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Question 1
Which of the following statements best describes pharmacodynamics?
a) The study of how drugs reach their target in the body and how the levels of a drug in the blood are affected by absorption, distribution,
metabolism and excretion.
b) The study of how drugs can be designed using molecular modelling based on a drug's pharmacophore.
c) The study of how a drug interacts with its target binding site at the molecular level.
d) The study of which functional groups are important in binding a drug to its target binding site and the identification of a pharmacophore.
Question 2
Which of the following statements best describes pharmacokinetics?
a) The study of how drugs reach their target in the body and how the levels of a drug in the blood are affected by various factors.
b) The study of how drugs can be designed using molecular modelling based on a drug's pharmacophore.
c) The study of how a drug interacts with its target binding site at the molecular level.
d) The study of which functional groups are important in binding a drug to its target binding site and the identification of a pharmacophore.
Question 3
Which of the following characteristics is detrimental to oral activity?
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4/1/2019 Oxford University Press | Online Resource Centre | Chapter 11
a) brain infection
b) kidney infection
c) gut infection
d) lung infection
Question 8
Which of the following statements is false regarding the blood-brain barrier?
a) The walls of the capillaries supplying the brain have tight fitting cells making it difficult for polar drugs to leave the capillaries.
b) The capillaries in the brain have a fatty coating making it more difficult for drugs to enter the brain.
c) The walls of the capillaries supplying the brain are made up of several layers of cells, which act as a barrier to the release of drugs.
d) Hydrophobic drugs pass through the blood brain barrier more easily than hydrophilic drugs.
Question 9
Which of the following statements is the closest description of Phase I metabolism?
a) Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites.
b) Reactions which occur in the blood supply.
c) Reactions which add a polar functional group to a drug.
d) Reactions which occur in the gut wall.
Question 10
Which of the following statements is the closest description of Phase II metabolism?
a) Reactions which add a polar molecule to a functional group already present on a drug or one of its metabolites.
b) Reactions which occur in the blood supply.
c) Reactions which add a polar functional group to a drug.
d) Reactions which occur in the gut wall.
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4/1/2019 Oxford University Press | Online Resource Centre | Chapter 11
Question 11
Which of the following statements is not true about cytochrome P450 enzymes?
a) flavin-containing monooxygenases
b) monoamine oxidases
c) glucuronyltransferase
d) esterases
Question 15
Which of the following reactions is not a Phase I metabolic transformation?
a) reduction of ketones
b) conjugation to alcohols
c) oxidation of alkyl groups
d) ester hydrolysis
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