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tates the responses of their panel of experts, reached consensus on a series of statements high risk of infection (according to statement
collects and analyzes them, thus identifying concerning the management of traumatic 2) depending on the epidemiological criteria of
the conflicting viewpoints. If consensus is not wounds. For each statement, selected refer- antibiotic resistance in the area. In high risk
reached, the process continues through thesis ences are provided. The statements are as list- wounds (all three variables considered) the EP
and antithesis, to gradually work towards syn- ed below. should explain clearly the reason for avoiding
thesis, and building consensus. the antibiotic administration (3B).14-19
To build this document we have composed a Statements
Statement 4
multidisciplinary panel consisting of EPs and Statement 1 The assessment of tetanus immunization
surgeons, as well as other experts in different All traumatic wounds are to be considered status in every traumatic wounded patient who
fields, coming from different countries. The contaminated at presentation in ED. arrives at the ED is desirable. Sub-statements
study, which lasted about four months, was
Statement 2 of Statement 4 are: all traumatic wounds are
divided into two different phases. In both phas-
es a dedicated questionnaire was sent by e- It is useful to provide an initial stratification potentially at risk for tetanus infection (4A);
mail to each member of the panel. In the first of the risk of infection for all the traumatic the assessment of tetanus immunization sta-
phase, there were three rounds. After that, wounds. The risk assessment should be based tus of patients should be performed through a
consensus was reached in eight of the topics on the following: i) type of wound; ii) location thorough history and consultation of documen-
addressed. As such, in the second step it was of the wound; iii) characteristics of the wound- tation confirming vaccination/booster, and
considered as appropriate to repeat the round ed patient. With the aim of simplifying and eventually using a diagnostic quick test in
in order to try to reach consensus on all the optimizing the management of patients in the doubtful cases (4B); items to be considered as
addressed issues. The external validation of ED, the following fields of stratification of the doubtful (i.e., cases for which it is not possible
the document was reached organizing a two risk of infection were identified: type of to determine the immunization status of the
days’ workshop, inviting a group of European wound, location of the wound, and characteris- patient: patient who does not remember the
experts to discuss and validate the tics of the patients. In Tables 2-4 the suggested date of the last booster; patient unconscious,
statements.7,8 items for risk assessment are summarized. intoxicated or cognitively impaired; patient
As such, the first step was based on a series Sub-statements of Statement 2 are: avoid who does not understand your language;
of key questions, as reported in Table 1. antibiotic administration in low risk wounds patient who, presumably, has never carried out
(for all three variables considered) (2A); con- a complete vaccination course) (4C); access to
Definitions sider antibiotic administration when one or vaccination data and the availability of a rapid
At the end of the work the panel and the ref- two high risk variables are present (2B); if the diagnostic test for assessing the status of
erees have reached an agreement on the fol- decision to avoid antibiotic administration in tetanus immunization permit to streamline
lowing definitions of traumatic wounds. high risk wounds is made the reason must costs and to act with greater appropriateness
Traumatic wound is a wound or laceration of always be clearly stated (2C); in every wound (4D).20-23
traumatic origin with no evidence of macro- consider the risk of tetanus according to the
patient’s immunization status (2D). Statement 5
scopic contamination or signs of active infec- It is desirable that in any ED the first admin-
tion (and likely low probability of infection). Statement 3 istration of rabies vaccine (for at least two
Dirty traumatic wound is a wound or lacera- It is useful to provide antibiotic prophylaxis patients) is available. Doses sufficient for full
tion of traumatic origin macroscopically con- (i.e., a preventive administration of an antibi- courses of rabies immunoglobulin treatment
taminated. Among these wounds we include otic before the emergence of an infection with for two patients should be available in Poison
those with simultaneous perforation of a vis- the aim to prevent it). It is desirable to imple- Control Centers and in 2nd level EDs (at least 1
cus; with presence of devitalized tissues; with ment prophylactic antibiotics in selected cases for every 5 million inhabitants and at least 1 in
foreign bodies; those that occurred in a con- of wounds at high risk of infection. Sub-state- each major island).24,25
taminated environment (dung, marshes); ani- ments of Statement 3 are: avoid antibiotic pro-
mal bites; puncture wounds; wounds with a phylaxis in a non-macroscopically contaminat- Statement 6
delayed treatment. Infected traumatic wound ed wound, well vascularized, at low risk of A proper and timely implementation of pro-
is a wound or laceration of traumatic origin infection (according to statements 2) (3A); cedures and methods for preventing infection
with signs of infection (secretions).9-13 antibiotic prophylaxis should be considered in in any traumatic wound is desirable. The iden-
After completing this step, the panel grossly contaminated wounds and in cases at tified methods of preventing infection are the
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