Professional Documents
Culture Documents
First
IBRO-‐UM5
Advanced
School
in
Neuroscience
On
Basal
Ganglia,
Parkinson’s
disease
And
Related
Disorders
May
9-‐21,
2016
Faculty
of
Sciences
Centre
of
Rehabilitation
and
Neuroscience
Rabat
MOROCCO
Chair
of
the
school:
Prof
Nouria
Lakhdar-‐Ghazal
Faculty
of
Sciences
–
Mohammed
V
University
IBRO
Scientific
Committee
of
the
school
Nouria
Lakhdar-‐Ghazal
(Morocco)
Abdesslam
El
Khamlichi
(Morocco)
Abdelhamid
Benazzouz
(France)
Abdeljabbar
El
Manira
(Sweden)
1
PROGRAM
May
8th:
Arrival
of
Students
May
9th
Venue:
Faculty
of
Sciences
“Salle
des
Actes”
15:00
Presentation
of
students
and
lecturers,
presentation
of
the
program
17:00
-‐
18:00:
Opening
lecture:
Wail
Benjelloun:
(Past
President
of
Mohammed
V
University;
Président
de
l’UNIMED
-‐Union
des
Universités
de
la
Méditerranée-‐
Rome,
Italy)
-‐
Neuroscience
and
the
early
exchange
of
knowledge
around
the
Mediterranean
18:00
-‐
19:00:
Welcome
reception
at
the
Faculty
of
Sciences
May
10th
Venue:
National
Centre
of
Rehabilitation
and
Neurosciences,
Ibn
Sina
Hospital,
Rabat
10:00
-‐
10:45:
Abdelhamid
Benazzouz
(Institut
des
maladies
neurodégénératives,
Equipe
Monoamines,
Stimulation
Cérébrale
Profonde
et
Maladie
de
Parkinson,
CNRS
UMR
5293,
Université
de
Bordeaux,
France):
-‐
Functional
organization
of
the
motor
and
non-‐motor
circuits
15’
min
discussion
11:00
-‐
11:20:
Coffee/Tea
11:20
-‐11:50:
Najia
El
Abbadi
(Service
de
Neurochirurgie,
Hôpital
Avicenne,
Centre
Hospitalier
Ibn
Sina,
Rabat)
-‐
Basal
ganglia
and
development
of
stereotaxic
surgery
in
humans:
15’
discussion
12:00
-‐
14:30:
Lunch
14:30
-‐
15:00:
W.
Regragui
(Service
de
Neurologie
B,
Hôpital
des
Spécialités
de
Rabat,
Centre
Hospitalier
Ibn
Sina)
-‐
Clinical
diagnosis
of
Parkinson's
disease
15’
discussion
15:15
-‐
15:45:
Coffee/tea
15:45-‐18:00:
Visit
to
the
National
Centre
of
Rehabilitation
and
Neurosciences
May
11th
Venue:
Faculty
of
Sciences
«Salle
des
Actes»
8:30
–
9:15:
Abdelhamid
Benazzouz
-‐
Involvement
of
basal
ganglia
in
the
pathophysiology
of
Parkinson’s
disease
15’
discussion
2
9:30
-‐
10:00:
Mounia
Rahmani
(Service
de
Neurologie
A
et
de
Neuropsychologie,
Hôpital
des
Spécialités
de
Rabat,
Centre
Hospitalier
Ibn
Sina)
-‐
Medical
management
of
Parkinson's
disease
15’
discussion
10:15
-‐
10:45:
Coffee/Tea
10:45
-‐
11:45:
Abdelhamid
Benazzouz
-‐
Deep
brain
stimulation
in
Parkinson’s
disease
15’
discussion
12:00
-‐
14:00:
Lunch
Venue:
Faculty
of
Sciences
«Salle
des
Actes»
Session
3:
Neurochemical
“signature”
of
Parkinson’s
disease
14:00
-‐
14:45:
Abdelhamid
Benazzouz
-‐
Dopamine
control
of
extrastriatal
basal
ganglia:
Physiology
and
Parkinson’s
disease
pathophysiology
15’
discussion
15:00
-‐
15:45:
Philippe
De
Deurwaerdère
(Institut
des
maladies
neurodégénératives,
Equipe
Monoamines,
Stimulation
Cérébrale
Profonde
et
Maladie
de
Parkinson,
CNRS
UMR
5293,
Université
de
Bordeaux).
-‐
The
status
of
monoaminergic
systems
in
Parkinson’s
disease.
15’discussion
16:00
-‐
16:20:
Coffee/Tea
16:20
-‐
19:00:
Teachers
and
students
Which
is
the
state
of
neuroscience
research
in
Africa
nowadays?
May
12th
Venue:
Faculty
of
Sciences
«Salle
des
Actes»
Session
4:
Pharmacology
of
dopamine-‐linked
therapies
8:30
-‐
9:15:
Philippe
De
Deurwaerdère
-‐
Neurochemistry
of
L-‐DOPA,
part
1:
Beyond
striatal
dopamine
in
the
benefit
and
motor
side
effects
of
L-‐DOPA
15’
discussion
9:30
-‐
10:15:
Philippe
De
Deurwaerdère
-‐
Neurochemistry
of
L-‐DOPA,
part
2:
Are
classical
antidepressant
drugs
adapted
to
the
situation
of
parkinsonian
patients
treated
with
L-‐DOPA?
15’
discussion
3
10:30
-‐
10:50:
Coffee/Tea
10:50
-‐
12:30:
Anas
Tinakoua
(IBRO
Alumni;
Post
Doc,
Unit
of
Biological
Rhythms,
Neuroscience
and
Environment,
Faculty
of
Sciences,
Mohammed
V
University,
Rabat,
Morocco)
-‐Journal
Club
«Are
pesticides
a
risk
factor
for
Parkinson’s
disease?”
12:50
-‐
14:30:
Lunch
Session
5:
Modelling
of
Parkinson’s
Disease
14:30
-‐
16:30:
Frédéric
Alexandre
(Institut
des
Maladies
Neurodégénératives,
MNEMOSYNE
team
–
INRIA
Bordeaux,
CNRS
UMR
5293,
France)
-‐Introduction
to
Reinforcement
Learning
I:
respondent
conditioning,
rewards
and
emotions
-‐
Introduction
to
Reinforcement
Learning
II:
instrumental
conditioning,
needs
and
motivations
16:30
-‐
17:00:
Coffee/tea
17:00
-‐
18:30:
Frédéric
Alexandre
-‐
Modelling
basal
ganglia
and
Parkinson's
disease
15’
discussion
May
13th
all
day
Venue:
Neuroscience
lab,
Faculty
of
Sciences
8:30
-‐
12:30:
Anas
Tinakoua
(IBRO
Alumni;
Post
Doc,
Unit
of
Biological
Rhythms,
Neuroscience
and
Environment,
Faculty
of
Sciences,
Mohammed
V
University,
Rabat,
Morocco)
&
Abdelhamid
Benazzouz
(Institut
des
maladies
neurodégénératives,
Equipe
Monoamines,
Stimulation
Cérébrale
Profonde
et
Maladie
de
Parkinson,
CNRS
UMR
5293,
Université
de
Bordeaux,
France)
Hands
on:
• Monoamine
depletion
as
animal
model
of
Parkinson’s
disease
• Stereotaxic
injection
in
the
medial
forebrain
bundle
of
pharmacological
agents
for
monoamine
depletion
• Cognitive
and
motor
tests
for
“Parkinsonian”
rats
(Rotarod,
Open
Field,
Plus
maze)
12:30
-‐
14:30:
Lunch
14:30
-‐
18:00:
Anas
Tinakoua,
Safa
Bouabid
&
Alamy
Meryem
(Unit
of
Biological
Rhythms,
Neuroscience
and
Environment,
Faculty
of
Sciences,
Mohammed
V
University,
Rabat)
• Hands
on:
Cognitive
and
motor
tests
for
“Parkinsonian”
rats
(Plus
Maze,
Morris
Water
Maze)
followed
by
perfusion
and
fixation
of
the
brains
for
tyrosin-‐hydroxylase
immunocytochemistry
4
May
14
Venue:
Neuroscience
Lab
&
Chemistry
Lab,
Faculty
of
Sciences
8:30
-‐
12:30:
Philippe
De
Deurwaerdère
• Hands
on:
High
Phase
Liquid
Chromatography
Technique
12:30
-‐
14:00:
Lunch
14:00
-‐
18:00:
Philippe
De
Deurwaerdère
• Hands
on:
High
Phase
Liquid
Chromatography
Technique
18:30
-‐
20:00:
Certificates
Ceremony
20:00:
Gala
dinner
May
15
Venue:
Faculty
of
Sciences
«Salle
des
Actes»
8:30
-‐9:15:
Karim
Fifel
(IBRO
alumni-‐post
Doc-‐
Leiden
University
Medical
Center,
The
Netherlands)
-‐Physiology
of
the
circadian
rhythm
function
15’
discussion
9:30-‐10:15:
KarimFifel
-‐Pathophysiology
of
circadian
rhythm
in
Parkinson’s
disease
and
animal
models
of
the
disease
15’
discussion
10:30
-‐
10:50:
Coffee/Tea
10:50
-‐
12:30:
Students'
oral
presentations
12:30
-‐
14:00:
Lunch
Venue:
Neuroscience
Lab,
Faculty
of
Sciences
14:00
-‐
18:00:
Karim
Fifel,
Safa
Bouabid
&
Anas
Tinakoua
• Hands
on:
Immunohistochemistry
(Cutting
brains
and
1st
step
of
incubation
with
tyrosine
hydroxylase
primary
antibody)
May
16
Venue:
Faculty
of
Sciences
«
Salle
des
Actes
»
5
8:30
-‐
9
.15:
Sten
Grillner
(Karolinska
Institute,
Departement
of
Neuroscience,
Nobel
Institute
of
Neurophysiology,
Stockholm,
Sweden;
Past
IBRO
Secretary
General)
"The
basal
ganglia
over
500
million
years”
9:30
-‐
10:15:
Marina
Bentivoglio
(Department
of
Neuroscience,
Biomedicine
and
Movement
Sciences,
University
of
Verona,
Verona,
Italy;
Past
IBRO
Secretary
General)
-‐
Neuroinflammation
in
Parkinson’s
disease
and
its
models
15’
discussion
10:15
-‐
10:35:
Coffee/Tea
10:35
-‐
11:20:
Marina
Bentivoglio
-‐
Neocortex,
hippocampus
and
Parkinson’s
disease
15’
discussion
11:35
-‐
12:30:
Sten
Grillner
-‐
Why
two
IBRO
Advanced
School
Sites
in
Africa?
12:30
-‐
14:30:
Lunch
14:30
-‐
15:15:
Marina
Bentivoglio
-‐Non-‐motor
symptoms
in
Parkinson’s
disease
15’
discussion
15:30
-‐
16:15:
Nouria
Lakhdar-‐Ghazal
(Unit
Biological
Rhythms,
Neuroscience
&
Environment,
Faculty
of
Sciences,
Mohammed
V
University,
Rabat)
-‐
Environmental
pollutant
as
risk
factor
for
Parkinson’s/Parkinsonism
diseases
15’
discussion
16:30
-‐
16:50:
Coffee/Tea
16:50
-‐
17:35:
Safa
Bouabid
(IBRO
Alumni;
Post
doc
at
Unit
Biological
Rhythms,
Neuroscience
&
Environment,
Faculty
of
Sciences,
Mohammed
V
University,
Rabat,
Morocco)
-‐
Manganism
versus
Parkinson's
disease:
similarities
and
differences
15’
discussion
17:50
-‐
18:50:
KarimFifel
-‐
Journal
Club
May
17
Venue:
Faculty
of
Sciences
«
Salle
des
Actes
»
8:30
-‐
9:15:
Mimoun
Azzouz
(Chair
of
Translational
Neuroscience,
Director
of
Research
&
Innovation,
Department
of
Neuroscience,
Sheffield
Institute
for
Translational
Neuroscience,
University
of
Sheffield,
UK)
-‐
Introduction
to
motor
neuron
diseases
15’
discussion
6
9:15
-‐
10:00:
Mimoun
Azzouz
-‐
“Principles
of
gene
therapy”
15’
discussion
10:15
-‐
10:45:
Coffee/Tea
10:45
-‐
11:45:
Mimoun
Azzouz
-‐
Gene-‐based
therapeutics
for
Parkinson’s
disease
and
related
motor
disorders
15’
discussion
12:00
-‐
14:30:
Lunch
14:30
-‐
18:00:
Marina
Bentivoglio
"Preparation
of
scientific
papers
and
publishing
business"
May
18
8:30
-‐
12:30:
Safa
Bouabid
&
Anas
Tinakoua
-‐
Hands
on:
Immunohistochemistry
(2nd
and
3rd
incubations,
revelation
in
3-‐3’
diaminobenzidine/H2O2;
observation)
12:30
-‐
14:30:
Lunch
14:30
-‐
17:30:
Safa
Bouabid
&
Anas
Tinakoua
(Unit
of
Biological
Rhythms,
Neuroscience
and
Environment,
Faculty
of
Sciences,
Mohammed
V
University,
Rabat,
Morocco)
-‐
Hands
on:
Immunohistochemistry
-‐
continuation:
observation
and
semi
quantification
of
labelled
neurons
May
19:
Free
May
20th
Venue:
Faculty
of
Sciences
“Salle
des
Actes"
8:30
-‐
9:15:
Abdeljabbar
El
Manira
(Karolinska
Institute,
Department
of
Neuroscience,
Nobel
Institute
of
Neurophysiology,
Sweden)
-‐
Neural
circuits
for
motor
actions
I
15’
discussion
9:30
-‐
10:15:
Abdeljabbar
El
Manira
-‐
Neural
circuits
for
motor
actions
II
15’
discussion
10:30
-‐10:50:
Coffee/Tea
7
10:50
-‐
11:20:
Maria
Benabdeljlil
(Service
de
Neurologie
A,
Hôpital
des
Spécialités
de
Rabat,
Centre
Hospitalier
Ibn
Sina)
-‐
Neuropsychology
of
basal
ganglia
15’
discussion
11:35
-‐
12:05:
M.
Boutarbouch
(Service
de
Neurochirurgie,
Hôpital
des
Spécialités
de
Rabat,
Département
d’Anatomie,
Faculté
de
Médecine
et
de
Pharmacie
de
Rabat)
&
M.
Jiddane
(Service
de
Neuroradiologie,
Hôpital
des
Spécialités
de
Rabat,
Centre
Hospitalier
Ibn
Sina)
-‐
Imaging
insight
into
basal
ganglia
function
and
pathology
15’
discussion
12:30
-‐
14:00:
Lunch
14:00
-‐
18:30:
Students'
oral
presentations
May
21st
8:30
-‐
9:00:
A.
Melhaoui
(Service
de
Neurochirurgie,
Hôpital
des
Spécialités
de
Rabat,
Centre
Hospitalier
Ibn
Sina)
-‐
Basal
ganglia
and
other
movement
disorders
15’
discussion
9:15
-‐
9:45:
Mounia
Rahmani
&
Mustapha
Alaoui-‐Faris
(Service
de
Neurologie
A
et
de
Neuropsychologie,
Hôpital
des
Spécialités
de
Rabat,
Centre
Hospitalier
Ibn
Sina)
-‐
Basal
ganglia
and
neuropsychiatric
diseases
15’
discussion
9:45
-‐
10:05:
Coffee/Tea
10:05
-‐
10:35:
Y.
Arkha
(Service
de
Neurochirurgie,
Hôpital
des
Spécialités,
Rabat)
-‐
Role
of
radiosurgery
in
the
management
of
lesions
located
in
basal
ganglia
10:35
-‐
12:30:
Workshops
at
Centre
National
de
Rehabilitation
et
de
Neurosciences,
Centre
Hospitalier
Ibn
Sina,
Rabat
W.
Regragui
(Service
de
Neurologie
B,
Hôpital
des
Spécialités
de
Rabat,
Centre
Hospitalier
Ibn
Sina)
&
M.
Rahmani
(Service
de
Neurologie
A
et
de
Neuropsychologie,
Hôpital
des
Spécialités
de
Rabat,
Centre
Hospitalier
Ibn
Sina)
-‐Patient
selection
for
surgery
of
Parkinson’s
disease
12:30
-‐
14:30:
Lunch
14:30
-‐
17:30:
Workshops
at
Centre
National
de
Rehabilitation
et
de
Neurosciences,
Centre
Hospitalier
Ibn
Sina,
Rabat
Continuation
Najia
El
Abbadi
(Service
de
Neurochirurgie,
Hôpital
Avicenne,
Rabat)
et
A.
Melhaoui
(Service
de
Neurochirurgie,
Hôpital
des
Spécialités,
Rabat)
8
9