FACULTY OF PHARMACY

MONTHLY EXAMINATION

MICROBIOLOGY 2 (Virology)

I. MULTIPLE CHOICE: Choose the BEST ANSWER.

1. Host cell DNA within the viral capsid:

A. virus B. viroid C. pseudovirion D. prion

2. Viral symmetry shaped like hallow protein cylinders which may be either rigid or flexible
A. icosahedral B. helical C. naked D. enveloped

3. Viral classification based on natural host range, mode of transmission, vector relationships and tissue tropisms
A. Antigenic properties C. Biological properties
B. Physiochemical properties D. Morphologic properties

4. Time in viral replication during which no virus is found inside the cell
A. Latent period C. Incubation period
B. Rise period D. Eclipse period

5. Enveloped viruses enter the host cell as cytoplasmic vacuole by this process
A. endocytosis B. fusion C. adsorption D. direct penetration

6. Viral specimen should be stored at this temperature if not process for more than 4 days:
A. 4ºC B. 25ºC C. -70ºC D. -20ºC

7. A cell infected with 2 different strains of segmented RNA viruses producing a genetically new virus.
A. Genetic Drift C. Genetic Shift
B. Phenotypic Mixing D. Gene Reassortment

8. Coinfection of two normal viruses produced a composite virus with totally different capsid.
A. Gene Reassortment C. Phenotypic Mixing
B. Phenotypic Masking D. Viral Complementation

9. These are giant-multinucleated cells formed from cell fusion as a result of virus infection
A. Syncytia B. Plaque C. Inclusion bodies D. Hemagglutination

10. Indication for Serology Testing:

A. Diagnosis of infection with culturable viral agents
B. Determination of nonimmune status in regard to rubella, measles, VZV, and HBV
C. Monitoring of immunocompetent patients
D. Epidemiologic and prevalence studies

11. DNA virus causing kidney disease in immunocompromised individuals

A. Papillomavirus B. Polyomavirus C. Mastadenovirus D. Erythrovirus

12. Genus of virus causing erythema infectiosum

A. Roseolovirus B. Rhadinovirus C. Erythrovirus D. Varicellovirus

13. Kaposi’s sarcoma-associated herpesvirus

A. HHV-5 B. HHV-6 C. HHV-7 D. HHV-8

14. Human papillomavirus type associated with high risk of malignancy

A. HPV 1 and 4 B. HPV 6 and 11 C. HPV 16 and 18 D. HPV 42, 43 and 44

15. Adenoviruses type 40 and 41 causes this epidemics in children

A. gastroenteritis C. keratoconjunctivitis
B. interstitial pneumonitis D. pharyngoconjunctivitis

16. Poxvirus causing milker’s nodules

A. Orf B. cowpox C. pseudocowpox D. tanapox

17. Herpes simplex infection commonly seen in medical personnel handling infected specimen
A. Herpes labialis B. eczema herpeticum C. herpes zoster D. herpetic whitlow

18. This is characterized by the appearance of clusters of vesicular lesions along a single sensory dermatome
A. Oral herpes B. herpes zoster C. herpes genitalis D. neonatal herpes

19. The only virus family assembled in the nucleus and whose envelop is from the host nuclear membrane
A. Herpesviridae B. Poxviridae C. Adenoviridae D. Hepadnaviridae

20. Naked icosahedral ds DNA viruses with fibers projecting from the penton subunits of their capsid
A. Mastadenovirus B. Simplexvirus C. Lymphocryptovirus D. Orthopoxvirus

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II. MATCHING: Match Column I with Column II

A. Viral Structure E. DNA Virus Diseases

21. Glycoprotein (D) A. genome 41. Neonatal herpes (D) A. Roseolovirus
22. Peplomer (D) B. capsid 42. Fifth disease (B) B. Erythrovirus

23. DNA or RNA (A) C. envelop 43. Sixth disease (A) C. Lymphocryptovirus
24. Protein coat (B) D. receptor 44. Exanthem subitum (A) D. Simplexvirus
25. Lipid bilayer (C) 45. Infectious mononucleosis (C)

B. Viral Replication F. Latency Sites

26. Capsid disintegration (B) A. Adsorption 46. Dorsal root ganglia (C) A. HSV 2
27. Packing of viral particle (C) B. Uncoating 47. Sacral nerve ganglia (A) B. CMV
28. Budding for enveloped virus (D) C. Assembly 48. B lymphocytes (D) C. VZV

29. Receptor binding (A) D. Release 49. cranial nerve ganglia (C) D. EBV
30. Cell lysis for naked viruses (D) 50. Monocytes (B)

C. Viral Genetics G. Cytopathic effect

31. Causes pandemics (C) A. Complementation 51. Cowdry type A bodies (C) A. CMV

32. Causes epidemics (D) B. Transfection 52. Downey type II cell (D) B. HPV
33. Spreads antibiotic resistance (B) C. Genetic Shift 53. Koilocytic cells (B) C. HSV
34. Occurs in segmented RNA virus (C) D. Genetic Drift 54. “owl’s eye appearance” (A) D. EBV

35. Minor changes in antigenicity (D) 55. plaques (C)

D. Viral Isolation H. Cancer causing DNA viruses

36. Human neonatal lung (B) A. Primary cell culture 56. Hepatocellular carcinoma (C) A. HPV
37. Minimal cell division (A) B. Diploid cell culture 57. Nasopharyngeal carcinoma (B) B. EBV

38. Heteroploid (C) C. Continuous cell culture 58. Cervical intraepithelial neoplasia(A) C. HBV
39. Indefinite passage (C) D. Mixed cell culture 59. Burkitt’s lymphoma(B) D. HHV
40. Engineered cell culture (D) 60. Kaposi sarcoma (D)

III. TRUE OR FALSE: Shade “A” for True and “C” for False.

61. Naked viruses are released thru lysis, thus they do not cause persistent productive infection. A
62. All symmetrically icosahedral viruses are naked. C
63. Viral glycoprotein which serves as receptors are only seen in enveloped viruses. C
64. All viruses produce an mRNA which serves as protein template. A
65. Most DNA viruses replicate in the cytoplasm except for Hepadnaviridae family. C
66. During the latent phase of replication, no intracellular or extracellular virus may be detected. C
67. Oncogenesis occurs when viruses inactivates tumor suppressor genes like p53 and RB. A
68. Specimen for viral isolation should be collected from the affected site. A
69. Heteroploid cell lines have an abnormal and variable number of chromosomes. A
70. Serologic test are usually retrospective demonstrating seroconversion. A
71. Poxviruses require a virion-associated transcriptase to make viral enzymes to synthesis all their nucleic acid. A
72. CMV produces heterophile antibodies which react with animal red blood cells. C
73. Smallpox lesions develop in a centripetal distribution and asynchronous manner. C
74. Parvovirus B19 may cause aplastic crisis in patients with chronic anemia. A
75. Varicella is a reactivation of zoster infection which has been dormant in the lymphoid tissues. C
76. HPV viruses exhibit different tissue tropisms for epithelial cells. A
77. HSV encephalitis is usually caused by HSV-2 in neonates and HSV-1 in older children and adults. A
78. Stress, caffeine and sunlight may reactivate latent herpesviruses. A
79. Polyomaviruses enter the body through the respiratory tract and goes to the kidney by viremia. A
80. Betaherpesvirinae targets mononuclear cells and epithelial cells. A

”Nothing is more expensive than missed opportunities.”

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