Probioticos- Cepas,

microbiota, disbiose,
infecções. Trabalhos
 The role of lactobacilli and probiotics in maintaining vaginal health

Arch Gynecol Obstet (2014) 289:479–489

Trabalhos
Probióticos
 Intestinal fermentation of lactose and prebiotic lactose derivatives, including human milk oligosaccharides

International Dairy Journal 22 (2012) 123e140

 Intestinal fermentation of lactose and prebiotic lactose derivatives, including human milk oligosaccharides

International Dairy Journal 22 (2012) 123e140

Short- and long-term effects of a lactose-restricted diet and probiotics in children with chronic abdominal pain: A
retrospective study

aged 1e4 years with 2 g of powder 1 109 cfu/g Bifidobacterium and Lactobacillus, aged
5e18 years with 1 capsule 1 109 cfu/g Bifidobacterium and Lactobacillus).

Complementary Therapies in Clinical Practice 18 (2012) 81e84

 Probiotics for the Prevention and Treatment of Antibiotic-Associated Diarrhea A Systematic Review and Meta-
analysis

JAMA. 2012;307(18):1959-1969
 Probiotics for the Prevention and Treatment of Antibiotic-Associated Diarrhea A Systematic Review and Meta-
analysis

JAMA. 2012;307(18):1959-1969
 Probiotics for the Prevention and Treatment of Antibiotic-Associated Diarrhea A Systematic Review and Meta-
analysis

JAMA. 2012;307(18):1959-1969
 A systematic review and meta-analysis of probiotics for the management of radiation induced bowel disease

Clinical Nutrition xxx (2013) 1e8

 A systematic review and meta-analysis of probiotics for the management of radiation induced bowel disease

Clinical Nutrition xxx (2013) 1e8

 A systematic review and meta-analysis of probiotics for the management of radiation induced bowel disease

Clinical Nutrition xxx (2013) 1e8

Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis
– current evidence and potential clinical applications

Aliment Pharmacol Ther 2014; 40: 409–421

Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis
– current evidence and potential clinical applications

Aliment Pharmacol Ther 2014; 40: 409–421

Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis
– current evidence and potential clinical applications

Aliment Pharmacol Ther 2014; 40: 409–421

Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis
– current evidence and potential clinical applications

Aliment Pharmacol Ther 2014; 40: 409–421

Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis
– current evidence and potential clinical applications

Aliment Pharmacol Ther 2014; 40: 409–421

Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis
– current evidence and potential clinical applications

Aliment Pharmacol Ther 2014; 40: 409–421

Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis
– current evidence and potential clinical applications

Aliment Pharmacol Ther 2014; 40: 409–421

Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis
– current evidence and potential clinical applications

Aliment Pharmacol Ther 2014; 40: 409–421

Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis
– current evidence and potential clinical applications

Aliment Pharmacol Ther 2014; 40: 409–421

Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis
– current evidence and potential clinical applications

Aliment Pharmacol Ther 2014; 40: 409–421

Systematic review: the role of the gut microbiota in chemotherapy- or radiation-induced gastrointestinal mucositis
– current evidence and potential clinical applications

Aliment Pharmacol Ther 2014; 40: 409–421

 Uremia and chronic kidney disease: The role of the gut microflora and therapies with pro- and prebiotics

Mol. Nutr. Food Res. 2013, 57, 824–832

 Uremia and chronic kidney disease: The role of the gut microflora and therapies with pro- and prebiotics

Mol. Nutr. Food Res. 2013, 57, 824–832

 The role of probiotics in gastrointestinal surgery

Nutrition 28 (2012) 230–234

 Probiotics in primary prevention of allergic disease – follow-up at 8–9 years of age

Allergy 68 (2013) 1015–1020

 Meta-Analysis of the Efficacy and Safety of Lactobacillus containing and Bifidobacterium-containing Probiotic
Compound Preparation in Helicobacter pylori Eradication Therapy

J Clin Gastroenterol 2013;47:25–32)

 Meta-Analysis of the Efficacy and Safety of Lactobacillus containing and Bifidobacterium-containing Probiotic
Compound Preparation in Helicobacter pylori Eradication Therapy

J Clin Gastroenterol 2013;47:25–32)

 Meta-Analysis of the Efficacy and Safety of Lactobacillus containing and Bifidobacterium-containing Probiotic
Compound Preparation in Helicobacter pylori Eradication Therapy

J Clin Gastroenterol 2013;47:25–32)

 Probiotic and Prebiotic Influence Beyond the Intestinal Tract

Nutrition Reviews, Vol. 65, No. 11

 Gut microbiota, probiotics and diabetes

Nutrition Journal 2014, 13:60

 Gut microbiota, probiotics and diabetes

Nutrition Journal 2014, 13:60

 Gut microbiota, probiotics and diabetes

Nutrition Journal 2014, 13:60

 Gut microbiota, probiotics and diabetes

Nutrition Journal 2014, 13:60

 Probiotics and prebiotics in dermatology

J Am Acad Dermatol 2014;71:814-21.)

 Probiotics and prebiotics in dermatology

J Am Acad Dermatol 2014;71:814-21.)

 The efficacy of Lactobacillus reuteri DSM 17938 in infants and children: a review of the current evidence

Eur J Pediatr (2014) 173:1327–1337

 The efficacy of Lactobacillus reuteri DSM 17938 in infants and children: a review of the current evidence

Eur J Pediatr (2014) 173:1327–1337

 Probiotics for childhood functional gastrointestinal disorders: a systematic review and meta-analysis

Acta Pædiatrica. 2014 103, pp. 365–372

 Probiotics for childhood functional gastrointestinal disorders: a systematic review and meta-analysis

Acta Pædiatrica. 2014 103, pp. 365–372

 Probiotics for childhood functional gastrointestinal disorders: a systematic review and meta-analysis

Acta Pædiatrica. 2014 103, pp. 365–372

 Probiotics for childhood functional gastrointestinal disorders: a systematic review and meta-analysis

Acta Pædiatrica. 2014 103, pp. 365–372

 A combination of calcium phosphate and probiotics beneficially influences intestinal lactobacilli and cholesterol
metabolism in humans

L. paracasei LPC37. Calcium supplementation of 1 g/d, CaP L. paracasei LPC37, was added to a yoghurt drink at a concentration
of 1010 CFU/g.
Clinical Nutrition 31 (2012) 230e237
 A combination of calcium phosphate and probiotics beneficially influences intestinal lactobacilli and cholesterol
metabolism in humans

L. paracasei LPC37. Calcium supplementation of 1 g/d, CaP L. paracasei LPC37, was added to
a yoghurt drink at a concentration of 1010 CFU/g.

Clinical Nutrition 31 (2012) 230e237

A trial of adding Lactobacillus johnsonii EM1 to levocetirizine for treatment of perennial allergic rhinitis in children
aged 7–12 years

levocetirizine plus Lj EM1 (TTY Biopharm Com. Taiwan) for 12 weeks, then vice versa for a further 12 weeks. For
the first 12 weeks, 32 subjects (group 1) took levocetirizine (5 mg) combined with Lj EM1 (1 1010 cfu/capsule),
International Journal of Pediatric Otorhinolaryngology 76 (2012) 994–1001
 Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial

Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis subsp. Lactis Bb-12 (Bb-12) and L. acidophilus La-
5 (La-5), equalling 5 · 1010 colony-forming units of LGG and Bb-12, and 5 · 109 of La-5 per day. 36 weeks of
gestation to 3 months postnatally

British Journal of Dermatology 2010 163, pp616–623

 Probiotics in pregnant women to prevent allergic disease: a randomized, double-blind trial

Lactobacillus rhamnosus GG (LGG), Bifidobacterium animalis subsp. Lactis Bb-12 (Bb-12) and L. acidophilus La-5
(La-5), equalling 5 · 1010 colony-forming units of LGG and Bb-12, and 5 · 109 of La-5 per day. 36 weeks of
gestation to 3 months postnatally
British Journal of Dermatology 2010 163, pp616–623
 Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: does it also
reduce atopic sensitization?

Clinical & Experimental Allergy, 43, 1048–1057

 Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: does it also
reduce atopic sensitization?

Clinical & Experimental Allergy, 43, 1048–1057

 Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: does it also
reduce atopic sensitization?

Clinical & Experimental Allergy, 43, 1048–1057

 Early supplementation with Lactobacillus rhamnosus HN001 reduces eczema prevalence to 6 years: does it also
reduce atopic sensitization?

Clinical & Experimental Allergy, 43, 1048–1057

 Oral administration of the probiotic Lactobacillus fermentum VRI-003 and mucosal immunity in endurance
athletes

Br J Sports Med 2010;44:222–226.

 Meta-Analysis: Lactobacillus Containing Quadruple Therapy Versus Standard Triple First-Line Therapy for
Helicobacter pylori Eradication

Helicobacter 14: 97–107

 Probiotic Effects on Cold and Influenza-Like Symptom Incidence and Duration in Children

Pediatrics 2009;124:e172–e179
 Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid
arthritis
patients: a randomized double-blind clinical trial

International Journal of Rheumatic Diseases 2014; 17: 519–527 L. casei

 Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid
arthritis
patients: a randomized double-blind clinical trial

International Journal of Rheumatic Diseases 2014; 17: 519–527 L. casei

 Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid
arthritis
patients: a randomized double-blind clinical trial

International Journal of Rheumatic Diseases 2014; 17: 519–527 L. casei

 Effects of Lactobacillus casei supplementation on disease activity and inflammatory cytokines in rheumatoid
arthritis
patients: a randomized double-blind clinical trial

International Journal of Rheumatic Diseases 2014; 17: 519–527 L. casei

 Randomised clinical trial: a liquid multi-strain probiotic vs. placebo in the irritable bowel syndrome – a 12 week
double blind
study

Lactobacillus rhamnosus, Lactobacillus plantarum,

Lactobacillus acidophilus and Enterococcus faecium
Aliment Pharmacol Ther 2014; 40: 51–62
 Effect of multispecies probiotics on irritable bowel syndrome: A randomized, double-blind, placebo-controlled
trial

Journal of Gastroenterology and Hepatology 29 (2014) 52–59

 Effect of multispecies probiotics on irritable bowel syndrome: A randomized, double-blind, placebo-controlled
trial

Journal of Gastroenterology and Hepatology 29 (2014) 52–59

 Probiotics Prevent Hepatic Encephalopathy in Patients With Cirrhosis: A Randomized Controlled Trial

Bifidobacterium breve, Bifidobacterium

Clinical Gastroenterology and Hepatology 2014;12:1003–1008
longum, Bifidobacterium infantis, Lactobacillus
acidophilus,
Lactobacillus plantarum, Lactobacillus paracasei,
Lactobacillus
bulgaricus, andStreptococcus thermophilus
 The role of lactobacilli and probiotics in maintaining vaginal health

Arch Gynecol Obstet (2014) 289:479–489

 The role of lactobacilli and probiotics in maintaining vaginal health

Arch Gynecol Obstet (2014) 289:479–489

 The role of lactobacilli and probiotics in maintaining vaginal health

Arch Gynecol Obstet (2014) 289:479–489

 The role of lactobacilli and probiotics in maintaining vaginal health

Arch Gynecol Obstet (2014) 289:479–489

 Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double-blind, randomized, placebo-
controlled study

8 billion colony-forming units of live lactic bacteria that included L rhamnosus (6.8 billion stabilized lactic ferments), L
acidophilus (0.4 billion stabilized lactic ferments), and Streptococcus thermophilus (0.8 billion stabilized lactic ferments)

Am J Obstet Gynecol 2010;203:120.e1-6.

 Efficacy of vaginal probiotic capsules for recurrent bacterial vaginosis: a double-blind, randomized, placebo-
controlled study

8 billion colony-forming units of live lactic bacteria that included L rhamnosus (6.8 billion stabilized lactic ferments), L
acidophilus (0.4 billion stabilized lactic ferments), and Streptococcus thermophilus (0.8 billion stabilized lactic ferments)
Am J Obstet Gynecol 2010;203:120.e1-6.
Effects of probiotics supplementation on gastrointestinal permeability, inflammation and exercise performance in
the heat

Eur J Appl Physiol (2014) 114:93–103

Lições de Probióticos.
• Uso apropriado dá resultados.
• Certificar da sobrevivência.
• Diferentes cepas... A diversidade é importante, mas há
trabalhos com uma única cepa.
• Diferentes cepas para diferentes problemas?
• Prebióticos são fundamentais.
Obrigado