.66 24.84 27.67 32.59 31.46
50.14 41.19 33.96 39.9 44.86 42.29
65 55.28 51.88 50.83 60.87 60.29
68.96 64.77 61.9 60.07 72.39 70.97
74.48 66.96 69.88 66.31 76.36 79.44
82.57 73.91 80.63 70.87 84.56 84.99
87.21 80.91 89.68 72.97 88.09 87.36
89.54 84.98 92.62 77.17 92.13 89.34
88.86 86.34 93.14 78.26 93.24 93.7
89.05 86.98 94.47 78.8 95.34 91.75
89.57 84.93 92.74 80.52 95.37 90.82