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  • Mekanisme Pruritus Pada Pasien DM

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    Desy R L
    91 views2 pages
    Mekanisme pruritus pada DM

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    Mekanisme pruritus pada pasien DM

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    Mekanisme pruritus pada DM

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    91 views2 pages

    Mekanisme Pruritus Pada Pasien DM

    Uploaded by

    Desy R L
    Mekanisme pruritus pada DM

    Copyright:

    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 2

    Mekanisme timbulnya pruritus pada pasien DM

    Pasien Diabetes Melitus

    Hiperglikemia

    Resistensi Insulin

    Glikosuria

    Osmotik Diuresis

    Dehidrasi

    Hemokonsentrasi

    Aterosklerosis

    Makrovaskuler Mikrovaskuler

    Jantung Cerebral

    Ekstremitas

    Menyebabkan iritasi
    kulit/peradangan

    Pelepasan histamin selama peradangan

    Timbul rasa gatal (pruritus)


    Patogenesis Akantosis Nigrikans

    Insulin resistence

    Hiperinsulinemia

    IGF BP-1, BP-2

    EGFR activation Free IGF-1


    FGFR activation Other factors
    IGF-1R activation

    Acanthosis nigricans

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