Polymorphism of interleukin 15 in childhood acute lymphoblastic leukemia

Debora Shinta Liana, Maria Christina Shanty Larasati, Mia Ratwita Andarsini,
Andi Cahyadi, I Dewa Gede Ugrasena, Bambang Permono

Department of Child Health, Faculty of Medicine,

Airlangga University/Dr. Soetomo Hospital, Surabaya-Indonesia

ABSTRACT

Background: High expression of IL15 has been known correlates with CNS
impairment and organ infiltration in primary acute lymphoblastic leukemia (ALL).
There are two SNPs of IL15 (rs17007695 and rs10519612) that observed as risk of
adult ALL in Chinese and Egypt population. Therefore, we hypotized that SNPs of
IL15 might also be associated with outcome in childhood ALL.
Objective: To analyze association between SNPs IL15 and outcome in children
with ALL after induction chemotherapy phase.
Methods: We evaluated SNP rs17007695 and rs10519612 by PCR-RFLP in
childhood ALL, aged 0-18 years who received Indonesian ALL chemotherapy
protocol 2013.
Results: There were 73 subjects, 58,9% was male, with mean age was 5.67
(SD3.58) years. There were 34.2% patients died during induction chemotherapy,
remission in 53.4% and non-remission in 12.3%. All patients have TC(44%) or
CC(56%) genotyped in rs17007695, no one has TT genotyped. There was one
patient with CC genotyped in rs10519612, 63% with AA genotyped, and 35,6%
with AC genotyped. There were no significant diferrences between SNPs IL15 and
patient outcome. Further investigation showed rs17007695 with TC genotyped was
associated with worse outcome in high risk ALL group (P=0,003).
Conclusion: There is association between both SNPs IL15 rs17007695 and
outcomes of childhood ALL after induction chemotherapy phase in high risk ALL
group.

Keywords: ALL, childhood, IL15, SNPs, patient outcome