Schematic Diagram Precipitating

Environmental conditions (open spaces with water

Predisposing pots, and plants)
Geographical area – tropical islands in the Immunocompromise
Pacific (Philippines) and Asia Aedes
aegypti (dengue virus carrier): 8- Mosquito carrying dengue virus
Soldier
12 days of viral replication on
Sweaty skin
mosquitos’ salivary glands

Bite from mosquito (Portal of Entry in

the Skin)

Allowing dengue virus to be inoculated

towards the circulation/blood
(Incubation Period: 3-14 days

Virus disseminated rapidly into the blood

and stimulates WBCs including B
lymphocytes that produces and secretes
immunoglobulins (antibodies), and
monocytes/macrophges, neutrophils
 Antibodies attach to the viral antigens,
and then monocytes/macrophages will
perform phagocytosis through Fc receptor
(FcR) within the cells and dengue virus
replicates in the cells

Recognition of dengue viral antigen on

infected monocyte

Entry to the Entry to the

spleen bone marrow

Release of cytokines which consist of vasoactive

agents such as interleukins, tumor necrosis factor,
urokinase and platelet activating factors which
stimulates WBCs and pyrogen release

Dengue
Virus ultimately targets liver Cellular direct destruction and
and spleen parenchymal cells infection of red bone marrow
where infection produces precursor cells as well as
apoptosis/cell death immunological shortened platelet

Hepatosplenomegaly Thrombocytopenia

Dengue Hemorrhagic

Increase number and size of the pores in the

capillaries which leads to a leakage of
fluid from the blood to the interstitial fluid
(capillary leakage) of the different
 Pleural effusion
Ascite

Complications:
Intense bleeding
Recovery
Pulmonary Edema
Shock
Very low blood
pressure
Liver cirrhosis
Death

http://rnspeak.com/community-health-nursing/dengue-hemorrhagic-fever-and-its-nursing-management/