Imaging sequences used by included studies

Year Study author High resolution sequences MRA Lower resolution sequences

3mm FLAIR
2mm T1 IR

gadolinium
3mm T2*

enhanced
3mm PD

3mm T2

Contrast
3D TOF

FLAIR
3D T1

DWI

Post
PD
T1

T2
1989 Wahlund w2 ? ? ? ? ? ? ? ?
1997 Yue w3 ● ● ●
w4
1999 Katzman ● ○ ●
w5
2001 Onizuka ? ? ? ● ? ?
2002 Lubman w6 ● ? ? ? ? ? ?
w7
Kim ○ ○ ○ ○
w8
2004 Illes ○ ○ ○ ○
2005 Goehde w9 ● ● ● ● ● ○
Tsushima w10 ● ● ● ●
2006 Weber w11 ● ● ○ ● ● ○
w12
Alphs ● ○ ● ●
w13
Kumra ● ● ● ●
w14 ●
2007 Baumgart ● ● ●
Vernooij w1 ● ● ● ●
w15
2008 Lee ● ● ● ●
w16
Kumar ● ●

Dimensions given in millimetres are slice thicknesses. Abbreviations: ○ = Some patients, ● = All patients, ? = unknown, MRA = magnetic resonance
angiography, 3D = three dimensional, IR = inversion recovery, PD = proton density, FLAIR = fluid attenuated inversion recovery, TOF = time of
flight.