2014-Efsa Journal SCLP

EFSA Journal 2014;12(1):3524
CONCLUSION ON PESTICIDE PEER REVIEW
Conclusion on the peer review of the pesticide risk assessment of the active
substance Straight Chain Lepidopteran Pheromones1
European Food Safety Authority2
European Food Safety Authority (EFSA), Parma, Italy
ABSTRACT
The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk
assessments carried out by the competent authority of the rapporteur Member State Austria, for the pesticide
active substance Straight Chain Lepidopteran Pheromones are reported. The context of the peer review was that
required by Commission Regulation (EC) No 2229/2004 as amended by Commission Regulation (EC) No
1095/2007. The conclusions were reached on the basis of the evaluation of the representative uses of Straight
Chain Lepidopteran Pheromones as a semio-chemical on stone fruit, pome fruit, tree nuts corn, vegetables,
citrus, olives, rice, grapes, cotton and flowers. The reliable endpoints concluded as being appropriate for use in
regulatory risk assessment, derived from the available studies and literature in the dossier peer reviewed, are
presented. Missing information identified as being required by the regulatory framework is listed.There is no
agreed technical specification covered by the toxicological and ecotoxicological assessments.
© European Food Safety Authority, 2014
KEY WORDS
Straight Chain Lepidopteran Pheromones, peer review, risk assessment, pesticide, semio-chemicals
1
On request from the European Commission, Question No EFSA-Q-2009-00294, approved on 13 December 2013.
2
Correspondence: pesticides.peerreview@efsa.europa.eu
Suggested citation: European Food Safety Authority, 2014. Conclusion on the peer review of the pesticide risk assessment of
the active substance Straight Chain Lepidopteran Pheromones. EFSA Journal 2014;12(1):3524. 537 pp.
doi:10.2903/j.efsa.2014.3524
Available online: www.efsa.europa.eu/efsajournal
© European Food Safety Authority, 2014

Peer review of the pesticide risk assessment of the active substance Straight Chain
Lepidopteran Pheromones
SUMMARY
Straight Chain Lepidopteran Pheromones is one of the 295 substances of the fourth stage of the review
programme covered by Commission Regulation (EC) No 2229/2004, as amended by Commission
Regulation (EC) No 1095/2007.
Straight Chain Lepidopteran Pheromones was included in Annex I to Directive 91/414/EEC on 18

December 2008 pursuant to Article 24b of the Regulation (EC) No 2229/2004 (hereinafter referred to
as „the Regulation‟) and has subsequently been deemed to be approved under Regulation (EC) No
1107/2009, in accordance with Commission Implementing Regulation (EU) No 540/2011, as amended
by Commission Implementing Regulation (EU) No 541/2011. In accordance with Article 25a of the
Regulation, as amended by Commission Regulation (EU) No 114/2010, the European Food Safety
Authority (EFSA) is required to deliver by 31 December 2012 its view on the draft review report
submitted by the European Commission in accordance with Article 25(1) of the Regulation. This
review report was established as a result of the initial evaluation provided by the designated rapporteur
Member State in the Draft Assessment Report (DAR). The EFSA therefore organised a peer review of
the DAR. The conclusions of the peer review are set out in this report.
Austria being the designated rapporteur Member State submitted the DAR on Straight Chain
Lepidopteran Pheromones in accordance with the provisions of Article 22(1) of the Regulation, which
was received by the EFSA on 2 April 2008. The peer review was initiated on 9 September 2011 by
dispatching the DAR for consultation of the Member States and the notifier International Bio-rationale
Manufacturing Association as the leader of the task force. Following consideration of the comments
received on the DAR, it was concluded that EFSA should conduct a focused peer review in the area of
mammalian toxicology and deliver its conclusions on Straight Chain Lepidopteran Pheromones.
The conclusions laid down in this report were reached on the basis of the evaluation of the
representative uses of Straight Chain Lepidopteran Pheromones as an semio-chemical on stone fruit,
pome fruit, tree nuts corn, vegetables, citrus, olives, rice, grapes, cotton and flowersas proposed by the
notifiers. Full details of the representative uses can be found in Appendix A to this report.
In the area of identity, physical/chemical/technical properties and methods of analysis numerous data
gaps were identified for all active substances.
In the mammalian toxicology section, data gaps were identified for the the identification of non-SCLP
impurities in the individual technical specifications and assessment of their toxicological relevance,
for the genotoxic potential of the SCLP aldehyde group, for the operator, worker and bystander
exposure to the spraying of microencapsulated vapour releasing system. Operator, worker and
bystander exposure risk assessment (to both application methods proposed) could not be finalised due
to a further data gap on the establishment of more reliable natural background levels.
In the residue section, the consumer risk assessment could not be finalised because of the data gaps
identified.
The information available on environmental fate and behaviour was insufficient to carry out the
necessary environmental exposure assessments or conclude that using products as proposed, would not
result in natural background levels being exceeded. This was because reliable observations or
measurements of natural background levels were not provided. This resulted in the conclusion that the
necessary assessments could not be finalised.
Data gaps were identified for suitable risk assessments for non-target organism (birds, mammals,
aquatic organisms, honey bees, non-target arthropods, earthworms, soil micro-organisms and non-
target plants). A low risk to sewage treatment organisms was concluded.
EFSA Journal 2014;12(1):3524 2

TABLE OF CONTENTS
Abstract .................................................................................................................................................... 1
Summary .................................................................................................................................................. 2
Table of contents ...................................................................................................................................... 3
Background .............................................................................................................................................. 4
The active substance and the formulated product .................................................................................... 6
Conclusions of the evaluation .................................................................................................................. 6
1. Identity, physical/chemical/technical properties and methods of analysis ...................................... 6
2. Mammalian toxicity ......................................................................................................................... 6
3. Residues ........................................................................................................................................... 8
4. Environmental fate and behaviour ................................................................................................... 8
5. Ecotoxicology .................................................................................................................................. 9
6. Overview of the risk assessment of compounds listed in residue definitions triggering assessment
of effects data for the environmental compartments .............................................................................. 10
6.1. Soil ........................................................................................................................................ 10
6.2. Ground water ........................................................................................................................ 11
6.3. Surface water and sediment .................................................................................................. 14
6.4. Air ......................................................................................................................................... 16
7. List of studies to be generated, still ongoing or available but not peer reviewed .......................... 18
8. Particular conditions proposed to be taken into account to manage the risk(s) identified............. 19
9. Concerns ........................................................................................................................................ 20
9.1. Issues that could not be finalised .......................................................................................... 20
9.2. Critical areas of concern ....................................................................................................... 20
9.3. Overview of the concerns identified for each representative use considered ....................... 20
References .............................................................................................................................................. 24
Appendices ............................................................................................................................................. 26
Abbreviations ....................................................................................................................................... 534
EFSA Journal 2014;12(1):3524 3

BACKGROUND
Straight Chain Lepidopteran Pheromones is one of the 295 substances of the fourth stage of the review
programme covered by Commission Regulation (EC) No 2229/2004,3 as amended by Commission
Regulation (EC) No 1095/2007.4
Straight Chain Lepidopteran Pheromones was included in Annex I to Directive 91/414/EEC5 on 18

December 2008 pursuant to Article 24b of the Regulation (EC) No 2229/2004 (hereinafter referred to
as „the Regulation‟) and has subsequently been deemed to be approved under Regulation (EC) No
1107/2009,6 in accordance with Commission Implementing Regulation (EU) No 540/2011,7 as
amended by Commission Implementing Regulation (EU) No 541/2011.8 In accordance with Article
25a of the Regulation, as amended by Commission Regulation (EU) No 114/20109 the European Food
Safety Authority (EFSA) is required to deliver by 31 December 2012 its view on the draft review
report submitted by the European Commission in accordance with Article 25(1) of the Regulation
(European Commission, 2008). This review report was established as a result of the initial evaluation
provided by the designated rapporteur Member State in the Draft Assessment Report (DAR). The
EFSA therefore organised a peer review of the DAR. The conclusions of the peer review are set out in
this report.
Austrai being the designated rapporteur Member State submitted the DAR on Straight Chain
Lepidopteran Pheromones in accordance with the provisions of Article 22(1) of the Regulation, which
was received by the EFSA on 2 April 2008 (Austria, 2008). The peer review was initiated on 9
September 2011 by dispatching the DAR to Member States and the notifier International Bio-rationale
Manufacturing Association as the leader of the task force for consultation and comments. In addition,
the EFSA conducted a public consultation on the DAR. The comments received were collated by the
EFSA and forwarded to the RMS for compilation and evaluation in the format of a Reporting Table.
The notifier was invited to respond to the comments in column 3 of the Reporting Table. The
comments were evaluated by the RMS in column 3 of the Reporting Table.
The scope of the peer review was considered in a telephone conference between the EFSA, the RMS,
and the European Commission on 25 June 2012. On the basis of the comments received and the
RMS‟ evaluation thereof it was concluded that the EFSA should organise a consultation with Member
State experts in the area of mammalian toxicology.
The outcome of the telephone conference, together with EFSA‟s further consideration of the
comments is reflected in the conclusions set out in column 4 of the Reporting Table. All points that
were identified as unresolved at the end of the comment evaluation phase and which required further
3
Commission Regulation (EC) No 2229/2004 of 3 December 2004 laying down further detailed rules for the
implementation of the fourth stage of the programme of work referred to in Article 8(2) of Council Directive 91/414/EEC.
OJ L 379, 24.12.2004, p.13-63.
4
Commission Regulation (EC) No 1095/2007 of 20 September 2007 amending Regulation (EC) No 1490/2002 laying down
further detailed rules for the implementation of the third stage of the programme of work referred to in Article 8(2) of
Council Directive 91/414/EEC and Regulation (EC) No 2229/2004 laying down further detailed rules for the
implementation of the fourth stage of the programme of work referred to in Article 8(2) of Council Directive 91/414/EEC.
OJ L 246, 21.9.2007, p.19-28.
5
Council Directive 91/414/EEC of 15 July 1991 concerning the placing of plant protection products on the market. OJ L
230, 19.8.1991, p. 1-32, as last amended.
6
Regulation (EC) No 1107/2009 of the European Parliament and of the Council of 21 October 2009 concerning the placing
of plant protection products on the market and repealing Council Directives 79/117/EEC and 91/414/EEC. OJ L 309,
24.11.2009, p.1-50.
7
Commission Implementing Regulation (EU) No 540/2011 of 25 May 2011 implementing Regulation (EC) No 1107/2009
of the European Parliament and of the Council as regards the list of approved active substances. OJ L 153, 11.6.2011, p.1-
186.
8
Commission Implementing Regulation (EU) No 541/2011 of 1 June 2011 amending Implementing Regulation (EU) No
540/2011 implementing Regulation (EC) No 1107/2009 of the European Parliament and of the Council as regards the list
of approved active substances. OJ L 153, 11.6.2011, p.187-188.
9
Commission Regulation (EU) No 114/2010 of 9 February 2010 amending Regulation (EC) No 2229/2004 as regards the
time period granted to EFSA for the delivery of its view on the draft review reports concerning the active substances for
which there are clear indications that they do not have any harmful effects. OJ L 37, 10.2.2010, p.12.
EFSA Journal 2014;12(1):3524 4

consideration, including those issues to be considered in consultation with Member State experts, and
additional information to be submitted by the notifier, were compiled by the EFSA in the format of an
Evaluation Table.
The conclusions arising from the consideration by the EFSA, and as appropriate by the RMS, of the
points identified in the Evaluation Table, together with the outcome of the expert discussions where
these took place, were reported in the final column of the Evaluation Table.
A final consultation on the conclusions arising from the peer review of the risk assessment took place
with Member States via a written procedure in October/November 2013.
This conclusion report summarises the outcome of the peer review of the risk assessment on the active
substance and the representative formulation evaluated on the basis of the representative uses as a
insecrticide on stone fruit as proposed by the notifier. A list of the relevant end points for the active
substance as well as the formulation is provided in Appendix A. In addition, a key supporting
document to this conclusion is the Peer Review Report, which is a compilation of the documentation
developed to evaluate and address all issues raised in the peer review, from the initial commenting
phase to the conclusion. The Peer Review Report (EFSA, 2013) comprises the following documents,
in which all views expressed during the course of the peer review, including minority views, can be
found:
• the comments received on the DAR,
• the Reporting Tables (25 June 2012)
• the Evaluation Tables (<<DD Month YYYY>>),
• the report(s) of the scientific consultation with Member State experts (where relevant),
• the comments received on the assessment of the points of clarification (where relevant),
• the comments received on the draft EFSA conclusion.
Given the importance of the DAR including its addendum (compiled version of October 2013
containing all individually submitted addenda (Austria, 2013)) and the Peer Review Report, both
documents are considered respectively as background documents A and B to this conclusion.
EFSA Journal 2014;12(1):3524 5

THE ACTIVE SUBSTANCE AND THE FORMULATED PRODUCT

None of the straight chain lepidopteran pheromones (SCLPs)10 have ISO common names. A full set of
IUPAC names can be found in the tables in section 6.
The representative formulated products for the evaluation were „Isomate C LR‟ containing (E,E)-8,10-
dodecadien-1-ol, 1-tetradecanol, 1-dodecanol, (Z)-9-tetradecen-1-yl acetate, (Z)-11-tetradecen-1-yl
acetate and „Checkmate CM-F‟ containing (E,E)-8,10-dodecadien-1-ol. For the other active substances
not contained in these formulations no formulation data were provided.
The representative uses for „Isomate C LR‟ comprise applications in dispensers in pome fruit, stone
fruit and tree nuts, and for „Checkmate CM-F‟ spray applications on pome fruit, stone fruit and tree
nuts. Full details of the GAPs can be found in the list of end points in Appendix A.
In the list of end points there are also other formulations and GAP tables, but none of these
formulations have been supported in the dossier and a data gap has been set. Also „Isomate C LR‟
contains the active substance 1-dodecanol, information for which was not presented in the dossier or
DAR, so a data gap has been identified.
CONCLUSIONS OF THE EVALUATION
1. Identity, physical/chemical/technical properties and methods of analysis

The following guidance documents were followed in the production of this conclusion:
SANCO/3030/99 rev.4 (European Commission, 2000), Sanco/10597/2003 – rev. 8.1 (European
Commission, 2009), and SANCO/825/00 rev. 7 (European Commission, 2004a).
The minimum purity for the BAS source of compound No. 5 is 87%, however the specification is not
finalised as there are methods issues and also the levels of some impurities are not accepted. For all
the other active substances no specifications have been accepted and for this a general data gap is
identified for a full set of data with regard to the method of manufacture, starting materials,
specifications, batch analysis and supporting analytical data.
For all active substances it could not be concluded if the physical-chemical properties of the active
substances were acceptable and what possible extrapolations could be made. A data gap is identified
and this issue remains open.
For the formulation „Isomate C LR‟ data gaps were identified for flammability and shelf life. For the
formulation „Checkmate CM-F‟ data gaps were identified for accelerated storage, shelf life and low
temperature stability.
Fully validated methods of analysis were not available for the formulations or technical materials and
a data gap is identified.
No methods were available for plants or the environment and a data gap is identified. Methods of
analysis for body fluids and tissues are not required as the active substances are not classified as toxic
or very toxic.
2. Mammalian toxicity
The following guidance documents were followed in the production of this conclusion:
SANCO/221/2000 rev. 10 - final (European Commission, 2003), SANCO/222/2000 rev. 7 (European
Commission, 2004b) and SANCO/10597/2003 – rev. 8.1 (European Commission, 2009).
10
The definition for SCLPs given in the OECD GD (2001) p.11, see list of references.
EFSA Journal 2014;12(1):3524 6

SCLPs were discussed at the Pesticides Peer Review Meeting 95 in September 2012.
The impurity profile of the batches used in the toxicological studies is not available and a data gap was
identified for the identification of non-SCLP impurities in the individual technical specifications and
assessment of their toxicological relevance (see section 7).
SCLPs are naturally occurring substances produced by insects in the order Lepidoptera, including
butterflies and moths. Waiving of toxicological data has been proposed based on the non-toxic,
targeted mode of action, their typically low rates of application expected to result in a low human
exposure and their low toxicological concern. However, this rationale is applicable when long term
exposure above background level can be excluded (OECD, 2001).
Acute toxicity (by the oral, dermal and inhalation routes) and in vitro genotoxicity studies were
provided on a number of SCLP substances and mixtures. It was agreed that bridging of studies within
a chemical group, i.e, within acetate, alcohol and aldehyde SCLPs was appropriate. SCLPs presented
low acute toxicity, by the oral, dermal or inhalation routes, except for the aldehyde group that was
found to be harmful by inhalation. Apart from the aldehydes group and isolated substances that were
properly tested, all SCLPs were proposed for classification as skin irritant. No potential for eye
irritation was observed, except for one blend mixture of (E)-5-decen-1-yl acetate and (E)-5-decen-1-ol
(no. 30). Potential for skin sensitisation was observed in the alcohol group and should be attributed
also to the aldehyde group based on their chemical structure.
A 28-day oral toxicity study conducted with (E,E)-8,10-dodecadien-1-ol (no. 18) was provided. The
study was performed as a limit dose test at 1000 mg/kg bw per day dose level. This dose level was
considered a NOAEL for females, and a LOAEL for males based on erosions of the glandular mucosa
of the stomach and tubular dilatation or vacuolation in the kidneys.
No genotoxic potential was observed in vitro in bacterial and mammalian cells gene mutation assays
and chromosome aberration test covering the acetate and alcohol groups, as no genotoxicity study was
presented on any aldehyde, a data gap was identified to address the genotoxic potential of aldehydes
(see section 7).
Waiving of further repeated dose studies, long term, reproductive and developmental studies,
including the setting of reference values was suggested based on low level of human exposure, not
exceeding the natural background level concentrations.
Two types of application were proposed: through a vapour releasing closed dispenser or spraying a
microencapsulated vapour releasing system. For the closed dispenser system, it was agreed that
exposure would essentially occur by inhalation and therefore could be compared to natural
background levels. However, it was concluded in the environmental fate section that the concentration
levels indicated by the applicant could not be independently verified (see chapter 4) and therefore, a
data gap was identified to present a range of robust natural background levels to assess operator,
worker and bystander exposure. This issue was therefore identified as a data gap (see section 7) and
assessment not finalised (see section 9.1).
Regarding application through spraying of microencapsulated vapour releasing system, dermal

exposure would also have to be considered besides the inhalation route. A comparison with natural
background level may also be possible, however, further to the robust natural background level
referred above, a realistic exposure assessment for operators, workers and bystanders is required and a
data gap was set on this issue. This issue was therefore identified as a further data gap (see section 7)
and assessment not finalised (see section 9.1).
EFSA Journal 2014;12(1):3524 7

3. Residues
The assessment in the residue section below is based on the guidance documents listed in the
document 1607/VI/97 rev.2 (European Commission, 1999), and the JMPR recommendations on
livestock burden calculations stated in the 2004 and 2007 JMPR reports.
For the intended use of the active substance SCLPs emitted via volatilisation from closed retrievable
dispensers on human and livestock edible crops, the natural concentration levels were not reported in
the DAR. The applicant refers to the OECD Guidance (2002) for pheromones that states that the
concentration of SCLPs in the environment after the use of SCLPs as a plant protection product
remains within the range of the concentrations released from target pests during naturally occurring
infestation periods. EFSA was unable to verify whether the reported concentrations were underpinned
by reliable field measurements. A data gap is set to address the natural background levels of SCLPs
based on field measurements and to demonstrate that the use of SCLPs as a plant protection product
according to the use pattern for the formulations emitted via volatilisation from closed retrievable
dispensers will result in concentrations not exceeding the naturally occurring SCLPs levels in the
environment.
For the low volume spray application of microencapsulated SCLPs, no specific studies to evaluate the
residues in plants upon the use of SCLPs as a plant protection product were submitted in the DAR. A
data gap was therefore identified to provide a sufficient residue data package in order to conduct a
reliable consumer dietary risk assessment.
4. Environmental fate and behaviour

The acetates group of SCLPs have vapour pressures reported in the range 0.00008 to 6.93 Pa at 20°C.
The alcohol and aldehyde group have vapour pressures reported in the range 0.0008 to 1.364Pa at 20-
25°C. The reported range of vapour pressures of the individual components in the blends group are in
the range 0.00008 to 1.364Pa at 20°C. Consequently these pheromone compounds fall into the classes
of medium volatility to volatile, with most being volatile (FOCUS, 2008). It should be noted however
(see section 1) that there is a data gap related to physical-chemical properties that includes vapour
pressures. For the compounds (E,E)-8,10-dodecadien-1-ol; (Z)-11-tetradecen-1-yl acetate and (Z)-9-
dodecen-1-yl acetate satisfactory information was provided to indicate that these compounds would
not be subject to long range atmospheric transport due to their calculated short atmospheric half lives
(calculated for the process of indirect photochemical oxidative degradation) of 2.75 to 5.6 hours, being
less than 2 days (FOCUS, 2008). Information in this respect was not provided for any of the other
compounds being assessed. This issue was therefore identified as a data gap (see section 7) and
The applicants dossier was prepared following OECD (2001) guidance for pheromones and other
semiochemicals that suggests that an application threshold of up to 375 g SCLPs ha-1 yr-1 is considered
appropriate to reflect the natural concentration levels of SCLPs. However observations or
measurements of natural concentrations were not included in the applicants dossier. Also the reference
in the OECD (2001) guidance is to a personal communication and not articles from the published peer
reviewed scientific literature. Consequently it is impossible to independently verify whether the
application threshold that originates from the OECD (2001) guidance is underpinned by the reliable
observations / measurements that are the usual evidence needed in the EU regulatory framework for
plant protection products. This issue was therefore identified as a data gap (see section 7) and
The RMS assessment (Austria, 2013) indicated that for spray application of microencapsulated SCLPs
(as opposed to products where the compounds are emitted via volatilisation from passive dispensers) it
could not be precluded that the use of these products would result in natural background levels (as
defined by the threshold of up to 375 g SCLPs ha-1 yr-1) in soil, or natural surface waters adjacent to
treated areas, being exceeded. As amounts that would be deposited in soil might in addition also have
the potential to leach to groundwater, the RMS also concluded that groundwater exposure would need
EFSA Journal 2014;12(1):3524 8

to be considered. These issues were therefore identified as data gaps (see section 7) and is covered by
the first point indicating assessment not finalised (see section 9.1).
For the dispenser applications, the indications of high vapour pressure for the different pheromones,
are considered sufficient to conclude that groundwater exposure by them is unlikely.
5. Ecotoxicology
Ecotoxicity data were not available for all groups of non-target organisms for each active substance. It
was agreed to extrapolate ecotoxicity data within each chemical class of straight chain lepidopteran
pheromones (SCLPs). Where no data were available for the chemical class, it was proposed to use the
lowest available toxicity endpoint from other chemical class of SCLPs. However, no scientific
reasoning was provided to support this proposal and therefore, pending the outcome of the exposure
assessment (see below), further information may be required to support the extrapolation of
ecotoxicity data between the different chemical classes.
As discussed in section 1, no technical specifications are available, therefore a data gap was identified
to demonstrate that the test material of the batches used in the ecotoxicity studies are suitably
representative of the technical specification.
No risk assessments were available for the representative uses of SCLPs as a foliar spray. Therefore,
data gaps were identified to address the risk to non-target organisms (birds, wild mammals, aquatic
organisms, honey bees, earthworms, soil micro-organisms and non-target plants).
The ecotoxicological risk assessments for the representative uses of SCLPs in passive dispersers was
based on the OECD (2001) guidance for pheromones and other semiochemicals that suggests that an
application threshold of up to 375 g SCLPs ha-1 yr-1 is considered appropriate to reflect the natural
concentration levels of SCLPs. It was proposed that the representative use of SCLPs in passive
dispensers will not lead to greater exposure than the natural background level which would therefore
allow a low risk to non-target organisms to be concluded. However, as discussed in detail in section 4,
it was not possible to independently validate this value with observations / measurements from
scientific literature and therefore the value was not considered suitable for the exposure assessment.
Consequently, a data gap was identified for further information to support the argumentation that the
representative use of SCLPs in passive dispensers will not lead to greater environmental exposure than
the natural background levels (see section 4). Although, it is acknowledged that the available
ecotoxicity data do not indicate high toxicity to non-target organisms, it was not possible to finalise
the risk assessment due to the exposure assessment data gap.
The representative uses of SCLPs are unlikely to lead to exposure of sewage treatment organisms and
therefore a low risk was concluded (relevant for all representative uses).
EFSA Journal 2014;12(1):3524 9

6. Overview of the risk assessment of compounds listed in residue definitions triggering assessment of effects data for the environmental
compartments
6.1 Soil
Compound name
(dossier code for the pheromone and or pheromone Persistence Ecotoxicology
mixture in which it is included)
Case made when application is via dispense that Case made when application is via dispense that
exposure will be within natural background levels exposure will be within natural background levels
(quoted as 375 g SCLP/ha/year), but data gaps (quoted as 375 g SCLP/ha/year), but data gaps
(E)-5-decen-1-yl acetate (No. 1, in 30) identified, as the way natural background levels have identified, as the way natural background levels have
been elucidated needs to be explained and the been elucidated needs to be explained and the
measurements used as the basis for elucidation have not measurements used as the basis for elucidation have not
been reported. For spray application data gap. been reported. For spray application data gap.
(E)-8-dodecen-1-yl acetate (No. 2 in 31) As above. As above.
(Z)-8-dodecen-1-yl acetate (No. 4, in 25 and 31) As above. As above.
(Z)-9-dodecen-1-yl acetate (No. 5, in 26) As above. As above.
(E,Z)-7,9-dodecadien-1-yl acetate (No. 6, in 27) As above. As above.
(E)-11-tetradecen-1-yl acetate (No. 7) As above. As above.
(Z)-9-tetradecen-1-yl acetate (No. 8) As above. As above.
(Z)-11-tetradecen-1-yl acetate (No. 9) As above. As above.
(Z, E)-9, 12-tetradecadien-1-yl acetate (No. 10) As above. As above.
(Z)-11-hexadecen-1-yl acetate (No. 11, in 32) As above. As above.
(Z, E)-7, 11-hexadecadien-1-yl acetate (No. 13, in 28) As above. As above.
EFSA Journal 2014;12(1):3524 10

(E, Z)-2, 13-octadecadien-1-yl acetate (No. 14) As above. As above.
(E)-5-decen-1-ol (No. 16, in 30) As above. As above.
(Z)-8-dodecen-1-ol (No. 17 in 31) As above. As above.
(E,E)-8,10-dodecadien-1-ol (No. 18) As above. As above.
tetradecan-1-ol (No. 19) As above. As above.
(Z)-11-hexadecen-1-ol (No. 20) As above. As above.
(Z)-7-tetradecenal (No. 21) As above. As above.
(Z)-9-hexadecenal (No. 22, in 29) As above. As above.
(Z)-11-hexadecenal (No. 23 in 29 & 32) As above. As above.
(Z)-13-octadecenal (No. 24, in 29) As above. As above.
dodecyl acetate (in 25 & 26) As above. As above.
(E,E)-7,9-dodecadien-1-yl acetate (in 27) As above. As above.
(Z,Z)-7,11-hexadecadien-1-yl acetate (in 28) As above. As above.
(E/Z)-8-dodecen-1-yl acetate (No. 3 in 31) As above. As above.
6.2 Ground water

>0.1 μg/L 1m depth for
Compound the representative uses
Mobility in soil (at least one FOCUS Pesticidal activity Toxicological relevance Ecotoxicological activity
(name and/or code)
scenario or relevant
lysimeter)(a)
EFSA Journal 2014;12(1):3524 11

Data not available, but

vapour pressure
considered to indicate that No dispenser application, Data gap for surface water
(E)-5-decen-1-yl acetate Yes Yes
leaching to groundwater is data gap spray application risk assessment.
unlikely for dispenser
products
No dispenser application, Data gap for surface water

(E)-8-dodecen-1-yl acetate As above. Yes Yes
data gap spray application risk assessment.

(Z)-8-dodecen-1-yl acetate As above. Yes Yes
Data gap for surface water

(Z)-9-dodecen-1-yl acetate As above. No Yes Yes
risk assessment.
(E,Z)-7,9-dodecadien-1-yl Data gap for surface water

As above. No Yes Yes
acetate risk assessment.
(E)-11-tetradecen-1-yl Data gap for surface water

(Z)-9-tetradecen-1-yl Data gap for surface water

(Z)-11-tetradecen-1-yl Data gap for surface water

(Z,E)-9, 12-tetradecadien- Data gap for surface water

1-yl acetate risk assessment.
(Z)-11-hexadecen-1-yl No dispenser application, Data gap for surface water

As above. Yes Yes
acetate data gap spray application risk assessment.
(Z,E)-7, 11-hexadecadien- Data gap for surface water

EFSA Journal 2014;12(1):3524 12

(E,Z)-2, 13-octadecadien- Data gap for surface water


(E)-5-decen-1-ol As above. Yes Yes

(Z)-8-dodecen-1-ol As above. Yes Yes
(E,E)-8,10-dodecadien-1- No dispenser application, Data gap for surface water

As above. Yes Yes
ol data gap spray application risk assessment.

tetradecan-1-ol As above. No Yes Yes
risk assessment.

(Z)-11-hexadecen-1-ol As above. No Yes Yes
risk assessment.

(Z)-7-tetradecenal As above. No Yes Yes
risk assessment.

(Z)-9-hexadecenal As above. No Yes Yes
risk assessment.

(Z)-11-hexadecenal As above. Yes Yes

(Z)-13-octadecenal As above. No Yes Yes
risk assessment.

dodecyl acetate As above. No Yes Yes
risk assessment.
(E,E)-7,9-dodecadien-1-yl Data gap for surface water

EFSA Journal 2014;12(1):3524 13

(Z,Z)-7,11-hexadecadien- No dispenser application, Data gap for surface water

As above. Yes Yes
1-yl acetate data gap spray application risk assessment.
(E/Z)-8-dodecen-1-yl Data gap for surface water

(a): EFSA‟s reading of Directive 98/83/EC11 is, that as these active substances are mating disrupters or attractants for mass trapping they are not considered pesticides under this directive, so the
parametric drinking water limit of 0.1µg/L for pesticides, that has been used as a decision making criteria under Directive 91/414/EEC regarding groundwater exposure, would not apply.
However it is of note that Directive 2006/118/EC12, that is the decision making criteria under Regulation (EC) No 1107/2009 regarding groundwater exposure, would consider these active
substances are pesticides, so the parametric drinking water limit of 0.1µg/L for pesticides would apply.
6.3 Surface water and sediment

Compound
Ecotoxicology
(name and/or code)
Case made when application is via dispense that exposure will be within natural background levels (quoted as 375
g SCLP/ha/year), but data gaps identified, as the way natural background levels have been elucidated needs to be
(E)-5-decen-1-yl acetate
explained and the measurements used as the basis for elucidation have not been reported. For spray application
data gap.
(E)-8-dodecen-1-yl acetate As above.
(Z)-8-dodecen-1-yl acetate As above.
(Z)-9-dodecen-1-yl acetate As above.
(E,Z)-7,9-dodecadien-1-yl acetate As above.
(E)-11-tetradecen-1-yl acetate As above.
(Z)-9-tetradecen-1-yl acetate As above.
11
Council Directive 98/83/EC of 3 November 1998 on the quality of water intended for human consumption. OJ L 350, 5.12.1998, p. 32-54.
12
Directive 2006/118/EC of the European Parliament and of the Council of 12 December 2006 on the protection of groundwater against pollution and deterioration. OJ L 372, 27.12.2006, p. 19-
31.
EFSA Journal 2014;12(1):3524 14

(Z)-11-tetradecen-1-yl acetate As above.
(Z,E)-9, 12-tetradecadien-1-yl acetate As above.
(Z)-11-hexadecen-1-yl acetate As above.
(Z,E)-7, 11-hexadecadien-1-yl acetate As above.
(E,Z)-2, 13-octadecadien-1-yl acetate As above.
(E)-5-decen-1-ol As above.
(Z)-8-dodecen-1-ol As above.
(E,E)-8,10-dodecadien-1-ol As above.
tetradecan-1-ol As above.
(Z)-11-hexadecen-1-ol As above.
(Z)-7-tetradecenal As above.
(Z)-9-hexadecenal As above.
(Z)-11-hexadecenal As above.
(Z)-13-octadecenal As above.
dodecyl acetate As above.
(E,E)-7,9-dodecadien-1-yl acetate As above.
(Z,Z)-7,11-hexadecadien-1-yl acetate As above.
(E/Z)-8-dodecen-1-yl acetate As above.
EFSA Journal 2014;12(1):3524 15

6.4 Air
Compound
Toxicology
(name and/or code)
(E)-5-decen-1-yl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(E)-8-dodecen-1-yl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(Z)-8-dodecen-1-yl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(Z)-9-dodecen-1-yl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(E,Z)-7,9-dodecadien-1-yl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(E)-11-tetradecen-1-yl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(Z)-9-tetradecen-1-yl acetate Rat LC50 inhalation > 5.29 mg/L air/4-hour (whole body); no classification required
(Z)-11-tetradecen-1-yl acetate Rat LC50 inhalation > 5.3 mg/L air/4-hour (whole body); no classification required
(Z,E)-9, 12-tetradecadien-1-yl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(Z)-11-hexadecen-1-yl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(Z)-13-hexadecen-11-yn-1-yl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(Z,E)-7, 11-hexadecadien-1-yl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(E,Z)-2, 13-octadecadien-1-yl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(Z,Z,Z,Z)-7,13,16,19-docosatetraen-1-yl isobutyrate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(E)-5-decen-1-ol Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(Z)-8-dodecen-1-ol Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
EFSA Journal 2014;12(1):3524 16

(E,E)-8,10-dodecadien-1-ol Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
tetradecan-1-ol Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(Z)-11-hexadecen-1-ol Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
Rat LC50 inhalation > 4.46 (females), 4.82 (males and sex combined) mg/L air/4-hour (whole body); R20 ‘harmful
(Z)-7-tetradecenal
by inhalation’
(Z)-9-hexadecenal
by inhalation’
(Z)-11-hexadecenal
by inhalation’
(Z)-13-octadecenal
by inhalation’
dodecyl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(E,E)-7,9-dodecadien-1-yl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(Z,Z)-7,11-hexadecadien-1-yl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
(E/Z)-8-dodecen-1-yl acetate Rat LC50 inhalation > 5 mg/L air/4-hour (whole body); no classification required
EFSA Journal 2014;12(1):3524 17

7. List of studies to be generated, still ongoing or available but not peer reviewed
This is a complete list of the data gaps identified during the peer review process, including those areas
where a study may have been made available during the peer review process but not considered for
procedural reasons (without prejudice to the provisions of Article 7 of Directive 91/414/EEC
concerning information on potentially harmful effects).
Complete set of data in all areas of the risk assessment for 1-dodecanol (relevant for 1-dodecanol;
submission date proposed by the notifier: unknown; see section 1)
For the SCLPs that are not contained in the formulations „Isomate C LR‟ or „Checkmate CM-F‟ a
full formulation data package is required (relevant for the active substances not present in the
named formulations; submission date proposed by the notifier: unknown; see section 1)
For the BASF source of (Z)-9-dodecen-1-yl acetate the notifier should explain the peak of another
octadecan at a retention time of approx. 6 min., the specifications for impurities 1 and 3 should be
reconsidered. (relevant for the BASF source of (Z)-9-dodecen-1-yl acetate; submission date
proposed by the notifier: unknown; see section 1)
For all sources other than BASF source of (Z)-9-dodecen-1-yl acetate a full set of data with regard
to method of manufacture, starting materials, specifications, batch analysis and supporting
analytical data (relevant for all sources other than BASF source of (Z)-9-dodecen-1-yl acetate;
For each physical and chemical property of all the SCLPs they should be put together and it
should be justified on the basis of structure what possible extrapolations can be made (relevant for
all representative uses evaluated ; submission date proposed by the notifier: unknown; see section
1)
For „Isomate C LR‟ data on flammability and shelf life (relevant for all representative uses of this
formulation; submission date proposed by the notifier: unknown; see section 1)
For „Checkmate CM-F‟ data on accelerated storage, shelf life and low temperature stability
(relevant for all representative uses of this formulation; submission date proposed by the notifier:
unknown; see section 1)
Fully validated methods of analysis for all formulations and technical materials (relevant for all
representative uses evaluated ; submission date proposed by the notifier: unknown; see section 1)
Methods of analysis for residues on/in plants and environmental matrices (relevant for all
representative uses evaluated; submission date proposed by the notifier: unknown; see section 1)
Identification of non-SCLP impurities in the individual technical specifications and assessment of

their toxicological relevance (relevant for all representative uses evaluated; submission date
The genotoxic potential of aldehyde SCLPs has not been addressed (relevant for aldehyde SCLPs
representative uses evaluated; submission date proposed by the notifier: unknown; see section 2)
Assessment of operator, worker and bystander exposure levels to the spraying of

microencapsulated vapour releasing system (relevant for the microencapsulated vapour releasing
system uses evaluated; submission date proposed by the notifier: unknown; see section 2
The experimental observations and measurements that underpin the OECD trigger dose of 375 g
SCLP/ha/year (OECD guidance, ENV/JM/MONO(2001)12) as representing natural background
EFSA Journal 2014;12(1):3524 18

levels, that may be encountered when there is a high level lepidopteran infestation, were not
available to the Member State peer review organised by EFSA (relevant for all representative uses
evaluated, submission date proposed by the notifier: unknown; see section 2, 3, 4 and 5).
Data gap to address the natural background levels of SCLPs based on field measurements and to
demonstrate that the use of SCLPs as a plant protection product according to the use pattern where
the compounds are emitted via volatilisation from passive dispensers will result in concentrations
not exceeding the naturally occurring SCLPs levels in the environment (relevant for the
representative uses evaluated where application is via volatilisation from passive dispensers;
A sufficient residue data package is required for the low volume spray application of
microencapsulated SCLPs formulation (relevant for the representative use evaluated where
application is via low volume spray application of microencapsulated SCLPs; submission date
The information available in the applicants dossier is insufficient to conclude on predicted

environmental concentrations (PEC) in soil, surface water and sediment and groundwater after
spray application of microencapsulated SCLPs. An exceedence of natural background levels of
SCLPs can not be excluded in these compartments following spray application (relevant for
representative uses evaluated where application is by spraying; submission date proposed by the
notifier: unknown; see section 4)
The information available in the applicants dossier is insufficient to conclude on the potential for
long range atmospheric transport via air after spray application of microencapsulated SCLPs that
may form aerosols at the time of spraying. Data (measurements) demonstrating that microcapsules
have a particle size range that would exclude long range transport (ie. > 80 µm) or information on
the atmospheric half life of the products would be 2 options for addressing this. (relevant for
representative uses evaluated where application is by spraying; submission date proposed by the
notifier: unknown; see section 4)
Atkinson half life calculations for indirect photolysis (for indirect photochemical oxidative
degradation) to give estimates of atmospheric half lives for each SCLP assessed except (E,E)-
8,10-dodecadien-1-ol; (Z)-11-tetradecen-1-yl acetate and (Z)-9-dodecen-1-yl acetate were not
available. (relevant for all representative uses except for products that exclusively contain these
three substances; submission date proposed by the notifier: unknown; see section 4)
Pending the outcome of the exposure assessment, risk assessments for birds, mammals, aquatic
organisms, honey bees, non-target arthropods, earthworms, soil micro-organism and non-target
plants (relevant for all representative uses evaluated; submission date proposed by the notifier:
unknown; see section 5).
Information to demonstrate that the test material of the batches used in the ecotoxicity studies are
suitably representative of the technical specification (relevant for all representative uses evaluated;
submission date proposed by the notifier: unknown; see section 5).
8. Particular conditions proposed to be taken into account to manage the risk(s) identified
None proposed.
EFSA Journal 2014;12(1):3524 19

9. Concerns
9.1 Issues that could not be finalised
An issue is listed as an issue that could not be finalised where there is not enough information
available to perform an assessment, even at the lowest tier level, for the representative uses in line
with the Uniform Principles of Annex VI to Directive 91/414/EEC and where the issue is of such
importance that it could, when finalised, become a concern (which would also be listed as a critical
area of concern if it is of relevance to all representative uses).
1. As it has not been demonstrated that the trigger dose of 375 g SCLP/ha/year (originating from
OECD (2001) guidance) is underpinned by robust observations or measurements, the operator,
worker, bystander, environmental exposure and risk assessments were not finalised.
Consequently risk assessments in these sectors could not be finalised.
2. For operators, workers and bystanders exposed to the sprayed microencapsulated vapour
releasing system products, further to robust background exposure, their level of exposure by
inhalation and skin contact needs to be addressed.
3. The consumer dietary risk assessment could not be finalised.
4. The potential for long range transport through the atmosphere of the substances assessed except
(E,E)-8,10-dodecadien-1-ol; (Z)-11-tetradecen-1-yl acetate and (Z)-9-dodecen-1-yl acetate could
not be finalised.
9.2 Critical areas of concern

An issue is listed as a critical area of concern where there is enough information available to perform
an assessment for the representative uses in line with the Uniform Principles of Annex VI to Directive
91/414/EEC, and where this assessment does not permit to conclude that for at least one of the
representative uses it may be expected that a plant protection product containing the active substance
will not have any harmful effect on human or animal health or on groundwater or any unacceptable
influence on the environment.
An issue is also listed as a critical area of concern where the assessment at a higher tier level could not
be finalised due to a lack of information, and where the assessment performed at the lower tier level
does not permit to conclude that for at least one of the representative uses it may be expected that a
plant protection product containing the active substance will not have any harmful effect on human or
animal health or on groundwater or any unacceptable influence on the environment.
There is no agreed technical specification covered by the toxicological and ecotoxicological

assessments.
9.3 Overview of the concerns identified for each representative use considered
(If a particular condition proposed to be taken into account to manage an identified risk, as listed in
section 8, has been evaluated as being effective, then „risk identified‟ is not indicated in this table.)
All columns are grey as there is no agreed technical material specification, no impurity profile of the
material used in the testing studies, which are proposed to be compared to natural background levels
and the potential for long range transport was not finalised except for (E,E)-8,10-dodecadien-1-ol; (Z)-
11-tetradecen-1-yl acetate and (Z)-9-dodecen-1-yl acetate.
EFSA Journal 2014;12(1):3524 20

Dispenser
in pome
Spray in
fruit, Dispenser
pome
stone Dispenser in maize,
fruit, Spray in
Representative use fruit, in grapes lucern,
stone fruit grapes
citrus, and olives rice and
and tree
banana cotton
nuts
and tree
nuts
Risk
identified
Operator risk
Assessment
not finalised
X1 X1, 2 X1 X1, 2 X1
Risk
identified
Worker risk
Assessment
not finalised
X1 X1, 2 X1 X1, 2 X1
Risk
identified
Bystander risk
Assessment
not finalised
X1 X1, 2 X1 X1, 2 X1
Risk
identified
Consumer risk
Assessment
not finalised
X3 X3 X3 X3 X3
Risk
Risk to wild non identified
target terrestrial
Assessment
vertebrates not finalised
X1 X1 X1 X1 X1
Risk to wild non Risk
target terrestrial identified
organisms other Assessment
not finalised
X1 X1 X1 X1 X1
than vertebrates
Risk
Risk to aquatic identified
organisms Assessment
not finalised
X1 X1 X1 X1 X1
Legal
parametric
Groundwater value
exposure active breached
substance Assessment
not finalised
X X
Legal
parametric
value
breached
Groundwater
Parametric
exposure value of
metabolites 10µg/L(a)
breached
Assessment
not finalised
Comments/Remarks
The superscript numbers in this table relate to the numbered points indicated in sections 9.1 and 9.2. Where there is no
superscript number see sections 2 to 6 for further information.
(a): Value for non-relevant metabolites prescribed in SANCO/221/2000-rev 10-final, European Commission, 2003.
EFSA Journal 2014;12(1):3524 21

Spray in
vegetables
Dispenser
including
in
leafy,
vegetables Spray in
Spray in brassica, Dispenser in spray in
Representative use including sugar
cotton stem, root ornamentals ornamentals
garlic and beet
and tuber
fruiting
and
vegetables
fruiting
vegetables
Risk
identified
Operator risk
Assessment
not finalised
X1, 2 X1 X1, 2 X1, 2 X1 X1, 2
Risk
identified
Worker risk
Assessment
not finalised
X1, 2 X1 X1, 2 X1, 2 X1 X1, 2
Risk
identified
Bystander risk
Assessment
not finalised
X1, 2 X1 X1, 2 X1, 2 X1 X1, 2
Risk
identified
Consumer risk
Assessment
not finalised
X3 X3 X3 X3 N/A N/A
Risk to wild Risk
non target identified
terrestrial Assessment
not finalised
X1 X1 X1 X1 X1 X1
vertebrates
Risk to wild Risk
non target identified
terrestrial
not finalised
X1 X1 X1 X1 X1 X1
other than
vertebrates
Risk
Risk to aquatic identified
not finalised
X1 X1 X1 X1 X1 X1
Legal
parametric
Groundwater value
exposure active breached
substance Assessment
not finalised
X X X X
Legal
parametric
value
breached
Groundwater
Parametric
exposure value of
metabolites 10µg/L(a)
breached
Assessment
not finalised
Comments/Remarks
EFSA Journal 2014;12(1):3524 22

The superscript numbers in this table relate to the numbered points indicated in sections 9.1 and 9.2. Where there is no
superscript number see sections 2 to 6 for further information.
(a): Value for non-relevant metabolites prescribed in SANCO/221/2000-rev 10-final, European Commission, 2003.
N/A: Not applicable
EFSA Journal 2014;12(1):3524 23

REFERENCES
Austria, 2008. Draft Assessment Report (DAR) on the active substance Straight Chain Lepidopteran
Pheromonesprepared by the rapporteur Member State Austria in the framework of Directive
91/414/EEC, Month YYYY.
Austria, 2013. Final Addendum to Draft Assessment Report on Straight Chain Lepidopteran
Pheromones, compiled by EFSA, October 2013.
EFSA (European Food Safety Authority), 2009. Guidance Document on Risk Assessment for Birds
and Mammals on request of EFSA. EFSA Journal 2009;7(12):1438, 358 pp.
doi:10.2903/j.efsa.2009.1438
EFSA (European Food Safety Authority), 2013. Peer Review Report to the conclusion regarding the
peer review of the pesticide risk assessment of the active substance Straight Chain Lepidopteran
Pheromones. Available online: www.efsa.europa.eu
European Commission, 1999. Guidelines for the generation of data concerning residues as provided in
Annex II part A, section 6 and Annex III, part A, section 8 of Directive 91/414/EEC concerning the
placing of plant protection products on the market, 1607/VI/97 rev.2, 10 June 1999.
European Commission, 2000. Technical Material and Preparations: Guidance for generating and
reporting methods of analysis in support of pre- and post-registration data requirements for Annex
II (part A, Section 4) and Annex III (part A, Section 5) of Directive 91/414. SANCO/3030/99
rev.4, 11 July 2000.
European Commission, 2001. Guidelines on comparability, extrapolation, group tolerances and data
requirements for setting MRLs. SANCO Doc 7525/VI/95-rev.7. pp.1-31.
European Commission, 2002a. Guidance Document on Terrestrial Ecotoxicology Under Council
Directive 91/414/EEC. SANCO/10329/2002 rev.2 final, 17 October 2002.
European Commission, 2002b. Guidance Document on Aquatic Ecotoxicology Under Council
Directive 91/414/EEC. SANCO/3268/2001 rev 4 (final), 17 October 2002.
European Commission, 2002c. Guidance Document on Risk Assessment for Birds and Mammals
Under Council Directive 91/414/EEC. SANCO/4145/2000.
European Commission, 2003. Guidance Document on Assessment of the Relevance of Metabolites in
Groundwater of Substances Regulated under Council Directive 91/414/EEC. SANCO/221/2000-
rev. 10 - final, 25 February 2003.
European Commission, 2004a. Guidance document on residue analytical methods. SANCO/825/00
rev. 7, 17 March 2004.
European Commission, 2004b. Guidance Document on Dermal Absorption. SANCO/222/2000 rev. 7,
19 March 2004.
European Commission, 2009. Guidance Document on the Assessment of the Equivalence of Technical
Materials of Substances Regulated under Council Directive 91/414/EEC. SANCO/10597/2003 –
rev. 8.1, May 2009.
European Commission, 2012. Review Report for the active substance Straight Chain Lepidopteran
Pheromones finalised in the Standing Committee on the Food Chain and Animal Health at its
meeting on 20November 2011 in view of the inclusion of Straight Chain Lepidopteran
Pheromones. in Annex I of Directive 91/414/EEC, SANCO/2633/08 – rev. 5 , 20 November 2012.
FOCUS, 2008. “Pesticides in Air: Considerations for Exposure Assessment”. Report of the FOCUS
Working Group on Pesticides in Air, EC Document Reference SANCO/10553/2006 Rev 2 June
2008.
EFSA Journal 2014;12(1):3524 24

JMPR (Joint Meeting on Pesticide Residues), 2004. Report of the Joint Meeting of the FAO Panel of
Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group
on Pesticide Residues Rome, Italy, 20–29 September 2004, Report 2004, 383 pp.
JMPR (Joint Meeting on Pesticide Residues), 2007. Report of the Joint Meeting of the FAO Panel of
Experts on Pesticide Residues in Food and the Environment and the WHO Core Assessment Group
on Pesticide Residues Geneva, Switzerland, 18–27 September 2007, Report 2007, 164 pp.
OECD (Organisation for Economic Co-operation and Development), 2001. Guidance for registration
requirements for pheromones and other semiochemicals used for arthropod pest control.
ENV/JM/MONO(2001)32, 26 February 2002.
SETAC (Society of Environmental Toxicology and Chemistry), 2001. Guidance Document on
Regulatory Testing and Risk Assessment procedures for Plant Protection Products with Non-Target
Arthropods. ESCORT 2.
EFSA Journal 2014;12(1):3524 25

APPENDICES
APPENDIX A – LIST OF END POINTS FOR THE ACTIVE SUBSTANCE AND THE REPRESENTATIVE
FORMULATION
General comment: Where appropriate, the lists of endpoints were modified according to the format for
the listing of endpoints proposed in appendix 9 of the OECD Series on Pesticides (Number 12):
Guidance for Registration Requirements for Pheromones and Other Semiochemicals Used for
Arthropod Pest Control ENV/JM/MONO(2001)12.
25 Acetate Blend: (Z)-8-Dodecenyl Acetate; Dodecan-1-yl Acetate

Listing of end points
Identity, Physical and Chemical Properties, Details of Uses, Further Information
Active substance (ISO Common Name) ‡ No ISO common name

Function (e.g. fungicide) Semio-chemicals
Rapporteur Member State Austria

Co-rapporteur Member State --
Identity (Annex IIA, point 1)

Chemical name (IUPAC) ‡ i) (Z)-8-dodecen-1-yl acetate
ii) Dodecyl acetate
Chemical name (CA) ‡ i) (Z)-8-dodecen-1-ol acetate
ii) Dodecyl acetate
CIPAC No ‡ i) 861
ii) 884
CAS No ‡ i) 28079-04-1
ii) 112-66-3
EC No (EINECS or ELINCS) ‡ i) 248-823-6
ii) 203-995-1
FAO Specification (including year of No specification exists at the time of evaluation
publication) ‡
Minimum purity of the active substance as Open
manufactured ‡
Identity of relevant impurities (of toxicological, Open
ecotoxicological and/or environmental
concern) in the active substance as
manufactured
Molecular formula ‡ i) C14H26O2
ii) C14H28O2
EFSA Journal 2014;12(1):3524 26

Molecular mass ‡ i) 226.359 g/mol

ii) 228.375 g/mol
Structural formula ‡ i)
O
O CH3
ii)
OAc
EFSA Journal 2014;12(1):3524 27

Physical and chemical properties (Annex IIA, point 2)
Melting point (state purity) ‡ Data required

Open for applicability of data to all the SCLP‘s
Boiling point (state purity) ‡ Z8-12:Ac 97.7% purity
12:Ac 98.9% purity
(Blend mix ratio 50.2:49.2)
242-249°C
Temperature of decomposition (state purity) Not relevant
Appearance (state purity) ‡ Z8-12:Ac 97.7% purity
12:Ac 98.9% purity
Yellow liquid
Vapour pressure (state temperature, state Z8-12:Ac 97.7% purity
purity) ‡ 12:Ac 98.9% purity
20°C
Z8-12Ac = 0.157 Pa
12:Ac = 0.094 Pa
25°C
Z8-12Ac = 0.245 Pa
12:Ac = 0.162 Pa
Henry‘s law constant ‡ 0.0003 – 0.12 kPa m3/mol
whole group of SCLP actives
80-99% purity
Solubility in water (state temperature, state Z8-12:Ac 97.7% purity
purity and pH) ‡ 12:Ac 98.9% purity
Z8-12:Ac (20°C)
Day 1 = 7.1 x 10-4 g/l (RSD 21.2%)
Day 2 = 8.0 x 10-4 g/l (RSD 6.8%)
Day 3 = 7.1 x 10-4 g/l (RSD 2.5%)
12:Ac (20°C)
Day 1 = 9 x 10-5 g/l (RSD 21.8%)
Day 2 = 13 x 10-4 g/l (RSD 1.5%)
Day 3 = 13 x 10-4 g/l (RSD 10.4%)
Effect of pH is not required*
EFSA Journal 2014;12(1):3524 28

Solubility in organic solvents ‡ Z8-12:Ac 97.7% purity

(state temperature, state purity) 12:Ac 98.9% purity
Totally soluble in organic solvents. No precipitate
was generated
Surface tension ‡ Z8-12:Ac 97.7% purity
(state concentration and temperature, state 12:Ac 98.9% purity
purity)
39.9mN/m
Partition co-efficient ‡ Z8-12:Ac 97.7% purity
(state temperature, pH and purity) 12:Ac 98.9% purity
Z8-12:Ac
log P = 5.61 (25°C)
12:Ac
log P = 6.25 (25°C)
Dissociation constant (state purity) ‡ Rapid degradation, evaporation and volatilization
can be expected for all SCLP actives
UV/VIS absorption (max.) incl. ‡ Z8-12:Ac 97.7% purity
(state purity, pH) 12:Ac 98.9% purity
UV VIS
52.88486486 cm-1 mol-1 l (204nm)
Flammability ‡ (state purity) SCLP actives are not flammables (statement)
Z8-12:Ac 97.7% purity
12:Ac 98.9% purity
Flash point: 126°C
Explosive properties ‡ (state purity) SCLP actives are not explosive (statement)
Oxidising properties ‡ (state purity) SCLP actives are not strong oxidising agents
(statement)
EFSA Journal 2014;12(1):3524 29

Summary of representative uses evaluated (Acetate Blend: (Z)-8-Dodecenyl Acetate; Dodecan-1-yl Acetate)
Crop and/ Member Product F Pests or PHI Remarks:
or situation State or name / G Group of Formulation Application Application rate per treatment (days)
Country Company or pests
I controlled
(a) (b) (l) (m)
(c)
Type Conc. method growth number interval kg water L/ha**) kg
of as kind stage & min max between as/hL**) as/ha**)
season application min max
s (min)
(d-f) (i) (f-h) (j) (k) min max min
max
Plum Italy ECODIAN® F Grapholita VP 20mg/ 2000- Before the 1st 2/3 60 days n. a. n. a. 2000- n. a.
And other (DPR CF / Isagro funebrana dispen 2500- generation/fli 2500-
Stone 290) ser 3000 ght of the 3000
Fruits dispenser moth dispense
s/ha (low- rs/ha x
mod-high 20mg =
density 40g-50g-
pest) 60g/ha
VP vapour releasing product in closed dispenser

n.a. not applicable
* filling amounts of ampoules
Remarks (a) For crops, the EU and Codex classifications (both) should be used; where relevant, the (i) g/kg or g/l
: use situation should be described (eg. fumigation of a structure) (j) Growth stage at last treatment (BBCH Monograph, Growth Stages of Plants, 1997,
(b) Outdoor or field use (F), glasshouse application (G) or indoor application (I) Blackwell, ISBN 3-8263-3152-4), including where relevant, information on season at
(c) eg. biting and suckling insects, soil born insects, foliar fungi, weeds time of application
(d) eg. wettable powder (WP), emulsifiable concentrate (EC), granule (GR) (k) The minimum and maximum number of application possible under practical conditions
(e) GCPF Codes - GIFAP Technical Monograph No 2, 1989 of use must be provided
(f) All abbreviations used must be explained (l) PHI - minimum pre-harvest interval
(g) Method, eg. high volume spraying, low volume spraying, spreading, dusting, drench (m) Remarks may include: Extent of use/economic importance/restrictions
(h) Kind, eg. overall, broadcast, aerial spraying, row, individual plant, between the plants -
type of equipment used must be indicated
EFSA Journal 2014;12(1):3524 30

Methods of Analysis
Analytical methods for the active substance (Annex IIA, point 4.1)
Technical as (analytical technique) Open

Impurities in technical as (analytical technique) Open
Plant protection product (analytical technique) Open
Analytical methods for residues (Annex IIA, point 4.2)

Residue definitions for monitoring purposes
Food of plant origin Open

Food of animal origin No residue definition is set
Soil Open
Water surface Open
drinking/ground Open
Air Open
Monitoring/Enforcement methods
Food/feed of plant origin (analytical technique Open

and LOQ for methods for monitoring purposes)
Food/feed of animal origin (analytical No residue definition set
technique and LOQ for methods for monitoring
purposes)
Soil (analytical technique and LOQ) Open
Water (analytical technique and LOQ) Open
Air (analytical technique and LOQ) Open
Body fluids and tissues (analytical technique Not relevant, active substance is not classified toxic
and LOQ) or highly toxic.
Classification and proposed labelling with regard to physical and chemical data
(Annex IIA, point 10)
RMS/peer review proposal

Active substance None
EFSA Journal 2014;12(1):3524 31

Impact on Human and Animal Health

Absorption, distribution, excretion and metabolism (toxicokinetics) (Annex IIA, point
5.1)
Rate and extent of oral absorption ‡ No data provided
Distribution ‡ No data provided
Potential for accumulation ‡ No data provided
Rate and extent of excretion ‡ No data provided
Metabolism in animals ‡ No data provided
Toxicologically relevant compounds ‡ i) (Z)-8-dodecen-1-yl acetate
(animals and plants) ii) Dodecyl acetate
(environment) ii) Dodecyl acetate
Acute toxicity (Annex IIA, point 5.2)
Rat LD50 oral ‡ > 5000 mg/kg bw

based on bridging from other SCLP
acetates:
(E/Z)-8-dodecen-1-yl acetate, (Z)-9-
dodecen-1-yl acetate, (E,Z)-7,9-
dodecadien-1-yl acetate, (Z)-9-tetradecen-
1-yl acetate, (Z)-11-tetradecen-1-yl acetate,
(Z,Z)-7,11-hexadecadien-1-yl acetate,
(Z,E)-7,11-hexadecadien-1-yl acetate
Rat LD50 dermal ‡ > 2000 mg/kg bw
acetates:
(Z)-9-tetradecen-1-yl acetate, (Z)-11-
tetradecen-1-yl acetate, (Z,Z)-7,11-
hexadecadien-1-yl acetate, (Z,E)-7,11-
hexadecadien-1-yl acetate
Rat LC50 inhalation ‡ > 5 mg/L air/4 h whole body exposure
acetate:
Skin irritation ‡ Irritant R38
acetate, and taking into consideration the
worst case results: (E,Z)-7,9-dodecadien-1-
yl acetate
Eye irritation ‡ Non-irritant
acetate:
EFSA Journal 2014;12(1):3524 32


Skin sensitisation ‡ Non-sensitiser (M&K Maximisation test)
acetate:
1-yl acetate, (Z,Z)-7,11-hexadecadien-1-yl
acetate, (Z,E)-7,11-hexadecadien-1-yl
acetate
Short term toxicity (Annex IIA, point 5.3)
Target / critical effect ‡ No data provided

Relevant oral NOAEL ‡ No data provided
Relevant dermal NOAEL ‡ No data provided
Relevant inhalation NOAEL ‡ No data provided
Genotoxicity ‡ (Annex IIA, point 5.4)

no genotoxic potential in vitro in gene
mutation assays in bacteria and
mammalian cells,
acetate:
Long term toxicity and carcinogenicity (Annex IIA, point 5.5)
Target/critical effect ‡ No data provided

Relevant NOAEL ‡ No data provided
Carcinogenicity ‡ No data provided
Reproductive toxicity (Annex IIA, point 5.6)

Reproduction toxicity
Reproduction target / critical effect ‡ No data provided
EFSA Journal 2014;12(1):3524 33

Relevant parental NOAEL ‡ No data provided

Relevant reproductive NOAEL ‡ No data provided
Relevant offspring NOAEL ‡ No data provided
Developmental toxicity
Developmental target / critical effect ‡ No data provided

Relevant maternal NOAEL ‡ No data provided
Relevant developmental NOAEL ‡ No data provided
Neurotoxicity (Annex IIA, point 5.7)
Acute neurotoxicity ‡ No data provided

Repeated neurotoxicity ‡ No data provided
Delayed neurotoxicity ‡ No data provided
Other toxicological studies (Annex IIA, point 5.8)
Mechanism studies ‡ No data provided

Studies performed on metabolites or impurities No data provided
‡
Medical data ‡ (Annex IIA, point 5.9)
Regular medical checks of manufacturing plant

personnel did not report any incidents of poisoning
or adverse effects.
Summary (Annex IIA, point 5.10) Value Study Safety

factor
ADI ‡ Not allocated No adequate
study available
AOEL ‡ Not allocated
for derivation of
ARfD ‡ Not allocated reference values
Dermal absorption ‡ (Annex IIIA, point 7.3)
Vapour releasing product in closed dispenser No data available

(VP)
Exposure scenarios (Annex IIIA, point 7.2)
Operator Vapour releasing product in closed dispenser (VP):
EFSA Journal 2014;12(1):3524 34

No reliable range of naturally occuring backgound

levels could be retrieved, a data gap has been
identified to provide naturally occuring background
level to allow a comparison with operator exposure
levels.
Workers Vapour releasing product in closed dispenser (VP):
level to allow a comparison with worker exposure
levels.
Bystanders Vapour releasing product in closed dispenser (VP):
level to allow a comparison with bystander
exposure levels.
Classification and proposed labelling with regard to toxicological data (Annex IIA,
point 10)
13
Substance classified: acetate blend: (Z)-8- Xi ―Irritant‖
dodecen-1-yl acetate and Dodecyl acetate R38 ―Irritating to skin‖
13
It should be noted that proposals for classification made in the context of the evaluation procedure under Regulation (EC)
No 1107/2009 are not formal proposals. Classification is formally proposed and decided in accordance with Regulation
(EC) No 1272/2008 of the European Parliament and of the Council of 16 December 2008 on classification, labelling and
packaging of substances and mixtures, amending and repealing Directives 67/548/EEC and 1999/45/EC, and amending
Regulation (EC) No 1907/2006. OJ L 353, 31.12.2008, 1-1355.
EFSA Journal 2014;12(1):3524 35

Residues
Summary of residues data according to the representative uses on raw agricultural
commodities and feedingstuffs (Annex IIA, point 6.3, Annex IIIA, point 8.2)
Data gap to address the natural background levels of SCLPs based on field measurements and to
demonstrate that the use of SCLPs as a plant protection product according to the use pattern will result
in concentrations not exceeding the naturally occurring SCLPs levels in the environment.
Proposed MRLs (Annex IIA, point 6.7, Annex IIIA, point 8.6)
Open.
EFSA Journal 2014;12(1):3524 36

Fate and Behaviour in the Environment

Route of degradation (aerobic) in soil (Annex IIA, point 7.1.1.1.1)
Dispenser application: open
Route of degradation in soil - Supplemental studies (Annex IIA, point 7.1.1.1.2)
Rate of degradation in soil (Annex IIA, point 7.1.1.2, Annex IIIA, point 9.1.1)
Soil adsorption/desorption (Annex IIA, point 7.1.2.)
Kf/Koc Dispenser application: open
Kd
pH dependence (yes/no) (if yes type of

dependence)
Mobility in soil (Annex IIA, point 7.1.3, Annex IIIA, point 9.1.2)
Column leaching Dispenser application: open
PEC (soil) (Annex IIIA, point 9.1.3)
Route and rate of degradation in water (Annex IIA, point 7.2.1)
Photolytic degradation of active substance and Dispenser application: open

relevant metabolites
PEC (surface water) (Annex IIIA, point 9.2.3)
PEC (sediment) (Annex IIIA, point 9.2.3)
EFSA Journal 2014;12(1):3524 37

PEC (groundwater) (Annex IIIA, point 9.2.1)
Dispenser application: not required
Fate and behaviour in air (Annex IIA point 7.2.2, Annex IIIA, point 9.3)
Laboratory study Dispenser application: open
Photochemical oxidative degradation in air Data gap
PEC (air) (Annex IIIA, point 9.3)
Definition of the residue (Annex IIA, point 7.3)
Relevant to the environment i) (Z)-8-dodecen-1-yl acetate

ii) Dodecyl acetate
Monitoring data, if available (Annex IIA, point 7.4)
Soil (indicate location and type of study) Not required, not available
Surface water (indicate location and type of study) Not required, not available
Ground water (indicate location and type of study) Not required, not available
Air (indicate location and type of study) Not required, not available
Classification and proposed labelling (Annex IIA, point 10)
with regard to fate and behaviour data Dispenser application: open
EFSA Journal 2014;12(1):3524 38

Ecotoxicology
General remark: As studies were not available for each substance for all groups of organisms it was
considered appropriate to regard the lowest endpoint from substances of a class (aldehyde
pheromones, acetate pheromones etc.) of pheromones as representative for this whole class of
pheromones (based on the principles of ―bridging‖ thoughout the whole group of SCLPs).
Effects on terrestrial vertebrates (Annex IIA, point 8.1, Annex IIIA, points 10.1 and 10.3)
Acute toxicity to birds LD50 > 2250 mg/kg bw (based on lowest endpoint of
SCLP Acetates)
Dietary toxicity to birds LC50 > 5620 mg/kg feed (based on lowest endpoint of
SCLP Acetates)
Acute toxicity to mammals LD50 > 2000 mg/kg bw (based on lowest endpoint of
SCLPs Acetates)
Toxicity/exposure ratios for terrestrial vertebrates (Annex IIIA, points 10.1 and 10.3)
Application
Category (e.g.
rate [kg Crop Time-scale TER Trigger
insectivorous bird)
as/ha]
Risk assessment open
Toxicity data for aquatic species (most sensitive species of each group) (Annex IIA, point 8.2,
Annex IIIA, point 10.2)
Time-scale Toxicity
Group Test substance Endpoint
(Test type) [mg/L]
Laboratory tests
Acetate Blend: (Z)-8-
96 hr No data
Fish Dodecenyl Acetate; LC50
provided
Dodecan-1-yl Acetate
Aquatic invertebrates 48 hr No data
Dodecenyl Acetate; EC50
(flow-through) provided
72 hr EbC50 No data
Algae Dodecenyl Acetate;
(static) ErC50 provided
n…nominal, im…initial measured, mm…mean measured
Toxicity/exposure ratios for the most sensitive aquatic organisms (Annex IIIA, point 10.2)
Application rate Time Distance
Crop Organism TER Trigger
[kg as/ha] scale (m)
Effects on honeybees (Annex IIA, point 8.7, Annex IIIA, point 10.4)
Acute oral toxicity No data available

Acute contact toxicity Limited toxic effects observed (Based study performed with SCLP
Acetates)
EFSA Journal 2014;12(1):3524 39

Inhalation toxicity (72 hour) Limited toxic effects observed (Based study performed with SCLP
Acetates)
Hazard quotients for honey bees (Annex IIIA, point 10.4)

Application rate
Crop Route Hazard quotient Trigger
[kg as/ha]
Effects on other arthropod species (Annex IIA, point 8.8, Annex IIIA, point 10.5)
Dose [g a.s./
Species Stage Test substance Endpoint Effect Trigger
dispenser]
Laboratory tests
Corrected
- 19%
Based study Mortality
Chrysoperla
Adults performed with 0.264 50%
carnea Oviposition 8.5%
SCLP Acetates
Larval Hatching - 7.1%
‗-‗ figure indicates a positive effect
Effects on earthworms (Annex IIA point 8.9, Annex IIIA, point 10.6)
Acute toxicity No data provided
Reproductive toxicity No data provided
Toxicity/exposure ratios for earthworms (Annex IIIA, point 10.6)

Application rate
Crop Time-scale TER Trigger
[kg as/ha]
Effects on soil micro-organisms (Annex IIA point 8.10, Annex IIIA, point 10.6)
Nitrogen mineralization No data provided
Carbon mineralization No data provided
Effects on terrestrial vascular plants (Annex IIA, point 8.12, Annex IIIA, point 10.8)
No data provided
Residues definition (consider all relevant metabolites requiring further assessment from the fate
section)
Compartment Ecotoxicologically relevant residue
soil i) (Z)-8-dodecen-1-yl acetate
ii) Dodecyl acetate
water i) (Z)-8-dodecen-1-yl acetate
ii) Dodecyl acetate
EFSA Journal 2014;12(1):3524 40

sediment i) (Z)-8-dodecen-1-yl acetate

ii) Dodecyl acetate
groundwater i) (Z)-8-dodecen-1-yl acetate
ii) Dodecyl acetate
Classification and proposed labeling with regard to ecotoxicological data (Annex IIA, point 10
and Annex IIIA, point 12.3)
RMS/EPCO proposal
Active substance R50/53
EFSA Journal 2014;12(1):3524 41

26 Acetate Blend: (Z)-9-Dodecenyl Acetate; Dodecan-1-yl Acetate

Active substance (ISO Common Name) ‡ no ISO common name

Function (e.g. fungicide) Insecticide

Chemical name (IUPAC) ‡ i) (Z)-9-dodecen-1-yl acetate

ii) Dodecyl acetate
Chemical name (CA) ‡ i) (Z)-9-dodecen-1-ol acetate
ii) Dodecyl acetate
CIPAC No ‡ i) 422
ii) 884
CAS No ‡ i) 16974-11-1
ii) 112-66-3
ii) 203-995-1
publication) ‡
manufactured ‡
manufactured
ii) C14H28O2
ii) 228.375 g/mol
O
O CH3
ii)
OAc
EFSA Journal 2014;12(1):3524 42


Boiling point (state purity) ‡ Z8-12:Ac 97.7% purity
12:Ac 98.9% purity
242-249°C
Appearance (state purity) ‡ Z8-12:Ac 97.7% purity
12:Ac 98.9% purity
Yellow liquid
Vapour pressure (state temperature, state Z8-12:Ac 97.7% purity
purity) ‡ 12:Ac 98.9% purity
20°C
Z8-12Ac = 0.157 Pa
12:Ac = 0.094 Pa
25°C
Z8-12Ac = 0.245 Pa
12:Ac = 0.162 Pa
80-99% purity
Solubility in water (state temperature, state Z8-12:Ac 97.7% purity
purity and pH) ‡ 12:Ac 98.9% purity
Z8-12:Ac (20°C)
Day 1 = 7.1 x 10-4 g/l (RSD 21.2%)
Day 2 = 8.0 x 10-4 g/l (RSD 6.8%)
Day 3 = 7.1 x 10-4 g/l (RSD 2.5%)
12:Ac (20°C)
Day 1 = 9 x 10-5 g/l (RSD 21.8%)
Day 2 = 13 x 10-4 g/l (RSD 1.5%)
Day 3 = 13 x 10-4 g/l (RSD 10.4%)
EFSA Journal 2014;12(1):3524 43

Solubility in organic solvents ‡ Z8-12:Ac 97.7% purity

(state temperature, state purity) 12:Ac 98.9% purity
Totally soluble in organic solvents. No precipitate
was generated
Surface tension ‡ Z8-12:Ac 97.7% purity
(state concentration and temperature, state 12:Ac 98.9% purity
purity)
39.9mN/m
Partition co-efficient ‡ Z8-12:Ac 97.7% purity
(state temperature, pH and purity) 12:Ac 98.9% purity
Z8-12:Ac
log P = 5.61 (25°C)
12:Ac
log P = 6.25 (25°C)
UV/VIS absorption (max.) incl. ‡ Z8-12:Ac 97.7% purity
(state purity, pH) 12:Ac 98.9% purity
UV VIS
52.88486486 cm-1 mol-1 l (204nm)
Z8-12:Ac 97.7% purity
12:Ac 98.9% purity
Flash point: 126°C
(statement)
* Reduced data requirement according to OECD document No 12 [Guidance for Registration

Requirements for Pheromones and Other Semiochemicals Used for Arthropod Pest Control (OECD
2001)] is considered.
EFSA Journal 2014;12(1):3524 44

Summary of representative uses evaluated (Acetate Blend: (Z)-9-Dodecenyl Acetate; Dodecan-1-yl Acetate)
I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Grape Italy ECODIAN® F Eupoecilia VP 20mg/ 2000 Before the 1st 2 60 days n. a. n. a. 2000 n. a.
EA / ambiguella dispen dispenser generation of dispense
Isagro ser s/ha the moth rs/ha x
20mg
=40g
Grape Italy ECODIAN® F Eupoecilia VP 20mg/ 2000- Before the 1st 2 60 days n. a. n. a. 2000 - n. a.
GRAPE / ambiguella dispen 2500 generation of 2500
Isagro ser dispenser the moth dispense
s/ha rs/ha x
20mg
=40g-
50g

n.a. not applicable
EFSA Journal 2014;12(1):3524 45

Remarks: (a) For crops, the EU and Codex classifications (both) should be used; where relevant, the (i) g/kg or g/l
use situation should be described (eg. fumigation of a structure) (j) Growth stage at last treatment (BBCH Monograph, Growth Stages of Plants, 1997,
EFSA Journal 2014;12(1):3524 46

Methods of Analysis



Soil Open
Water surface Open
Air Open

Food/feed of animal origin (analytical No residue definition is set
purposes)

EFSA Journal 2014;12(1):3524 47


5.1)
(animals and plants) ii) Dodecyl acetate
Toxicologically relevant compounds ‡ ii) (Z)-9-dodecen-1-yl acetate
(environment) ii) Dodecyl acetate

acetates:
acetates:
acetate:
yl acetate
acetate:
EFSA Journal 2014;12(1):3524 48


acetate:
acetate


mammalian cells,
acetate:


EFSA Journal 2014;12(1):3524 49





‡

or adverse effects.

factor
study available
for derivation of

(VP)
EFSA Journal 2014;12(1):3524 50


levels.
levels.
exposure levels.
point 10)
14
Substance classified: Acetate Blend:(Z)-9- Xi ―Irritant‖
dodecen-1-yl acetate; dodecyl acetate R38 ―Irritating to skin‖
14
EFSA Journal 2014;12(1):3524 51

Residues
Data gap is set to address the natural background levels of SCLPs based on field measurements and to
Open.
EFSA Journal 2014;12(1):3524 52


Kd

dependence)

EFSA Journal 2014;12(1):3524 53

Relevant to the environment i) (Z)-9-dodecen-1-yl acetate

ii) Dodecyl acetate
EFSA Journal 2014;12(1):3524 54

Ecotoxicology
pheromones(based on the principles of ―bridging‖ thoughout the whole group of SCLPs).
SCLP Acetates)
SCLP Acetates
SCLP Acetates)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
96 hr No data
Fish Dodecenyl Acetate; LC50
provided
48 hr No data
Aquatic invertebrates Dodecenyl Acetate; EC50
72 hr EbC50 No data
Algae Dodecenyl Acetate;

Acetates)
EFSA Journal 2014;12(1):3524 55

Acetates)

Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates

Application rate
[kg as/ha]
No data provided
section)
soil i) (Z)-9-dodecen-1-yl acetate
ii) Dodecyl acetate
water i) (Z)-9-dodecen-1-yl acetate
ii) Dodecyl acetate
EFSA Journal 2014;12(1):3524 56

sediment i) (Z)-9-dodecen-1-yl acetate

ii) Dodecyl acetate
groundwater i) (Z)-9-dodecen-1-yl acetate
ii) Dodecyl acetate
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 57

27 Acetate Blend: (7E, 9Z)-Dodecadienyl Acetate; (7E, 9E)-Dodecadienyl Acetate



Chemical name (IUPAC) ‡ i) (E,Z)-7,9-dodecadien-1-yl acetate

ii) (E,E)-7,9-dodecadien-1-yl acetate
Chemical name (CA) ‡ i) (E,Z)-7,9-dodecadien-1-ol acetate
ii) (E,E)-7,9-dodecadien-1-ol acetate
CIPAC No ‡ i) 864
ii) 863
CAS No ‡ i) 55774-32-8
ii) 54364-63-5
ii) --
publication) ‡
manufactured ‡
manufactured
Molecular formula ‡ i) C12H22O
ii) C12H22O
ii) 224.344 g/mol
O
O CH3
ii)
O
O CH3
EFSA Journal 2014;12(1):3524 58


Boiling point (state purity) ‡ 97.2% purity
298°C at atmospheric pressure; aluminium pierced pan
Temperature of decomposition (state purity) 97.2% purity
Decomposition starts at 250°C; steel closed ‗high
pressure‘ pan;
Appearance (state purity) ‡ >75% purity
(19% other geometric isomers)
Total with isomers 94% purity
light yellow transparent liquid
Vapour pressure (state temperature, state 97.2% purity
1.7E-2 Pa (20°C)
purity) ‡ 3.2E-1 Pa (25°C)
Henry‘s law constant ‡ 3

H = 0.006 kPa m /mol
Solubility in water (state temperature, state 97.5% purity
-3
0.67 x 10 g/l (20°C)
purity and pH) ‡ pH 6.2
Solubility in organic solvents ‡ 97.5% purity
Solubilities at 20°C
(state temperature, state purity)

Surface tension ‡ 97.2% purity
49.7mN/m at 0.01% in pure water (20°C)
(state concentration and temperature, state
purity)
Partition co-efficient ‡ The study for Z-8-dodecenyl acetate can be
(state temperature, pH and purity) regarded as representative.
log P = 5.61 (25°C)
UV/VIS absorption (max.) incl. ‡ Not required as section fate and behaviour does not
(state purity, pH) indicate any concern for dispenser application
EFSA Journal 2014;12(1):3524 59


82.21% purity
Flash point: 138°C
(statement)

EFSA Journal 2014;12(1):3524 60

Summary of representative uses evaluated Acetate Blend: ((7E, 9Z)-Dodecadienyl Acetate; (7E, 9E)-Dodecadienyl Acetate)
I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Grape AT Pheromone F Lobesia VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n. a.

ES dispenser / botrana mg/dis dispenser/ of 1st generatio dispense
FR DKSH penser ha, generation n r/ha x 1
GE (SiberHegne dispenser moth flight of mg =
IT r) in Funnel 1st species 10-12
NL trap occurring mg /ha
UK
Grape AT XLure F Lobesia VP 2 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n. a.

GE (SiberHegne dispenser moth flight of mg = 20-
IT r) in Funnel 1st species 24
NL trap occurring mg/ha
UK

IT r) in Delta 1st species 100-120
UK

n.a. not applicable
EFSA Journal 2014;12(1):3524 61

EFSA Journal 2014;12(1):3524 62

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)
Open

EFSA Journal 2014;12(1):3524 63


5.1)
Toxicologically relevant compounds ‡ i) (E,Z)-7,9-dodecadien-1-yl acetate
(animals and plants) ii) (E,E)-7,9-dodecadien-1-yl acetate
Toxicologically relevant compounds ‡ i) (E,Z)-7,9-dodecadien-1-yl acetate
(environment) ii) (E,E)-7,9-dodecadien-1-yl acetate

acetates:
acetates:
acetate:
yl acetate
acetate:
EFSA Journal 2014;12(1):3524 64


acetate:
acetate


mammalian cells,
acetate:


EFSA Journal 2014;12(1):3524 65





‡

or adverse effects.

factor
study available
for derivation of

(VP)
EFSA Journal 2014;12(1):3524 66


levels.
levels.
exposure levels.
point 10)
15
Substance classified: Acetate blend: (E,Z)-7,9- Xi ―Irritant‖
dodecadien-1-yl acetate, (E,E)-7,9- R38 ―Irritating to skin‖
dodecadien-1-yl acetate
15
EFSA Journal 2014;12(1):3524 67

Residues
Open.
EFSA Journal 2014;12(1):3524 68


Kd

dependence)

EFSA Journal 2014;12(1):3524 69

Relevant to the environment i) (E,Z)-7,9-dodecadien-1-yl acetate

EFSA Journal 2014;12(1):3524 70

Ecotoxicology
SCLP Acetates)
SCLP Acetates
SCLP Acetates)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
Acetate Blend: (7E, 9Z)- No data
Dodecadienyl Acetate; 96 hr provided
Fish LC50
(7E, 9E)-Dodecadienyl (semi-static)
Acetate
Dodecadienyl Acetate; 48 hr provided
Aquatic invertebrates EC50
(7E, 9E)-Dodecadienyl (flow-through)
Acetate
Dodecadienyl Acetate; 72 hr EbC50 provided
Algae
(7E, 9E)-Dodecadienyl (static) ErC50
Acetate
EFSA Journal 2014;12(1):3524 71


Acetates)
Acetates)

Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates

Application rate
[kg as/ha]
No data provided
section)
EFSA Journal 2014;12(1):3524 72

soil i) (E,Z)-7,9-dodecadien-1-yl acetate

water i) (E,Z)-7,9-dodecadien-1-yl acetate
sediment i) (E,Z)-7,9-dodecadien-1-yl acetate
groundwater i) (E,Z)-7,9-dodecadien-1-yl acetate
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 73

28 Acetate Blend: (7Z, 11Z)-Hexadecadien-1-yl Acetate; (7Z, 11E)-Hexadecadien-1-yl

Acetate


Chemical name (IUPAC) ‡ i) (Z,Z)-7,11-hexadecadien-1-yl acetate

ii) (Z,E)-7,11-hexadecadien-1-yl acetate
Chemical name (CA) ‡ i) (Z,Z)-7,11-hexadecadien-1-ol acetate
ii) (Z,E)-7,11-hexadecadien-1-ol acetate
CIPAC No ‡ i) 866
ii) 865
CAS No ‡ i) & ii) 53042-79-8
i) 52207-99-5
ii) 51606-94-4
ii) --
publication) ‡
manufactured ‡
manufactured
ii) C18H32O2
ii) 280.451 g/mol
O
O CH3
ii)
O
O CH3
EFSA Journal 2014;12(1):3524 74


Boiling point (state purity) ‡ blend >90.1% purity (ZZ 47.4%, ZE 42.7%)
(other geometric isomers <3.5%)
Total blend with isomers: >93.6%
170~175°C/3Pa
Appearance (state purity) ‡ blend >90.1% purity (ZZ 47.4%, ZE 42.7%)
light yellow transparent oily liquid
Vapour pressure (state temperature, state blend >90.1% purity (ZZ 47.4%, ZE 42.7%)
purity) ‡ (other geometric isomers <3.5%)
0.00008Pa (20°C)
80-99% purity
Solubility in water (state temperature, state 7.1 x 10-4 – 0.14 g/L
purity and pH) ‡ 80-99% purity
bridged from SCLP acetates summary
Solubility in organic solvents ‡ blend >90.1% purity (ZZ 47.4%, ZE 42.7%)
(state temperature, state purity) (other geometric isomers <3.5%)
soluble in n-hexane, n-pentane, benzene, toluene,
methanol, ethanol, ethyl ether, acetone, methylene
chloride, chloroform, acetonitrile, THF, DMF, acetic
acid
Insoluble in DMSO and ethylene glycol
Surface tension ‡ 38 - 50 mN/m at 0.01% in pure water
(state concentration and temperature, state whole group of SCLP actives
purity)
80-99% purity
EFSA Journal 2014;12(1):3524 75

Partition co-efficient ‡ blend >90.1% purity (ZZ 47.4%, ZE 42.7%)

(state temperature, pH and purity) (other geometric isomers <3.5%)
more than 4 (log P o/w) (25°C)
(state purity, pH) indicate any concern for dispenser application*
blend >90.1% purity (ZZ 47.4%, ZE 42.7%)
Flash point: 167°C
(statement)

EFSA Journal 2014;12(1):3524 76

Summary of representative uses evaluated (Acetate Blend: (7Z, 11Z)-Hexadecadien-1-yl Acetate; (7Z, 11E)-Hexadecadien-1-yl Acetate)
I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Cotton Greece Frustrate F Pectinophora VP 160mg 160mg/ha Before the 1st 1 n. a. n. a. n. a. 250 n. a.
Spain PBW / gossypiella /dispe generation of dispense
AgriSense nser the moth rs/ha x
160mg =
40g/ha
Cotton AT Pheromone F Pectinophora VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

ES dispenser / gossypiella mg/dis dispenser/ of 1st generatio dispense
UK
Cotton Greece CHECKMAT F Pectinophora CS 28- 28- Before the 1st 8 When n. a. n a. 28- n. a.
Spain E PBW-FXL gossypiella LVS 140ml 140ml/ha generation of required 140ml/h
(All / the moth a x 8
Field Suterra applicati
Trials) (Consep ons =
GmbH) 224-
1120
ml/ha
EFSA Journal 2014;12(1):3524 77


n.a. not applicable
EFSA Journal 2014;12(1):3524 78

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 79


5.1)
Toxicologically relevant compounds ‡ i) (Z,Z)-7,11-hexadecadien-1-yl acetate
(animals and plants) ii) (Z,E)-7,11-hexadecadien-1-yl acetate
Toxicologically relevant compounds ‡ i) (Z,Z)-7,11-hexadecadien-1-yl acetate
(environment) ii) (Z,E)-7,11-hexadecadien-1-yl acetate

Rat LC50 inhalation ‡ > 6.72 mg/L air/4h, (whole-body)
> 4.84 mg/L air/4h (nose-only)
Skin irritation ‡ Non-irritant


mutation assays in bacteria;
and in vitro gene mutation in mammalian
cells based on bridging from other SCLP
acetate:
dodecadien-1-yl acetate
EFSA Journal 2014;12(1):3524 80






‡

or adverse effects.

factor
study available
EFSA Journal 2014;12(1):3524 81

ARfD ‡ Not allocated for derivation of

reference values

(VP); Microencapsulated vapour releasing
system, spray application
Operator Vapour releasing product in closed dispenser (VP)

and microcapsule suspension, spray application:
levels.
Microcapsule suspension, spray application:
data gap: a realistic exposure assessment for the
operators is required, to be compared with natural
background levels.
Workers Vapour releasing product in closed dispenser (VP)
levels.
workers is required, to be compared with natural
background levels.
Bystanders Vapour releasing product in closed dispenser (VP)
exposure levels.
bystanders is required, to be compared with natural
background levels.
EFSA Journal 2014;12(1):3524 82

point 10)
16
Substance classified: Acetate Blend: (Z,Z)- None
7,11-hexadecadien-1-yl acetate, (Z,E)-7,11-
16
EFSA Journal 2014;12(1):3524 83

Residues
-For the intended use of the active substance SCLPs emitted via volatilisation from closed retrievable
dispensers, a data gap is set to address the natural background levels and to demonstrate that these are
not exceeded when using the SCLPs as a plant protection product according to the use pattern.
-For the low volume spray application of microencapsulated SCLPs, a data gap is set to provide a
sufficient residue data package in order to conduct a reliable consumer dietary risk assessment.
Open.
EFSA Journal 2014;12(1):3524 84



Spray application: not fully established



Kd

dependence)


Spray application: no risk assessment submitted

relevant metabolites Spray application: not fully established

EFSA Journal 2014;12(1):3524 85





Relevant to the environment i) (Z,Z)-7,11-hexadecadien-1-yl acetate


EFSA Journal 2014;12(1):3524 86

Ecotoxicology
SCLP Acetates)
SCLP Acetates
SCLP Acetates)
Application
Category (e.g.
insectivorous bird)
as/ha]
Dispenser application: Risk assessment open
Spray application: Risk assessment open
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
Acetate Blend: (7Z, 11Z)-
No reliable
Hexadecadien-1-yl 96 hr
Fish LC50 data
Acetate; (7Z, 11E)-
provided
Hexadecadien-1-yl Acetate
No reliable
Hexadecadien-1-yl 48 hr
Aquatic invertebrates EC50 data
Acetate; (7Z, 11E)- (flow-through)
provided
No reliable
Algae Hexadecadien-1-yl 72 hr EbC50
data
Acetate; (7Z, 11E)- (static) ErC50
provided
EFSA Journal 2014;12(1):3524 87


Acetates)
Acetates)

Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates

Application rate
[kg as/ha]
No data provided
section)
EFSA Journal 2014;12(1):3524 88


soil i) (Z,Z)-7,11-hexadecadien-1-yl acetate
water i) (Z,Z)-7,11-hexadecadien-1-yl acetate
sediment i) (Z,Z)-7,11-hexadecadien-1-yl acetate
groundwater i) (Z,Z)-7,11-hexadecadien-1-yl acetate
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 89

29 Aldehyde Blend: (Z)-9-hexadecenal; (Z)-11-hexadecenal; (Z)-13-octadecenal


Chemical name (IUPAC) ‡ i) (Z)-9-hexadecenal

ii) (Z)-11-hexadecenal
iii) (Z)-13-octadecenal
Chemical name (CA) ‡ i) (Z)-9-hexadecenal
CIPAC No ‡ i) 881
ii) 875
iii) 878
CAS No ‡ i) 56219-04-6
ii) 53939-28-9
iii) 58594-45-9
ii) 258-876-7
iii) 261-349-4
publication) ‡
manufactured ‡
manufactured
ii) C16H30O
iii) C18H34O
ii) 238.41 g/mol
iii) 266.468 g/mol
O
EFSA Journal 2014;12(1):3524 90

ii)
O
iii)
O
EFSA Journal 2014;12(1):3524 91


Boiling point (state purity) ‡ blend >92% purity
(Z9-16:Al = 8.4%, Z11-16:Al = 81.4%, Z13:Al =
10.2%)
Z9-16:Al = 136°C/0.9mmHg
Z11-16:Al = 125°C/0.2mmHg
Z13:Al = 167 °C/1.5mmHg
Appearance (state purity) ‡ blend >92% purity
(Z9-16:Al = 8.4%, Z11-16:Al = 81.4%, Z13:Al =
10.2%)
light yellow liquid
Vapour pressure (state temperature, state The study for (Z)-9-Hexadecenal can be regarded
purity) ‡ as representative.
-2
3.11 x 10 Pa (25°C)
80-99% purity
Solubility in organic solvents ‡ blend >92% purity
(state temperature, state purity) (Z9-16:Al = 8.4%, Z11-16:Al = 81.4%, Z13:Al =
10.2%)
readily soluble in common organic solvents
including n-heptane, xylene, acetone
purity)
80-99% purity
Partition co-efficient ‡ Data required
(state temperature, pH and purity) Open for applicability of data to all the SCLP‘s
EFSA Journal 2014;12(1):3524 92

Flash point: 61°C
blend >92% purity
(Z9-16:Al = 8.4%, Z11-16:Al = 81.4%, Z13:Al =
10.2%)
Reference required
(statement)

EFSA Journal 2014;12(1):3524 93

Summary of representative uses evaluated (Aldehyde Blend: (Z)-9-hexadecenal; (Z)-11-hexadecenal; (Z)-13-octadecenal)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Rice Spain Selibate CS F Chilo VP 400mg 50-100 Before begin 1 n. a. n. a. n. a. 50-100 n. a.

/ suppressalis dispen dispenser/ of 1.st dispense
AgriSense ser ha generation r x
moth flight of 400mg =
1.st species 20-
occurs 40g/ha
Rice Spain FERSEX F Chilo VP 6mg/di 5 Before begin 1 n. a. n. a. n. a. 5 n. a.

ChS / suppressalis spens dispenser/ of 1.st dispense
SEDQ er ha generation r x 6mg
4,6 mass moth flight of =
g/kg trapping 1.st species 0.03g/ha
(1) occurs
0,4 80-100 Before begin 1 80-100

g/disp dispenser of 1.st disp./ha
enser s/ha generation x 0,4 g
(2) mating moth flight of /disp.=
disruption 1.st species 32-40
occurs g/ha

n.a. not applicable
EFSA Journal 2014;12(1):3524 94

EFSA Journal 2014;12(1):3524 95

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 96


5.1)
Toxicologically relevant compounds ‡ i) (Z)-9-hexadecenal
(animals and plants) ii) (Z)-11-hexadecenal
(environment) ii) (Z)-11-hexadecenal

based on bridging from: (Z)-11-
hexadecenal
hexadecenal
Rat LC50 inhalation ‡ 4.46 (females) mg/L air/4 h whole body R20
exposure
hexadecenal
hexadecenal
hexadecenal
Skin sensitisation ‡ Sensitiser (based on chemical structure) R43

EFSA Journal 2014;12(1):3524 97

Data gap: Genotoxicity tests with SCLP

aldehydes have to be provided






‡

or adverse effects.
EFSA Journal 2014;12(1):3524 98


factor
study available
for derivation of

levels.
levels.
exposure levels.
point 10)
17
Substance classified: Aldehyde Blend: (Z)-9- Xn ―Harmful‖
hexadecenal, (Z)-11-hexadecenal, (Z)-13- R20 ―Harmful by inhalation‖
octadecenal
R43 ―May cause sensitisation by skin contact‖
17
EFSA Journal 2014;12(1):3524 99

Residues
Data gap is set to address the natural background levels of SCLPs based on field measurements and
to demonstrate that the use of SCLPs as a plant protection product according to the use pattern will
result in concentrations not exceeding the naturally occurring SCLPs levels in the environment.
Open.
EFSA Journal 2014;12(1):3524 100


Kd

dependence)

EFSA Journal 2014;12(1):3524 101

Relevant to the environment i) (Z)-9-hexadecenal

EFSA Journal 2014;12(1):3524 102

Ecotoxicology
SCLP Aldehydes)
SCLP Aldehydes)
Acute toxicity to mammals LD50 > 5000 mg/kg bw
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
Aldehyde Blend: (Z)-9-
hexadecenal; (Z)-11- No data
Fish 96 hr LC50
hexadecenal; (Z)-13- provided
octadecenal
hexadecenal; (Z)-11- 48 hr No data
Aquatic invertebrates EC50
hexadecenal; (Z)-13- (flow-through) provided
octadecenal
hexadecenal; (Z)-11- 72 hr EbC50 No data
Algae
hexadecenal; (Z)-13- (static) ErC50 provided
octadecenal
Acute oral toxicity No data provided

Acute contact toxicity No data provided
EFSA Journal 2014;12(1):3524 103


Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
No data provided.

Application rate
[kg as/ha]
No data provided
section)
soil i) (Z)-9-hexadecenal
water i) (Z)-9-hexadecenal
sediment i) (Z)-9-hexadecenal
groundwater i) (Z)-9-hexadecenal
EFSA Journal 2014;12(1):3524 104

RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 105

30 Blend Mixture: E-5-Decen-1-yl Acetate; E-5-Decen-1-ol



Chemical name (IUPAC) ‡ i) (E)-5-decen-1-yl acetate

ii) (E)-5-decen-1-ol
Chemical name (CA) ‡ i) (E)-5-decen-1-ol acetate
CIPAC No ‡ i) 870
ii) 869
CAS No ‡ i) 38421-90-8
ii) 56578-18-8
ii) 260-267-6
publication) ‡
manufactured ‡
manufactured
ii) C10H20O
ii) 156.269 g/mol
O
O CH3
ii)
OH
EFSA Journal 2014;12(1):3524 106


Boiling point (state purity) ‡ blend: 98.6% purity (E5-10:Ac = 84.2%, E5-10OH =
14.4%)
226-230°C
Appearance (state purity) ‡ blend: 98.6% purity (E5-10:Ac = 84.2%, E5-10OH =
14.4%)
colourless liquid
Vapour pressure (state temperature, state blend: 98.6% purity (E5-10:Ac = 84.2%, E5-10OH =
purity) ‡ 14.4%)
E5-10:Ac = 1.085 Pa (20°C)
E5-10OH = 1.364 Pa (20°C)
80-99% purity
Solubility in water (state temperature, state blend: 98.6% purity (E5-10:Ac = 84.2%, E5-10OH =
purity and pH) ‡ 14.4%)
E5-10:Ac (20°C)
Day 1 = 6.0 x 10-3 g/l (RSD 6.1%)
Day 2 = 8.6 x 10-3 g/l (RSD 4.8%)
Day 3 = 7.2 x 10-3 g/l (RSD 10.4%)
E5-10:OH (20°C)
Day 1 = 0.138 g/l (RSD 0.84%)
Day 2 = 0.139 g/l (RSD 0.46%)
Day 3 = 0.137 g/l (RSD 1.68%)
Solubility in organic solvents ‡ blend: 98.6% purity (E5-10:Ac = 84.2%, E5-10OH =
(state temperature, state purity) 14.4%)
easily soluble in common organic solvent, no
precipitate generated
Surface tension ‡ blend: 98.6% purity (E5-10:Ac = 84.2%, E5-10OH =
(state concentration and temperature, state 14.4%)
purity) 37mN/m at in pure water
EFSA Journal 2014;12(1):3524 107

Partition co-efficient ‡ blend: 98.6% purity (E5-10:Ac = 84.2%, E5-10OH =

(state temperature, pH and purity) 14.4%)
log p = 4.95 (20°C)
UV/VIS absorption (max.) incl. ‡ blend: 98.6% purity (E5-10:Ac = 84.2%, E5-10OH =
(state purity, pH) 14.4%)
UV VIS spectrum
232.8081967 cm-1 mol-1 l (206nm)
5.384153005 cm-1 mol-1 l (580nm)
Flash point: 110°C
blend: 98.6% purity (E5-10:Ac = 84.2%, E5-10OH =
14.4%)
(statement)

EFSA Journal 2014;12(1):3524 108

Summary of representative uses evaluated (Blend Mixture: 5-Decen-1-yl Acetate; 5-Decen-1-ol)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Peach Italy RAK 5+6 / F Anarsia VP 550 500 Before begin 1 n. a. n. a. n. a. 500 n. a.
BASF lineatella mg dispenser/ of 1.st dispense
/dispe ha generation r x 550
nser moth flight of mg =
1.st species 275 g/ha
occurring
Stone Spain CHECKMAT F Anarsia VP 100mg 500 Before the 1st 2 When n. a. n. a. 500 n. a.
Fruits, E lineatella /dispe dispenser generation of required dispense
Tree Nut PTB / nser s/ha the moth rs/ha x
Crops Suterra 100mg =
(Consep 50g/ha x
GmbH) 2
applicati
ons =
100g/ha
Stone Italy CHECKMAT F Anarsia VP 200mg 375 Before the 1st 2 When n. a. n. a. 375 n. a.
Fruits, E lineatella /dispe dispenser generation of required dispense
Tree Nut Spain - PTB-XL 7 nser s/ha the moth rs/ha x
Crops (Field Suterra 100mg =
Trials) (Consep 50g/ha x
GmbH) 2
applicati
ons =
100g/ha
EFSA Journal 2014;12(1):3524 109


I controlled
(a) (b) (l) (m)
(c)
(j) s (min) min max min
(d-f) (i) (f-h) (k)
max
Stone Spain CHECKMAT F Anarsia CS 143- 143- Before the 1st 7 When n. a. n. a. 143- n. a.
Fruits, Italy E lineatella LVS 571ml/ 571ml/ha generation of required 571ml/h
Tree Nut Greece PTB-F / CS the moth a X 7
Crops (All Suterra applicati
Field (Consep ons =
Trials) GmbH) 1001-
3997ml/
ha
Stone fruit, Italy CHECKMAT F Grapholita VP 255 375 Before the 1st 2 When n. a. n. a. 375 n. a.
tree nut E SF-XL / molesta + mg dispenser generation of required dispense
crops Suterra Anarsia PTB s/ha the moth rs/ha x
(Consep lineatella 255 mg
GmbH) = 95.6
g/ha x 2
applicati
ons =
191.2
g/ha
EFSA Journal 2014;12(1):3524 110


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Stone fruit, Spain CHECKMAT F Grapholita VP 200 375-500 Before the 1st 2 When n. a. n. a. 375- n. a.
tree nut E SF / molesta + mg dispenser generation of required dispense
crops Suterra Anarsia s/ha the moth rs/ha x
GmbH) = 75
g/ha x 2
applicati
ons =
150g/ha
500-
dispense
rs/ha x
200 mg
= 100
g/ha x 2
applicati
ons =
200g/ha
Italy ECODIAN® F Anarsia VP 10mg/ 2000- Before the 1st 2 50 days n. a. n. a. 2000- n. a.
Peach (DPR AL / lineatella dispen 2500- generation of 2500-
Apricot 290) Isagro ser 3000 the moth 3000
Spain dispenser dispense
s/ha (low- rs/ha x
mod-high 10mg =
density 20g-25g-
pest) 30g/ha
EFSA Journal 2014;12(1):3524 111


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Peach AT Pheromone F Anarsia VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

Nectarine ES dispenser / lineatella mg/dis dispenser/ of 1st generatio dispense
IT r in Funnel 1st species 12
UK 10
mg/dis 10-12
penser 10-12 dispense
dispenser/ r/ha x 10
ha, mg =
dispenser 100-120
in Funnel mg/ha
trap

n.a. not applicable
EFSA Journal 2014;12(1):3524 112

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 113


5.1)
Toxicologically relevant compounds ‡ i) (E)-5-decen-1-yl acetate
(animals and plants) ii) (E)-5-decen-1-ol
Toxicologically relevant compounds ‡ i) (E)-5-decen-1-yl acetate
(environment) ii) (E)-5-decen-1-ol

Rat LC50 inhalation ‡ > 5.045 mg/L air/4h (nose-only)
Eye irritation ‡ Irritant R36


and no genotoxic potential in vitro gene
mutation assay in mammalian cells and
chromosome aberration tests based on
bridging from other SCLP acetate and
alcohol: (E/Z)-8-dodecen-1-yl acetate, (Z)-
9-dodecen-1-yl acetate, (E,Z)-7,9-
dodecadien-1-yl acetate, (E, E)-8,10-
dodecadien-1-ol
EFSA Journal 2014;12(1):3524 114







‡

or adverse effects.
EFSA Journal 2014;12(1):3524 115


factor
study available
for derivation of
Vapour releasing product in closed dispenser, No data available

microencapsulated vapour releasing system,
spray application

levels.
background levels.
levels.
background levels.
exposure levels.
background levels.
EFSA Journal 2014;12(1):3524 116

point 10)
18
Substance classified: Blend Mixture: (E)-5- Xi ―Irritant‖
decen-1-yl acetate, (E)-5-decen-1-ol R36 ―Irritating to eyes‖
R38 ―Irritating to skin‖
18
EFSA Journal 2014;12(1):3524 117

Residues
Open.
EFSA Journal 2014;12(1):3524 118






Kd

dependence)




EFSA Journal 2014;12(1):3524 119





Relevant to the environment i) (E)-5-decen-1-yl acetate


EFSA Journal 2014;12(1):3524 120

Ecotoxicology
Acute toxicity to birds LD50 > 2050 mg/kg bw

SCLPs)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
Blend Mixture: 5-Decen-1-
Fish 96 hr
yl acetate LC50 1.089 mm
(Brachydanio rerio) (semi-static)
5-decen-1-ol
Aquatic invertebrates 48 hr
yl acetate EC50 1.9 mm
(Daphnia magna) (flow-through)
5-decen-1-ol
Algae 72 hr EbC50 0.261 mm
yl acetate
(Scenedesmus subspicatus) (static) ErC50 1.109 mm
5-decen-1-ol
Acute oral toxicity LD50 > 85 µg a.s./bee (based on lowest endpoint of SCLPs)
Acute contact toxicity LD50 > 100 µg a.s./bee (based on lowest endpoint of SCLPs)
EFSA Journal 2014;12(1):3524 121


Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Based on Mortality
Chrysoperla
Adults lowest endpoint 0.264 50%
of SCLPs

Application rate
[kg as/ha]
No data provided
section)
soil i) (E)-5-decen-1-yl acetate
water i) (E)-5-decen-1-yl acetate
sediment i) (E)-5-decen-1-yl acetate
EFSA Journal 2014;12(1):3524 122

groundwater i) (E)-5-decen-1-yl acetate
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 123

31 Blend Mixture: (E/Z)-8-Dodecenyl Acetate; (Z)-8-Dodecenol



Chemical name (IUPAC) ‡ i) (E/Z)-8-dodecen-1-yl acetate

ii) (Z)-8-dodecen-1-ol
Chemical name (CA) ‡ i) (E/Z)-8-dodecen-1-ol acetate
CIPAC No ‡ i) 871
ii) 880
CAS No ‡ i)—
as individual isomers:
(E) 38363-29-0
(Z) 28079-04-1
ii) 40642-40-8
EC No (EINECS or ELINCS) ‡ i)—
as individual isomers:
(E) 253-904-4
(Z) 248-823-6
ii) 255-019-9
publication) ‡
manufactured ‡
manufactured
ii) C12H22O
ii) 184.32 g/mol
Structural formula ‡ i) –
E/Z as individual isomers
EFSA Journal 2014;12(1):3524 124

O CH3
O CH3
ii)
OH
EFSA Journal 2014;12(1):3524 125


Boiling point (state purity) ‡ blend >95% (Z8-12:Ac >89.6%, E8-12:Ac >4.7%,
Z8-12:OH >0.7%)
115-125°C/3mmHg
Appearance (state purity) ‡ blend >95% (Z8-12:Ac >89.6%, E8-12:Ac >4.7%,
Z8-12:OH >0.7%)
Vapour pressure (state temperature, state blend >95% (Z8-12:Ac >89.6%, E8-12:Ac >4.7%,
purity) ‡ Z8-12:OH >0.7%)
5.31 x 10-3 mmHg (20°C)
or
0.71 Pa
80-99% purity
Solubility in organic solvents ‡ blend >95% (Z8-12:Ac >89.6%, E8-12:Ac >4.7%,
(state temperature, state purity) Z8-12:OH >0.7%)
easily soluble in common organic solvent except
DMSO and ethylene glycol
purity)
80-99% purity
Partition co-efficient ‡ blend >95% (Z8-12:Ac >89.6%, E8-12:Ac >4.7%,
(state temperature, pH and purity) Z8-12:OH >0.7%)
>10000
EFSA Journal 2014;12(1):3524 126

Flash point: 108°C
blend >95% (Z8-12:Ac >89.6%, E8-12:Ac >4.7%,
Z8-12:OH >0.7%)
(statement)

EFSA Journal 2014;12(1):3524 127

Summary of representative uses evaluated (Blend Mixture: (E/Z)-8-Dodecenyl Acetate; (Z)-8-Dodecenol)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Stone fruit, Spain CHECKMAT F Grapholita VP 180mg 270 Before the 1st 2 When n.a n.a 270 n.a
Pome fruit, E OFM / molesta /dispe dispenser generation of required dispense
Tree Nut Suterra nser s/ha the pest rs/ha x
crops (Consep 180mg =
GmbH) 48.6g/ha
x 2
applicati
ons =
97.2g/ha
Stone fruit, Italy CHECKMAT F Grapholita VP 250mg 270 Before the 1st 2 When n.a n.a 270 n.a
Pome fruit, Spain E OFM-XL / molesta /dispe dispenser generation of required dispense
Tree Nut (All Suterra nser s/ha the pest rs/ha x
crops Field (Consep 250mg =
Trials) GmbH) 67.5g/ha
x 2
applicati
ons =
135g/ha
Pome fruit, Spain CHECKMAT F Grapholita CSL 96- 96- Before the 1st 7 When n.a n.a 96- n.a
Tree Nut Greece E OFM-F / molesta VS 215ml/ 215ml/ha generation of required 215ml/h
crops Germa Suterra CS the pest a x 7
ny (Consep applicati
(All GmbH) ons =
Field 0.672-
Trials) 1.505l/h
a
Italy (In
Review
)
EFSA Journal 2014;12(1):3524 128


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Stone fruit, Italy CHECKMAT F Grapholita VP 250 375 Before the 1st 2 When n.a. n.a. 375 n.a.
tree nut E SF-XL / molesta + mg dispenser generation of required dispense
crops Suterra Anarsia OFM s/ha the moth rs/ha x
GmbH) (255 mg)
= 93.75
(95.63)
g/ha x 2
applicati
ons =
187.5
(191.3)
g/ha
Stone fruit, Spain CHECKMAT F Grapholita VP 180 375-500 Before the 1st 2 When n.a. n.a. 375- n.a.
tree nut E SF / molesta + mg dispenser generation of required dispense
crops Suterra Anarsia OFM s/ha the moth rs/ha x
GmbH) = 67.5
g/ha x 2
applicati
ons =
135.0g/h
a
500-
dispense
rs/ha x
180 mg
= 90
g/ha x 2
applicati
ons =
180g/ha
EFSA Journal 2014;12(1):3524 129


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Peach Italy ECODIAN® F Cydia VP 10mg/ 2000- Before the 1st 2/3 60 days n.a. n.a. 2000- N.A.
Nectarine CM / molesta dispen 2500- generation of 2500-
Apple Isagro ser 3000 the moth 3000
Pear dispenser dispense
s/ha (low- rs/ha x
mod-high 10mg =
density 20g-25g-
pest) 30g/ha
Apricot, Spain Grapholita F Cydia VP (1) (1) Before the 1st 1 n.a. n.a. n.a. (1) N.A.
Plum, Molesta sex molesta generation of
Almond pheromone / the moth
SEDQ

n.a. not applicable
EFSA Journal 2014;12(1):3524 130

EFSA Journal 2014;12(1):3524 131

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 132


5.1)
Toxicologically relevant compounds ‡ i) (E/Z)-8-dodecen-1-yl acetate
(animals and plants) ii) (Z)-8-dodecen-1-ol
Toxicologically relevant compounds ‡ i) (E/Z)-8-dodecen-1-yl acetate
(environment) ii) (Z)-8-dodecen-1-ol

Rat LC50 inhalation ‡ > 4.74 mg/L air/4h (nose-only)
Skin sensitisation ‡ Sensitiser (M&K test) R43
based on bridging from SCLP alcohol: (E,
E)-8,10-dodecadien-1-ol


and in vitro gene mutation assay in
mammalian cells and chromosome
aberration tests based on bridging from
other SCLP acetate and alcohol: (E/Z)-8-
dodecen-1-yl acetate, (Z)-9-dodecen-1-yl
acetate, (E,Z)-7,9-dodecadien-1-yl acetate,
(E, E)-8,10-dodecadien-1-ol
EFSA Journal 2014;12(1):3524 133







‡

or adverse effects.
EFSA Journal 2014;12(1):3524 134


factor
study available
for derivation of
Vapour releasing product in closed dispenser, No data available

microencapsulated vapour releasing system,
spray application

levels.
background levels.
levels.
background levels.
exposure levels.
background levels.
EFSA Journal 2014;12(1):3524 135

point 10)
19
Substance classified: Blend Mixture: (E/Z)-8- Xi ―Irritant‖
dodecen-1-yl acetate, (Z)-8-dodecen-1-ol R43 ―May cause sensitisation by skin contact‖
19
EFSA Journal 2014;12(1):3524 136

Residues
Open.
EFSA Journal 2014;12(1):3524 137






Kd

dependence)




EFSA Journal 2014;12(1):3524 138





Relevant to the environment i) (E/Z)-8-dodecen-1-yl acetate


EFSA Journal 2014;12(1):3524 139

Ecotoxicology

Dietary toxicity to birds LC50 > 5000 mg/kg feed
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
Blend Mixture: E/Z-8- No reliable
96 hr
Fish Dodecenyl acetate LC50 data
(semi-static)
Z-8-Dodecen-1-ol provided
Blend Mixture: E/Z-8-
Dodecenyl acetate EC50 0.31 n
(Daphnia magna) (semi-static)
Z-8-Dodecen-1-ol
Blend Mixture: E/Z-8-
Algae 72 hr EbC50 No data
Dodecenyl acetate
Z-8-Dodecen-1-ol
EFSA Journal 2014;12(1):3524 140


Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Based on Mortality
Chrysoperla
Adults lowest endpoint 0.264 50%
of SCLPs

Application rate
[kg as/ha]
No data provided
section)
soil i) (E/Z)-8-dodecen-1-yl acetate
water i) (E/Z)-8-dodecen-1-yl acetate
sediment i) (E/Z)-8-dodecen-1-yl acetate
EFSA Journal 2014;12(1):3524 141

groundwater i) (E/Z)-8-dodecen-1-yl acetate
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 142

32 Blend Mixture: (Z)-11-Hexadecenal; (Z)-11-Hexadecen-1-yl Acetate


Chemical name (IUPAC) ‡ i) (Z)-11-hexadecenal

ii) (Z)-11-hexadecen-1-yl acetate
Chemical name (CA) ‡ i) (Z)-11-hexadecenal
ii) (Z)-11-hexadecen-1-ol acetate
CIPAC No ‡ i) 875
ii) 874
CAS No ‡ i) 53939-28-9
ii) 34010-21-4
ii) 251-791-6
publication) ‡
manufactured ‡
manufactured
ii) C18H34O2
ii) 282.467g/mol
O
ii)
O
O CH3
EFSA Journal 2014;12(1):3524 143


Boiling point (state purity) ‡ blend >92.5% (Z11-16:Ac/Z-11-16:Al ratio
0.83:1.07)
120-132°C/0.3mmHg
Reference required
Appearance (state purity) ‡ blend >92.5% (Z11-16:Ac/Z-11-16:Al ratio
0.83:1.07)
colourless or light yellow transparent liquid
Vapour pressure (state temperature, state blend >92.5% (Z11-16:Ac/Z-11-16:Al ratio
purity) ‡ 0.83:1.07)
1.2 X 10-3 - 6 X 10-5 mmHg (20°C)
or
0.16 - 0.008 Pa
80-99% purity
Solubility in organic solvents ‡ blend >92.5% (Z11-16:Ac/Z-11-16:Al ratio
(state temperature, state purity) 0.83:1.07)
soluble in n-hexane, cyclohexane, benzene,
toluene, methylene chloride, carbon tetrachloride,
chloroform, acetonitrile, THF, acetone, DMF,
methanol, ethanol, ethyl ether
Insoluble in DMSO and ethylene glycol
purity)
80-99% purity
EFSA Journal 2014;12(1):3524 144

Partition co-efficient ‡ blend >92.5% (Z11-16:Ac/Z-11-16:Al ratio

(state temperature, pH and purity) 0.83:1.07)
>10000
Reference required
Flash point: 152°C
blend >92.5% (Z11-16:Ac/Z-11-16:Al ratio
0.83:1.07)
Reference required#
(statement)

EFSA Journal 2014;12(1):3524 145

Summary of representative uses evaluated (Blend Mixture: (Z)-11-Hexadecanal; (Z)-11-Hexadecen-1-yl Acetate)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Vegetables Spain CHECKMAT F Plutella CSL 225- 225- Before the 1st 3 Per crop n.a. n.a. 225- n.a.
, (Field E DBM-F / xylostella VS 450ml/ 450ml/ha generation of cycle 450ml/h
Annual and Trials) Suterra CS the moth a X 3
Perennial (Consep applicati
Flowers, GmbH) ons =
Flowering 0.675-
Shrubs, 1.35l/ha
Ornamenta
l Plants

n.a. not applicable
EFSA Journal 2014;12(1):3524 146

Methods of Analysis



Soil Open
Water surface Open
Air Open

Food/feed of animal origin (analytical No residue definition is set.
purposes)

EFSA Journal 2014;12(1):3524 147


5.1)

(animals and plants) ii) (Z)-11-hexadecen-1-yl acetate
(environment) ii) (Z)-11-hexadecen-1-yl acetate

based on bridging from other SCLP acetate
and aldehyde: (E/Z)-8-dodecen-1-yl
acetate, (Z)-9-dodecen-1-yl acetate, (E,Z)-
7,9-dodecadien-1-yl acetate, (Z)-9-
tetradecen-1-yl acetate, (Z)-11-tetradecen-
acetate, (Z)-11-hexadecenal
and aldehyde: (Z)-9-tetradecen-1-yl
acetate, (Z)-11-tetradecen-1-yl acetate,
(Z,E)-7,11-hexadecadien-1-yl acetate, (Z)-
11-hexadecenal
Rat LC50 inhalation ‡ 4.46 (females) mg/L air/4h whole body R20
exposure
based on bridging from SCLP aldehyde:
(Z)-11-hexadecenal
based on bridging from SCLP acetate :
(E,Z)-7,9-dodecadien-1-yl acetate
and aldehyde: (E/Z)-8-dodecen-1-yl
acetate, (Z)-9-dodecen-1-yl acetate, (E,Z)-
7,9-dodecadien-1-yl acetate, (Z)-9-
tetradecen-1-yl acetate, (Z)-11-tetradecen-
acetate, (Z)-11-hexadecenal
EFSA Journal 2014;12(1):3524 148

Skin sensitisation ‡ Sensitiser (based on chemical structure of R43

SCLP aldehydes)







EFSA Journal 2014;12(1):3524 149


‡

or adverse effects.

factor
study available
for derivation of

(VP), microencapsulated vapour releasing

levels.
background levels.
EFSA Journal 2014;12(1):3524 150


levels.
background levels.
exposure levels.
background levels.
point 10)
20
Substance classified: Blend Mixture: (Z)-11- Xn ―Harmful‖
hexadecenal; (Z)-11-hexadecen-1-yl acetate R20 ―Harmful by inhalation‖
20
EFSA Journal 2014;12(1):3524 151

Residues
Open
EFSA Journal 2014;12(1):3524 152






Kd

dependence)




EFSA Journal 2014;12(1):3524 153





Relevant to the environment i) (Z)-11-hexadecenal


EFSA Journal 2014;12(1):3524 154

Ecotoxicology
SCLPs)
SCLPs)
SCLPs)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
Blend Mixture: (Z)-11-
96 hr No data
Fish Hexadecenal; (Z)-11- LC50
provided
Hexadecen-1-yl Acetate
48 hr No data
Aquatic invertebrates Hexadecenal; (Z)-11- EC50
72 hr EbC50 No data
Algae Hexadecenal; (Z)-11-
EFSA Journal 2014;12(1):3524 155


Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
Based on - 19%
Mortality
Chrysoperla lowest
Adults 0.264 50%
carnea endpoint of Oviposition 8.5%
SCLPs

Application rate
[kg as/ha]
No data provided
section)
soil i) (Z)-11-hexadecenal
water i) (Z)-11-hexadecenal
EFSA Journal 2014;12(1):3524 156


sediment i) (Z)-11-hexadecenal
groundwater i) (Z)-11-hexadecenal
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 157

The monograph was prepared under the responsibility of:
Physical and chemical properties and methods of analysis:

Angelina Jirgal, Wolfgang Bergermayer
Toxicology and metabolism:
Alexandra Fischer, Marion Burger
Residue data:
Claudia Wacha
Environmental fate and behaviour:
Michael Stemmer, Natalie Hutzenlaub
Ecotoxicology:
Anja Bartels, Wolfgang Krämer, Daniela Jölli, Britta Möbes-Hansen
Coordinators:
Gabriele Kovacs (former coordinator), Marion Richter (now Burger, former coordinator),
Wolfgang Bergermayer (current coordinator)
EFSA Journal 2014;12(1):3524 158

EFSA Journal 2014;12(1):3524 159

1 E-5-Decen-1-yl Acetate


Chemical name (IUPAC) ‡ (E)-5-decen-1-yl acetate

Chemical name (CA) ‡ (E)-5-decen-1-ol acetate
CIPAC No ‡ 870
CAS No ‡ 38421-90-8
EC No (EINECS or ELINCS) ‡ 253-923-8
publication) ‡
manufactured ‡
manufactured
Molecular formula ‡ C12H22O2
Molecular mass ‡ 198.305 g/mol
Structural formula ‡ O
O CH3
EFSA Journal 2014;12(1):3524 160


Boiling point (state purity) ‡ Data required
Appearance (state purity) ‡ Data required
Vapour pressure (state temperature, state 1.085 Pa (20°C)
purity) ‡ 99% purity
80-99% purity
Solubility in water (state temperature, state 99% purity
purity and pH) ‡ 20°C
Day 1 = 6.0 x 10-3 g/l (RSD 6.1%)
Day 2 = 8.6 x 10-3 g/l (RSD 4.8%)
Day 3 = 7.2 x 10-3 g/l (RSD 10.4%)
Solubility in organic solvents ‡ 80-100% soluble
(state temperature, state purity) whole SCLP acetate group
80-99%purity.
purity)
80-99% purity
The study for Z-8-dodecenyl acetate can be regarded as
Partition co-efficient ‡
representative.
(state temperature, pH and purity) log P = 5.61 (25°C)
Open for applicability of data to all the SCLP‟s
EFSA Journal 2014;12(1):3524 161

(statement)
EFSA Journal 2014;12(1):3524 162

Summary of representative uses evaluated (5-Decen-1-yl Acetate)

or situation State or name G Group of Formulation Application Application rate per treatment (days)
Country (Company) or pests
I controlled
(a) (b) (l) (m)
(c)

season application
min max
(d-f) (i) (f-h) (k)
max
Peach Italy RAK 5+6 F Anarsia VP 550 500 Before begin 1 n. a. n. a. n. a. 500 n. a.
(BASF) lineatella mg dispenser/ of 1.st dispense
occurring
Peach, Italy ISONET A F Anarsia VP 420 500 Before begin 1 n. a. n. a. n. a. 500 n. a.

Nectarine, Spain (BASF) lineatella mg dispenser/ of 1.st dispense
Apricot, Portug /dispe ha generation r x 420
Plum al nser moth flight of mg =
occurring

n.a. not applicable
EFSA Journal 2014;12(1):3524 163

Methods of Analysis
Technical as (analytical technique)

Open


Soil Open
Water surface Open
Air Open

Food/feed of animal origin (analytical
technique and LOQ for methods for monitoring No residue definition set
purposes)
EFSA Journal 2014;12(1):3524 164


5.1)
Toxicologically relevant compounds ‡ (E)-5-decen-1-yl acetate
(animals and plants)
Toxicologically relevant compounds ‡ (E)-5-decen-1-yl acetate
(environment)

acetates:
acetates:
acetate:
yl acetate
acetate:
EFSA Journal 2014;12(1):3524 165


acetate:
acetate


mammalian cells,
acetate:


EFSA Journal 2014;12(1):3524 166





‡

or adverse effects.

factor
study available
for derivation of

EFSA Journal 2014;12(1):3524 167


levels.
levels.
exposure levels.
point 10)
21
Substance classified: (E)-5-decen-1-yl acetate Xi ―Irritant‖
21
EFSA Journal 2014;12(1):3524 168

Residues
Open.
EFSA Journal 2014;12(1):3524 169


Route of degradation in soil – Supplemental studies (Annex IIA, point 7.1.1.1.2)
Kd

dependence)

EFSA Journal 2014;12(1):3524 170

Relevant to the environment (E)-5-decen-1-yl acetate
EFSA Journal 2014;12(1):3524 171

Ecotoxicology
SCLP Acetates)
SCLP Acetates)
SCLP Acetates)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
Fish Based on lowest endpoint of 96 hr
LC50 6.35 mm
(Oncorhynchus mykiss) SCLP Acetates (static)
Aquatic invertebrates Based on lowest endpoint of 48 hr
EC50 0.38 mm
(Daphnia magna) SCLP Acetates (static)
Algae 72 hr EbC50
E-5-Decen-1-yl Acetate No data
ErC50

Acetates)
Acetates)
EFSA Journal 2014;12(1):3524 172


Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates

Application rate
[kg as/ha]
No data provided
section)
soil (E)-5-decen-1-yl acetate
water (E)-5-decen-1-yl acetate
sediment (E)-5-decen-1-yl acetate
groundwater (E)-5-decen-1-yl acetate
EFSA Journal 2014;12(1):3524 173

RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 174

2 (E)-8-Dodecenyl Acetate


Chemical name (IUPAC) ‡ (E)-8-dodecen-1-yl acetate

Chemical name (CA) ‡ (E)-8-dodecen-1-ol acetate
CIPAC No ‡ 871
CAS No ‡ 38363-29-0
publication) ‡
manufactured ‡
manufactured
O CH3
EFSA Journal 2014;12(1):3524 175


Boiling point (state purity) ‡ 120-125°C/390Pa
Purity 57%
Appearance (state purity) ‡ Light yellow transparent liquid
Purity 57%
purity) ‡ Purity 57%
80-99% purity
Solubility in water (state temperature, state Insoluble in water, <0.002g/l
pH= 4.8
80-99%purity.
Surface tension ‡ 38 – 50 mN/m at 0.01% in pure water
purity)
80-99% purity
representative.
(state temperature, pH and purity)
Log P = 5.61 (25°C)
Flash point: 108°C (purity and reference not
stated)
EFSA Journal 2014;12(1):3524 176

(statement)

EFSA Journal 2014;12(1):3524 177

Summary of representative uses evaluated ((E)-8-Dodecenyl Acetate)

I controlled
(a) (b) (l) (m)
I
s (min)
max
Peach AT Pheromone F Cydia molesta VP 1 10-12 Before begin 1 per n.a. n.a. n.a. 10-12 n.a.
Nectarine ES dispenser mg/dis dispenser/ of 1st generatio dispense
FR (DKSH, penser ha, generation n r/ha x 1
GE Siber dispenser moth flight of mg = 10-
IT Hegner) in Funnel 1st species 12
UK
10-12
10 10-12 dispense
mg/dis dispenser/ r/ha x 1
penser ha, mg =
dispenser 100-120
in Delta mg/ha
trap
Peach, Italy ISOMATE-M F Grapholita VP 75 mg 1000 Before begin 1 n. a. n. a. n. a. 1000 n. a.

Nectarine, Spain (Shin Etsu, molesta /dispe dispenser/ of 1.st dispense
Apricot, Portug CBC- nser ha generation r x 75
Plum, al Europe) (6% moth flight of mg = 75
Apple, a.i. = 1.st species g/ha (6%
Pear, 4.5mg occurring a.i. =
Quince ) 1000
dispense
r x
4.5mg =
4.5g/ha)
EFSA Journal 2014;12(1):3524 178


I controlled
(a) (b) (l) (m)
I
(d-f) (i) (f-h) (k)
max
Peach, Italy ISOMATE F Grapholita VP 140 250 Before begin 1 n. a. n. a. n. a. 250 n. a.

Nectarine, Spain M-100 molesta mg dispenser/ of 1.st dispense
Apricot, Portug (Shin Etsu, /dispe ha generation r x 140
Plum, al CBC- nser moth flight of mg = 10
Apple, Europe) (6% 1.st species g/ha
Pear, a.i. = occurring (6% a.i.
Quince 8.4mg = 250
) dispense
r x
8.4mg =
2.1g/ha)
Peach, Italy ISOMATE- F Grapholita VP 240 500 Before begin 1 n. a. n. a. n. a. 500 n. a.

Nectarine, Spain OFM molesta mg dispenser/ of 1.st dispense
Apricot, Portug (Shin Etsu, /dispe ha generation r x 240
Plum, al CBC- nser moth flight of mg =
Apple, Europe) (6% 1.st species 120 g/ha
Quince 14.4) = 500
dispense
r x 14.4
=
7.2g/ha)

n.a. not applicable
EFSA Journal 2014;12(1):3524 179

use situation should be described (eg. Fumigation of a structure) (j) Growth stage at last treatment (BBCH Monograph, Growth Stages of Plants, 1997,
I eg. Biting and suckling insects, soil born insects, foliar fungi, weeds time of application
(d) eg. Wettable powder (WP), emulsifiable concentrate (EC), granule (GR) (k) The minimum and maximum number of application possible under practical conditions
(e) GCPF Codes – GIFAP Technical Monograph No 2, 1989 of use must be provided
(f) All abbreviations used must be explained (l) PHI – minimum pre-harvest interval
(g) Method, eg. High volume spraying, low volume spraying, spreading, dusting, drench (m) Remarks may include: Extent of use/economic importance/restrictions
(h) Kind, eg. Overall, broadcast, aerial spraying, row, individual plant, between the plants
– type of equipment used must be indicated
EFSA Journal 2014;12(1):3524 180

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)
EFSA Journal 2014;12(1):3524 181


5.1)
Toxicologically relevant compounds ‡ (E)-8-dodecenyl acetate
Toxicologically relevant compounds ‡ (E)-8-dodecenyl acetate
(environment)

acetates:
acetates:
acetate:
yl acetate
acetate:
EFSA Journal 2014;12(1):3524 182


acetate:
acetate


mammalian cells,
acetate:


EFSA Journal 2014;12(1):3524 183





‡

or adverse effects.

factor
study available
for derivation of

EFSA Journal 2014;12(1):3524 184


levels.
levels.
exposure levels.
point 10)
22
Substance classified: (E)-8-dodecenyl acetate) Xi ―Irritant‖
22
EFSA Journal 2014;12(1):3524 185

Residues
Open.
EFSA Journal 2014;12(1):3524 186


Kd

dependence)

EFSA Journal 2014;12(1):3524 187

Relevant to the environment (E)-8-dodecen-1-yl acetate
EFSA Journal 2014;12(1):3524 188

Ecotoxicology
SCLP Acetates)
SCLP Acetates)
SCLP Acetates)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
LC50 6.35 mm
EC50 0.38 mm
Algae Based on lowest endpoint of 72 hr EbC50 0.3 n
(Pseudokirchneriella subcapitata) SCLP Acetates (static) ErC50 1.3 n

Acetates)
EFSA Journal 2014;12(1):3524 189

Acetates)

Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates

Application rate
[kg as/ha]
No data provided
section)
soil (E)-8-dodecen-1-yl acetate
water (E)-8-dodecen-1-yl acetate
sediment (E)-8-dodecen-1-yl acetate
groundwater (E)-8-dodecen-1-yl acetate
EFSA Journal 2014;12(1):3524 190

RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 191

3 (E/Z)-8-Dodecenyl Acetate


Chemical name (IUPAC) ‡ (E/Z)-8-dodecen-1-yl acetate

as individual isomers
(E)-8-dodecen-1-yl acetate
(Z)-8-dodecen-1-yl acetate
Chemical name (CA) ‡ (E/Z)-8-dodecen-1-ol acetate
as individual isomers
(E)-8-dodecen-1-ol acetate
(Z)-8-dodecen-1-ol acetate
CIPAC No ‡ 872
CAS No ‡ not allocated
individual isomers:
38363-29-0
28079-04-1
EC No (EINECS or ELINCS) ‡ not allocated
individual isomers:
253-904-4
248-823-6
publication) ‡
manufactured ‡
manufactured
Structural formula ‡ individual isomers:
O
O CH3
O
O CH3
EFSA Journal 2014;12(1):3524 192


Boiling point (state purity) ‡ 208-212°C
99% purity
Noted reference has not been submitted, is
required
Appearance (state purity) ‡ Slightly yellow transparent liquid
99% purity
required
Vapour pressure (state temperature, state 5.2 x 10-2 mmHg or 6.93 Pa (20°C)
required
80-99% purity
80-99%purity.
purity)
80-99% purity
Partition co-efficient ‡ >10000
(state temperature, pH and purity) 99% purity
required
EFSA Journal 2014;12(1):3524 193


Flash point: 108°C, 99% purity (noted reference
has not been submitted)
(statement)

EFSA Journal 2014;12(1):3524 194

Summary of representative uses evaluated ((E/Z)-8-Dodecenyl Acetate)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Peach Italy RAK 5+6 F Anarsia VP 550 500 Before begin 1 n. a. n. a. n. a. 500 n. a.
(BASF) lineatella mg dispenser/ of 1.st dispense
occurring
Peach France RAK 5

(BASF)
500
Before begin
Italy RAK 5 450mg 500 dispense
Grapholita of 1.st
(BASF) F VP /dispe dispenser/ 1 n. a. n. a. n. a. r x 450 n. a.
molesta generation
nser ha mg =
moth flight
Spain Quant GM 225 g/ha
(BASF)

n.a. not applicable
EFSA Journal 2014;12(1):3524 195

EFSA Journal 2014;12(1):3524 196

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)
EFSA Journal 2014;12(1):3524 197


5.1)
Toxicologically relevant compounds ‡ (E/Z)-8-dodecenyl acetate
Toxicologically relevant compounds ‡ (E/Z)-8-dodecenyl acetate
(environment)

acetates:
acetate:
Skin sensitisation ‡ Non-sensitiser (Maximisation test)

EFSA Journal 2014;12(1):3524 198


mammalian cells






‡

or adverse effects.
EFSA Journal 2014;12(1):3524 199


factor
study available
for derivation of

levels.
levels.
exposure levels.
point 10)
23
Substance classified: (E/Z)-8-dodecenyl None
acetate
23
EFSA Journal 2014;12(1):3524 200

Residues
Open
EFSA Journal 2014;12(1):3524 201


Kd

dependence)

EFSA Journal 2014;12(1):3524 202

Relevant to the environment (Z)-8-dodecen-1-yl acetate
EFSA Journal 2014;12(1):3524 203

Ecotoxicology
SCLP Acetates)
SCLP Acetates)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
LC50 6.35 mm
EC50 0.38 mm

Acetates)
Acetates)
EFSA Journal 2014;12(1):3524 204


Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates

Application rate
[kg as/ha]
No data provided
section)
soil (E)-8-dodecen-1-yl acetate, (Z)-8-dodecen-1-yl acetate
water (E)-8-dodecen-1-yl acetate, (Z)-8-dodecen-1-yl acetate
sediment (E)-8-dodecen-1-yl acetate, (Z)-8-dodecen-1-yl acetate
groundwater (E)-8-dodecen-1-yl acetate, (Z)-8-dodecen-1-yl acetate
EFSA Journal 2014;12(1):3524 205

RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 206

5.4 (Z)-8-Dodecenyl Acetate



Chemical name (IUPAC) ‡ (Z)-8-dodecen-1-yl acetate

Chemical name (CA) ‡ (Z)-8-dodecen-1-ol acetate
CIPAC No ‡ 861
CAS No ‡ 28079-04-1
publication) ‡
manufactured ‡
manufactured
O CH3
EFSA Journal 2014;12(1):3524 207


Boiling point (state purity) ‡ Data required
Appearance (state purity) ‡ Data required
purity) ‡ 0.245 Pa (25°C)
97.7% purity
80-99% purity
Day 1 = 7.1 x 10-4 g/l (RSD 21.2%)
Day 2 = 8.0 x 10-4 g/l (RSD 6.8%)
Day 3 = 7.1 x 10-4 g/l (RSD 2.5%)
(state temperature, state purity) Organic solvents: n-heptane, xylene, 1,2-
dichloromethane,, methanol, acetone, ethyl acetate)
Totally soluble in all organic solvents. No precipitate

was generated
purity)
80-99% purity
Partition co-efficient ‡ 97.7% purity
(state temperature, pH and purity) log P = 5.61 (25°C)
EFSA Journal 2014;12(1):3524 208


(statement)

EFSA Journal 2014;12(1):3524 209

Summary of representative uses evaluated ((Z)-8-Dodecenyl Acetate)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Peach AT Pheromone F Cydia molesta VP 1 10-12 Before begin 1 per n.a. n.a. n.a. 10-12 n.a.
Nectarine ES dispenser mg/dis dispenser/ of 1st generatio dispense
UK 10
mg/dis 10-12 10-12
penser dispenser/ dispense
ha, r/ha x 1
dispenser mg =
in Delta 100-120
trap mg/ha
Plum AT Pheromone F Grapholita VP 1 10-12 Before begin 1 per n.a. n.a. n.a. 10-12 n.a.
ES dispenser funebrana mg/dis dispenser/ of 1st generatio dispense
UK
EFSA Journal 2014;12(1):3524 210


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Plum France Cydia F Grapholita VP (1) (1) Before begin 1 n. a. n. a. n. a. (1) n. a.

funebrana funebrana of 1.st
sex generation
pheromone moth flight of
(SEDQ) 1.st species
occurring
Peach, Italy ISOMATE-M F Grapholita VP 75 mg 1000 Before begin 1 n. a. n. a. n. a. 1000 n. a.

Nectarine, Spain (Shin Etsu, molesta /dispe dispenser/ of 1.st dispense
Apricot, Portug CBC- nser ha generation r x 75
Plum, al Europe) (93% moth flight of mg = 75
Apple, a.i. = 1.st species g/ha
Pear, 69.75 occurring (93% a.i.
Quince mg) = 1000
dispense
r x
69.75mg
=
69.75g/h
a)
EFSA Journal 2014;12(1):3524 211


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max

Nectarine, Spain M-100 molesta mg dispenser/ of 1.st dispense
Apricot, Portugal (Shin Etsu, /dispe ha generation r x 140
Plum, CBC- nser moth flight of mg = 10
Apple, Europe) (93% 1.st species g/ha
Quince 130.2 = 250
mg) dispense
r x
130.2mg
=
32.55g/h
a)

Nectarine, Spain OFM molesta mg dispenser/ of 1.st dispense
Apricot, Portugal (Shin Etsu, /dispe ha generation r x 240
Plum, CBC- nser moth flight of mg =
Apple, Europe) (93% 1.st species 120 g/ha
Quince 223.2 = 500
mg) dispense
r x
223.2mg
=
111.6g/h
a)

n.a. not applicable
EFSA Journal 2014;12(1):3524 212

EFSA Journal 2014;12(1):3524 213

Methods of Analysis



Soil Open
Water surface Open
Air Open

Food/feed of animal origin (analytical No residue definition is et
purposes)

EFSA Journal 2014;12(1):3524 214


5.1)
Toxicologically relevant compounds ‡ (Z)-8-dodecenyl acetate
Toxicologically relevant compounds ‡ (Z)-8-dodecenyl acetate
(environment)

acetates:
acetates:
acetate:
acetate:
EFSA Journal 2014;12(1):3524 215

acetate:
acetate


mammalian cells,
acetate:



EFSA Journal 2014;12(1):3524 216




‡

or adverse effects.

factor
study available
for derivation of

levels.
EFSA Journal 2014;12(1):3524 217


levels.
exposure levels.
point 10)
24
Substance classified: (Z)-8-Dodecenyl Acetate None
24
EFSA Journal 2014;12(1):3524 218

Residues
Open.
EFSA Journal 2014;12(1):3524 219


Kd

dependence)

EFSA Journal 2014;12(1):3524 220

EFSA Journal 2014;12(1):3524 221

Ecotoxicology
SCLP Acetates)
SCLP Acetates)
SCLP Acetates)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
LC50 6.35 mm
EC50 0.38 mm

Acetates)
Acetates)
EFSA Journal 2014;12(1):3524 222


Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates

Application rate
[kg as/ha]
No data provided
section)
soil (Z)-8-dodecen-1-yl acetate
water (Z)-8-dodecen-1-yl acetate
sediment (Z)-8-dodecen-1-yl acetate
groundwater (Z)-8-dodecen-1-yl acetate
EFSA Journal 2014;12(1):3524 223

RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 224

5 (Z)-9-Dodecenyl Acetate


Chemical name (IUPAC) ‡ (Z)-9-dodecen-1-yl acetate

Chemical name (CA) ‡ (Z)-9-dodecen-1-ol acetate
CIPAC No ‡ 422
CAS No ‡ 16974-11-1
publication) ‡
Minimum purity of the active substance as Min. 87% (BASF)
manufactured ‡ Open for other sources
manufactured
O CH3
EFSA Journal 2014;12(1):3524 225


BP=97°C at 100Pa
170°C (onset)
Appearance (state purity) ‡ 92% purity
colourless/light transparent yellow liquid
purity) ‡ 7.3E-2 Pa (20°C)
1.3E-1 Pa (25°C)
Henry‘s law constant ‡ H = 0.1181 kPa m3/mol
98.6% purity
Solubility in water (state temperature, state 99% purity
purity and pH) ‡ 0.14 x 10-3 g/l (20°C)
pH 6.2
(state temperature, state purity) readily soluble in methanol, toluene, n-heptane,
ethyl acetate, dichloromethane and acetone (20°C)

Surface tension ‡ 98.6%
(state concentration and temperature, state 20°C
purity)
38.4mN/m at 0.01% in pure water
Partition co-efficient ‡ 95.4% purity
(state temperature, pH and purity) log pow = 6.36 (25°C)
pH = 7
EFSA Journal 2014;12(1):3524 226

UV/VIS absorption (max.) incl. ‡ 99.2% purity

(state purity, pH) UV VIS (20°C)
Solvent Methanol
1.4276 cm-1 mol-1 l (221.1nm)
380.6 cm-1 mol-1 l (300.34 nm)
Solvent Water
6411.9 cm-1 mol-1 l (200.8nm)
864.2 cm-1 mol-1 l (299.69 nm)
Alkali conditions
-70 cm-1 mol-1 l (300.34nm)
Acidic conditions
1741.3 cm-1 mol-1 l (206.04nm)
397.6 cm-1 mol-1 l (299.69nm)
(statement)

EFSA Journal 2014;12(1):3524 227

Summary of representative uses evaluated ((Z)-9-Dodecenyl Acetate)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Grape Germany RAK1 Neu

/ BASF
RAK1
Luxembour Neu/
g BASF
RAKI 500
230 Before begin
Cochylis/ 500 dispenser
France Eupoecilia mg/ of 1.st
BASF F VP dispenser/h 1 n.a. n.a. n.a. x 230 mg n.a.
ambiguella dispens generation
a = 115
er moth flight
g/ha
Switzerlan Bocep Vit/

d BASF
Italy RAK1/
BASF
EFSA Journal 2014;12(1):3524 228


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Grape Germany RAK 1+2

BRD/
BASF
Before begin
500
France RAK 1+2 230mg of 1.st
500 dispenser
Cochylis + Eupoecilia BAS generation
F VP dispenser/h 1 n. a. n. a. n. a. x 230mg n. a.
Eudemis / ambiguella 281I/di moth flight of
a = 115
BASF spenser 1.st species
g/ha
occuring
Italy RAK 1+2 /

BASF
Grape France RAK 1+2,

3
generation
s/ Before begin
BASF 500
350mg of 1.st
500 dispenser
Eupoecilia BAS generation
F VP dispenser/h 1 n. a. n. a. n. a. x 350mg n. a.
ambiguella 281/dis moth of 1.st
a = 175
RAK 1+2 / penser occurring
Switzerland g/ha
BASF species
EFSA Journal 2014;12(1):3524 229


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Grape Italy CHECKM F Eupoecilia CSL 25g 25 g/ha Before the 1st 3 30 n.a n.a. 25g/ha x n.a.
France ATE ambiguella VS generation of 3
Germany EA-F / the moth applicatio
(All Field ns =
Trials) Suterra 75g/ha
(Consep
GmbH)
Grape Switzerla CHECKM F Eupoecilia CSL 12.5g 12.5 (1st Before the 1st 2-4 14 days for n.a. n.a. 12.5 x 6 n.a.
nd ATE ambiguella VS and generatio generation of 1st applicati
(Field EA-F / 25g n and the moth Generation ons
Trials) Suterra heavy (every 2
(Consep rain) 30 days for weeks) =
GmbH) normal use 75g/ha
25g/ha
(normal 25 x 3
use) applicati
ons
(every 4
weeks) =
75 g/ha
EFSA Journal 2014;12(1):3524 230


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Grape AT Pheromon F Eupoecilia VP 1 mg 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n. a.

ES e ambiguella /dispe dispenser/ of 1.st generatio dispense
FR dispenser / nser ha, generation n r/ha x 1
GE DKSH dispenser moth flight of mg = 10-
IT (SiberHeg in Funnel 1.st species 12
NL ner) trap occurring mg/ha
UK
Tomato AT Pheromon F Plusia VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

ES e chalcites mg/dis dispenser/ of 1st generatio dispense
FR dispenser / penser ha, generation n r/ha x 1
GE DKSH dispenser moth flight of mg = 10-
IT (SiberHeg in Funnel 1st species 12
NL ner) trap occurring mg/ha
UK
Vine and Spain Eupoecilia F Eupoecilia VP (1) (1) Before begin 1 n. a. n. a. n. a. (1) n. a.
Lucerne ambiguell ambiguella of 1.st
(Grape) a sex generation
pheromon moth flight of
e/ 1.st species
SEDQ occurring
EFSA Journal 2014;12(1):3524 231


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Grape Italy ISONET F Eupoecilia VP 380mg 500 Before begin 1 n. a. n. a. n. a. 500 n. a.

LE / ambiguella /dispe dispenser/ of 1.st dispense
Shin Etsu nser ha generation r x mg =
(CBC- (50% moth flight of g/ha
Europe) a.i. 1.st species (50% a.i.
=190 occurring =
mg) 500dispe
nser
x190mg
=95g/ha)
Grape Italy ISONET L F Eupoecilia VP 180mg 500 Before begin 1 n. a. n. a. n. a. 500 n. a.
PLUS / ambiguella /dispe dispenser/ of 1.st dispense
Shin Etsu nser ha generation r x
(CBC- (8.3% moth flight of 180mg =
Europe) a.i. 1.st species 90 g/ha
=15m occurring (8.3%
g) a.i. =
500dispe
nser
x15mg
=7.5g/ha
)

n.a. not applicable
EFSA Journal 2014;12(1):3524 232

EFSA Journal 2014;12(1):3524 233

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 234


5.1)
Toxicologically relevant compounds ‡ (Z)-9-dodecen-1-yl acetate
Toxicologically relevant compounds ‡ (Z)-9-dodecen-1-yl acetate
(environment)

acetates:
acetate:

EFSA Journal 2014;12(1):3524 235


mammalian cells






‡

or adverse effects.
EFSA Journal 2014;12(1):3524 236


factor
study available
for derivation of

(VP) / Microencapsulated vapour releasing

levels.
background levels.
levels.
background levels.
exposure levels.
background levels.
EFSA Journal 2014;12(1):3524 237

point 10)
25
Substance classified: (Z)-9-dodecen-1-yl None
acetate
25
EFSA Journal 2014;12(1):3524 238

Residues
Open.
EFSA Journal 2014;12(1):3524 239






Kd

dependence)




EFSA Journal 2014;12(1):3524 240



Laboratory study Dispenser application and spray application: open
Photochemical oxidative degradation in air calculated according to Atkinson (24 h day, Hydroxyl
5 -3
concentration 5 x10 cm ): T1/2 = 5.6 hours
Dispenser application and spray application: open

EFSA Journal 2014;12(1):3524 241

Ecotoxicology
SCLP Acetates)
SCLP Acetates)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
Fish 96 hr
Z-9-Dodecenyl acetate LC50 6.37 mm
(Brachydanio rerio) (static)
Z-9-Dodecenyl acetate EC50 1.1 mm
(Daphnia magna) (static)
Algae 72 hr EbC50 0.3 n
Z-9-Dodecenyl acetate
(Pseudokirchneriella subcapitata) (static) ErC50 1.3 n

Acetates)
Acetates)
EFSA Journal 2014;12(1):3524 242


Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates

Application rate
[kg as/ha]
No data provided
section)
soil (Z)-9-dodecen-1-yl acetate
water (Z)-9-dodecen-1-yl acetate
sediment (Z)-9-dodecen-1-yl acetate
groundwater Z)-9-dodecen-1-yl acetate
EFSA Journal 2014;12(1):3524 243

RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 244

6 (7E, 9Z)-Dodecadien-1-yl Acetate



Chemical name (IUPAC) ‡ (E,Z)-7,9-dodecadien-1-yl acetate

Chemical name (CA) ‡ (E,Z)-7,9-dodecadien-1-ol acetate
CIPAC No ‡ 864
CAS No ‡ 54364-62-4
publication) ‡
manufactured ‡
manufactured
O CH3
EFSA Journal 2014;12(1):3524 245


298°C at atmospheric pressure; aluminium pierced
pan
Decomposition starts at 250°C; steel closed ‗high
pressure‘ pan;
(19% other geometric isomers)
Total with isomers 94% purity
purity) ‡ 1.7E-2 Pa (20°C)
3.2E-1 Pa (25°C)
purity and pH) ‡ 0.67 x 10-3 g/l (20°C)
pH 6.2
(state temperature, state purity) Solubilities at 20°C

Surface tension ‡ 97.2% purity
(state concentration and temperature, state 49.7mN/m at 0.01% in pure water (20°C)
purity)
representative.
log P = 5.61 (25°C)
EFSA Journal 2014;12(1):3524 246


(state purity, pH) indicate any concern for dispenser application
82.21% purity
Flash point: 138°C
(statement)

EFSA Journal 2014;12(1):3524 247

Summary of representative uses evaluated (7E, 9Z)-Dodecadien-1-yl Acetate

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Grape France RAK2

Eudemis 3
Generations 500
/ BASF 350 500 Begin of 1.st dispense
Lobesia
F VP mg/dis dispenser/ generation 1 n. a. n. a. n. a. r x 350 n. a.
botrana
penser ha moth flight mg =
Spain Quant LB / 175 g/ha
BASF
Grape Switzerla RAK 2 Extra

nd /
BASF
500
120 500 Begin of 1.st dispense
Lobesia
F VP mg/dis dispenser/ generation 1 n. a. n. a. n. a. r x 120 n. a.
Italy RAK 2 / botrana
penser ha moth flight mg = 60
BASF g/ha
France RAK 2 Extra

/ BASF
EFSA Journal 2014;12(1):3524 248


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Grape Spain Quant LBR/ F Lobesia VP 500 250 –500 Before begin 1 n. a. n. a. n. a. 250 – n. a.
BASF botrana mg/dis dispenser/ of 1.st 500
penser ha generation dispense
(+ 800 moth flight r x 500
RAK 2R / mg mg =
Hellas
Citral) 125 -
(Greece) BASF
250 g/ha
Grape Germany RAK 1+2

BRD /
BASF
RAK 1+2 140 Before begin

500
Cochylis + mg of 1.st
500 dispense
France Eudemis / Lobesia BAS generation
F VP dispenser/ 1 n. a. n. a. n. a. r x 140
BASF botrana 288 moth flight of
ha mg = 70
I/dispe 1.st species
g/ha
RAK 1+2 / nser occuring
n. a.
BASF
Italy
EFSA Journal 2014;12(1):3524 249


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Grape France RAK 1+2, 3

generations /
BASF
240 Before begin
500
Switzer mg of 1.st
500 dispense
land RAK 1+2 / Lobesia BAS generation
F VP dispenser/ 1 n. a. n. a. n. a. r x n. a.
BASF botrana 288 moth of 1.st
ha 240mg =
I/dispe occurring
120 g/ha
nser species
Grape Italy CHECKMAT F Lobesia CSL 25g 25 g/ha Before the 1st 3 30 n. a n. a. 25g/ha x n.a.
Spain E botrana VS generation of 3
France LB-F / the moth applicati
Germa Suterra ons =
ny (Consep 75g/ha
Greece GmbH)
(All
Field
Trials)
EFSA Journal 2014;12(1):3524 250


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Grape Switzer CHECKMAT F Lobesia CSL 12.5g 12.5 g/ha Before the 1st 2-4 14 days for n. a. n. a. 12.5 x 6 n.a.
land E botrana VS and (1st generation of 1st applicati
(Field LB-F / 25g generatio the moth Generation ons
Trial) Suterra n and (every 2
(Consep heavy 30 days for weeks) =
GmbH) rain) normal use 75g/ha
25g/ha 25 x 3
(normal applicati
use) ons
(every 4
weeks) =
75 g/ha
Peach AT Pheromone F Cydia molesta VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.
Nectarine ES dispenser / mg/dis dispenser/ of 1st generatio dispense
st
IT r) in Funnel 1 species 12
UK
EFSA Journal 2014;12(1):3524 251


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Peach AT Pheromone F Cydia molesta VP 10 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.
Nectarine ES dispenser / mg/dis dispenser/ of 1st generatio dispense
UK

IT r) in Funnel 1st species 10-12
UK
EFSA Journal 2014;12(1):3524 252


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Grape AT XLure F Lobesia VP 2 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n. a.

UK

UK
EFSA Journal 2014;12(1):3524 253


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Grape Italy ECODIAN® F Lobesia VP 10mg/ 2000- Before the 1st 2 60 days n. a. n. a. 2000 - n.a.
LB / Isagro botrana dispen 2500 generation of 2500
ser dispenser the moth dispense
s/ha rs/ha x
10mg
=20g-
25g
Grape Italy ECODIAN® F Lobesia VP 10mg/ 2000- Before the 1st 2 60 days n. a. n. a. 2000 - n.a.
GRAPE / botrana dispen 2500 generation of 2500
Isagro ser dispenser the moth dispense
s/ha rs/ha x
10mg
=20g-
25g
EFSA Journal 2014;12(1):3524 254


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Vine Spain Lobesia F Lobesia VP (1) (1) Before begin 1 n. a. n. a. n. a. (1) n. a. Active Ingredient
(Grape) botrana sex botrana of 1.st Supplier Only
pheromone / generation
SEDQ moth flight of
1.st species
occurring
Grape Italy ISONET L / F Lobesia VP 172 500 Before begin 1 n. a. n. a. n. a. 500 n. a.

Spain Shin Etsu botrana mg dispenser/ of 1.st dispense
Portug (CBC- /dispe ha generation r x 172
al Europe) nser moth flight of mg = 86
1.st species g/ha
occurring
EFSA Journal 2014;12(1):3524 255


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Grape Italy ISONET LE F Lobesia VP ?? mg 500 Before begin 1 n. a. n. a. n. a. 500 n. a.

Spain / botrana /dispe dispenser/ of 1.st dispense
Portug Shin Etsu nser ha generation r x ??
al (CBC- (?% moth flight of mg = ??
Europe) a.i. = 1.st species g/ha
?mg) occurring (??% a.i.
= 500
dispense
r x ??mg
=
??g/ha)
Grape Italy ISONET L F Lobesia VP ?? mg 500 Before begin 1 n. a. n. a. n. a. 500 n. a.

Spain PLUS / botrana /dispe dispenser/ of 1.st dispense
Portug Shin Etsu nser ha generation r x ??
al (CBC- (?% moth flight of mg = ??
?mg) occurring (??% a.i.
= 500
dispense
r x ?? =
??g/ha)

n.a. not applicable
EFSA Journal 2014;12(1):3524 256

EFSA Journal 2014;12(1):3524 257

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)
Open

EFSA Journal 2014;12(1):3524 258


5.1)
Toxicologically relevant compounds ‡ (E,Z)-7,9-dodecadien-1-yl acetate
Toxicologically relevant compounds ‡ (E,Z)-7,9-dodecadien-1-yl acetate
(environment)

acetates:
acetate:

EFSA Journal 2014;12(1):3524 259


mammalian cells






‡

or adverse effects.
EFSA Journal 2014;12(1):3524 260


factor
study available
for derivation of
Vapour releasing product in closed dispenser / No data available

Microcapsule suspension, spray application

levels.
background levels.
levels.
background levels.
exposure levels.
background levels.
EFSA Journal 2014;12(1):3524 261

point 10)
26
Substance classified: (E,Z)-7,9-dodecadien-1- Xi ―Irritant‖
yl acetate R38 ―Irritating to skin‖
26
EFSA Journal 2014;12(1):3524 262

Residues
Open.
EFSA Journal 2014;12(1):3524 263






Kd

dependence)




EFSA Journal 2014;12(1):3524 264



Laboratory study Dispenser and spray application: open
Dispenser and spray application: open
Relevant to the environment (E,Z)-7,9-dodecadien-1-yl acetate

EFSA Journal 2014;12(1):3524 265

Ecotoxicology
SCLP Acetates)
SCLP Acetates)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
Fish E,Z-7,9-Dodecadien-1-yl 96 hr
LC50 6.35 mm
(Oncorhynchus mykiss) acetate (static)
Aquatic invertebrates E,Z-7,9-Dodecadien-1-yl 48 hr
EC50 0.38 mm
(Daphnia magna) acetate (static)
Algae E,Z-7,9-Dodecadien-1-yl 72 hr EbC50 0.45 n
(Pseudokirchneriella subcapitata) acetate (static) ErC50 1.2 n

Acetates)
EFSA Journal 2014;12(1):3524 266

Acetates)

Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates
Acute toxicity No data submitted

Application rate
[kg as/ha]
Not required
section)
soil (E,Z)-7,9-dodecadien-1-yl acetate
water (E,Z)-7,9-dodecadien-1-yl acetate
sediment (E,Z)-7,9-dodecadien-1-yl acetate
EFSA Journal 2014;12(1):3524 267

groundwater (E,Z)-7,9-dodecadien-1-yl acetate
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 268

7 (E)-11-Tetradecenyl Acetate

Active substance (ISO Common Name) ‡ (no ISO common name


Chemical name (IUPAC) ‡ (E)-11-tetradecen-1-yl acetate

Chemical name (CA) ‡ (E)-11-tetradecen-1-ol acetate
CIPAC No ‡ 868
CAS No ‡ 33189-72-9
publication) ‡
manufactured ‡
manufactured
O CH3
EFSA Journal 2014;12(1):3524 269


Purity not stated
Reference required
Appearance (state purity) ‡ Light transparent liquid
Vapour pressure (state temperature, state 0.078-0.49Pa (20°C)
purity) ‡ Purity not stated
Reference required
80-99% purity
Solubility in water (state temperature, state >0.004g/l
purity and pH) ‡ Purity, pH and temperature not stated
Reference required
Solubility in organic solvents ‡ Soluble in n-hexane, cyclohexane, benzene,
(state temperature, state purity) toluene, methylene chloride, chloroform, ethyl ether,
acetonitrile, THF, acetone, DMF, etc. Insoluble in
DMSO and ethylene glycol
Purity and temperature not stated
Reference required
purity)
80-99% purity
representative.
log P = 5.61 (25°C)
EFSA Journal 2014;12(1):3524 270


stated)
(statement)

EFSA Journal 2014;12(1):3524 271

Summary of representative uses evaluated ((E)-11-Tetradecenyl Acetate)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Corn Italy ISONET-ON F Ostrinia VP 400mg 400dispen Before begin 1 n. a. n. a. n. a. 400 n. a.

/ nubilalis /dispe ser/ha of 1.st dispense
Shin Etsu nser generation r x
(CBC- (50% moth flight of 400mg =
Europe) a.i. 1.st species 160g/ha
=200 occurring (50% a.i.
mg) = 400
dispense
r
x200mg
=80g/ha)

n.a. not applicable
EFSA Journal 2014;12(1):3524 272

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 273


5.1)
Toxicologically relevant compounds ‡ (E)-11-tetradecen-1-yl acetate
Toxicologically relevant compounds ‡ (E)-11-tetradecen-1-yl acetate
(environment)

acetates:
acetates:
acetate:
yl acetate
acetate:
EFSA Journal 2014;12(1):3524 274


acetate:
acetate


mammalian cells,
acetate:


EFSA Journal 2014;12(1):3524 275





‡

or adverse effects.

factor
study available
for derivation of

EFSA Journal 2014;12(1):3524 276


levels.
levels.
exposure levels.
point 10)
27
Substance classified: (E)-11-tetradecen-1-yl Xi ―Irritant‖
acetate R38 ―Irritating to skin‖
27
EFSA Journal 2014;12(1):3524 277

Residues
commodities and feedingstuffs (Annex IIA, point 6.3, Annex IIIA, point 8.2).
Open.
EFSA Journal 2014;12(1):3524 278


Kd

dependence)

EFSA Journal 2014;12(1):3524 279

Relevant to the environment (E)-11-tetradecen-1-yl acetate
EFSA Journal 2014;12(1):3524 280

Ecotoxicology
SCLP Acetates)
SCLP Acetates)
SCLP Acetates)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
LC50 6.35 mm
EC50 0.38 mm

Acetates)
Acetates)
EFSA Journal 2014;12(1):3524 281


Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates

Application rate
[kg as/ha]
No data provided
section)
soil (E)-11-tetradecen-1-yl acetate
water (E)-11-tetradecen-1-yl acetate
sediment (E)-11-tetradecen-1-yl acetate
groundwater (E)-11-tetradecen-1-yl acetate
EFSA Journal 2014;12(1):3524 282

RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 283

8 (Z)-9-Tetradecenyl Acetate



Chemical name (IUPAC) ‡ (Z)-9-tetradecen-1-yl acetate

Chemical name (CA) ‡ (Z)-9-tetradecen-1-ol acetate
CIPAC No ‡ 882
CAS No ‡ 16725-53-4
publication) ‡
manufactured ‡
manufactured
O CH3
EFSA Journal 2014;12(1):3524 284

Melting point (state purity) ‡ 81% purity

12-14°C
Reference required
80% purity
Appearance (state purity) ‡ light yellow transparent oily liquid
Vapour pressure (state temperature, state 3.47 x 10-2 mmHg (20°C)
80-99% purity
Solubility in water (state temperature, state Blend: >92% purity(Z9-14:Ac: 81% purity, Z11-
purity and pH) ‡ 14:Ac: 14% purity)
insoluble in water <0.002g/l
Solubility in organic solvents ‡ Blend: >92% purity(Z9-14:Ac: 81% purity, Z11-
(state temperature, state purity) 14:Ac: 14% purity)
Soluble in most organic solvents except ethylene
glycol and DMSO
purity)
80-99% purity
representative.
log P = 5.61 (25°C)
UV/VIS absorption (max.) incl. ‡ UV Visible Spectrum
(state purity, pH) 45454.55 cm -1 mol-1
(220 nm) @ 0.1wt%
92% purity
EFSA Journal 2014;12(1):3524 285


stated)
(statement)

EFSA Journal 2014;12(1):3524 286

Summary of representative uses evaluated ((Z)-9-Tetradecenyl Acetate)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Pome Fruit Southe Shin-Etsu F Biting insects VP 240 Manual Prior to moth 1 n. a. n. a. n. a. 240 g/ha n. a.
(Apple, rn (CBC Cydia mg distribu- emergence of
pear, Europe Europe) pomonella, (total tion of 1st pest (1000
quince); (Italy) ISOMATE Adoxophyes of 5
1000 generation or dispense
Stone Fruit CLR orana, as) / dispen- prior to first r x 240
(Peach,nec Pandemis dispen sers per moth mg)
ta-rine, heparana ser ha; emergence of
apricot, (see uniform any other
plum); level 1distribu- generation
Tree nuts table tion
(Walnut) 1.5.3.1through-
1) out
orchards
Apple AT Pheromone F Adoxophyes VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.
Pear ES dispenser / orana mg/dis dispenser/ of 1st generatio dispense
UK
EFSA Journal 2014;12(1):3524 287


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Vegetables AT Pheromone F Agrotis VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

ES dispenser / exclamationis mg/dis dispenser/ of 1st generatio dispense
UK
Apple AT Pheromone F Pandemis VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

Pear ES dispenser / heparana mg/dis dispenser/ of 1st generatio dispense
UK
EFSA Journal 2014;12(1):3524 288


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Vegetables AT Pheromone F Spodoptera VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

ES dispenser / exigua mg/dis dispenser/ of 1st generatio dispense
UK

n.a. not applicable
EFSA Journal 2014;12(1):3524 289

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)
Body fluids and tissues (analytical technique Open

and LOQ)

EFSA Journal 2014;12(1):3524 290


5.1)
Toxicologically relevant compounds ‡ (Z)-9-tetradecen-1-yl acetate
(environment)

Rat LC50 inhalation ‡ > 5.29 mg/L air/4 h whole body exposure
Skin irritation ‡ Non irritant


mutation assays in bacteria,
and based on bridging in vitro gene
mutation assays in mammalian cells: (E/Z)-
8-dodecen-1-yl acetate, (Z)-9-dodecen-1-yl
acetate, (E,Z)-7,9-dodecadien-1-yl acetate
EFSA Journal 2014;12(1):3524 291







‡

or adverse effects.

factor
study available
for derivation of
EFSA Journal 2014;12(1):3524 292


levels.
levels.
exposure levels.
point 10)
28
Substance classified: (Z)-9-tetradecen-1-yl None
acetate
28
EFSA Journal 2014;12(1):3524 293

Residues
Open.
EFSA Journal 2014;12(1):3524 294


Kd

dependence)

EFSA Journal 2014;12(1):3524 295

Relevant to the environment (Z)-9-tetradecen-1-yl acetate
EFSA Journal 2014;12(1):3524 296

Ecotoxicology
SCLP Acetates)
SCLP Acetates)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
LC50 6.35 mm
EC50 0.38 mm

Acetates)
Acetates)
EFSA Journal 2014;12(1):3524 297


Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates

Application rate
[kg as/ha]
No data provided
section)
soil (Z)-9-tetradecen-1-yl acetate
water (Z)-9-tetradecen-1-yl acetate
sediment (Z)-9-tetradecen-1-yl acetate
groundwater (Z)-9-tetradecen-1-yl acetate
EFSA Journal 2014;12(1):3524 298

RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 299

9 (Z)-11-Tetradecenyl Acetate



Chemical name (IUPAC) ‡ (Z)-11-tetradecen-1-yl acetate

Chemical name (CA) ‡ (Z)-11-tetradecen-1-ol acetate
CIPAC No ‡ 876
CAS No ‡ 20711-10-8
publication) ‡
manufactured ‡
manufactured
O CH3
EFSA Journal 2014;12(1):3524 300

Melting point (state purity) ‡ Z9-14:Ac: 81% purity

Z11-14Ac: 14% purity
Blend: >92%
12-14°C
Boiling point (state purity) ‡ Z9-14:Ac: 81% purity
Blend: >92%
110-134°C/ 2mmHg
Appearance (state purity) ‡ light yellow transparent oily liquid
Z9-14:Ac: 81% purity
Blend: >92%
purity) ‡ 1.6E-2 Pa (20°C)
2.9E-1 Pa (25°C)
Blend: >92%
Solubility in water (state temperature, state 94.0%
purity and pH) ‡ ≈ 0.13 mg/l in pure water
Solubility in organic solvents ‡ 94.0%
(state temperature, state purity) Solubilities at 20°C

purity)
80-99% purity
EFSA Journal 2014;12(1):3524 301

Partition co-efficient ‡ 96.4%


UV/VIS absorption (max.) incl. ‡ UV Visible Spectrum/ cm-1 mol-1
(state purity, pH) 48780.49 cm-1
(205nm)
92% purity
Flash point: 150°C (80% purity)
(statement)

EFSA Journal 2014;12(1):3524 302

Summary of representative uses evaluated ((Z)-11-Tetradecenyl Acetate)

Country /Company or pests
I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Apple Netherl RAK 4 / F Adoxophyes VP No 500 Before begin 1 n. a. n. a. n. a. No n. a.

ands BASF orana produc dispenser/ of 1.st producti
tion ha generation on
moth flight
Apple Italy RAK 3+4 / F Adoxophys VP 225 500 Before begin 1 n. a. n. a. n. a. 500 n. a.
BASF Orana mg dispenser/ of 1.st dispense
BAS ha generation r x 225
280 moth flight of mg =
I/dispe 1.st species 112.5
nser occurring g/ha
Apple Netherl RAK 3+4 / F Adoxophys VP 155 500 Before begin 1 n. a. n. a. n. a. 500 n. a.
ands BASF Orana mg dispenser/ of 1.st dispense
BAS ha generation r x 155
280 moth flight of mg =
I/dispe 1.st species 77.5
nser occurring g/ha
EFSA Journal 2014;12(1):3524 303


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Apple AT Pheromone F Adoxophyes VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

Pear ES dispenser / orana mg/dis dispenser/ of 1st generatio dispense
UK
Apple AT Pheromone F Archips VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

Pear ES dispenser / rosanus mg/dis dispenser/ of 1st generatio dispense
UK
Ornamenta AT Pheromone F Cacoecimorph VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

ls ES dispenser / a pronubana mg/dis dispenser/ of 1st generatio dispense
Organe FR DKSH penser ha, generation n r/ha x 1
Sweet GE (SiberHegne dispenser moth flight of mg = 10-
fruits IT r) in Funnel 1st species 12
UK
EFSA Journal 2014;12(1):3524 304


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Corn AT Pheromone F Heliothis zea VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.
ES dispenser / mg/dis dispenser/ of 1st generatio dispense
UK
Corn AT Pheromone F Ostrinia VP 1 10-12 Before begin 1 per n. a. N .a. n. a. 10-12 n.a.
ES dispenser nubilalis mg/dis dispenser/ of 1st generatio dispense
UK
Apple AT Pheromone F Pandemis VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

Pear ES dispenser / heparana mg/dis dispenser/ of 1st generatio dispense
UK
EFSA Journal 2014;12(1):3524 305


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
quince); (Italy) ISOMATE Adoxophyes of 5 1000 generation or dispense
(Peach,nec not listed in Pandemis dispen sers per moth mg)
ta-rine, D1 for this heparana ser ha; emergence of
apricot, compound (see uniform any other
plum); level 1 distribu- generation
(Walnut) 1.5.3.1 through-
1) out
orchards

n.a. not applicable
EFSA Journal 2014;12(1):3524 306

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 307


5.1)
(environment)

Rat LC50 inhalation ‡ > 5.3 mg/L air/4 h. whole-body exposure
acetate:
acetate


mutation assays in bacteria,
and based on bridging in vitro gene
mutation assays in mammalian cells: (E/Z)-
EFSA Journal 2014;12(1):3524 308

8-dodecen-1-yl acetate, (Z)-9-dodecen-1-yl

acetate, (E,Z)-7,9-dodecadien-1-yl acetate






‡

or adverse effects.
EFSA Journal 2014;12(1):3524 309


factor
study available
for derivation of

levels.
levels.
exposure levels.
point 10)
29
Substance classified (Z)-11-tetradecen-1-yl None
acetate
29
EFSA Journal 2014;12(1):3524 310

Residues
.
Open.
EFSA Journal 2014;12(1):3524 311


Kd

dependence)

EFSA Journal 2014;12(1):3524 312

Photochemical oxidative degradation in air calculated according to Atkinson (24 h day, Hydroxyl
5 -3
concentration 5 x10 cm ): T1/2 = 4.89 hrs
Relevant to the environment (Z)-11-tetradecen-1-yl acetate
EFSA Journal 2014;12(1):3524 313

Ecotoxicology
SCLP Acetates)
SCLP Acetates)
Application
Category (e.g.
rate [kg Crop Time-scale TER
insectivorous bird) Trigger
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
LC50 6.35 mm
EC50 0.38 mm

Acetates)
Acetates)
EFSA Journal 2014;12(1):3524 314


Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates

Application rate
[kg as/ha]
No data provided
section)
soil (Z)-11-tetradecen-1-yl acetate
water (Z)-11-tetradecen-1-yl acetate
sediment (Z)-11-tetradecen-1-yl acetate
groundwater (Z)-11-tetradecen-1-yl acetate
EFSA Journal 2014;12(1):3524 315

RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 316

10 (9Z, 12E)-Tetradecadien-1-yl acetate



Chemical name (IUPAC) ‡ (Z, E)-9, 12-tetradecadien-1-yl acetate

Chemical name (CA) ‡ (Z, E)-9, 12-tetradecadien-1-ol acetate
CIPAC No ‡ 867
CAS No ‡ 31654-77-0
publication) ‡
manufactured ‡
manufactured
O CH3
EFSA Journal 2014;12(1):3524 317


Boiling point (state purity) ‡ 140°C/0.5mmHg
, reference required
93% (Z,E isomer)
Appearance (state purity) ‡ Colourless liquid
Vapour pressure (state temperature, state The study for Z-8-dodecenyl acetate can be
purity) ‡ regarded as representative.
80-99% purity
80-99%purity.
purity)
80-99% purity
log P = 5.61 (25°C)
EFSA Journal 2014;12(1):3524 318


Flash point: >110°C
No purity, no reference stated.
Reference required
(statement)

EFSA Journal 2014;12(1):3524 319

Summary of representative uses evaluated ((9Z, 12E)-Tetradecadien-1-yl Acetate)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
EFSA Journal 2014;12(1):3524 320


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Sugar Spain CHECKMAT F Spodoptera CS 74.59- 74.59- Before the 1st 3 Per crop n. a. n. a. 74.59- n.a.
beet, (Field E BAW-F / exigua LVS 595.2 595.2 generation of cycle 595.2
parsley, Trials) Suterra ml/CS ml/ha the moth ml/ha X
parsnip, (Consep 3
and other GmbH) applicati
root tuber ons =
vegetables 0.224-
; celery, 1.79 l/ha
head
lettuce, leaf
lettuce,
spinach
and other
leafy
vegetables
; broccoli,
Brussels
sprouts,
cabbage,
cauliflower
and other
cole crops;
tomato,
bell
pepper,
chilli
pepper,
sweet
pepper,
tomatillo,
and other
fruiting
vegetables
; cotton;
alfalfa; and
other crops
EFSA Journal 2014;12(1):3524
where 321
BAW is a
pest

I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max

ES dispenser / exigua mg/dis dispenser/ of 1st generatio dispense
UK

ES dispenser / littoralis mg/dis dispenser/ of 1st generatio dispense
st
UK

n.a. not applicable
EFSA Journal 2014;12(1):3524 322

EFSA Journal 2014;12(1):3524 323

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 324


5.1)
Toxicologically relevant compounds ‡ (Z, E)-9, 12-tetradecadien-1-yl acetate
Toxicologically relevant compounds ‡ (Z, E)-9, 12-tetradecadien-1-yl acetate
(environment)

acetates:
acetates:
acetate:
yl acetate
acetate:
EFSA Journal 2014;12(1):3524 325


acetate:
acetate


mammalian cells,
acetate:


EFSA Journal 2014;12(1):3524 326





‡

or adverse effects.

factor
study available
for derivation of

EFSA Journal 2014;12(1):3524 327


levels.
background levels.
levels.
background levels.
exposure levels.
background levels.
point 10)
30
Substance classified (Z, E)-9, 12- Xi ―Irritant‖
tetradecadien-1-yl acetate R38 ―Irritating to skin‖
30
EFSA Journal 2014;12(1):3524 328

Residues
Open.
EFSA Journal 2014;12(1):3524 329






Kd

dependence)




EFSA Journal 2014;12(1):3524 330



Relevant to the environment (Z, E)-9, 12-tetradecadien-1-yl acetate

EFSA Journal 2014;12(1):3524 331

Ecotoxicology
SCLP Acetates)
SCLP Acetates)
SCLP Acetates)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
LC50 6.35 mm
EC50 0.38 mm

Acetates)
EFSA Journal 2014;12(1):3524 332

Acetates)

Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates
Application rate
[kg as/ha]
No data provided
section)
soil (Z, E)-9, 12-tetradecadien-1-yl acetate
water (Z, E)-9, 12-tetradecadien-1-yl acetate
sediment (Z, E)-9, 12-tetradecadien-1-yl acetate
EFSA Journal 2014;12(1):3524 333

groundwater (Z, E)-9, 12-tetradecadien-1-yl acetate
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 334

11 (Z)-11-Hexadecen-1-yl Acetate



Chemical name (IUPAC) ‡ Z-11-hexadecen-1-yl acetate

Chemical name (CA) ‡ Z-11-hexadecen-1-ol acetate
CIPAC No ‡ 874
CAS No ‡ 34010-21-4
EC No (EINECS or ELINCS) ‡ 251-791-6-
publication) ‡
manufactured ‡
manufactured
O CH3
EFSA Journal 2014;12(1):3524 335


Boiling point (state purity) ‡ Blend purity 92.5%
(blend ratio Z11-16Ac/Z-11-16Al, 0.83:1.07)
120-132°C/0.3mmHg
Appearance (state purity) ‡ Blend purity 92.5%
Colourless or light yellow transparent liquid
Vapour pressure (state temperature, state Blend purity 92.5%
purity) ‡ (blend ratio Z11-16Ac/Z-11-16Al, 0.83:1.07)
1.2 x 10-3 – 6 x 10-5 mmHg (20°C)
80-99% purity
Solubility in organic solvents ‡ Blend purity 92.5%
(state temperature, state purity) (blend ratio Z11-16Ac/Z-11-16Al, 0.83:1.07)
Soluble in n-hexane, cyclohexane, benzene,
toluene, methylene chloride, carbon tetrachloride,
chloroform, acetonitrile, THF, acetone, DMF,
methanol, ethanol, ethyl ether. Insoluble in DMSO,
ethylene glycol
Reference required
purity)
80-99% purity
log P = 5.61 (25°C)
EFSA Journal 2014;12(1):3524 336


Flash point: 152°C
Blend purity 92.5%
Reference required
(statement)

EFSA Journal 2014;12(1):3524 337

Summary of representative uses evaluated ((Z)-11-Hexadecen-1-yl Acetate)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Sugar beet, Spain CHECKMAT F Spodoptera CSL 74.59- 74.59- Before the 1st 3 Per crop n. a. n. a. 74.59- n.a.
parsley, (Field E BAW-F / exigua VS 595.2 595.2 generation of cycle 595.2
parsnip, and Trials) Suterra ml/CS ml/ha the moth ml/ha X
other root tuber (Consep 3
vegetables; GmbH) applicati
celery, head ons =
lettuce, leaf 0.224-
lettuce, 1.79 l/ha
spinach and
other leafy
vegetables;
broccoli,
Brussels
sprouts,
cabbage,
cauliflower and
other cole
crops; tomato,
bell pepper,
chilli pepper,
sweet pepper,
tomatillo, and
other fruiting
vegetables;
cotton; alfalfa;
and other
crops where
BAW is a pest
EFSA Journal 2014;12(1):3524 338


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Vegetable Italy Konaga-con F Plutella VP 250mg 1000 Before begin 1 n. a. n. a. n. a. 1000m x n. a.

/ Shin Etsu xylostella /m m/ha of 1.st 250mg =
(CBC- (50%a generation 250g/ha
Europe) .i. = moth flight of (50% a.i.
120mg 1.st species = 1000m
) occurring x 125mg
=
125g/ha)
Garlic AT Pheromone F Acrolepiopsis VP 1 20 Before begin 1 per n. a. n. a. n. a. 20 n.a.

ES dispenser / assectella mg/dis dispenser/ of 1st generatio dispense
GE (SiberHegne dispenser moth flight of mg = 20
st
IT r) in Funnel 1 species mg/ha
NL trap occurring
UK
EFSA Journal 2014;12(1):3524 339


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Cauliflower AT Pheromone F Mamestra VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

Cabbage ES dispenser / brassicae mg/dis dispenser/ of 1st generatio dispense
UK
Tomato AT Pheromone F Mamestra VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

ES dispenser / oleracea mg/dis dispenser/ of 1st generatio dispense
UK
EFSA Journal 2014;12(1):3524 340


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Cabagge AT Pheromone F Plutella VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

Vegetables ES dispenser / xylostella mg/dis dispenser/ of 1st generatio dispense
UK

n.a. not applicable
EFSA Journal 2014;12(1):3524 341

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 342


5.1)
Toxicologically relevant compounds ‡ Z-11-hexadecen-1-yl acetate
Toxicologically relevant compounds ‡ Z-11-hexadecen-1-yl acetate
(environment)

acetates:
acetates:
acetate:
yl acetate
acetate:
EFSA Journal 2014;12(1):3524 343


acetate:
acetate


mammalian cells,
acetate:


EFSA Journal 2014;12(1):3524 344





‡

or adverse effects.

factor
study available
for derivation of

EFSA Journal 2014;12(1):3524 345


levels.
background levels.
levels.
background levels.
exposure levels.
background levels.
point 10)
31
Substance classified: Z-11-hexadecen-1-yl Xi ―Irritant‖
acetate R38 ―Irritating to skin‖
31
EFSA Journal 2014;12(1):3524 346

Residues
Open.
EFSA Journal 2014;12(1):3524 347






Kd

dependence)




EFSA Journal 2014;12(1):3524 348



Relevant to the environment Z-11-hexadecen-1-yl acetate

EFSA Journal 2014;12(1):3524 349

Ecotoxicology
SCLP Acetates)
SCLP Acetates)
SCLP Acetates)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
LC50 6.35 mm
EC50 0.38 mm

Acetates)
EFSA Journal 2014;12(1):3524 350

Acetates)

Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates

Application rate
[kg as/ha]
No data provided
section)
soil Z-11-hexadecen-1-yl acetate
water Z-11-hexadecen-1-yl acetate
EFSA Journal 2014;12(1):3524 351

sediment Z-11-hexadecen-1-yl acetate

groundwater Z-11-hexadecen-1-yl acetate
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 352

13 (7Z, 11E)-Hexadecadien-1-yl Acetate



Chemical name (IUPAC) ‡ (Z, E)-7, 11-hexadecadien-1-yl acetate

Chemical name (CA) ‡ (Z, E)-7, 11-hexadecadien-1-ol acetate
CIPAC No ‡ 865
CAS No ‡ 110-60-1
EC No (EINECS or ELINCS) ‡ not allocated
publication) ‡
manufactured ‡
manufactured
O CH3
EFSA Journal 2014;12(1):3524 353


Boiling point (state purity) ‡ Blend 90%
(% of ZZ/ZE
47.4/42.7)
170-175°C/3Pa
Appearance (state purity) ‡ Blend 90%
(% of ZZ/ZE
47.4/42.7)
Light yellow transparent liquid
Vapour pressure (state temperature, state Blend 90%
purity) ‡ (% of ZZ/ZE
47.4/42.7)
8.0 x 10-5Pa
80-99% purity
Solubility in water (state temperature, state Blend 90%
purity and pH) ‡ (ratio 1:1)
0.2ppm (25°C)
Solubility in organic solvents ‡ Blend 90%
(state temperature, state purity) (% of ZZ/ZE
47.4/42.7)
Soluble in hexane, pentane, benzene, toluene,
methanol, ethanol, ethyl ether, acetone, methylene
chloride, chloroform, acetonitrile, THF, DMSO,
acetic acid, etc. Insoluble in DMSO and ethylene
glycol
purity)
80-99% purity
EFSA Journal 2014;12(1):3524 354


log P = 5.61 (25°C)
Flash point: 167°C
Blend 90%
(% of ZZ/ZE
47.4/42.7)
(statement)

EFSA Journal 2014;12(1):3524 355

Summary of representative uses evaluated (7Z, 11E)-Hexadecadien-1-yl Acetate

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Cotton Spain PB-ROPE L F Pectinophora VP 140mg 500dispen Before begin 1 n. a. n. a. n. a. 500dispe n. a.

/ Shin Etsu gossypiella /dispe sers/ha of 1.st nsers x
(CBC- nser generation 140mg =
Europe) (47.4 moth flight of 70g/ha
% a.i. 1.st species (47.4%
= occurring a.i. =
66.3m 1000
g) dispense
r
x66.3mg
=33.2g/h
a)
Cotton Greece PB-ROPE 7 F Pectinophora VP 72mg 1000dispe Before begin 1 n. a. n. a. n. a. 1000 n. a.
Shin Etsu gossypiella /dispe nsers/ha of 1.st dispense
(CBC- nser generation rs x
Europe) (50.6 moth flight of 72mg =
% a.i. 1.st species 72g/ha
= occurring (50.6%
36.4m a.i. =
g) 1000
dispense
r
x36.4mg
=36.4g/h
a)

n.a. not applicable
EFSA Journal 2014;12(1):3524 356

EFSA Journal 2014;12(1):3524 357

Methods of Analysis



Soil Open
Water surface Open
Air Open

Food/feed of animal origin (analytical Residue definition is not set
purposes)

EFSA Journal 2014;12(1):3524 358


5.1)
Toxicologically relevant compounds ‡ (Z, E)-7, 11-hexadecadien-1-yl acetate
Toxicologically relevant compounds ‡ (Z, E)-7, 11-hexadecadien-1-yl acetate
(environment)

acetates:
acetates:
acetate:
yl acetate
acetate:
EFSA Journal 2014;12(1):3524 359


acetate:
acetate


mammalian cells,
acetate:


EFSA Journal 2014;12(1):3524 360





‡

or adverse effects.

factor
study available
for derivation of
Operator Vapour releasing product in closed dispenser:

EFSA Journal 2014;12(1):3524 361


levels.
Workers Vapour releasing product in closed dispenser; No
reliable range of naturally occuring backgound
levels.
Bystanders Vapour releasing product in closed dispenser
exposure levels.
point 10)
32
Substance classified (Z, E)-7, 11- Xi ―Irritant‖
hexadecadien-1-yl acetate R38 ―Irritating to skin‖
32
EFSA Journal 2014;12(1):3524 362

Residues
Open.
EFSA Journal 2014;12(1):3524 363


Kd

dependence)

EFSA Journal 2014;12(1):3524 364

Relevant to the environment (Z, E)-7, 11-hexadecadien-1-yl acetate
EFSA Journal 2014;12(1):3524 365

Ecotoxicology
pheromones (based on the principles of ―bridging‖ thoughout the whole group of SCLPs

Application
Category (e.g. Data point number
insectivorous bird) VI Trigger
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
LC50 6.35 mm
EC50 0.38 mm

Acetates)
Acetates)
EFSA Journal 2014;12(1):3524 366


Data point
Application rate
Crop Route Hazard quotient number VI
[kg as/ha]
Trigger
Data
point
Dose [g a.s./
Species Stage Test substance Endpoint Effect number
dispenser]
VI
Trigger
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates

Data point
Application rate
Crop Time-scale TER number VI
[kg as/ha]
Trigger
No data provided
section)
soil (Z, E)-7, 11-hexadecadien-1-yl acetate
water (Z, E)-7, 11-hexadecadien-1-yl acetate
sediment (Z, E)-7, 11-hexadecadien-1-yl acetate
EFSA Journal 2014;12(1):3524 367

groundwater (Z, E)-7, 11-hexadecadien-1-yl acetate
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 368

14 (2E, 13Z)-Octadecadien-1-yl Acetate



Chemical name (IUPAC) ‡ (E, Z)-2, 13-octadecadien-1-yl acetate

Chemical name (CA) ‡ (E, Z)-2, 13-octadecadien-1-ol acetate
CIPAC No ‡ not allocated yet
CAS No ‡ 86252-65-5
EC No (EINECS or ELINCS) ‡ 862
publication) ‡
manufactured ‡
manufactured
O CH3
EFSA Journal 2014;12(1):3524 369


Boiling point (state purity) ‡ 190-203°C /66Pa
Purity: 82%
Appearance (state purity) ‡ Light yellow transparent liquid
Vapour pressure (state temperature, state 3 x 10-4Pa (20°C)
purity) ‡ Purity: 82%
80-99% purity
Solubility in organic solvents ‡ Soluble in hexane, pentane, benzene, toluene,
(state temperature, state purity) methanol, ethanol, ethyl ether, acetone, methylene
chloride, chloroform, acetonitrile, THF, DMSO,
acetic acid, etc. Insoluble in DMSO and ethylene
Purity not stated
Reference required
purity)
80-99% purity
log P = 5.61 (25°C)
EFSA Journal 2014;12(1):3524 370


Flash point: 186°C
Purity not stated
Reference required
(statement)

EFSA Journal 2014;12(1):3524 371

Summary of representative uses evaluated ((2E, 13Z)-Octadecadien-1-yl Acetate)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Apple, Spain ISONET Z / F Zeuzera VP 70mg 300 Before begin 1 n. a. n. a. n. a. 300 n. a.

Pear, Italy Shin Etsu pyrina /dispe dispenser of 1.st dispense
Olive, Portug (CBC- nser s/ha generation rs x
Hazlenut, al Europe) moth flight of 70mg =
Walnut 1.st species 21g/ha
occurring
Apple AT Pheromone F Zeuzera VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

Pear ES dispenser / pyrina mg/dis dispenser/ of 1st generatio dispense
IT r) in Tree 1st species 12
NL Safe, occurring mg/ha
UK Delta trap
Apple AT Pheromone F Zeuzera VP 10 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

Pear ES dispenser / pyrina mg/dis dispenser/ of 1st generatio dispense
IT r) in Tree 1st species 100-120
NL Safe, occurring mg/ha
UK Delta trap

n.a. not applicable
EFSA Journal 2014;12(1):3524 372

EFSA Journal 2014;12(1):3524 373

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 374


5.1)

Toxicologically relevant compounds ‡ (E, Z)-2, 13-octadecadien-1-yl acetate
Toxicologically relevant compounds ‡ (E, Z)-2, 13-octadecadien-1-yl acetate
(environment)

acetates:
acetates:
acetate:
yl acetate
acetate:
EFSA Journal 2014;12(1):3524 375


acetate:
acetate


mammalian cells,
acetate:


EFSA Journal 2014;12(1):3524 376





‡

or adverse effects.

factor
study available
for derivation of

EFSA Journal 2014;12(1):3524 377


levels.
levels.
exposure levels.
point 10)
33
Substance classified: (E, Z)-2, 13- Xi ―Irritant‖
octadecadien-1-yl acetate R38 ―Irritating to skin‖
33
EFSA Journal 2014;12(1):3524 378

Residues
Open.
EFSA Journal 2014;12(1):3524 379


Kd

dependence)

EFSA Journal 2014;12(1):3524 380

Relevant to the environment (E, Z)-2, 13-octadecadien-1-yl acetate
EFSA Journal 2014;12(1):3524 381

Ecotoxicology
SCLP Acetates)
SCLP Acetates)
SCLP Acetates)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
LC50 6.35 mm
EC50 0.38 mm

Acetates)
Acetates)
EFSA Journal 2014;12(1):3524 382


Application rate
[kg as/ha]
Data
point
Dose [g a.s./
Species Stage Test substance Endpoint Effect number
dispenser]
VI
Trigger
Laboratory tests
Corrected
- 19%
Chrysoperla
SCLP Acetates

Data point
Application rate
Crop Time-scale TER number VI
[kg as/ha]
Trigger
No data provided
section)
soil (E, Z)-2, 13-octadecadien-1-yl acetate
water (E, Z)-2, 13-octadecadien-1-yl acetate
sediment (E, Z)-2, 13-octadecadien-1-yl acetate
EFSA Journal 2014;12(1):3524 383

groundwater (E, Z)-2, 13-octadecadien-1-yl acetate
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 384

EFSA Journal 2014;12(1):3524 385

16 E-5-Decenol


Chemical name (IUPAC) ‡ (E)-5-decen-1-ol

Chemical name (CA) ‡ (E)-5-decenol
CIPAC No ‡ 869
CAS No ‡ 56578-18-8
publication) ‡
manufactured ‡
manufactured
Molecular formula ‡ C10H20O
Structural formula ‡ OH
EFSA Journal 2014;12(1):3524 386


Boiling point (state purity) ‡ 226-230°C
14.4%)
Appearance (state purity) ‡ colourless liquid
14.4%)
Vapour pressure (state temperature, state E5-10:Ac = 1.085 Pa (20°C)
purity) ‡ E5-10OH = 1.364 Pa (20°C)
14.4%)
3
Henry‘s law constant ‡ 0.100 - 0.0003 kPa m /mol
Range bridged from E,E-8,10-dodecadienol
(80-99% purity)
Solubility in water (state temperature, state 0.138 g/l (20°C)
purity and pH) ‡ Open for applicability of data to all the SCLP‘s
Solubility in organic solvents ‡ Easily soluble in common organic solvent, no
(state temperature, state purity) precipitate generated
14.4%)
(state concentration and temperature, state whole group of SCLP actives 80-99% purity
purity)
Partition co-efficient ‡ 4.95 (20°C)
(state temperature, pH and purity) blend: 98.6% purity (E5-10:Ac = 84.2%, E5-10OH =
14.4%)
-1 -1
UV/VIS absorption (max.) incl. ‡ 5.38 [cm mol L (580nm)]
(state purity, pH) blend: 98.6% purity (E5-10:Ac = 84.2%, E5-10OH =
14.4%)
EFSA Journal 2014;12(1):3524 387


(statement)
EFSA Journal 2014;12(1):3524 388

Summary of representative uses evaluated (E-5-Decenol)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Peach Italy RAK 5+6 / F Anarsia VP 550 500 Before begin 1 n. a. n. a. n. a. 500 n. a.
BASF lineatella mg dispenser/ of 1.st dispense
occurring
Peach, Italy ISONET A / F Anarsia VP 160 1000 Before begin 1 n. a. n. a. n. a. 1000 n. a.

Nectarine, Spain Shin Etsu lineatella mg dispenser/ of 1.st dispense
Apricot, Portug (CBC- /dispe ha generation r x 160
Plum al Europe) nser moth flight of mg =
(1% 1.st species 160 g/ha
a.i. = occurs (1% a.i.
1.6mg = 1000
) dispense
r x 1.6
mg = 1.6
g/ha)
n.a. not applicable
EFSA Journal 2014;12(1):3524 389

Methods of Analysis
Technical as (analytical technique)

Open


Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 390


5.1)
Toxicologically relevant compounds ‡ (E)-5-decen-1-ol
Toxicologically relevant compounds ‡ (E)-5-decen-1-ol
(environment)

based on bridging from other SCLP alcohol:
(E,E)-8,10-dodecadien-1-ol
Skin sensitisation ‡ Sensitiser (M&K Maximisation test) R43

EFSA Journal 2014;12(1):3524 391


chromosome aberration test





‡
EFSA Journal 2014;12(1):3524 392


or adverse effects.

factor
study available
for derivation of

levels.
levels.
exposure levels.
point 10)
34
34
EFSA Journal 2014;12(1):3524 393

Substance classified: (E)-5-decen-1-ol Xi ―Irritant‖

EFSA Journal 2014;12(1):3524 394

Residues
Open.
EFSA Journal 2014;12(1):3524 395


Kd

dependence)

EFSA Journal 2014;12(1):3524 396

Relevant to the environment (E)-5-decen-1-ol
EFSA Journal 2014;12(1):3524 397

Ecotoxicology
SCLP Alcohols)
Dietary toxicity to birds No data provided
SCLP Alcohols)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
Fish Based on lowest endpoint 96 hr
LC50 >0.685 mm
(Brachydanio rerio) of SCLP Alcohols (semi- static)
Aquatic invertebrates Based on lowest endpoint 48 hr
EC50 0.3 mm
(Daphnia magna) of SCLP Alcohols (static)
Algae Based on lowest endpoint 72 hr EbC50 0.074 mm
(Scenedesmus subspicatus) of SCLP Alcohols (static) ErC50 0.221 mm
Acute oral toxicity LD50 > 85 µg a.s./bee (based on lowest endpoint of SCLPs
Alcohols)
Acute contact toxicity LD50 203.3 µg a.s./bee (based on lowest endpoint of SCLP SCLP
Alcohols)
EFSA Journal 2014;12(1):3524 398


Application rate
[kg as/ha]
Species Stage Test substance Exposure Endpoint Effect Trigger
Laboratory tests
Based on 20 day No
inhalation Mortality and
Chrysoperla available data adverse
Adults behavioral 50%
carnea for SCLP 0.12 g / 3.17 effects
effects
alcohols ppm reported

Application rate
[kg as/ha]
No data provided
section)
soil (E)-5-decen-1-ol
water (E)-5-decen-1-ol
sediment (E)-5-decen-1-ol
groundwater (E)-5-decen-1-ol
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 399

EFSA Journal 2014;12(1):3524 400

17 (Z)-8-Dodecenol



Chemical name (IUPAC) ‡ (Z)-8-dodecen-1-ol

Chemical name (CA) ‡ (Z)-8-dodecenol
CIPAC No ‡ 880
CAS No ‡ 40642-40-8
publication) ‡
manufactured ‡
manufactured
EFSA Journal 2014;12(1):3524 401


Boiling point (state purity) ‡ 115-118 °C
Purity=92%
Appearance (state purity) ‡ Light yellow liquid
Purity=92%
purity) ‡ Purity=92%
3
(80-99% purity)
-4
Solubility in water (state temperature, state 7.1 x 10 – 0.14 g/L (80-99% purity)
purity and pH) ‡ bridged from SCLP acetates summary
Solubility in organic solvents ‡ Average 80-100% soluble (80-99% purity)
(state temperature, state purity) bridged from SCLP acetates summary
(state concentration and temperature, state whole group of SCLP actives (80-99% purity)
purity)
Partition co-efficient ‡ The study for E,E-8,10-dodecadienol can be
mean pow log = 4.36 (21°C)
Flash point: 134 °C (purity not stated)
(statement)
EFSA Journal 2014;12(1):3524 402


EFSA Journal 2014;12(1):3524 403

Summary of representative uses evaluated ((Z)-8-Dodecenol)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Nectarine, Spain M-100 / Shin molesta mg dispenser/ of 1.st dispense
Apricot, Portug Etsu /dispe ha generation r x 240
Plum, al (CBC- nser moth flight of mg = 60
Plum, Europe) (1% 1.st species g/ha
Apple, a.i. = occurring (1% a.i.
Pear, 2.4mg = 250
Quince ) dispense
r x
2.4mg =
0.6g/ha)
Nectarine, Spain OFM Rosso molesta mg dispenser/ of 1.st dispense
Apricot, Portug / Shin Etsu /dispe ha generation r x 240
Plum, al (CBC- nser moth flight of mg =
Plum, Europe) (1% 1.st species 120 g/ha
Apple, a.i. = occurring (1% a.i.
Pear, 2.4mg = 500
Quince ) dispense
r x
2.4mg =
1.2g/ha)

n.a. not applicable
EFSA Journal 2014;12(1):3524 404

EFSA Journal 2014;12(1):3524 405

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 406


5.1)
Toxicologically relevant compounds ‡ (Z)-8-dodecen-1-ol
Toxicologically relevant compounds ‡ (Z)-8-dodecen-1-ol
(environment)


EFSA Journal 2014;12(1):3524 407







‡
EFSA Journal 2014;12(1):3524 408


or adverse effects.

factor
study available
for derivation of

levels.
levels.
exposure levels.
point 10)
35
35
EFSA Journal 2014;12(1):3524 409

Substance classified: (Z)-8-dodecen-1-ol Xi ―Irritant‖

EFSA Journal 2014;12(1):3524 410

Residues
Open.
EFSA Journal 2014;12(1):3524 411


Kd

dependence)

EFSA Journal 2014;12(1):3524 412

Relevant to the environment (Z)-8-dodecen-1-ol
EFSA Journal 2014;12(1):3524 413

Ecotoxicology
Acute toxicity to birds
LD50 > 2050 mg/kg bw (based on lowest endpoint of
SCLP Alcohols)
Dietary toxicity to birds
No data provided
Acute toxicity to mammals
LD50 > 5000 mg/kg bw (based on lowest endpoint of
SCLP Alcohols)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
LC50 >0.685 mm
EC50 0.3 mm
Alcohols)
Acute contact toxicity LD50 203.3 µg a.s./bee (based on lowest endpoint of SCLP
Alcohols)
EFSA Journal 2014;12(1):3524 414


Application rate
[kg as/ha]
Laboratory tests
Based on 20 day No
effects

Application rate
[kg as/ha]
No data provided
section)
soil (Z)-8-dodecen-1-ol
water (Z)-8-dodecen-1-ol
sediment (Z)-8-dodecen-1-ol
groundwater (Z)-8-dodecen-1-ol
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 415

EFSA Journal 2014;12(1):3524 416

18 (E,E)-8,10-Dodecadien-1-ol



Chemical name (IUPAC) ‡ (E,E)-8,10-dodecadien-1-ol

Chemical name (CA) ‡ (E,E)-8,10-dodecadienol
CIPAC No ‡ 860
CAS No ‡ 33956-49-9
publication) ‡
manufactured ‡
manufactured
EFSA Journal 2014;12(1):3524 417

Melting point (state purity) ‡ 30 – 32 °C

(>89.0% purity (geometric isomers <12.5%)
total blend: 99%)
Boiling point (state purity) ‡ 120-122 °C (reduced pressure 267 Pa)
total blend: 99%)
Appearance (state purity) ‡ Solid, light yellow powder < 30-32 °C
light yellow transparent oily liquid > 30-32 °C
total blend: 99%)
Vapour pressure (state temperature, state 0.033 Pa (20 °C) (95.2%)
purity) ‡ 0.062 Pa (25 °C)
-4 3
Henry‘s law constant ‡ 2.833 x 10 kPa m /mol
Solubility in water (state temperature, state 21.2 ± 1.5mg/L (20 °C) (95.2%)Open for
purity and pH) ‡ applicability of data to all the SCLP‘s
Solubility in organic solvents ‡ 96.4%
(state temperature, state purity)

Surface tension ‡ Not required*
(state concentration and temperature, state Open for applicability of data to all the SCLP‘s
purity)
mean pow log = 4.36 (21 °C) (95.2%)
pow log ≥3.32 ± 0.02 (20 °C) (99.46%)
Partition co-efficient ‡ mean pow log = 4.36 (21°C)

(state temperature, pH and purity) Open for applicability of data to all the SCLP‟s
EFSA Journal 2014;12(1):3524 418


Flash point: 135 °C (79%)
(statement)

EFSA Journal 2014;12(1):3524 419

Summary of representative uses evaluated ((E,E)-8,10-Dodecadien-1-ol)

or State or name / G Group of Formulation Application Application rate per treatment (days)
situation Country Company or pests
I controlled
(b) (l) (m)
(a) (c)
s (min)
max
Apple Germany RAK 3+4

Nur
Apfelwickler
/ BASF
500
Before begin dispense
225 500
Cydia of 1.st r x 225
F VP mg/dis dispenser/ 1 n. a. n. a. n. a. n. a.
Austria pomonella generation mg =
penser ha
Slovenia moth flight 112.5
Italy RAK 3 / g/ha
BASF
Apple Netherla RAK 3 NEU F Cydia VP 125mg 500 Before begin 1 n. a. n. a. n. a. 500 n. a.
nds / BASF pomonella /dispe dispenser/ of 1.st dispense
nser ha generation r x 125
moth flight mg =
62.5
g/ha
EFSA Journal 2014;12(1):3524 420


I controlled
(b) (l) (m)
(a) (c)
(d-f) (i) (f-h) (k)
max
Apple Italy RAK 3+4 / F Cydia VP 225mg 500 Before begin 1 n. a. n. a. n. a. 500 n. a.
BASF pomonella, BAS dispenser/ of 1.st dispense
285 ha generation r x 225
I,/disp moth flight of mg =
enser 1.st species 112.5
occurring g/ha
Apple Netherla RAK 3+4 / F Cydia VP 125mg 500 Before begin 1 n. a. n. a. n. a. 500 n. a.
nds BASF pomonella, BAS dispenser/ of 1.st dispense
285 ha generation r x 125
I,/disp moth flight of mg =
enser 1.st species 62.5
occurring g/ha
EFSA Journal 2014;12(1):3524 421


I controlled
(b) (l) (m)
(a) (c)
(d-f) (i) (f-h) (k)
max
Pome fruit, Spain CHECKMA F Laspeyresia VP 180 300-400 Before the 1st 1-2 When n. a n. a 300-400 n. a
Stone fruit, TE CM-CS [Cydia] mg/dis dispenser generation of required dispense
(Known as pomonella penser s/ha the moth rs/ha x
CM) / 180 mg
Suterra = 54-72
(Consep g/ha
GmbH) X 2
applicati
ons
= 108-
144 g/ha
Tree nut Spain CHECKMA F Laspeyresia VP 180 375-500 Before the 1st 1-2 When n. a n. a 375-500 n. a
crops TE CM-CS [Cydia] mg/dis dispenser generation of required dispense
CM) / 180 mg
Suterra = 67.5-
(Consep 90 g/ha
GmbH) X 2
applicati
ons
= 135-
180 g/ha
EFSA Journal 2014;12(1):3524 422


I controlled
(b) (l) (m)
(a) (c)
(d-f) (i) (f-h) (k)
max
Pome fruit, German CHECKMA F Laspeyresia VP 180 300-400 Before the 1st 1-2 When n. a n. a 300-400 n. a
Stone fruit, y TE CM-CS [Cydia] mg/dis dispenser generation of required dispense
CM) / 180 mg
Suterra = 54-72
(Consep g/ha
GmbH) X 2
applicati
ons
= 108-
144 g/ha
Pome fruit, Italy CHECKMA F Laspeyresia VP 240 300 Before the 1st 1-2 When n. a n. a 300 n. a
Stone fruit, TE CM-WS [Cydia] mg/dis dispenser generation of required dispense
Tree nut / Suterra pomonella penser s/ha the moth rs/ha x
crops (Consep 240 mg
GmbH) = 72
g/ha
X 2
applicati
ons
= 144
g/ha
EFSA Journal 2014;12(1):3524 423


I controlled
(b) (l) (m)
(a) (c)
(d-f) (i) (f-h) (k)
max
Pome fruit, France CHECKMA F Laspeyresia VP 270 300 Before the 1st 1-2 (max) When n. a n. a 300 n. a
Stone fruit, (In TE CM-WS [Cydia] mg/dis dispenser generation of required dispense
Tree nut Review) / Suterra pomonella penser s/ha the moth rs/ha x
GmbH) = 81
g/ha
X 2
applicati
ons
= 162
g/ha
Pome fruit, Italy CHECKMA F Laspeyresia VP 180 300-400 Before the 1st 1-2 When n. a n. a 300-400 n. a
Stone fruit, (Field TE CM / [Cydia] mg/dis dispenser generation of required dispense
Tree nut Trials) Suterra pomonella penser s/ha the moth rs/ha x
GmbH) = 54-72
g/ha
X 2
applicati
ons
= 108-
144 g/ha
EFSA Journal 2014;12(1):3524 424


I controlled
(b) (l) (m)
(a) (c)
(d-f) (i) (f-h) (k)
max
Pome fruit, Spain CHECKMA F Laspeyresia VP 270 500 Before the 1st 1 When n. a n. a 500 n.a
Stone fruit, Germany TE CM- [Cydia] mg/dis dispenser generation of required dispense
Tree nut (All Field XL1000 / pomonella penser s/ha the moth rs/ha x
crops Trials) Suterra 270 mg
(Consep = 135
GmbH) g/ha
Pome fruit Southern Suterra F Biting insects CSL 0.143 Low Prior to moth Max. 3 30 days Max. Low volume 4.1 g – n. a. 24.3 g as/ha/
(Apple, Europe (Consep Cydia VS g / ml volume emergence of 2.025 spraying 8.1 g year
pear, (Spain) GmbH) pomonella = 143 spraying 1st pest g/hl = (max. 400 l as/ha
quince), CHECKMA (Cydia g/l generation 0.002025 /ha) =
Stone fruit TE CM-F caryana – not and/or prior to kg/hl 0.0041 –
(Peach, relevant pest moth 0.0081
nectarine, in Europe) emergence of kg as/ha
plum, Tree any other
nuts generation
(Walnuts)
Pome fruit Northern Suterra F Biting insects CSL 0.143 Low Prior to moth 3 30 days Max. Low volume 4.1 g – n. a. 24.3 g as/ha/
(Apple, Europe (Consep Cydia VS g / ml volume emergence of 2.025 spraying 8.1 g year
pear, (no GmbH) pomonella = 143 spraying 1st pest g/hl = (max. 400 l as/ha
quince), authoriz CHECKMA (Cydia g/l generation 0.002025 /ha) =
Stone fruit ation) TE CM-F caryana – not and/or prior to kg/hl 0.0041 –
(Peach, relevant pest first moth 0.0081
nectarine, in Europe) emergence of kg as/ha
plum, Tree any other
nuts generation
(Walnuts)
EFSA Journal 2014;12(1):3524 425


I controlled
(b) (l) (m)
(a) (c)
(d-f) (i) (f-h) (k)
max
Pome fruit, Spain Puffer CM / F Laspeyresia AD 69.33 6.95 Before the 1st 1 When n. a n. a 2 n. a
Stone fruit, (Field Suterra [Cydia] g/cani mg/40 generation of required aerosol
Tree nut Trials) (Consep pomonella ster microliter the moth dispense
crops GmbH) puff rs/ha x
69.33 g
2 aerosol = 138.7
dispenser g/ha
s/ha
Chestnut AT Pheromone F Cydia VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

ES dispenser / fagiglandana mg/dis dispenser/ of 1st generatio dispense
GE (SiberHegn dispenser moth flight of mg = 10-
IT er) in Funnel 1st species 12
UK
EFSA Journal 2014;12(1):3524 426


I controlled
(b) (l) (m)
(a) (c)
(d-f) (i) (f-h) (k)
max
Apple AT Pheromone F Cydia VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n. a.

Pear ES dispenser / pomonella mg/dis dispenser/ of 1st generatio dispense
GE (SiberHegn dispenser moth flight of mg =
IT er) in Funnel 1st species 10-12
UK
Apple AT XLure F Cydia VP 2 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n. a.

GE (SiberHegn dispenser moth flight of mg = 20-
IT er) in Funnel 1st species 24
UK
EFSA Journal 2014;12(1):3524 427


I controlled
(b) (l) (m)
(a) (c)
(d-f) (i) (f-h) (k)
max
Apple AT Pheromone F Cydia VP 10 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n. a.

GE (SiberHegn dispenser moth flight of mg =
IT er) in Delta 1st species 100-120
UK
Apple Italy ECODIAN® F Cydia VP 13mg/ 2000- Before the 1st 2 60-70 days n .a. n. a. 2000- n .a.
Pear France CP / Pomonella dispen 3000 generation of 3000
Walnut Portugal Isagro ser dispenser the moth dispense
Austria s/ha (low- rs/ha x
high 10mg
density =26g-
pest) 39g/ha
EFSA Journal 2014;12(1):3524 428


I controlled
(b) (l) (m)
(a) (c)
(d-f) (i) (f-h) (k)
max
Apple, Spain Cydia F Laspeyresia VP (1) (1) Before begin 1 n. a. n. a. n. a. (1) n. a.

Pear, pomonella Cydia) of 1.st
Peach, sex (pomonella generation
Walnut pheromone (1) moth flight of
/ 1.st species
SEDQ occurs
Apple, Spain ISOMATE F Laspeyresia VP 190 1000 Before begin 1 n. a. n. a. n. a. 1000 n. a.

Pear, Italy C PLUS (Cydia) mg dispenser/ of 1.st dispense
Walnut, France (Spain, pomonella /dispe ha generation r x
Quince Portugal Italy, nser moth flight of 190mg =
Portugal), (50% 1.st species 190g/ha
ISOMATE- a.i. occurring (50% a.i.
C(France) / =95m = 1000
Shin Etsu g) dispense
(CBC- r x95mg
Europe ) =95g/ha)
EFSA Journal 2014;12(1):3524 429


I controlled
(b) (l) (m)
(a) (c)
(d-f) (i) (f-h) (k)
max
Apple, Spain ISOMATE F Laspeyresia VP 380 500 Before begin 1 n. a. n. a. n. a. 500 n. a.

Pear, Italy C TT (Cydia) mg dispenser/ of 1.st dispense
Walnut, France (Spain, pomonella /dispe ha generation r x
Quince Portugal Italy, nser moth flight of 380mg =
Portugal), (50% 1.st species 190g/ha
GINKO(Fra a.i. = occurring (50% a.i.
nce) / 190mg = 500
Shin Etsu ) dispense
(CBC- r x
Europe) 190mg
=95g/ha)
Pome Southern Shin-Etsu F Biting insects VP 240 Manual Prior to moth 1 n. a. n. a. n. a. 240 g/ha n. a.
Fruit Europe (CBC Cydia mg distribu- emergence of
(Apple, (Italy) Europe) pomonella, (total tion of 1st pest (1000
pear, ISOMATE Adoxophyes of 5 1000 generation or dispense
quince); CLR orana, as) / dispen- prior to first r x 240
Stone Pandemis dispen sers per moth mg)
Fruit heparana ser ha; emergence of
(Peach,ne (see uniform any other
cta-rine, level 1 distribu- generation
apricot, table tion
plum); 1.5.3.1 through-
Tree nuts 1) out
(Walnut) orchards
EFSA Journal 2014;12(1):3524 430


I controlled
(b) (l) (m)
(a) (c)
(d-f) (i) (f-h) (k)
max
Apple, Italy ISOMATE F Laspeyresia VP 340 1000 Before begin 1 n. a. n. a. n. a. 1000 n. a.

Pear, C LR PLUS (Cydia) mg dispenser/ of 1.st dispense
Walnut, / Shin Etsu pomonella /dispe ha generation r x
Quince (CBC- nser moth flight of 340mg =
Europe) (42% 1.st species 340g/ha
a.i. occurring (42% a.i.
=145 = 1000
mg) dispense
r
x145mg
=
145g/ha)
Apple, Italy ISOMATE F Laspeyresia VP 210mg 1000 Before begin 1 n. a. n. a. n. a. 1000 n. a.
Pear, C OFM / (Cydia) /dispe dispenser/ of 1.st dispense
Walnut, Shin Etsu pomonella nser ha generation r
Quince (CBC- (68% moth flight of x210mg
Europe) a.i. = 1.st species =
143mg occurring 210g/ha
) (68% a.i.
= 1000
dispense
r x
143mg =
143g/ha)

n.a. not applicable
CS capsule suspension
LVS low volume spraying
n.a. not applicable
Reason for greying out: Spray Application not supported by complete data package
EFSA Journal 2014;12(1):3524 431

EFSA Journal 2014;12(1):3524 432

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 433


5.1)
Toxicologically relevant compounds ‡ (E,E)-8,10-dodecadien-1-ol
Toxicologically relevant compounds ‡ (E,E)-8,10-dodecadien-1-ol
(environment)

Skin sensitisation ‡ Sensitiser (Magnusson & Kligman) R43
Target / critical effect ‡ Rat:

Males: stomach / erosion of glandular mucosa,
kidney / tubular dilatation and vacuolation
Females: no adverse effect up to the limit dose
Relevant oral NOAEL ‡ 28-day, rat: LOAEL 1000 mg/kg bw per day
(males)

EFSA Journal 2014;12(1):3524 434






‡

or adverse effects.

factor
study available
EFSA Journal 2014;12(1):3524 435

ARfD ‡ Not allocated for derivation of

reference values


levels.
background levels.
levels.
background levels.
exposure levels.
background levels.
EFSA Journal 2014;12(1):3524 436

point 10)
36
Substance classified: (E,E)-8,10-dodecadien- Xi ―Irritant‖
1-ol R38 ―Irritating to skin‖
36
EFSA Journal 2014;12(1):3524 437

Residues
Open.
EFSA Journal 2014;12(1):3524 438






Kd

dependence)




EFSA Journal 2014;12(1):3524 439



Photochemical oxidative degradation in air: Calculation according to Atkinson (24h day, hydroxyl
5 -3
concentration 5 x10 cm ): T1/2 = 2.75 hrs
Relevant to the environment (E,E)-8,10-Dodecadien-1-ol

EFSA Journal 2014;12(1):3524 440

Ecotoxicology

Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
Fish 96 hr
E,E-8,10-Dodecadien-1-ol LC50 >0.685 mm
(Brachydanio rerio) (semi- static)
E,E-8,10-Dodecadien-1-ol EC50 0.3 mm
(Daphnia magna) (static)
Algae 72 hr EbC50 0.074 mm
E,E-8,10-Dodecadien-1-ol
(Scenedesmus subspicatus) (static) ErC50 0.221 mm
Alcohols)
Alcohols)
EFSA Journal 2014;12(1):3524 441


Application rate
Crop Route Hazard quotient rigger
[kg as/ha]
Laboratory tests
Based on 20 day No
effects

Application rate
[kg as/ha]
No data provided
section)
soil (E,E)-8,10-Dodecadien-1-ol
water (E,E)-8,10-Dodecadien-1-ol
sediment (E,E)-8,10-Dodecadien-1-ol
groundwater (E,E)-8,10-Dodecadien-1-ol
EFSA Journal 2014;12(1):3524 442

RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 443

19 1-Tetradecanol


Chemical name (IUPAC) ‡ tetradecan-1-ol

Chemical name (CA) ‡ 1-tetradecanol
CIPAC No ‡ 856
CAS No ‡ 112-72-1
publication) ‡
manufactured ‡
manufactured
EFSA Journal 2014;12(1):3524 444

Melting point (state purity) ‡ 36-39 °C (>95%)

Boiling point (state purity) ‡ 289 °C (>95%)
Appearance (state purity) ‡ Solid, white powder at room temperature (>95%)
Vapour pressure (state temperature, state The study for E,E-8,10-dodecadienol can be
purity) ‡ regarded as representative.
3.3 X 10-4 mbar or hPa (20°C) (0.033 Pa)
6.2 X 10-4 mbar or hPa (25°C) (0.062 Pa)
[3.3E-04 (20°C)
6.2E-04 (25°C)]
Henry‘s law constant ‡ 0.100 - 0.0003 kPa m3/mol
(80-99% purity)
Solubility in water (state temperature, state 7.1 x 10-4 – 0.14 g/L (80-99% purity)
purity and pH) ‡ bridged from SCLP acetates summary
Solubility in organic solvents ‡ soluble in methanol, THF, n-hexane, acetone,
(state temperature, state purity) DMSO, chloroform, ethylether, benzene, toluene
(>95%)
Surface tension ‡ Not required*
(state concentration and temperature, state Open for applicability of data to all the SCLP‘s
purity)
Partition co-efficient ‡ log P = 5.75 (software calculation)
The study for E,E-8,10-dodecadienol can be
regarded as representative.
mean pow log = 4.36 (21°C)
EFSA Journal 2014;12(1):3524 445

Flammability ‡ (state purity) Not required*

Flash point: 110°C °C
Explosive properties ‡ (state purity) Not required*
Oxidising properties ‡ (state purity) Not required*

EFSA Journal 2014;12(1):3524 446

Summary of representative uses evaluated (1-Tetradecanol)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Apple, Spain ISOMATE C F Laspeyresia VP 190 1000 Before begin 1 n. a. n. a. n. a. 1000 n. a.

Pear, Italy PLUS (Cydia) mg dispenser/ of 1.st dispense
Walnut, France (Spain, Italy, pomonella /dispe ha generation r x
Quince Portugal Portugal), nser moth flight of 190mg =
ISOMATE- (5% 1.st species 190g/ha
C(France) / a.i. = occurring (5 % a.i.
Shin Etsu 10mg) = 1000
(CBC- dispense
Europe) r x 10mg
=
10g/ha)
Apple, Spain ISOMATE C F Laspeyresia VP 380 500 Before begin 1 n. a. n. a. n. a. 500 n. a.
Pear, Italy TT (Cydia) mg dispenser/ of 1.st dispense
Walnut, France (Spain,Italy, pomonella /dispe ha generation r x
Quince Portugal Portugal), nser moth flight of 380mg =
GINKO(Fran (5% 1.st species 190g/ha
ce) / a.i. = occurring (5% a.i.
Shin Etsu 19mg) = 500
(CBC- dispense
Europe) r x 19mg
=
10g/ha)
EFSA Journal 2014;12(1):3524 447


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
quince); (Italy) ISOMATE Adoxophyes of 5
1000 generation or dispense
(Peach,nec Pandemis dispen sers per moth mg)
ta-rine, heparana ser ha; emergence of
apricot, (see uniform any other
plum); level 1distribu- generation
(Walnut) 1.5.3.1through-
1) out
orchards
Apple, Italy ISOMATE C F Laspeyresia VP 340 1000 Before begin 1 n. a. n. a. n. a. 1000 n. a.
Pear, LR PLUS / (Cydia) mg dispenser/ of 1.st dispense
Walnut, Shin Etsu pomonella /dispe ha generation r x
Quince (CBC- nser moth flight of 240mg =
Europe) (1.3% 1.st species 240g/ha
a.i. = occurring (1.3%
4mg) a.i. =
1000
dispense
r x 4mg
=4g/ha)
EFSA Journal 2014;12(1):3524 448


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Apple, Italy ISOMATE C F Laspeyresia VP 210mg 1000 Before begin 1 n. a. n. a. n. a. 1000 n. a.

Pear, OFM / (Cydia) /dispe dispenser/ of 1.st dispense
Walnut, Shin Etsu pomonella, nser ha generation r x
Quince (CBC- (2% moth flight of 210mg =
Europe) a.i. = 1.st species 210g/ha
4mg) occurring (2% a.i.
= 1000
dispense
r x 4mg
= 4g/ha)

n.a. not applicable
EFSA Journal 2014;12(1):3524 449

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 450


5.1)
Toxicologically relevant compounds ‡ tetradecan-1-ol
Toxicologically relevant compounds ‡ tetradecan-1-ol
(environment)


EFSA Journal 2014;12(1):3524 451







‡
EFSA Journal 2014;12(1):3524 452


or adverse effects.

factor
study available
for derivation of

levels.
levels.
exposure levels.
point 10)
37
37
EFSA Journal 2014;12(1):3524 453

Substance classified: tetradecan-1-ol Xi ―Irritant‖

EFSA Journal 2014;12(1):3524 454

Residues
Proposed MRLs (Annex IIA, point 6.7, Annex IIIA, point 8.6).
Open.
EFSA Journal 2014;12(1):3524 455


Kd

dependence)

EFSA Journal 2014;12(1):3524 456

Relevant to the environment tetradecan-1-ol
EFSA Journal 2014;12(1):3524 457

Ecotoxicology
pheromones (based on the principles of ―bridging‖ thoughout the whole group of SCLPs). In general
the grouping is based on chemical properties (functional groups) of the SCLPs.
SCLP Alcohols)
SCLP Alcohols)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
LC50 >0.685 mm
EC50 0.3 mm
Alcohols)
Alcohols)
EFSA Journal 2014;12(1):3524 458


Application rate
[kg as/ha]
Test
Species Stage Exposure Endpoint Effect Trigger
substance
Laboratory tests
Based on 20 day No
effects

Application rate
[kg as/ha]
No data provided
section)
soil tetradecan-1-ol
water tetradecan-1-ol
sediment tetradecan-1-ol
groundwater tetradecan-1-ol
EFSA Journal 2014;12(1):3524 459

RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 460

20 (Z)-11-Hexadecen-1-ol



Chemical name (IUPAC) ‡ (Z)-11-hexadecen-1-ol

Chemical name (CA) ‡ Z-11-hexadecen-1-ol
CIPAC No ‡ 873
CAS No ‡ 56683-54-6
publication) ‡
manufactured ‡
manufactured
EFSA Journal 2014;12(1):3524 461

Melting point (state purity) ‡ >91% purity

(geometric isomers <6%)
Total blend with isomer: >97%
-0.2°C
Reference required
Boiling point (state purity) ‡ >91% purity
151-156°C (266Pa)
Vapour pressure (state temperature, state >91% purity
purity) ‡ (geometric isomers <6%)
2.63 x 10-2 Pa (25°C)
3
(80-99% purity)
Solubility in organic solvents ‡ >91% purity
(state temperature, state purity) (geometric isomers <6%)
soluble in n-hexane, heptane, xylene, toluene,
dichloromethane, acetone, methanol, ethanol, ethyl
acetate
Reference required
purity)
80-99% purity
EFSA Journal 2014;12(1):3524 462

Partition co-efficient ‡ >91% purity

(state temperature, pH and purity) (geometric isomers <6%)
>10000
Oxidising properties ‡ (state purity) Rapid degradation, evaporation and volatilization

EFSA Journal 2014;12(1):3524 463

Summary of representative uses evaluated ((Z)-11-Hexadecen-1-ol)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Corn AT Pheromone F Sesamia VP 1 10-12 Before begin 1 per n. a. n. a. n .a. 10-12 n.a.
ES dispenser / nonagrioides mg/dis dispenser/ of 1st generatio dispense
UK
Vegetable Spain Konaga-con F Plutella VP 220mg 1000 Before begin 1 n. a. n. a. n. a. 1000dis. n. a.
Plus / xylostella /m dis./ha of 1.st x 220mg
Shin Etsu (1%a.i generation =
(CBC- . = moth flight of 220g/ha
Europe) 2.2mg 1.st species (1% a.i.
) occurs =
1000dis.
x 2.2mg
=
2.2g/ha)

n.a. not applicable
EFSA Journal 2014;12(1):3524 464

EFSA Journal 2014;12(1):3524 465

Methods of Analysis



Soil Open
Water surface Open
Air Open

Food/feed of animal origin (analytical No residue definiotion is set
purposes)

EFSA Journal 2014;12(1):3524 466


5.1)
Toxicologically relevant compounds ‡ (Z)-11-hexadecen-1-ol
Toxicologically relevant compounds ‡ (Z)-11-hexadecen-1-ol
(environment)


EFSA Journal 2014;12(1):3524 467







‡
EFSA Journal 2014;12(1):3524 468


or adverse effects.

factor
study available
for derivation of

levels.
levels.
exposure levels.
point 10)
38
38
EFSA Journal 2014;12(1):3524 469

Substance classified: (Z)-11-hexadecen-1-ol Xi ―Irritant‖

EFSA Journal 2014;12(1):3524 470

Residues
Open.
EFSA Journal 2014;12(1):3524 471


Kd

dependence)

EFSA Journal 2014;12(1):3524 472

Relevant to the environment (Z)-11-hexadecen-1-ol
EFSA Journal 2014;12(1):3524 473

Ecotoxicology
SCLP Alcohols)
SCLP Alcohols)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
LC50 >0.685 mm
EC50 0.3 mm
Alcohols)
Alcohols)
EFSA Journal 2014;12(1):3524 474


Application rate
[kg as/ha]
Laboratory tests
Based on 20 day No
effects

Application rate
[kg as/ha]
No data provided
section)
soil (Z)-11-hexadecen-1-ol
water (Z)-11-hexadecen-1-ol
sediment (Z)-11-hexadecen-1-ol
groundwater (Z)-11-hexadecen-1-ol
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 475

EFSA Journal 2014;12(1):3524 476

21 (Z)-7-Tetradecenal



Chemical name (IUPAC) ‡ (Z)-7-tetradecenal

Chemical name (CA) ‡ Z-7-tetradecenal
CIPAC No ‡ 879
CAS No ‡ 65128-96-3
publication) ‡
manufactured ‡

manufactured
EFSA Journal 2014;12(1):3524 477


Boiling point (state purity) ‡ Purity not stated
308°C
required
Appearance (state purity) ‡ 95%
Colourless liquid
Vapour pressure (state temperature, state The study for (Z)-9-Hexadecenal can be regarded as
purity) ‡ representative.
3.11 x 10-2 Pa (25°C)
Henry‘s law constant ‡ Data required
(state temperature, state purity) bridged from SCLP acetates summary
80-99%purity.
purity)
80-99% purity
Flash point: 110°C, 95% purity
Reference required
EFSA Journal 2014;12(1):3524 478

(statement)

EFSA Journal 2014;12(1):3524 479

Summary of representative uses evaluated ((Z)-7-Tetradecenal)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Lemon AT Pheromone F Prays citri VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.
Orange ES dispenser / mg/dis dispenser/ of 1st generatio dispense
UK
Olives AT Pheromone F Prays oleae VP 1 10-12 Before begin 1 per n .a. n. a. n. a. 10-12 n.a.
st
UK
Lemon Portugal Isonet-P / F Prays oleae VP 135mg 1000 Before begin 1 n. a. n. a. n. a. 1000 n. a.
Shin Etsu Prays citri /dispe dispenser/ of 1.st dispense
(CBC- nser ha generation r x 135
Europe) (65% moth flight of mg =
a.i. = 1.st species 135 g/ha
87.8m occurs (65% a.i.
g) =
87.8g/ha
)
EFSA Journal 2014;12(1):3524 480


n.a. not applicable
EFSA Journal 2014;12(1):3524 481

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 482


5.1)
Toxicologically relevant compounds ‡ (Z)-7-tetradecenal
Toxicologically relevant compounds ‡ (Z)-7-tetradecenal
(environment)

aldehyde: (Z)-11-hexadecenal
exposure

EFSA Journal 2014;12(1):3524 483








‡

or adverse effects.
EFSA Journal 2014;12(1):3524 484


factor
study available
for derivation of

levels.
levels.
exposure levels.
point 10)
39
Substance classified: (Z)-7-tetradecenal Xn ―Harmful‖
R20 ―Harmful by inhalation‖
39
EFSA Journal 2014;12(1):3524 485

Residues
Open.
EFSA Journal 2014;12(1):3524 486


Kd

dependence)

EFSA Journal 2014;12(1):3524 487

Relevant to the environment (Z)-7-tetradecenal
EFSA Journal 2014;12(1):3524 488

Ecotoxicology
SCLP Aldehydes)
SCLP Aldehydes)
SCLP Aldehydes)
Application
Category (e.g.
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
No data
Fish 96 hr LC50
(Z)-7-Tetradecenal provided

EC50 0.58 mm
(Daphnia magna) of SCLP Aldehydes (flow-through)
72 hr EbC50 No data
Algae (Z)-7-Tetradecenal
ErC50 provided

EFSA Journal 2014;12(1):3524 489


Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
No data provided.

Application rate
[kg as/ha]
No data provided
section)
soil (Z)-7-tetradecenal
water (Z)-7-tetradecenal
sediment (Z)-7-tetradecenal
groundwater (Z)-7-tetradecenal
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 490

22 (Z)-9-Hexadecenal



Chemical name (IUPAC) ‡ (Z)-9-hexadecenal

Chemical name (CA) ‡ (Z)-9-hexadecenal
CIPAC No ‡ 881
CAS No ‡ 56219-04-6
publication) ‡
manufactured ‡
manufactured
EFSA Journal 2014;12(1):3524 491

Melting point (state purity) ‡ >90% purity

(geometric isomers <5.5%)
Total blend with isomer: >95.5%
-26.3°C
Boiling point (state purity) ‡ >90% purity
138-142°C (40Pa)
Vapour pressure (state temperature, state >90% purity
purity) ‡ (geometric isomers <5.5%)
3.11 x 10-2 Pa (25°C)
Reference required
Solubility in water (state temperature, state >90% purity
purity and pH) ‡ (geometric isomers <5.5%)
0.106mg/l (20°C)
Solubility in organic solvents ‡ >90% purity
(state temperature, state purity) (geometric isomers <5.5%)
soluble in n-hexane, heptane, xylene, toluene,
dichloromethane, acetone, methanol, ethanol, ethyl
acetate
purity)
80-99% purity
EFSA Journal 2014;12(1):3524 492

Partition co-efficient ‡ >90% purity

(state temperature, pH and purity) (geometric isomers <5.5%)
>10000
Reference required
Flash point: both 62°C and 155 °C stated
Clarification requested
Reference required
(statement)

EFSA Journal 2014;12(1):3524 493

Summary of representative uses evaluated ((Z)-9-Hexadecenal)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Corn AT Pheromone F Heliothis zea VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.
UK
Vegetables Italy Konaga-con F Plutella VP 220mg 1000 Before begin 1 n. a. n. a. n. a. 1000 n. a.

, Spain Plus / xylostella /dispe dispenser/ of 1.st dispense
(CBC- (1.5% moth flight of 220mg =
3.3mg/ occurs (1.5%
dispen a.i. =
ser) 3.3g/ha)
Rice Italy Isomate- F Chilo VP 320mg 100 Before begin 1 n. a. n. a. n. a. 100 n. a.

Spain RSB / suppressalis /dispe dispenser/ of 1.st dispense
16mg/ occurs (5% a.i.
m) =
1.6g/ha)

n.a. not applicable
EFSA Journal 2014;12(1):3524 494

EFSA Journal 2014;12(1):3524 495

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 496


5.1)
Toxicologically relevant compounds ‡ (Z)-9-hexadecenal
(environment)

exposure

EFSA Journal 2014;12(1):3524 497








‡

or adverse effects.
EFSA Journal 2014;12(1):3524 498


factor
study available
for derivation of

levels.
levels.
exposure levels.
point 10)
40
Substance classified: (Z)-9-hexadecenal Xn ―Harmful‖
40
EFSA Journal 2014;12(1):3524 499

Residues
Open.
EFSA Journal 2014;12(1):3524 500


Kd

dependence)


EFSA Journal 2014;12(1):3524 501

Relevant to the environment (Z)-9-hexadecenal
EFSA Journal 2014;12(1):3524 502

Ecotoxicology
SCLP Aldehydes)
SCLP Aldehydes)
SCLP Aldehydes)
Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
96 hr No data
Fish Z)-9-Hexadecenal LC50
provided
EC50 0.58 mm
(Z)-9-Hexadecenal
ErC50 provided

EFSA Journal 2014;12(1):3524 503


Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
No data provided.

Application rate
[kg as/ha]
No data provided
section)
soil (Z)-9-hexadecenal
water (Z)-9-hexadecenal
sediment (Z)-9-hexadecenal
groundwater (Z)-9-hexadecenal
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 504

23 (Z)-11-Hexadecenal



Chemical name (IUPAC) ‡ (Z)-11-hexadecenal

Chemical name (CA) ‡ (Z)-11-hexadecenal
CIPAC No ‡ 875
CAS No ‡ 53939-28-9
publication) ‡
manufactured ‡

manufactured
EFSA Journal 2014;12(1):3524 505

Melting point (state purity) ‡ 90%

-4 to -2°C
Boiling point (state purity) ‡ 90%
120-126°c 0.3mmHg
Appearance (state purity) ‡ not stated, assume >90% purity
light yellow liquid
Vapour pressure (state temperature, state 90%
purity) ‡ 1.2 x 10-3 mmHg or 0.16Pa (20°C)
Solubility in organic solvents ‡ not stated assume >90% purity
(state temperature, state purity) readily soluble in common organic solvents
purity)
80-99% purity
Flash point: both 61°C and 152°C have been stated
90% purity
Clarification requested
Reference required
EFSA Journal 2014;12(1):3524 506

(statement)

EFSA Journal 2014;12(1):3524 507

Summary of representative uses evaluated ((Z)-11-Hexadecenal)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Vegetables Italy Konaga-con F Plutella VP 220mg 1000 Before begin 1 n. a. n. a. n. a. 1000 n. a.

, Spain Plus / xylostella /dispe dispenser/ of 1.st dispense
(CBC- (41.6 moth flight of 220mg =
Europe) % a.i. 1.st species 220g/ha
= occurs (41.6%
91.5m a.i. =
g/disp 91.5g/ha
enser) )
Rice Italy Isomate- F Chilo VP 320mg 100 Before begin 1 n. a. n. a. n. a. 100 n. a.
Spain RSB / suppressalis /dispe dispenser/ of 1.st dispense
107.6 occurs (58% a.i.
mg/m) =
10.8g/ha
)
Rice AT Pheromone F Chilo VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.
ES dispenser / suppressalis mg/dis dispenser/ of 1st generatio dispense
UK
EFSA Journal 2014;12(1):3524 508


I controlled
(a) (b) (l) (m)
(c)
(d-f) (i) (f-h) (k)
max
Vegetables AT Pheromone F Heliothis VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

ES dispenser 7 armigera mg/dis dispenser/ of 1st generatio dispense
UK
Banana AT Pheromone F Opogona VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

ES dispenser / sacchari mg/dis dispenser/ of 1st generatio dispense
st
UK

n.a. not applicable
EFSA Journal 2014;12(1):3524 509

Methods of Analysis



Soil Open
Water surface Open
Air Open

Food/feed of animal origin (analytical No residuie definition set
purposes)

EFSA Journal 2014;12(1):3524 510


5.1)
(environment)

exposure



EFSA Journal 2014;12(1):3524 511






‡

or adverse effects.

factor
study available
for derivation of
EFSA Journal 2014;12(1):3524 512


levels.
levels.
exposure levels.
point 10)
41
Substance classified: (Z)-11-hexadecenal Xn ―Harmful‖
41
EFSA Journal 2014;12(1):3524 513

Residues
Open.
EFSA Journal 2014;12(1):3524 514


Kd

dependence)

EFSA Journal 2014;12(1):3524 515

Relevant to the environment (Z)-11-hexadecenal
EFSA Journal 2014;12(1):3524 516

Ecotoxicology

Application
Category (e.g.
insectivorous bird)
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
Fish 96 hr No data
Z-11-Hexadecenal LC50
provided
No reliable
Z-11-Hexadecenal EC50 data
(Daphnia magna) (flow-through)
provided
Z-11-Hexadecenal
ErC50 provided


Application rate
[kg as/ha]
EFSA Journal 2014;12(1):3524 517

Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
No data provided.

Application rate
[kg as/ha]
No data provided
section)
soil (Z)-11-hexadecenal
water (Z)-11-hexadecenal
sediment (Z)-11-hexadecenal
groundwater (Z)-11-hexadecenal
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 518

24 (Z)-13-Octadecenal



Chemical name (IUPAC) ‡ (Z)-13-octadecenal

Chemical name (CA) ‡ (Z)-13-octadecenal
CIPAC No ‡ 878
CAS No ‡ 58594-45-9
publication) ‡
manufactured ‡
manufactured
EFSA Journal 2014;12(1):3524 519

Melting point (state purity) ‡ Purity not stated

-12 to -8°C
Reference and purity required
Boiling point (state purity) ‡ 90% purity
165 - 174°C 2.5mmHg
Reference required
Appearance (state purity) ‡ Purity not stated, assume >90% purity
light yellow liquid
Vapour pressure (state temperature, state 90%
purity) ‡ 2.0 – 6.0 x 10-4mmHg (20°C) or 0.03 – 0.0008Pa
Solubility in organic solvents ‡ Purity not stated, assume >90% purity
(state temperature, state purity) readily soluble in common organic solvents
purity)
80-99% purity
EFSA Journal 2014;12(1):3524 520


Flash point: 61°C
Purity not stated, assume >90% purity
Reference required
(statement)

EFSA Journal 2014;12(1):3524 521

Summary of representative uses evaluated ((Z)-13-Octadecenal)

I controlled
(a) (b) (l) (m)
(c)
s (min)
max
Rice Spain Isomate- F Chilo VP 320mg 100 Before begin 1 n. a. n. a. n. a. 100 n. a.

RSB / suppressalis /dispe dispenser of 1.st dispense
Shin Etsu nser s/ha generation r x 320
(CBC- (11% moth flight of mg = 32
35.2m occurs (11% a.i.
g) =
3.5g/ha)
Rice AT Pheromone F Chilo VP 1 10-12 Before begin 1 per n. a. n. a. n. a. 10-12 n.a.

ES dispenser / suppressalis mg/dis dispenser/ of 1st generatio dispense
st
UK

n.a. not applicable
EFSA Journal 2014;12(1):3524 522

EFSA Journal 2014;12(1):3524 523

Methods of Analysis



Soil Open
Water surface Open
Air Open

purposes)

EFSA Journal 2014;12(1):3524 524


5.1)

Toxicologically relevant compounds ‡ (Z)-13-octadecenal
Toxicologically relevant compounds ‡ (Z)-13-octadecenal
(environment)

exposure

EFSA Journal 2014;12(1):3524 525








‡

or adverse effects.
EFSA Journal 2014;12(1):3524 526


factor
study available
for derivation of

levels.
levels.
exposure levels.
point 10)
42
Substance classified: (Z)-13-octadecenal Xn ―Harmful‖
42
EFSA Journal 2014;12(1):3524 527

Residues
Open.
EFSA Journal 2014;12(1):3524 528


Kd

dependence)

EFSA Journal 2014;12(1):3524 529

Relevant to the environment (Z)-13-octadecenal
EFSA Journal 2014;12(1):3524 530

Ecotoxicology
SCLP Aldehydes)
SCLP Aldehydes)
SCLP Aldehydes)
Application
Category (e.g.
as/ha]
Time-scale Toxicity
(Test type) [mg/L]
Laboratory tests
No data
Fish (Z)-13-Octadecenal 96 hr LC50
provided
EC50 0.58 mm
EbC50 No data
Algae Z)-13-Octadecenal 72 hr
ErC50 provided

EFSA Journal 2014;12(1):3524 531


Application rate
[kg as/ha]
Dose [g a.s./
dispenser]
Laboratory tests
No data provided.

Application rate
[kg as/ha]
No data provided
section)
soil (Z)-13-octadecenal
water (Z)-13-octadecenal
sediment (Z)-13-octadecenal
groundwater (Z)-13-octadecenal
RMS/EPCO proposal
EFSA Journal 2014;12(1):3524 532

APPENDIX B – USED COMPOUND CODE(S)
Code/Trivial name* Chemical name Structural formula
--- --- ---
EFSA Journal 2014;12(1):3524 533

ABBREVIATIONS
1/n slope of Freundlich isotherm
λ wavelength
decadic molar extinction coefficient
°C degree Celsius (centigrade)
µg microgram
µm micrometer (micron)
a.s. active substance
AChE acetylcholinesterase
ADE actual dermal exposure
ADI acceptable daily intake
AF assessment factor
AOEL acceptable operator exposure level
AP alkaline phosphatase
AR applied radioactivity
ARfD acute reference dose
AST aspartate aminotransferase (SGOT)
AV avoidance factor
BCF bioconcentration factor
BUN blood urea nitrogen
bw body weight
CAS Chemical Abstracts Service
CFU colony forming units
ChE cholinesterase
CI confidence interval
CIPAC Collaborative International Pesticides Analytical Council Limited
CL confidence limits
cm centimetre
d day
DAA days after application
DAR draft assessment report
DAT days after treatment
DM dry matter
DT50 period required for 50 percent disappearance (define method of estimation)
DT90 period required for 90 percent disappearance (define method of estimation)
dw dry weight
EbC50 effective concentration (biomass)
EC50 effective concentration
ECHA European Chemical Agency
EEC European Economic Community
EFSA European Food Safety Authority
EINECS European Inventory of Existing Commercial Chemical Substances
ELINCS European List of New Chemical Substances
EMDI estimated maximum daily intake
ER50 emergence rate/effective rate, median
ErC50 effective concentration (growth rate)
EU European Union
EUROPOEM European Predictive Operator Exposure Model
f(twa) time weighted average factor
FAO Food and Agriculture Organisation of the United Nations
FIR Food intake rate
FOB functional observation battery
FOCUS Forum for the Co-ordination of Pesticide Fate Models and their Use
g gram
EFSA Journal 2014;12(1):3524 534

GAP good agricultural practice

GC gas chromatography
GCPF Global Crop Protection Federation (formerly known as GIFAP)
GGT gamma glutamyl transferase
GM geometric mean
GS growth stage
GSH glutathion
h hour(s)
ha hectare
Hb haemoglobin
Hct haematocrit
hL hectolitre
HPLC high pressure liquid chromatography
or high performance liquid chromatography
HPLC-MS high pressure liquid chromatography – mass spectrometry
HQ hazard quotient
IEDI international estimated daily intake
IESTI international estimated short-term intake
ISO International Organisation for Standardisation
IUPAC International Union of Pure and Applied Chemistry
JMPR Joint Meeting on the FAO Panel of Experts on Pesticide Residues in Food and
the Environment and the WHO Expert Group on Pesticide Residues (Joint
Meeting on Pesticide Residues)
Kdoc organic carbon linear adsorption coefficient
kg kilogram
KFoc Freundlich organic carbon adsorption coefficient
L litre
LC liquid chromatography
LC50 lethal concentration, median
LC-MS liquid chromatography-mass spectrometry
LC-MS-MS liquid chromatography with tandem mass spectrometry
LD50 lethal dose, median; dosis letalis media
LDH lactate dehydrogenase
LOAEL lowest observable adverse effect level
LOD limit of detection
LOQ limit of quantification (determination)
m metre
M/L mixing and loading
MAF multiple application factor
MCH mean corpuscular haemoglobin
MCHC mean corpuscular haemoglobin concentration
MCV mean corpuscular volume
mg milligram
M&K Magnusson & Kligman
mL millilitre
mm millimetre
mN milli-newton
MRL maximum residue limit or level
MS mass spectrometry
MSDS material safety data sheet
MTD maximum tolerated dose
MWHC maximum water holding capacity
NESTI national estimated short-term intake
ng nanogram
NOAEC no observed adverse effect concentration
EFSA Journal 2014;12(1):3524 535

NOAEL no observed adverse effect level

NOEC no observed effect concentration
NOEL no observed effect level
OECD Organisation for Economic Co-operation and Development
OM organic matter content
Pa pascal
PD proportion of different food types
PEC predicted environmental concentration
PECair predicted environmental concentration in air
PECgw predicted environmental concentration in ground water
PECsed predicted environmental concentration in sediment
PECsoil predicted environmental concentration in soil
PECsw predicted environmental concentration in surface water
pH pH-value
PHED pesticide handler's exposure data
PHI pre-harvest interval
PIE potential inhalation exposure
pKa negative logarithm (to the base 10) of the dissociation constant
Pow partition coefficient between n-octanol and water
PPE personal protective equipment
ppm parts per million (10-6)
ppp plant protection product
PT proportion of diet obtained in the treated area
PTT partial thromboplastin time
QSAR quantitative structure-activity relationship
r2 coefficient of determination
REACH Registration, Evaluation, Authorisation of CHemicals
RMS rapporteur Member State
RPE respiratory protective equipment
RUD residue per unit dose
SANCO Directorate-General for Health and Consumers
SC suspension concentrate
SCLP straight chain Lepidopteran pheromones
SD standard deviation
SFO single first-order
SSD species sensitivity distribution
STMR supervised trials median residue
t1/2 half-life (define method of estimation)
TER toxicity exposure ratio
TERA toxicity exposure ratio for acute exposure
TERLT toxicity exposure ratio following chronic exposure
TERST toxicity exposure ratio following repeated exposure
TK technical concentrate
TLV threshold limit value
TMDI theoretical maximum daily intake
TRR total radioactive residue
TSH thyroid stimulating hormone (thyrotropin)
TWA time weighted average
UDS unscheduled DNA synthesis
UV ultraviolet
W/S water/sediment
w/v weight per volume
w/w weight per weight
WBC white blood cell
WG water dispersible granule
EFSA Journal 2014;12(1):3524 536

WHO World Health Organization

wk week
yr year
EFSA Journal 2014;12(1):3524 537

2014-Efsa Journal SCLP

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EFSA Journal 2014;12(1):3524

CONCLUSION ON PESTICIDE PEER REVIEW

European Food Safety Authority (EFSA), Parma, Italy

© European Food Safety Authority, 2014

© European Food Safety Authority, 2014

Straight Chain Lepidopteran Pheromones was included in Annex I to Directive 91/414/EEC on 18

EFSA Journal 2014;12(1):3524 2

EFSA Journal 2014;12(1):3524 3

Straight Chain Lepidopteran Pheromones was included in Annex I to Directive 91/414/EEC5 on 18

EFSA Journal 2014;12(1):3524 4

• the comments received on the DAR,

• the Reporting Tables (25 June 2012)

• the Evaluation Tables (<<DD Month YYYY>>),

• the comments received on the draft EFSA conclusion.

EFSA Journal 2014;12(1):3524 5

THE ACTIVE SUBSTANCE AND THE FORMULATED PRODUCT

CONCLUSIONS OF THE EVALUATION

1. Identity, physical/chemical/technical properties and methods of analysis

EFSA Journal 2014;12(1):3524 6

Regarding application through spraying of microencapsulated vapour releasing system, dermal

EFSA Journal 2014;12(1):3524 7

4. Environmental fate and behaviour

EFSA Journal 2014;12(1):3524 8

EFSA Journal 2014;12(1):3524 9

(E)-8-dodecen-1-yl acetate (No. 2 in 31) As above. As above.

(Z)-8-dodecen-1-yl acetate (No. 4, in 25 and 31) As above. As above.

(Z)-9-dodecen-1-yl acetate (No. 5, in 26) As above. As above.

(E,Z)-7,9-dodecadien-1-yl acetate (No. 6, in 27) As above. As above.

(E)-11-tetradecen-1-yl acetate (No. 7) As above. As above.

(Z)-9-tetradecen-1-yl acetate (No. 8) As above. As above.

(Z)-11-tetradecen-1-yl acetate (No. 9) As above. As above.

(Z, E)-9, 12-tetradecadien-1-yl acetate (No. 10) As above. As above.

(Z)-11-hexadecen-1-yl acetate (No. 11, in 32) As above. As above.

(Z, E)-7, 11-hexadecadien-1-yl acetate (No. 13, in 28) As above. As above.

EFSA Journal 2014;12(1):3524 10

(E, Z)-2, 13-octadecadien-1-yl acetate (No. 14) As above. As above.

(E)-5-decen-1-ol (No. 16, in 30) As above. As above.

(Z)-8-dodecen-1-ol (No. 17 in 31) As above. As above.

(E,E)-8,10-dodecadien-1-ol (No. 18) As above. As above.

tetradecan-1-ol (No. 19) As above. As above.

(Z)-11-hexadecen-1-ol (No. 20) As above. As above.

(Z)-7-tetradecenal (No. 21) As above. As above.

(Z)-9-hexadecenal (No. 22, in 29) As above. As above.

(Z)-11-hexadecenal (No. 23 in 29 & 32) As above. As above.

(Z)-13-octadecenal (No. 24, in 29) As above. As above.

dodecyl acetate (in 25 & 26) As above. As above.

(E,E)-7,9-dodecadien-1-yl acetate (in 27) As above. As above.

(Z,Z)-7,11-hexadecadien-1-yl acetate (in 28) As above. As above.

(E/Z)-8-dodecen-1-yl acetate (No. 3 in 31) As above. As above.

6.2 Ground water

EFSA Journal 2014;12(1):3524 11

Data not available, but

No dispenser application, Data gap for surface water

No dispenser application, Data gap for surface water

Data gap for surface water

(E,Z)-7,9-dodecadien-1-yl Data gap for surface water

(E)-11-tetradecen-1-yl Data gap for surface water

(Z)-9-tetradecen-1-yl Data gap for surface water

(Z)-11-tetradecen-1-yl Data gap for surface water

(Z,E)-9, 12-tetradecadien- Data gap for surface water

(Z)-11-hexadecen-1-yl No dispenser application, Data gap for surface water

(Z,E)-7, 11-hexadecadien- Data gap for surface water

EFSA Journal 2014;12(1):3524 12