Nama Sari Utami

Nim 050217A090
UTS Farmakokinetika

Soal 1
data pengambilan sample suatu senyawa sebagai berikut

waktu(menobat A(mg)ln waktu (menit)

4 70 4.248495 0 90 4.49981
10 58 4.060443 20 80 4.382027
20 42 3.73767 40 68 4.219508
30 31 3.433987 60 56 4.025352
60 12 2.484907 80 50 3.912023
90 4.5 1.504077 100 38 3.637586
120 1.7 0.530628 120 26 3.258097
soal 2

suatu xenobiotik diberikan dalam dosis tunggal 100 mg secara intra vaskuler, dengan pengambilan sample darah sampai pada 3

waktu cuplkadar (mg/ln waktu cuplln

0.5 29.0 3.367296 0.5 3.367296
1 28.0 3.332205 1 3.332205
3 22.0 3.091042 3 3.091042
5 18.5 2.917771 5 2.917771
10 10 2.302585 10 2.302585
15 6.8 1.916923 15 1.916923
20 3.4 1.223775 20 1.223775
25 1.9 0.641854 25 0.641854
30 1.1 0.09531 30 0.09531

a 3.4491 Cp˚ 31.4608 mg/L

b -0.111
r 0.9981
k 0.111 jam⁻¹
t½ 6.243243 jam
dosis 100 mg 100000 µg
AUC 31.07297 mg.jam/ml
Cl 3218.231 ml/jam
Vd 3178.559 ml
ilan sample darah sampai pada 30 jam terlampir dalam tabel beriku:

Chart Title
4

3.5
f(x) = - 0.1109911551x + 3.4491435788
3 R² = 0.9980851224

2.5 Col umn I

Linear (Col umn I)
2

1.5

0.5

0
0 5 10 15 20 25 30 35
waktu (jamkadar (mg/ln cp
0 0 0 Chart T
0.167 0.06 -2.81341 4
0.333 3.59 1.278152
3
0.5 7.79 2.052841
1 13.3 2.587764 2
1.5 14.5 2.674149 1
2 16.9 2.827314
0
3 16.6 2.809403 0 2 4 6
4 11.9 2.476538 -1
6 6.31 1.842136
-2
8 3.54 1.264127
10 1.36 0.307485 -3
12 0.63 -0.46204 -4

Fase Eliminasi
Chart T
waktu (jamkadar (mg/L) 3
3 2.809403 f(x) = - 0.3617408261x + 3.96541804
2.5 R² = 0.9931088958
4 2.476538
6 1.842136 2

8 1.264127 1.5
10 0.307485
1
12 -0.46204
0.5
a 3.9654 Cp˚ 52.71968 mg/L 0
b -0.3617 2 4 6 8 10 12
r 0.9931 -0.5

k 0.3617 jam⁻¹ -1
t½ 1.915952 jam

Chart Title
Fase Absorbsi 2
waktu kadar (mg/L)
0 0 1

0
0 f(x)0.05
= 3.8175270139x
0.1 0.15- 1.1480073404
0.2 0.25 0.3 0.35
R² = 0.0922056059
-1
 Chart Title
2

1
0.167 -2.81341
0.333 1.278152 0
0 f(x)0.05
= 3.8175270139x
0.1 0.15- 1.1480073404
0.2 0.25 0.3 0.35
R² = 0.0922056059
-1

-2

-3

-4

waktu (jamkadar (mg/ln cp ln ekstrapocp eks cp residualln cp resi

0 0 0 3.9654 52.71968 52.71968 3.964989
0.167 0.06 -2.81341 4.024732 55.94198 55.88198 4.023242
0.333 3.59 1.278152 4.023605 55.87894 52.28894 3.956785
0.5 7.79 2.052841 4.014698 55.38351 47.59351 3.862696

a 4.0079 cp 55.00832 mg/L

b -0.224
r 0.5259
k 0.224 jam⁻¹
t½ 3.09375 jam
tTmax -0.77373
AUC
 Chart Title

2 4 6 8 10 12 14

Chart Title

f(x) = - 0.3617408261x + 3.9654180435

R² = 0.9931088958

Col umn C
Li near (Col umn C)

4 6 8 10 12 14

Chart Title

15- 1.1480073404
0.2 0.25 0.3 0.35 Col umn C
Li near (Col umn C)
 Chart Title

15- 1.1480073404
0.2 0.25 0.3 0.35 Col umn C
Li near (Col umn C)

Chart Title
4.05

4 f(x) = - 0.2240200753x + 4.0079330225

R² = 0.525940346
3.95
Col umn H
Li near (Col umn H)
3.9

3.85

3.8

3.75
0 0.1 0.2 0.3 0.4 0.5 0.6