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BIOC/ANAT 458 - Membranes and Cellular Signaling

TIMETABLE - WINTER 2019


Instructors:
M. Denis (Co-coordinator), McIntyre Bldg., Room 903b, Tel: 514-398-1421 (maxime.denis@mcgill.ca)
N. Lamarche-Vane, (Co-coordinator), MUHC, Glen site, 1001 Boul Decarie, Room E02.6230, Tel: 514-934-1934 ext.76166 (nathalie.lamarche@mcgill.ca)
D. Reinhardt, Strathcona Anatomy & Dentistry Bldg., Room 114, Tel: 514-398-4243 (dieter.reinhardt@mcgill.ca)
C. Autexier, Lady Davis Inst. for Medical Research, 3755 Cote St. Catherine Rd., Room 426, Tel: 514-340-8260, loc. 4651 (chantal.autexier@mcgill.ca)
Teaching Assistant: Kamilia Daldoul, Goodman Cancer Center, 1160, Pine Avenue, Room 507, Tel: 514-398-4147 (kamilia.daldoul@mail.mcgill.ca)
Location: MCMED 1034 Day & Time: M / W / F from 1:35 PM – 2:25 PM
Date Lecture Title Lecture Instructor
Jan. 07 M Intro, Membrane Structure and Components 01 MD
09 W Lipids and Protein Topology 02 MD
11 F Analysis of Membrane Components 03 MD
14 M Analysis of Membrane Components 04 MD
16 W Analysis of Membrane Components 05 MD
18 F Model Membranes: Membrane Solubilization and Reconstitution 06 MD
21 M Membrane Trafficking Mechanisms: Endocytosis 07 MD
23 W Membrane Trafficking Mechanisms: Endocytosis 08 MD
25 F Trafficking and Cholesterol Homeostasis 09 MD
28 M Fundamentals of Membrane Transport 10 MD
30 W Membrane Dynamics and Function 11 MD
Feb. 01 F Carriers and Channels 12 MD
04 M Carriers and Channels 13 MD
06 W Signaling Complexes in the Dentritic Spine 14 MD
08 F Signaling Complexes in the Dendritic Spine 15 MD
11 M Background Lecture – Molecular-Biological Methods 16 NLV
13 W Heterotrimeric G-protein Signaling 17 DR
15 F Heterotrimeric G-protein Signaling 18 DR
18 M Pre-midterm Tutorial 19 T.A.
20 W Heterotrimeric G-protein Signaling 20 DR
MIDTERM EXAM (Covers lectures 1- 15, 19) McIntyre 1027, 6:30-8:30
22 F PI-Signaling 21 CA
25 M PI-Signaling 22 CA
27 W PI-Signaling 23 CA
Mar. 01 F PI-Signaling 24 CA
04-08 March Study Break
11 M Tyrosine Kinases and Small G-protein Signaling 25 NLV
13 W Tyrosine Kinases and Small G-protein Signaling 26 NLV
15 F Tyrosine Kinases and Small G-protein Signaling 27 NLV
18 M Tyrosine Kinases and Small G-protein Signaling 28 NLV
20 W Cell-Matrix Interactions and Signaling 29 DR
22 F Cell-Matrix Interactions and Signaling 30 DR
25 M Prepare oral/video presentations 31 T.A.
27 W Oral/video presentations 32 MD
29 F Oral/video presentations 33 MD
Apr. 01 M Oral/video presentations 34 MD
03 W Oral/video presentations 35 MD
05 F Oral/video presentations 36 CA
08 M Oral/video presentations 37 DR
10 W Oral/video presentations 38 NLV
12 F Pre-final Tutorial 39 NL/CA/DR
15-30 FINAL EXAM PERIOD (Final exam covers lectures 16-19, 21-39)
ANAT/BIOC 458 – MEMBRANES AND CELLULAR SIGNALING

Pre-requisites
BIOC 212, ANAT 262; one of PHGY 201, PHGY 209 or BIOL 205; one of BIOC 312 or ANAT 365; and BIOC 311 or permission of
instructors. RESTRICTIONS: Students with credit for BIOC 458 may not take ANAT 458, and vice versa.

Course Description
The course presents an integrated treatment of the properties of biological membranes and of intracellular signaling, including
the major role that membranes play in transducing and integrating cellular regulatory signals. Biological membrane
organization and dynamics: membrane transport; membrane receptors and their associated effectors; mechanisms of
regulation of cell growth, morphology, differentiation and death.

Recommended Textbook
There is no assigned text for this course; readings will be posted on myCourses.

Instructional Methods in this Course


 Conventional lectures
 Active learning strategies (flipped learning, problem-solving, etc)
 Project-based learning

© Instructor generated course materials (e.g., handouts, notes, summaries, exam questions, etc.) are protected by law and may NOT be copied or
distributed in any form or in any medium without explicit permission of the instructor. Note that infringements of copyright can be subject to follow up
by the University under the Code of Student Conduct and Disciplinary Procedures.

Evaluation Method
 10 % In-class problem solving (lectures #1-15)
 30 % Midterm exam (covers material up to and including lectures #1-15, 19)
 20 % Oral (or video) presentation
 40 % Final exam (covers lectures #16-39 inclusive)

Please Note: Calculators are permitted in examinations as long as they are not programmable and do not have
alphanumeric memory.

Medical Notes
Students unable to attend the midterm exam for medical reasons must bring a valid medical note within 1 week of the
scheduled midterm to: Undergraduate Affairs Administrator
McIntyre Medical Building Room 905A
undergrad.biochem@mcgill.ca

A make-up deferred midterm will be scheduled after the 2 weeks. If a legitimate doctor’s note is not provided, you will
receive a zero on the midterm.

Grading:
The department will NOT revise/upgrade marks except on sound academic grounds. Once computed, the marks in this
course will NOT be altered/increased. Decimal points will be “rounded of” as follows: if the final aggregate mark is
computed to be 79.5%, the mark will be reported as 80% (an A-); a final aggregate mark of 79.4% will be reported as 79%
(a B+). These marks are FINAL and NON-NEGOTIABLE.
Oral presentations
1. In teams of 3-4 students (team size varies upon enrollment), choose a topic among:
M. Denis Aquaporin 1-2, Nav vs Kv channels, Glut 4, Caveolin1, CFTR, ABCA1, SREBP/SCAP, LDLR, Dynamin,
CD-36, Perilipin-1, Hepatitis C, Hyaluronidase-2, Glutamate receptor, A, LeuT, SERT

N. Lamarche-Vane Insulin receptor, EGFR, RhoA, p190RhoGAP, DOCK180, GSK-3, ERK1/2, Smad4, TGFDLL4, WASP

D. Reinhardt Cannabinoid receptor, μ-opioid receptors, Integrin β1, Integrin β4, laminin 332, collagen VII, Focal
adhesion kinase, dystroglycan, DDR receptor, CD44.

C. Autexier phospholipase C (PLC)-gamma 1, atypical protein kinase C (PKC) zeta and/or iota, Class III
PI3K Vps34p, SH2 domain-containing inositol phosphatase(SHIP) 1 and/or 2, scaffold protein
Par6

2. Get your choice approved by the instructor before March 01


3. Prepare a 15-minutes oral (or video) presentation that covers:
- Structure and physiological function(s) of the normal protein
- Disease(s) associated with the protein
- Propose one experimental approach to study its function in vitro
 (i.e. application of concepts and techniques learnt in class)
- Perspectives
4. Present your work in front of class – Answer questions (5 min)

Useful resources
 Student Rights and Responsibilities
https://www.mcgill.ca/students/srr/academicrights
McGill University values academic integrity. Therefore, all students must understand the meaning and consequences of cheating , plagiarism and
other academic offences under the Code of Student Conduct and Disciplinary Procedures (see http://www.mcgill.ca/students/srr/honest/ for
more information).

 McGill Academic Calendar (add/drop, withdrawal and other deadlines)


https://www.mcgill.ca/study/2018-2019/important-dates

 Time management
https://www.mcgill.ca/osd/student-resources/learningresources/time-management

 Stress management
https://www.mcgill.ca/osd/student-resources/learningresources/stress-management

 Office for Students with Disabilities (OSD)


https://www.mcgill.ca/osd/