Medicinal Chemistry-2 (PC332) Questions model Dr.

Ashraf Kareem

Q1. Select the correct answer letter for each of the following questions.

1) Which of the following statements is true for Triprolidine?

a. (Z)-isomer is more active as antihistamine than (E) isomer

b. An example of unsaturated propylamine H2-antagonist.
c. Insertion of propionic acid on pyridine decreases the sedation property.
d. The terminal nitrogen is included in a cyclic structure (piperazine).
Triprolidine

2) What is the most favorable form of histamine in the physiologic pH?

a. b. c. d.

3) Which of the following statements is false for Omeprazole?

a. Its in vivo activation requires strong acidic conditions.
b. Its active form binds reversibly with proton-pump cysteine-SH.
c. It is a pyridyl methylsulphinyl benzimidazole derivative
d. It is used for treatment of peptic & duodenal ulcers.
Omeprazole

4) Which of the following statements is false for Clemastine?

a. (D)-isomer with R absolute configuration is more active than (L) isomer.
b. It is an example of sedating H1-antagonist.
c. The terminal nitrogen is included in a cyclic structure (piperidine).
d. Para-chlorophenyl ring is favorable for antihistamine activity. Clemastine

5) Which of following statements is correct for Antazoline?

a. The terminal nitrogen is included in a small cyclic structure (pyridine).
b. It is one of the most potent antihistamine drugs.
c. The tertiary amino and diaryl system are connected through propyl linker.
d. Its phosphate salt is suitable for ophthalmic use.
Antazoline

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Medicinal Chemistry-2 (PC332) Questions model Dr. Ashraf Kareem

Q2. Complete the missing parts in the following table with the suitable information.

Drugs Questions

 Draw the structure of the active metabolite.

Terfenadine

 Generic name: ………………………………………………………

 Mode of action:
…………………………………………………………………………

 Mention the main advantage of Nizatidine over Ranitidine.

………………………………………………………………………

 Encircle the important moiety responsible for this advantage.

Nizatidine

 Draw the structure of a similar derivative with reduced sedation

& dizziness effects.

Triprolidine

 Best Wishes 

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