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SENSITIVITY AND SPECIFICITY OF

ROUTINE DIAGNOSTIC PROCEDURE OF PULMONARY TUBERCULOSIS


USING THE GOLD STANDARD EXAMINATION OF XPERT MTB/RIF
IN WANGAYA GENERAL HOSPITAL (TYPE-B TRAINING HOSPITAL), DENPASAR -
BALI

A.A. Gd Ocha Rama K. Putra1, Ketut Suryana2, I.B. Suta2, I.B. Ngurah Rai2

Postgraduate Program of Pulmonology Specialist of Udayana University Bali

ABSTRACT

Background: Indonesia is currently ranked second after India in the case of Tuberculosis
(TB). TB infection mostly occurs in the lungs (around 66.7% of cases). Diagnostic procedures
for pulmonary tuberculosis are radiological examination, sputum smear, and a gold standard
examination using the Xpert MTB/Rif method. Xpert MTB/Rif examination is not readily
accessible in every healthcare facilities.
Objective: The aim of this study was to determine the sensitivity and specificity of routine
diagnostic procedures for pulmonary tuberculosis (X-ray and Sputum smear) with Xpert
MTB/Rif examination at Wangaya General Hospital, Denpasar, Bali.
Methods: This study used a cross sectional method by retrieving the AFB Sputum laboratory
data, chest X-ray, and Xpert MTB/Rif, in patients with clinically pulmonary TB in June - August
2018 at Wangaya General Hospital, Denpasar, Bali.
Results: Of the 43 patients who were clinically examined for pulmonary tuberculosis, there
were more males than females (72.1% vs 27.9%). The mean age of patients was 46.37 (18.58)
years. The diagnostic test results of chest X-ray against Xpert MTB/Rif have sensitivity of
89.47% and specificity of 26.92%, whereas AFB sputum against Xpert MTB/Rif has a
sensitivity of 38.89% and specificity of 72.22%.
Conclusion: Chest X-ray examination has a higher sensitivity and AFB sputum examination
has a higher specificity against Xpert MTB/Rif examination as a gold standard.

Keywords: Sensitivity and Specificity, Routine Diagnostic Procedure, Pulmonary TB,


Xpert MTB/Rif