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A 60-year-old man comes to the office due to erectile
dysfunction that has progressed
slowly over the last year. He finds it difficult to attain an
erection and has noted a
decrease in nocturnal erections. Medical history is
significant for type 2 diabetes mellitus
and benign prostatic hyperplasia. Ophthalmologic
evaluation 6 months ago revealed
diabetic retinopathy that was treated with
photocoagulation. The patient also had a
negative treadmill cardiac stress test 4 months ago after
presenting with atypical chest
discomfort. Current medications include metformin,
sitagliptin, rosuvastatin, and
doxazosin. Blood pressure is 122/70 mm Hg and pulse is
76/min. Cardiopulmonary
examination is unremarkable except for mildly decreased
pedal pulses on the right.
There is decreased vibration sensation in both feet.
Hemoglobin A 1 c measured 2 weeks
ago was 8%. The patient requests a prescription for
sildenafil. Which of the following is
the most important concern in prescribing sildenafil to
this patient?
o A Diabetic retinopathy
o B. Interaction with doxazosin
o C. Interaction with metformin
o D. Peripheral neuropathy
o E. Peripheral vascular disease
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