Izagani Aquino

Chris Griggy
Simon Moattar
Izzy Cozier

Type 2 Diabetes (the diabetes rap) 

Tasks:
-Research type 2 diabetes and get needed information
-Write lyrics
-come up with a beat
-Record song
-Film music video
-Edit video
-Poster: Process, Symptoms,

Today’s Reflection:
Today, we were able to look up possible diseases. We settled on Type 2 Diabetes and came up
with tasks

● Type 2 Diabetes is a chronic condition that affects the way your body metabolizes sugar.
● It affects the heart, blood vessels, nerves, eyes, and kidneys.
● Diabetes is a problem with your body that causes blood glucose (sugar) levels to rise
higher than normal
● Type 2 diabetes affects the way the body processes blood sugar.
● Type 2 diabetes is characterized by excessive sugar (glucose) in the blood due
to the development of resistance to insulin
● Diabetes is a problem with your body that causes blood glucose (sugar) levels to rise
higher than normal
● People are more likely to develop type 2 diabetes due to genetics or eating habits/weight
problems.
● Signs of Diabetes: Increased thirst and frequent urination, increased hunger, weight
loss, fatigue, blurred vision slow-healing sores or frequent infections, areas of darkened
skin.
● Your risk of type 2 diabetes typically increases when you are:
● Older

● Less active

● Overweight or obese

● Some common treatments of type 2 diabetes are regular exercise, healthy eating, blood
sugar monitoring, or diabetes medication/treatment.
● Other risk factors are:
● Family history of diabetes in close relatives
 ● Being of African, Asian, Native American, Latino, or Pacific Islander ancestry

● High blood pressure

● High blood levels of fats, known as triglycerides, coupled with low levels of

high-density lipoprotein, known as HDL, in the bloodstream

● Prior diagnosis of pre-diabetes such as glucose intolerance or elevated blood sugar

● In women, a history of giving birth to large babies (over 9 lbs) and/or diabetes during

pregnancy

● Common side effects: ​frequent urination, blurred vision, or poor wound healing 

● If type 2 diabetes goes untreated, the high blood sugar can affect various cells and
organs in the body
● Complications include kidney damage, often leading to dialysis, eye damage, which 
could result in blindness, or an increased risk for heart disease or stroke 
● Type 2 diabetes is 90-95% diabetics in America 
● In the past 20 years the number of adults with diabetes has tripled. 
What is it? Itś a disease that changes the way that the body uses insulin resulting in high blood 
sugar levels.  
What part of the body does it affect? It affects the way the pancreas produces insulin. High 
blood sugar can cause, kidney damage, eye damage, or an increased risk of heart disease or 
stroke. 
Who is likely to get it? People with family history of diabetes. High blood pressure, high blood 
fat levels, pre-diabetes, or common side effects(frequent urination, blurred vision, or poor wound 
healing). People who live a sedentary lifestyle are more likely to be affected by diabetes. 
What are the treatments? Cure? Treatments include, regular exercise, healthy eating, blood 
sugar monitoring and insulin medication.  
What are the barriers to curing it? Diabetes can be managed to a point where the body shows no 
symptoms but it cannot go away/be cured. 
Any interesting research going on? Many foundations are trying to find a cure but none of them 
are close. Some new findings may point to stress leading to diabetes in older people, there has 
also been very recent developments that will help speed up the treatment and developments of 
diabetes. 
Protein synthesis:   

Sequence:
dna:

G T T​​ ​T A C ​G G G​​ ​G C G​​ ​ T C G​​ ​G G T​​ ​A A A

C A A​​ ​A T G ​C C C​​ ​C G C​​ ​A G C​​ ​C C A​​ T T T
mrna:
C A A​​ ​A T G ​C C C​​ ​C G C​​ ​A G C​​ ​C C A​​ T T T

mrna+trna
C A A​​ ​A T G ​C C C​​ ​C G C​​ ​A G C​​ ​C C A​​ T T T
G U U​​ ​U A C​​ ​G G G ​G C G ​U C G ​G G U ​A A A

http://www.diabetes.org/diabetes-basics/type-2/
https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/symptoms-causes/syc-2035119
3

https://invisiverse.wonderhowto.com/news/defective-infectious-proteins-linked-type-2-diabetes-0
179122/

https://www.niddk.nih.gov/health-information/diabetes/overview/risk-factors-type-2-diabetes

https://www.mayoclinic.org/diseases-conditions/type-2-diabetes/diagnosis-treatment/drc-203511
99

https://www.cdc.gov/diabetes/statistics/slides/maps_diabetes_trends.pdf
End product​:
You will give an explanation in any way you choose besides slides to show your
understanding of the disease, the protein and the synthesis of proteins.
What needs to be included:
Disease info:
● What is it
○ Type 2 Diabetes is a chronic
condition that affects the way
your body metabolizes sugar.
○ Insulin not secreted correctly
from the pancreas
● What parts of the body does it
affect, symptoms
○ It affects the heart, blood
vessels, nerves, eyes, and
kidneys.
○ pancreas
○ Signs of Diabetes: Increased
thirst and frequent urination,
increased hunger, weight
loss, fatigue, blurred vision
slow-healing sores or
frequent infections, areas of
darkened skin.
● What protein is affected
○ Insulin
○ Not transported correctly
○ pancreas
● Who is likely to get it
○ Older
○ Less active
○ Overweight or obese
● What are the treatments? Cure?
○ Treatments are exercise,
maintaining a good diet,
and oftentimes taking
insulin by injection
○ No cure
● What are the barriers to curing it?
○ No one is quite sure why
the insulin can’t be
transferred
● Any interesting research going on
now?
○ There is research taking
place linking diabetes to
stress
Protein Synthesis Detail:
Use this to help explain the difference
between normal and diseased protein
For each stage:
What is happening→ how and why
Where is it happening
What are the major players
What is the code/ sequence
End with a 3D model of the protein

A. Transcription
a. Takes place in the nucleus
b. DNA is decoded into
mRNA
c. RNA polymerase (an
enzyme) connects
complementary RNA
bases to the DNA
d. RNA bases create mRNA
e. mRNA leaves nucleus,
goes to cytoplasm and
travels to a ribosome
f. Ribosomes composed of
rRNA
B. Translation
a. tRNA (transfer RNA) found
in the cytoplasm carry an
amino acid which makes
up protein
b. mRNA dictates what
amino acids from tRNA
are utilized
c. tRNA attaches to
complementary bases on
mRNA
d. Reads bases in triplets
(codons)
e. Different codons apply to
different amino acids
f. Amino acids link together
in a peptide bond
C. Folding
a. Folding give the protein
shape and the ability to
actually function
b. There are 4 parts
i. Primary
ii. Secondary
iii. Tertiary
iv. Quaternary
c. Primary
 i. Just the chain of ii. Because type 2
amino acids in diabetes has a
cytoplasm problem with insulin
d. Secondary being secreted from
i. Begins to fold in the the pancreas, this is
rough ER where the problem
ii. Forms the takes place
secondary DNA
structures of a helix G T T​​ ​T A C ​G G G​​ ​G C G​​ ​ T C G​​ ​G G T​​ ​A A
A
and b sheets
C A A​​ ​A T G ​C C C​​ ​C G C​​ ​A G C​​ ​C C A​​ T T
e. Tertiary T
mRNA:
i. More folding takes
C A A​​ ​A T G ​C C C​​ ​C G C​​ ​A G C​​ ​C C A​​ T T
place, based on the T
hydrophobic and mRNA+tRNA
C A A​​ ​A T G ​C C C​​ ​C G C​​ ​A G C​​ ​C C A​​ T T
hydrophilic parts of T
the protein G U U​​ ​U A C​​ ​G G G ​G C G ​U C G ​G G U ​A A
A
ii. Takes place in ER Amino Acids:
and golgi Valine, tyrosine, valine, alanine, serine,
glycine, lysine
f. Quaternary
i. From golgi,
transferred where
needed
Hold up, let me get it started
‘Betes with the sugar, lookin' disregarded
Insulin saggin', pancreas lackin
This ain’t a trick 'cause my blood sugar trashin

Diabetes, think im stupid, I ain’t stupid

Doctor’s say I have too much sugar they stupid
Blood sugar in my body, it is unfit
Insulin not really working, it is stupid
I didn’t even exercise and I am fat now
Sedentary lifestyle is cool, I eat like a cow
I never exercise, look like paul blart now
Like the stock market, health level’s been going down
Hold up, let me get it started
‘Betes with the sugar, lookin' disregarded
Insulin saggin', pancreas lackin
This ain’t a trick 'cause my blood sugar trashin

Diabetes, lookin really tubby uh

Unhealthy healthy, lookin really chubby uh
Protein folding, not really working uh
Transporting porting, going all wrong yuh
Why am I peeing
A sign of diabetes?
Wounds not healing
I’m having trouble seeing
Why am I unfit
Ate too much banana splits
You used to feed me so much sugar and fat dang it

Went to my house and I drank some juice juice

My momma told me “it ain’t good for you you”
I asked her, “why momma, this can’t be true true”
“you’ll get diabetes, that’s something you can’t undo”

Diabetes will increase my blood sugar, can’t have it

Can’t secrete the insulin, thats an L, not a win

Diabetes haunt my dreams, I don’t know what happened

Insulin protein not working, this not for laughin’

Matters not for laughing’, sugar makes me panic

Gotta get a tactic, diabetes not lit
Control gotta happen, disease is not a win
Gotta fix insulin, my pancreas within

Diabetes sucks, glucose is up

Shout out Ms. Mathews, that's my favorite STEM teacher yuh
Go, go, go diabetes
Go, go, diabetes

Diabetes, lookin really tubby uh

Unhealthy healthy, lookin really chubby uh
Protein folding, not really working uh
Transporting porting, going all wrong yuh
Why am I peeing
A sign of diabetes?
Wounds not healing
I’m having trouble seeing
Why am I unfit
Ate too much banana splits
You used to feed me so much sugar and fat dang it