Metabolic Syndrome

How Do We Protect our

Future Generation?
Ayu Luh Ratri Wening, S.Ked
METABOLIC SYNDROME

(O'Neill and O'Driscoll, 2015)

25% of world’s population
has Metabolic Syndrome
(International Diabetes Foundation
estimation)
(O'Neill and O'Driscoll, 2015)
Obesity currently affects approximately
one-third of reproductive age women
leading to a high prevalence of obesity
in pregnancy
(Howell and Powell, 2017).

’’
 Metabolic Syndrome in
Pregnancy

5-7% ⅓ 2-9%
Metabolic syndrome One-third of all GDM occurs in 2-9% of
occurs in 5-7% of pregnancies complicated pregnancies.
pregnancy. by maternal obesity.

(Eslamian et. al., 2013; Ryckman et. al., 2013; O'Neill and O'Driscoll, 2015)
(Howell and Powell., 2017)
 Metabolic Syndrome Consequences
during Pregnancy
Early pregnancy Spontaneous abortion
Recurrent miscarriage
Congenital anomalies
Late pregnancy Hypertensive disorder of pregnancy
Gestational nonproteinuric hypertension
Preeclamsia
Gestational Diebetes Mellitus
Preterm birth
Intrauterine fetal demise (stillbirth)
Peripartum Caesarean delivery
Decreased VBAC success
Operative morbidity
Fetal/neonatal complication Fetal macrosomia
Shoulder dystorcia
Childhood obesity

(Leddy et. al., 2008)

Adjustment to Routine ANC in Obese Pregnant Woman

(Leddy et. al., 2008)

6-
39%
children and adolescents
has metabolic syndrome.

(Bussler et. al., 2017)

Parenteral Contribution for metabolic Disease Programming

(Sales et. al., 2007)

Metabolic Syndrome in
Children

(Bussler et. al., 2017)

MetSyn consequences
in children

CVD

Type II DM

PCOS

Cancer

Fatty liver

Obstructive sleep apnea

Osteoarthritis

Growth restriction

Psychological disorder

(Kelishadi et. al., 2012;

Wu et. al., 2016; Bussler et. al., 2017).
 HOW TO PROTECT OUR FUTURE GENERATION?

PREVENTIVE CURATIVE

Healthy parents Life style modification

Create healthy lifestyle Manage the abnormalities

Early detection and screening Treat the disease

Management interventions should focus on parents as the

‘agents of change’ for physical activity and nutrition while
integrating behavioral therapy techniques and interactive
education.

(Ling et. al., 2016)

Obesity
increased the
risk of
musculoskeletal
disorder.

(Vissher and Seidell, 2017)

Reference • Al-Hamad D and Raman V. 2017. Metabolic syndrome in children and
adolescents. Transl Pediatr 17;6(4):397-407.
• Bussler S, Penke M, Flemming G, Elhassan YS, Kratzsch J, Sergeyev E, Lipek
T, et. al. 2017. Novel Insights in the Metabolic Syndrome in Childhood and
Adolescence. Horm Res Pediatr, DOI: 10.1159/000479510.
• Gultom LC, Sjarif DR, Ifran EKB, Trihono PP, Batubara JRL. 2007. Metabolic
syndrome and visceral fat thickness in obese adolescents.PediatrIndones,
47:124-9.
• Kelishadi R, Poursafa P, de Ferranti S, Schwandt P, Adeli K, Onat A, Gidding
SS. 2012. PediatricMetabolic Syndrome: From Prevention to Treatment.
Cholesterol, 2012: 1-3.
• Leddy MA, Power ML, Schulkin J. 2008. The Impact of Maternal Obesity on
Maternal and Fetal Health. Reviews in Obstetrics & Gynecology, 1 (4): 170-
178.
• Nelson SM, Matthews P, Poston L. 2010. Maternal metabolism and obesity:
modifiable determinants of pregnancy outcome. Human Reproduction
Update, 16 (3): 255–275.
• Pulungan AB, Puspitadewi A, Sekartini R. 2013. Prevalence of insulin
resistance in obese adolescents Paediatrica Indonesiana, 53:167-72.
• Sales VM, Smith ACF, Patti ME. 2017. Epigenetic Mechanisms of
Transmission of Metabolic Disease across Generations. Cell Metabolism, 25:
559-571.
• Wu Y, Zhang CL, Zhen Q. 2016. Metabolic syndrome in children (Review).
Experimental and Therapeutic Medicine, 12: 2390-2394

(Vissher and Seidell, 2017)

 Than
k
you-
C R E A T I N I N E
Prevalence of
metabolic
syndrome (MS)
components in
mothers and
their children
(Hischler, 2007)