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EBV‑LMP1 is involved in vasculogenic mimicry
Current Issue formation via VEGFA/VEGFR1 signaling in
Early Online nasopharyngeal carcinoma
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Authors: San Xu, Ju Bai, Zhou Zhuan, Bo Li, Zhibao Zhang, Xia Wu, Xiangjian Luo,
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Lifang Yang
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July 2018
Social Media Published online on: May 3, 2018     https://doi.org/10.3892/or.2018.6414 Volume 40 Issue 1
Print ISSN: 1021-335X
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Pages: 377-384 Online ISSN:1791-2431
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Editorial Policies The Epstein-Barr virus latent membrane protein 1 (EBV‑LMP1) is an oncoviral protein
that plays an important role in oncogenic transformation in EBV‑associated Cite This Article
Editorial Board
nasopharyngeal carcinoma (NPC). Our previous studies demonstrated that LMP1 Create Citation Alert
Aims and Scope increased VEGFA expression and upregulated angiogenesis in NPC. Vasculogenic Cited By
Abstracting and mimicry (VM) is a mechanism by which tumor cells can obtain nutrients to survive, and
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Indexing VM has been observed in numerous types of tumors. However, the occurrence and
Bibliographic significance of VM in NPC and the relationship between LMP1 and VM have not yet been on Spandidos
evaluated. In the present study, we observed that it was almost impossible for LMP1- Publications
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negative NPC cells to form tubular structures, whereas LMP1-positive NPC cells were Similar Articles
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Librarians able to form tubular structures. Moreover, VEGFA was found to be involved in VM
on Google Scholar
formation in LMP1-positive NPC cells. Knockdown of LMP1 or VEGFR1 distinctly
Information for on Pub Med
disrupted tubular structures, whereas inhibition of VEGFR2 did not affect the process,
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indicating that VEGFR1 not VEGFR2 signaling was involved in LMP1-mediated VM Copyright
Reprints and formation. Furthermore, the data of immunohistochemistry (IHC) and CD34/PAS double © Get Permissions
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staining in a tumor tissue array showed that LMP1 was positively correlated with
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 VEGFR1 and VM. Meanwhile, after analyzing the clinicopathological features, we found Journal Metrics
that VM formation was associated with a poor prognosis in NPC patients. These results
General suggest that VM formation is increased by EBV‑LMP1 via VEGF/VEGFR1 signaling and Impact Factor: 2.976
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provide additional information to clarify the role of EBV‑LMP1 in NPC pathophysiology. Ranked #29/222
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Epstein-Barr virus oncoprotein LMP1 mediates survivin upregulation by p53 CiteScore: 3.03
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contributing to G1/S cell cycle progression in nasopharyngeal carcinoma CiteScore Rank: #99/323
Contact Mammalian target of rapamycin signaling is involved in the vasculogenic mimicry of Oncology
Terms and glioma via hypoxia-inducible factor-1α Source Normalized
Conditions Low dosage of arsenic trioxide inhibits vasculogenic mimicry in hepatoblastoma without Impact per Paper (SNIP):
cell apoptosis 0.754
Vasculogenic mimicry is associated with poor survival in patients with mesothelial SCImago Journal Rank
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