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BUNDA CAMPUS
2018- 2019 FIRST SEMESTER QUIZ # 3
BACHELOR OF VETERINARY MEDICINE YEAR I
NAME
STUDENT NUMBER
INSTRUCTIONS
All questions should be answered in the space provided in this question booklet.
This whole booklet should be submitted at the end of the quiz.
2. Below is a list of the first 10 residues of the B helix in myoglobin from different organisms.
Based on this information, which positions:
(a)
(b)
(c)
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3. The grelag goose lives year-round in the Indian plains, while its close relative, the bar-headed
goose, spends the summer months in the Tibetan lake region. The p50 value for bar-headed
goose hemoglobin is less than the p50 for grelag goose hemoglobin. What is the significance
of this adaptation? (3 marks)
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4. Highly active muscle generates lactic acid by respiration so fast that the blood passing
through the muscle actually experiences a drop in pH from about 7.4 to about 7.2. Under these
conditions, hemoglobin releases about 10% more O2 than it does at pH 7.4. Explain. (3 marks)
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6. The graph below shows several oxygen-dissociation curves. Assume that curve 3
corresponds to hemoglobin with physiological concentrations of CO2 and 2,3-BPG at pH 7.
Which curves represent each of the following perturbations? (4 marks)
a) Decrease in CO2
b) Increase in 2,3-BPG
c) Increase in pH
d) Loss of quaternary structure
(a)
(b)
(c)
(d)
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8. Rigor mortis is the stiffening of a corpse that occurs in the hours following death. Using
what you know about the mechanism of motor proteins, explain what causes this stiffness. (3
marks)
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9. Describe the primary, secondary, tertiary, and quaternary structures of:
a) Actin (4 marks)
b) Collagen (4 marks)
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10. Compare and contrast globular and fibrous proteins. (6 marks)
END OF QUIZ
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