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Growth factors
RTK Hypoxia
Ca2+
Glucose
Amino
acids
PIP2
PIP3
Grb IRS1
PI3K
SOS
Ras
GDP
Ras PTEN MO25 STRAD Ca2+
GTP LKB1 CaM ATP
Raf MEK PDK1
CAMKKβ
{
NF1
GTP
ERK AKT REDD1 AMP:ATP RAG A/B
Cytoskeleton α γ
ZMP RAG C/D
organization GTP AMPKβ
GDP
Rheb
TSC2
PKCα TSC1
Deptor SIN1 GDP GTP
mTOR mTORC2 Rheb Rheb
Protor LST8
PDK1 Rictor
PRAS40
Raptor
Ion PDK1 mTOR ULK1 FIP200
transport Deptor LST8 ATG13 Autophagy
SGK1
Growth
S6K1 mTORC1 4EBP1
eIF4E AUG