Professional Documents
Culture Documents
the Epidemic
• Same-day appointments
• Flexible provider scheduling (on-call back-up)
• ART-regimen preapproval prior to genotyping or lab
testing
• Availability of 5-day ART starter packs (Oh, San
Francisco!...)
• Accelerated process for health-insurance initiation
• Observation of first ART dose in clinic (recommended)
Male, 84.10%
Male, 74.80%
Latinx/Other 8.0%
STIs with diagnosis
Category Dx %
Syphilis 23.81%
CCSI Gonorrhea or Chlamydia 26.03%
Hepatitis B or C 4.76%
Syphilis 33%
EIS Gonorrhea or Chlamydia 24.1%
Hepatitis B or C 9.1%
Poverty Level and Insurance
Insured 44%
EIS Under 100% 36.62% EIS
Uninsured 56%
Linkage time for CCSI (Hours from Knowledge
of Diagnosis to Appointment with a Provider)
Linkage Time (Hours)
15,
11%
20,
14% Under 12 hours
69,
47% 24 hours
48 hours
72 hours
43,
29%
Baseline Data
• Baseline CD4
Category CD4 Median CD4% Median
CCSI 420 cells/mm3 27.65%
EIS 340 cells/mm3 18.4%
Suppressed Suppressed
Non-Suppressed Non-Suppressed
Suppressed Suppressed 91%
99%
145/147 Patients
achieved Viral 80/88 patients
suppression achieved viral
suppression
Results
1. Time from Diagnosis to First Viral Load Suppression: CCSI
2. Time from Linkage to Care to First Viral Load Suppression: EIS
CCSI 1 28 40.4
EIS2 27 51.28
CD4 Count, Viral Suppression, Transmitted Resistance
CCSI: EIS:
• All but two patients received TAF/FTC
+ DTG • All but five patients received TAF/FTC +
• 135/146 genotypes were performed DTG
and reviewed. • 87/95 genotypes were performed
• 26/135 (19%) with transmitted • 11/96 (11.4%) with transmitted
resistance resistance.
• 13 with NNRTI resistance • 9 with NNRTI mutations
• 3/26 with M184V/I with two • 2/9 with M184V/I no previous PrEP
previously on PrEP exposure
• 4/26 with multiple PI mutations
including L90M
• All patients with transmitted
resistance achieved viral suppression.
EIS Continuum of Care
70 67
63
60
55 56
50
100%
40 94%
90%
30 89%
20
10
0
Linked Prescribed Same Day ART Retained* Virally Suppressed in last 6
months**
Linked Prescribed Same Day ART Retained* Virally Suppressed in last 6 months**
*Retained at our facility. 4 patients moved out of state, 1 switched clinics in state.
** Viral load obtained from our clinic or the state database. 5 patients moved out of state.
Comparing Published Outcomes
1. CrescentCare Cohort Comparison
29 patients who were diagnosed the year before we initiated CCSI at our testing sites using
the same linkage coordinator and an integrase regimen but not immediate ART.
Mean time from diagnosis to suppression: 89 Days
Difference 43 days (CI: 30 – 55 days) P< 0.0001 (Published in AIDS Patient Care & STDs)
2. Grady Hospital:
90 Patients including new diagnosis, ART naïve and ART experienced immediate start within
72 hours of referral.
Median CD4 count 152 cells/mm
Median time to VS: 41 days
Yet, only 68/90 attended second provider visit
3. San Francisco:
2016: 80/265 patients diagnosed in SF were Rapid Start
Presented at CROI awaiting follow up data
.
NOLA EMA Data
How to Start ART Safely
With Minimal Clinical Data
• DHHS Recommendations, 20181 • Rationale for Recommendations1
– Transmitted mutations conferring
– Recognize International Data and resistance to NNRTI > PI or INSTI
Resource-intensive – Resistance to DRV and DTG emerge
– Avoid NNRTI-based regimens slowly
– Recommended regimensa – Transmitted HIVDR to DRV is rare
• BIC/TAF/FTC (recommended, but not – Single case of transmitted
yet listed
HIVDR to DTG
in DHHS guidelines)
• Subsequently randomized to
• DTG + tenofovirc/FTC
BIC/TAF/FTC and achieved VS
• DRV/r or DRV/cb + tenofovirc/FTC