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C 00021812----------------~~--------------------------
.,

.}June J 5, 1966 ....


·.

Dear Dr•

. Pleas~ find enclosed for your review ond tron~mhsion J


. - ·. jon unsolicited proposal entitled, ''Psychophysiologic
ond Verbal Correlates of Altered Consciousness during Amytol lntetview.a · •

The proposed research will correlate "efectrophysiofogicol, psychological ond


yerbol measures oF both patients awaiting trial at rhe mole psy::hioJric prison word of
. tond normal control subjects
Iin the omytol interview situotio."'l. It is believed that
the approach ~escribed in the proposal will further elucidate the effects of omytol
with regard to behavioral aspects of emotion, deception, ond memory~

. A starting oote of October 1, 1966 (alternate November 1, 1966) V:.ith the


· project to extend for one year is requested; ty.-o additional years ore recommended.
Direct cost sup?ort in the amount o( $~ .is requested (or the first year, estimated
budgetary requirements Ofe S _.for the two succeeding yean. The
erinci~al investigator is ;and the co-principal inve~tigotor is

I may be contocted ot i j
II will be out of the United States from July 28th through
August 18th,_1966. Dr. '\is curren~ly studying technique$ of eye mov~ment ·
r:cording o~
1His temporary r~sidence oddre~ _ is.
J "
Your consideration in thh matter is appreciated and I lock forward too favorable
reply.

Sincerely yours,

\
C00021812------------------------------------------
·. 1·
. ··._;/": . ·•
~. privilc3ed C'>mmunicotion

.
PSYCHOPHYSIOLOGIC AND VERBAL CORRELATES OF ALTERED CQNSCIOUSNESS
~~~ (ltf(j /.1
\ I
ond

I
ABSTRACT

. . . .
The proposed re~earch is on·experimentol exploration of altered consciousness during on omo-
borbHol int~rview in order to more accurately define and evaluate clinicoUy ob~erved changes in verb
behavior. Hypotheses bosic to this reseorc!l and derived from severo( years of dinicol experience with
amytal interview on the , . pre: (1) The primary ond predom·
nont effect of intravenous omytol is on "onxiety-tension 11 and the u;uolly ossociored constriction of off
(2) While imminent and focal issues or the patient's attention (e.g., the crime for .which he cmoits trio ...
rnolinge•ed hemiplegia, ete.) remain particularly impervious to the effects oF omytol, more peripheral
tnoteriol is dealt with in greoter dctoil, elaboration and indescretion as though the patient were confrc
ing the material wi!hout constriction or caution due to appropriate oppreheMion pre-programmed unde1
stress prior to the amyt:JI interview, i.e. the subject consciously ot unconsciously decides how to deal
with certain questions before the interview. {3) Amnesia for the contents of the interview moy'be due
to on impairment of "~onsotidotion" processes of me:nory O$S:>cioted with disco~jugote eye movements.
Exoerimen:al and cant ol subjects will be sefer.ted from potienls ot the rnole psychiatric prison word of
\ Additional control ~ubjecfs will be recruited from the student pop
'lotion at) . . . . _ _J Psychiatric interviews o.nd psychologkol test!
will be employed to evaluate personality structure, anxiety levels, intelligence, ond suggestibility oi
the subjects. Verbal responses will be recorded to equated word association, biogrophicol dolo, and
test questions before, during, and orter omytol interview administered in 0 double-blind control proc ,;
Elecfro~ulogroph, EEG, and GSR will be monitored and correlated with the interview and verbal test
materia\ Verbal re~ponses will be evaluated against independently verifiable control moteriol, psycf-.
physiologic and psych::>logicol variables in o double-blind fashion._

,.
C00021812----------------------------------------
' .. '.
\ . ~
Pri'..,ilcged Communi coli on
Page 2

f. RESEARCH PLAN
.-
A. Introduction

(I) Current status or work in this orea

lntro..,enous sodiumomytol has long been observed to exert o significant influence on on fndivi~
dual's mental stole. The rnost dromoti~ effect wos the temporary resolution or catatonic stupor in schiz
ophrenia and reactive de,;>ression {Biockween, 1930; lorenz, 1932). A.s "amytal interview" intraveno
amytol has fonnecf the bosis or special diagnostic and therapeutic techniques,''Narcoonolysis" (Houle}
1943), 11 No rcqsynlhesis" {Grinker & SiJiegel 1 1945). Underlying principles ond theoretical basis in
regard to clinical application remain obscure. At tf,e some time its e~toblished clinical use over the
post tnrf'~ decades e~able~ one to ayoid unexplored pharmacologic pitfalls~
/

· Mony early theories explain Jhe effect of Or.lytol based on Hugh ling Jackson's concept of the
release of lower centers resulting in "release of unconscious rnoteriol·os in dreo.ns" Hermo11 (1938);
Delay (t 949).attempted to gi..,e this a structural basis by claiming that omytol narcosis 11 led too tempe
ory depression oF activities of cortical cells". lindemonn (1932) stated thot the drug in tv;n permittee
an ''increose in neurophysiologicol activities in older ports oF the brain". Freed (1946) felt t'hot the
release of strong affects occurred frequently enough to justify the locolizotion of th.e site of oction to
the diencephalon. Grinker (1945) also suggested tl1ot the action was on the diencep.~olon, and was
d~pressive in
nature, so 'hot anxiety producing impulses "no longer ~ombcrd the cortex". Kubie &
Margolin (1945) agreed that the drug by its ''p>ychologicolly analgesic" oction lessening the patient'!
need to defend protective sr.mptomotic structures permitted exploration or painful areos of experience .
which hod been repressed. Mosserman (19.58) stressed the commonality of the oction of Qmytol and o!i
drugs, ond concluded, "there is no doubt -that alcohol, morphine, barbiturates and bromides and most
so called atoroctks., one similar drugs u~ed in 'psychophannocologic doses' oct 0$ cortical depressont
causing impairment of finer percept ions and discriminations, con~trictions of the int~rpretive field on
progre$sive disorganization of adoptive responses". Weinstein (1954) sow the sh ift in behavior os "ch
in symbolic expression" representing an adoptive and more effec~ive defense in o situation of greoter
stress. Brickner (1954) r~lt tho ~ verbal moteriol elicited under omylol VIOS OS systemoti:ted OS any olh·
mentolion and demonstrated underlying mental mechanisms of fractionalization, reuniting ond compo
words. These underlying verbal structures were not senerolly evident in the waking state.

Gottschalk {196 ~ ) summarized the effect oF horbiturotes on hvmon behavior os characterized


"(a) decreased attention to stimuli; {b) wormer, more appropriate mood; (c) decreased anxiety;
(d) increased contact and communication; (e) reduction of psychot:c manifestation". Despite lhe l
work of Meuhlberger (I 951) and Lorenz (1932), Gerson and Victororr (1948) demonstrated the follibi
of omytol as o truth serum. •

Recent experimental investigation has revealed ~hot the affective changes du_e to amytol ore
readily measurable with a stondordized rofing scale technique (Trent,. 1962). Likewise, no evidencl
been fovnd for specific ::>r generol effects of differing pentobarbital dosages on six different measure
{poOJsing time, talking time, total elapsed· time, fluency, total power, ond mean pitch} oF vocal bel
(Starkweather and Hargrea..,es, 1964). Moreover, although Chlorpromazine affected pausing time or
related verbal content, .Amytal had no selective effect on Jhese constituents of spon:oncovs speech
(Goldman- Ei sler, 1965). Nonetf,eless, it is important that Amytol was fovnd to increose the subjec
certainty of recall in the perception of s~ometric figures (Brengieman, 1958}. Kelley, et al, (194
usi ng Anytal as an aid to the Rorschach method found on increase in the number of responses ond le
constriction and steroty:ly. Soto (1,962) cxomined students under Amytol and found increased produc
c_o_
o_6_2isl~2~----------------------

----
..., .
--
p~;~ilc~cd Commvnicotion Peg~ 3

in affective responses on. the Rorschach while the GSP. revealed diminished levels of c.utonomic: excite·
ment. Miller (J 964} studied ;_ _ escape ond avoidance in rots and oH~ibutcd the behavioral efFect of
Amytol to a "differential effect on the fear mechanism". The finding;; of the above studies as well as
our own clinical impres~ions suggest that Amytol influences behavior by o reduction of "anxiety-
tension."

(2) Rationale of approach to problem

It is well known 'that the evaluation of drug effects is difficult doe to individual differences in
·psychological, biological, physical and social status. Thus, ·the dosage administration of drugs usvoll;
is regulottd by the phys!don according to the patient's response. Jn -generol, !he omoborbitol intervic.
has been conducted on the bosis of the clinician's skill in rnonitoring and detecting the patient's stole
·consciousness. ft is proposed here that psychophysiological responses during amobarbital interview ma:
index the patient's offective-cogniti.ve status. ·

The g~neral hypothesis of this proposal is that intravenous om;,-tol affects behavior through the
mitigation of anxiety ond on alleviation of ten;ion. An independent measure of the drvg effect on the
level of consciousness is required. Shogoss (1954) introduced measures of EEG ond behaviorol responSf
os indicators of sedative roleronce. However, other investigators hove reported _difficulty in determin·
-the sedation threshold according to Shagoss' criteria (Acknar & Pampigtione, 1959}. More recently, t
inhibition of the galvanic skin reflex by sodium thiopental has been demonsfroted to indicate both sed·
ond sleep thresholds ond differences in these measures between psychotic ond psychoneurotic depresse<
subjects (Perez-Reyes, Shands, ond Johnson, 1962). It would seem pertinent to employ the GSR in od
_tion to the EEG os a monitoring response during the omyrai interview.

Current research on dreaming hos produced definitive dat.:z Jinking eye movements to dream
material (Kieitman, 19c3). likewise, the subiect's lock of ottention t:> the environment ossocioted
with reverie ho$ been related to the oppeoronce of wondering eye movements during eondit;ons norm-
oily eliciting a vestibui·:H nystagmus ~endt, 1941i Collins, 1963}. Ront ond Mo~zia (1965) found the
disconjugate eye moverrents occurred during anesthesia ond were correlated with o loss of memory for
pictorial material, Westheimer and Roshboss (1961) provide evidence thot borbituotes interfere with
eye vergence movements. The value of using eye movements to ascertain the patient's oltered state o '
consciousne·s~ in the om:,.tol interview must be exp-lored. Aport from the possible relation to the verbo'
qualitative ..Jspects of the patient's altered store of consciousness, e)•e movement monitoring moy also
provide on effective index of both sedation ond sleep thresholds. In summary 1 the psychophysiologico
variables in the proposed research on the omoborbitol interview ore the galvanic skin response (GSR),
electroencephofogrom {EEG), and electro~~logrom {EOG). _ .

Another aspect ond the primary Focus of this problem will be in. the delimiting ond cho.rocter-
izotion of altered consciousness. Artusio, (1955) hos shown that there is o stage during ether onesthe :
at which patients ore unable to fonn new memories although their mental functio ., is-inlcct os meosu,.:
by responses to spoken words, problem solving, old memory, etc. This orea has been troditionolly
handled throvsh clinical interpretation of the patient's verbolizotions vis~b-vis the interviewer's quet
Gottschalk (1961) emphasized that different methods of sampling the verbal bP.-hovior of a subieet und
drugs moy give somewh·::Jt different information about the psychopharmacologic effect of the drug. In
order to obtain additional evidence of both affective ond cognitive changes, it would be appropriate
employ a standardized verbal test, in equated fonns, previous to, do.~rin~, ond following the omytol
interview. The eorlie\t vsed and most fruitful verbol test has been 6ot of word association ~oodwor·
1938). Rmponses in word association tests ore regulated by both affective and cognitive processes. T
C00021812------------------·---------------------------
Poge 4

proposed study will e :nploy o stondord free association te~t ond a special variant. In the fil:t. stimuli
word lists will be prcpo,red from established norms (Palcnno & Jenkins, 1964) into sets motcheci for
associative "preference" (Moron, et al., 1964). In the second, bofh stimuli ond responses Qte avoilc
in a forced-choice item. A more complete dP~cription oF these tests is presented below in the procedt
section.

An important os"pect of our proiect is t!,e "non-laboratory" subject. In essence, the ortificiali
of experimental work with contrived and difficult to manage loboroJory stress is absent. The experimc
subjects ore to be selected from omon~ those ind1ted foe serious charges under observation ot the psycl
tric prison word or lthes'e subiects ore living under realistic stress
of overwhelming personal significance. The imme~s;onnual admission rote of J '500 pennifs selection.
the "higher-ca:liber", cunning criminal without gross personality deteriorotion or psychosis.

The approach to the evaluation or the subject's state of con~dousness during omytal interview
consists of: (a) subjects under real-life stress, (b) psychophysiological indices of EEG, GSR, and e
movemer.ts, {c) psychological test-s of personality, anxiety, intelligence and suggestibility, (d) psl
tric-clinical interpretation of the subject's store or conscioust'less, and (e) interview and word ossoc:ic
tests to inde>< ofrect and content of thought processes._

(3) . Specific Aim~

a.
.
To explore cognitive and affective verbal pc:ittern.s in individuofs under stress during
o ltered sto tes of consciousness resulting from introv~nous omoba rbirol.

b. To corre 1ate-ond monitor alterations in consciousness as indicated in verbal responsiven!


under intravenous omytal by meons of EOG, EEG, and GSR.

B. Methods of Procedure

(T) s.. biects


The experimental subjects for this project will be the patients of the male psychiatric prison"'
of j These subiects will be selected ot random ~o include 20 crimir
16 years or older, ot average oroerret intelligence and without overt psychosis. The first control gro
will consist of 10 criminals, approximately matched to the experimental group os to oge, alcohol. or
drug addiction, and p;ychiatric diagnoses. Concomito.ntly 1 a second control gro~ consistin9 of 10
paid; normal volunteer subjects will be recruited from the student population at"
personne I office. Fifteen subjects, the first control group and five or
the second control grcoup, wffireceive, independent of the experimenter's knowledge, only sol~oe dv
the suppcr.edly omytol interview. It is planned that the study should continue for three years to compl
a total sample of 120, i.e. 60 experimental ond 60 control subjects.

(2) .Apporo Ius and tests

a. Psychobgieol Variables. All subjects will be inltiJIIy screened on'J evaluated along th
following dimensions: (1) Personality chorocler:stics interpreted from the Minnesota Multipht
Personality Inventory (MMPI) on the clinical scales (Hathaway & McKinley 1 1951), (2} Anxi
level estimatE-d from the Taylor scale of manifest anxiety (Taylor, 1963) ond the IPAT-8-poro
form anxiety bcttery (Scheier & Cattell, 1960), (3} Intellectual functioning as mcosured by
C00021812·----------------------------------------------~

Poge 5

Wechsler Adult Intelligence' Scale CN AIS), ond {4) SuDgcstibility ~endeneies os indicated by
.
the Barber Suggestibil.ity Scale (BSS) with both o!>jective and subjective scores (Barber, 1965).

b. Psychiatric interview-- This proced,J re involves o relatively exploratory, dynamically


oriented, and open-end interview designed to elicit material on the person's basic p<usonolity
pattern os well os material related to recent cvenls leading to his uime ond ho~pitolizotion
on the prison word. ln,erviews with control .subjects will be aimed ot the evaluation of their
basic personality orgorizotion and their response to stress os altere& by I.V. amytol. All inter-
. views will be toped, transcribed, and then evaluated in light oF corroborative material from
eye witness accounts, arresting orficer's report, parole und trial records. Control subiect material
will be aSSe$sed along similar personality dimensions by three independent roters.

c:. . Word o5.sociotion tests-- Two different types of word ossociotic.n tests will be used, nomefy
Free association gnd bL"lOry forced-choice. ln the free association lest, c:ritic'lt words relating
to the ~vbject's recent <:rime or.:f/or oreo~ of personality conflict will be inter1persed with
stondard "neutrol" stimuli, Measurements will be mode For response latencies, thematic content,
associative "set" or preference, and commonality. ·

The binary forced-choice association test is designed to meos=Jre individual differences in


semantic habits os diffe-rent From syntactic or relational association habits {Nunno.lly, Flaugher,
and Hedges, 1963). Fc·ur types of choices, eva luotive-go~d (pleosont words), :evc.luotive-bad
(negative words, eg. ugly, sour), denotative (attributes, eg. long, $harp), and categorization
(classificatory, eg. reptile, coed} ore combined into subscoles. For example, conlrosting the
evaluative-good ond the denotative tendencies, Oronge: sweet round
In this manner individu:JI differences in the use of different modes of semantic response to ---
objects in the human and material environment ore measured. The test instrument subscoles as now
constructed hove Kuder-Richordson fonnufa 20 reliability coefficients ronging from .62 to .79• .
Measurements will consist of scores obtained on the combined evaluative and the categorization-
denotative balance scales.

d. Examination rooms Amobarbital inte1views will be conducted in the seclusion room on

'., -··
M

the male prison word ot . · f


-· ·
e. Psychophysiologi:al Variables- These variables will be recor:ied on a six-channel poly- ·
groph.Four channels will be used fat: EOG in the detennination of eye movements by use of
periorbitally placed surface electr<Jdes. flectrodcs will be located on each eye ot the outer •
ond inner canthus for horizontal movement and directly above the supraorbital margin and below
the infraorbital ridge for verticol movement, The electrodes will be oF the nanpolorizable
silver chbride type. One cho nnel will be used to record the galvanic skin response. Silver-
silver chloride electrodes with o starch peste of 0.05 N sodium chloride solution will be used
in measuring the GSR (8 1 Conr.ell, et ol., 1960; Edelberg & Burch, 1962). The opporent
electrical resistance to on applied current of 8 microamps/cin~: between the potm ond the forearm
rererence site will be continuously recorded. The EEG will be monitored with o monopolor
occipital electrode orrongement. The5e variables will be synchronized with the verbal material
through the use of voice operated relays and event markers.

(3) Proc edure

The experimenta! subjects will be allowed five days to adont to th,.. -.. ....~ .... -~- ... ~-!~- •- •'·-
·- ..... L ~ ........ r ! • • • • ·
C00021812----------------------------------------
-· -:
- p,;.,ilcgcd Communication Pcge 6

psycho!ogicol tests, psy_o;hiotric interview, and word association fesls. Within Inc following week the
omytol interview will be conducted. with pre~elecfed material, eqva•ed for porticulor relevonce, that
earlier was Or WO$ not directly probed ror by the interviewer.
The subject will recline in bed ond be prepared for EOG, EEG, ond GSR recordingl rhot will
be token throughout the, test period. After on_initial rest period of five minvtes 1 o continuous drip of
normal saline $Oiution will start. A second Five minute period will elapse to allow lhe subj~ct to
accommodate to the needle in his arm, During this interval, on eye fixation test ond on obbrevioted
form of the binary forced-choice word association test will be administered. The eye
fixation test will
requi ·e the subiect to rixote successively illuminated targeh at varied but preset degrees or sepororion
in horizontal, vertical and intennedio te loci from a centro! reference point of fixation. The word
association test will corsist of a randomized sample of items ftQrn the subscoles of the binary forced·
choice test. At the end of this interval, o 2-l/2% sodium omytof so,ution will be injected ot the role
of 1.6cc/minute. Or 1 in !he case of certain con~rof subjects, the normal so fine will continue and no
cmytal will be introduced.

The omytof soful-ion will be slorted without the subject's knowledge. Concurrently, the subjec
will be interviewed os to standard classificatory information, eg. age, residenc~, occupation, etc,
The interview will cont:nue until clinfc:al signs of altered consciousness, eg. slurred speech, effective
appear ond the non-specific or spontaneous GSR activity has changed. This Iotter event is regarded o
indicative of the drug effect threshold. The odministrotion of the dr.Jg will now: be_ slowed to moinroir. ~
wakefulness in the subject. The subject •·_: ill now receive toped word ossociotion tests (free ond binal)'
forced-choice) for a 15 minute pe riod, and eye fixation tests befor.:, between, ond after the word
ossociotion tests, Material for r ~ .:- AI f.Jllowing the it ,·.::view will be presented to the subject%orefult
-. ·· timed intervals with referen.:o i.:.t th~ pre!.enc.e of d ' ..;onjiJgate eye movements. A concluding .inter·
view of about 10 minutes will attempt to elicit material of particular relevance to the idividual's
psychiotric-fegol slo.tus, The entire session will be completed bef\veen from 45 to 60 minutes. All ve
responses and interview material will be lope recorded for subsequent onalysis,

The control subjects will receive identical tests. However, in the case of. the normo( volunte•
group, no word adaptation time will be scheduled although the some testing intervals will be maint-oi:
These subjects will be interviewed with respect to specially prepared factual material ond items of p£
sonol in(ormotion to be withheld unknown to the experimenter. Motivation of the subjects will be re!
fated by combinations of aversive consequences 1 eg. electric shock to the leg, decrements in monet-a
compensation. Standardized instructi'=>ns ond procedures will be use:! to control for any bias due to st
ject-experimenter relations ond other social variables.
.
Test data will be treated by the following methods: Interview doto will be summarized and t'
Ia ted according to topics and stenotyped for independent ro~ing of categories and affective content ~
• · qualified staff psychiatrists. Topic categories will be divided between spontaneous and nonspontanec
material relevant to central or focal issues ond peripherol matters. Further subdivision will be mode
OOSed upon detailed SC~utiny of the obtained dota 1 fitting Such fopics 05 illegal OCti.OnS, Sexual beho
social relationships, elc, into standard units of subiect matter, orie,,totion {pro 1 con, ond nevtrol),
standards c;nd values (Femises of material), traits and subjective states (feelings). Each topical recc
will be checked for completeness, comprehensibility, consistency, uniformity oF coding units, and
inappropriate responses. All statements will also be classified as to factual, preference, and identif
nature. Numerical ratings will be made of the coded sfalements os to the intensity of affect and the
degree of clo~eness to focal issues, Amenable data will be tr~nsformcd to mutually exhoiJstive classc
coded, and key punched for computer handling. Response profiles of psychological test scores, won
associations, GSR activity, (nonsp~cific ond ~timulus-elicited), EEG mcosure.,and eye movement

---------------------~<•
C00021812-------------------------------------------

. (
./ . .
:; , .._ llco~d Commun,cot,ons i'uuc: ']

/ po«>mero" (o, individual ,;,bjecl> and di<.,ibution• o( the<e va,ioble• fo, 9"'"P' and toto! <ample
studied will be prcpored. Correlational procedures ond where indicated multivariate analysis of
vorionce and covariance will be carried out to establish the significance of findings. Comparisons
will be mode between th" nondrug ond omytol dolo within individuals and within ond b~tween the
experimenral and control groups.
'
Particular attention will be given t:> the analysis of eye movencnts during ohered stoles of
consciovsnes~. This measure will be e.~omined for <:hon9es in the role ond sequence of spontaneous
and smooth tracking movements, the incidence ond frequency of Fixation change and blinking, :he
coincidence of "type" of eye motion with specific emotionally toned interview material, the qvo!ity
of directed er,e vergence motions during target fixation tesls, -ond the variations in binocular coordin-
otion (conjugate and disconjugote movement). Since preliminory tests hove revealed that, visuotfy
observed, disconjugote end divergent eye movemenrs ore os~ociated with amnesia, it Is planned to in-
corporote real-time data reduct:on of this variable by an analog signal corrclotor after further confinn-
ctory testing, n1e experimental design OS described above is schematically giver. in figures 1 Ond 2.

Significance

The results of these st~dies will odd to basic knowledge on the mode of inferoction between
•Jnxiety and thought os e)(pressed through verbal productions. This hos for reoching implications for
the theoretical concepts of psychotheropy. An opportunity will he o'forded to test' clinically derived
postulates formulated on the change of behavior under intravenous omytol end related drug,. In par-
ticular, a significant evaluation of the use of omytol in eliciting informalion during interrogation will
be obtained, Standardization of these techniques will permit their application ond comparison with the
effects other phormcicolo_gic agents have on verbal responses. Particdor phenomena such os the dromot
resolution of catatonia and stress inducted stupors will be further elu-;idoted. Predictive methods to
ossess potential for explosive aHoultive and homicidal behavior of hcbitvol drug ond ofeohot tr>ers will
be explored, This is of timely importance in view of the fact that fuHy half of the currently recorded
homicides ~reassociated with drug or alcohol use.

Facilities

The general ward facilities of the' __ _ , \. . _ 1


lis in charge ore ovoiloble for these studie~. Included ore personnel familiar with handling
Patients under stress os well os assisting in patient core during amytal interviews. Appropriate neuro-
rodiologicol and electroencephologrophic studies of selected patients ore performed os part of hospital
care. fn addition to the usual equipment and medication necessary for patient core there is available
two Norelco tope recorders with special booms ond microphones for recording the patients• production:
during on omytol interview and foot pedal for transcribing afterword. There is also o Gray Au~ogroph
• and Dictaphone to assJst in handling the detailed biographical !!JOteriaf. · Office and loborotory space
ore provided by rhe I
I is avoilahle for con- .
s•Jitation and use of their equipment and personnel. Dr. . jChair:mon of the Deportm£
of Anesthesiology 1 has o Iso offered the use of his foci lities.

General facilities at _jare avoiloble for control ospects of these studie


Off ice and laborotory spoce ore provided by the Deportment of Psychiatry. Reody access to <:onsultot i
wilh experts in efectroencephalo9rophy in the Deportment of Neurology end liason activities with the
Deportment of Physiology and Pharmacology exi . t. The Deportment of Biomedical Engineering is over
C00021812•·----------....~-~~--------------------------

Profile and S~andard score


Standard Scores
·...:::lc:- Sc:1le and IPAT
IQ;verbal;performance
Objective and Subjective
::J:1rbcr S. Scale Scores

Verbal Behavior
Cc-r:unonali ty, Probab111 ty 1
.-.. . . :: :1~~ota and Navy Tests CC?ntent 1 Latency-
Evaluat1ve,Catego~1zing,
i ~ nnally 1 s $cales and Denotative Scores
Categor1zed .Top1cs,
Psych ~ atrlc Interview Content Arialys1s,Intens1tY '
and Relevancy Ratings

Psycho?hysiolo;ical
\-lave pattern,~ alpha ··
conjugate-oisconJugate,
fixati~ns and blinks,qual1
of ver&ence,seq~ence and
Record:i.n£S rate of tracking movements
etc. ·
conductance units,latency,
amplitude changes,frequenc
of nonspecifiC responses
C00021812
Page 9

figure 2. EXPERIMENTAl SEQUENCE AND DATA ANALYSIS


·.

Psychiotr~c Evaluation
& Screening Interview

Word Association Tests & Interview


Simultaneous ff.G, f.OG, & GSR Monitoring

Intravenous Amylol
or Saline Control

Session 1 Seosion 2 Session 3 ..


l

All Parameters
--.
Measured, Scored, Coded, & ColloteC:

Summary Statistics on
Individuals & Groups by
Session & Experiment

Correlation oF Verbal
Inferential
ond
Statistical
Psychophysiologic Sto tistics
Analysis

Descriptive
Ouolitotive
Report of findings
C00021812·----------------------------------------------
~~~ed
. .. ·Communi co~ ions
~.
·,.~

Page fO

for consultation ond limited use of varied equipment, e.g. onolog computer. A Tand'ocrg tope recorder,
microphones, Edison Voice Writer, and office equipment are available for 1:se throu9h the Sub-Deport-
ment of Behavioral Sciences. A computer unit and services ore present for dota reduction and analysis.
A six-channel Gros7,olysroph:with appropriate preamplifiers is_ovoiloble. on a IOQJLbosis rrom the.
Department of Neurology, for use with the control subjects ot, ; 1 .
"""'
II Supporting Data

A. Previous work
C00021812----------------------------------------------

y::i.r1
· .*~:.~??'
~ilec;ed Con":lunica tion Page 12 ·
· References
Ackner, B., and Pampi[;lione., G.l An evaluatoion or the sedation
threshold test.J.PsychQ'in.Res._,l959,2_,271.
Artu3io,J.F.JEther analsesia dur1n8 major surgery. J.A.M.A.,
1955,157,33-~6 • .

Barber,T.X. ,1·1easuring 11 hypnot1e-l1ke"sugGestib111ty with and 0

tr1thout"hypnotic induction".,psychometric propert1es.,norms, and


variables influencin~ response to the Barber Su~est1b111ty Scales
(BSS). Psychol.Rep., 1965.,:01ongr. Suppl. 3-Vl6,809-8ll4. .
Blecl<.\·: enn.,l-I.J.,Narcosis as therapy in neuropoychiatric conditions,
J.A.M.A.,l930,15:1168.
Brenglemen,J.C • .,d-Amphetamin~ and amytal:Effect on certainty and
adequacy of certainty J.n recall and recognition, J.Ment.Sc1.,19.58,
104,160-166. 0

Br1clci1er,R.M • .,A neural fra~t1onating and combining system, J.A.M.A.,


1954.,1.,g_,l-10.
Collins,l-l.E.,r~nipulation or arousal and its effects on ·human
vestibular nystag~us induced by caloric Irrigation and angular
accelera t1ons 1 Aerospace Me<!. 1 1963 1 34 1 121!-129.
Delay,J., ;Narcoanalysis and methedrine shock., Proc.Roy.Soc.
t•1ed • .,1949, 42: 491".
0

Edelbe:rg,R. ,and Burch,N.R. ,Sl<in resistance .and galvanic skin


response. Influ~nce of surface variables and methodological
imolications.
. -
Arch.gen.Psych1at.,l962,7,163-169.
Freed,H.,Narcosynthesis of the civilian neuros1&1 Psychiat.Quart.,
l946,_g£,39-.55.
Gerson.,M.J., and Victoroff,V.I-1.,EXperimental investigation
into the validity of confessions obtained under sodium amytal
narcosis.,J.Cl1n.Psychooath • .,1948,2,359-37.5.
Goldman-Eisler,F.,Speech production and the predictabiiity of
l-TOrds in context., Qua~t. J. Exp. Ps~rchol., 1958.,10, 96. 0

Gottschalk,L.,The use of drugs in interroGation.,Biderman,A.E.,·


Zimmer 1 H. , (Ed s . ) , !:.:H~an~iJ:p~u~l~a~t~i:.::o:::.n:.....::o~f~H~u:.:.:m:.:::a~n.:........:Be:..:::..:h..:.:a::..v::...:i::..o::.::..ro, N.Y. : t-111 e y, 1961, 96.
Grinker,R.R., and Spiegel,J .P. ,Men Under Stress,l94S.,McCrai-1-Hill.
Hatha\·lay,S.R. and McKin1ey,J.C. NJ'.IPI Hanual. NeN York:Psychol. 0

Co:rp.,1951.
Herman H.,The use of intravenous :>odium amytal in psychogenic
amnesi~ states, Psych_!~-~~Sluart .,1938,g, 738-742.
C00021812·-----------------------------------------------
· ~'?$~~_:;;-,.-. PrivileGed Colowiiun~cation Pose 13
...
,~~ ~..,. .......
'}f.-:." Hors"'ey ,J. S., Ha:-:::oa.nalysis .1~~3 .. London,O;,fo4d ;.;edical ?uolicatlor
Kelley,~. 11 • .~LevinE; 1 K., Pembe:-!:~n, \·! .etal. Intravenous sodiur:~. a:-:~y~
mcdi:<lt1~n as an aid to the ::\o:-sch~ch rncthod.Psych1at.Quart • .,l94:
15,68-73.
Kleitma~,N.,Slcep ~nd Nal<c!':..:.lness. ChicaGo.,U.Chic~o Press,1963.
Kub1e,L.S. and Yoreolin,s., ?he therape~tic role or drues in the
pr-ocess of repression,dis:;oc::.ation and :sy:lthcsis.Psychosom.f.'ied.!
1945,1,147. .
.
L1ndema~n,E.,Psycholog1cal c~anges in norwal and abnormal
individuals under the influe~ce of sodiu~ amytal.Arn.J.Psychiat ••
1932,11,1083.
Lorenz.,\~ .F., Criminal confessions and narcosis .Hiscons1n, M.J • .,
1932.,31,245.
l1asserman.,J.,The' practice of dynamic psych1atry,1958. Saunders,
Ph:lla.
I~ller.,N.E.,The analysis o; ~otivationa1 effects illustrated by
experiments on amylobarb1to~e sod1cm,Cnapter 1, in Animal
behavior and drug action,196~,ciba Foundation Sympos1~m • .
Moran,I.• J .,Mefferd~ R.B. ,and ?:irnble ,J. P.Jr. Idiodynamic sets in
\'lOrd association. Psychol. i·!o::~~r., 1964,78,1-22.
l1uehlberger, C. \v., !nterroga ~!.on under drug influence ,J .Crim •.
La\·1 and Pol.Sc.,l951,42.~513.
Nunnally, J .c. ,Flaugher ,R. L., and Hodges,\·: .F., Heasurement
ot semz..ntiC;habi ts, Educ. Ps~·c:-. '1. i•'ieas., 1963,23,419-434.
o•connell 1 D.N.,Turslcy 1 B. and O:-ne 1 l:i.T.,Electrodes for the recorc
of skin potential:An evalua~:on.Arcn.Gen.?s~rch1at.,l960,J.,252-2:

Palerr.~o, D. S. and Jen1<1ns 1 J. J. ;·rord assoeia tion norms. lo11.nn. U.


l'linn. Press 1 1964.
Per-ez-Reyes,rif.,Shands,H.C.,a::d Johnson,G. 1 Galvan1c sldn reflex
inhibition threshold:a new psychophysiolosic technique.,
Psychosom.Hed., 1962,24,274-277. .. -
Rant 1 C. and · ~~zz1a,V.,l965. ?ersonal co~~~nication.
Sato.I.,Rorschach perform~n~~ under Ravena dosage. Part 1,
Toholw Psychol Folia, 1962-63,21 (1-2-3) 1-17.
. .
Scheier,I.H.,and Cattell,R.3.,IPAT-8-Parallel-Form Anxiety
Battery~ 1960, Champaign, Ill.: Inst .rerso:1. ana 'Aolli ty 'j:estlng.
C00021812

Com.ilunication
Poge 14
ShaGass#c.# A sedation threshold:A nethod for estimat1nc tension
in psychiatric patients# E~C and Clin. Ncurophys!ol.#l954,6,
2~. - -

Starkv1eathcit', J.A. and Har(;reaves,t·l.A., The influence or sodium


pentobarbital
123-126. . on vocal beh~vio~.
. J.Abn.Soc.Psychol.,l964,69
. - (1),

Taylor,J., A persona1ity scale or manifest anxiety, l·Abnorm.


Soc.,Psychol.#l953,~#2~5-290.
~ent,C.,Changes in the Clyde Mood Scale produced by a sleep
threshold dc·se or amobarbital. Psychopharm.,1962,~#498-472 • .
t·leinstein,F.A. and loialitz,s.,chances in syznl:-olic e..lfPression
'dth amytal sodium .• Am.J.P.sych1at.,l954,III,l98-206.
\'iestheimer, G. #Rashbass c. #Barbiturates and eye vergence,
Natu~e,1961,!.2.!.,833-83 4•

\Y'oodworth,R.,Expcrimental psychology. l938,Ne,., York:Holt.

•.
C00021812

Pose 15
C00021812

rr.~~. . .
~t'ilegt?d Commun,cot,on
~
Poge 17

-BIOGRAPHICAL SKETCHES .·
C00021812

Page JS
BIOGRAPH/C~s ~
(Continued)

\I

I
.I


C00021812·'- ------------------------------------------

:~communication Page 10
~--··£?=- .·
BUDGET ESTIMATE FROM OCTOBER 1, 1966 (ALTERNATE NOVEMBER 1, 1966} THROUGH
SEPUMBER 30, 1967 (ALTERNATE OCTOoER 31, 196n

AMOUNT Rt0UES1EO
TOTAL
PERSONNEL

-
NAME TITLE OF POSITION
--
0 lo TIME

25
SALARY

$
., . Principal lnvestitjator
Co-Principal Investigator so
Reseorc'h Assistant 10
Research Technician 20
30
.·'. Secrete ry- Typht (svb-totol) S
~f toto! ><>lo•le•)
$
t;nge Benefir. (9%

...onsultation Services
Engineering · \each) \
Pstchiotrists- -(!ndependent rotings of qvolitotive dolo in
\Research Phormocologist

Iquipment
Polygraph recorder 6 chooneh with _preamplifiers ond accessories

:onsumoble Supp\ ie$


Electrodes
1

Electrical ports (relay~, timers, stimulus lights)


Polygraph paper \
Magnetic sovnd recording tope
Office Materials
Psychological Testing Materials

rove I .}(estimated 30 round trips)


Domestic,

ospi tal iz.otion


None
\
\
.Iterations
Nc.one

ubiect Costs ~per experiment (toto\ of 3 sessions)


Ten paid volunteers ot

Jblicotion Costs

· ::~to Preporo~ion and Processing (includes computer services)


$
Sub-Total
Overhead (47.8% of solaries)
:
$ l

TOTAL =
C00021812---------------------------------------------

~~- ·
:~ ... ·;.. r-· . .
1':_jvfles~o ... . om:nvn• c:o t 10n Page 21
.
DI~ECT COST BUDGET ·tSTl/AATE fOR FIRST YEAR AND CONTINUATION OF PROJECT

ADDITIONAL YEARS
ITEM FIRST YEAR SECOND YEAR THIRD YEAR

?ersonnel $ \ $ $
(including fringe benefits)

;qvipment
i
I
lupp
I.
1e$

ravel (Dome~tic)
I
I
:..~bject Costs
i
Lblkation
I
~to Preparation ond.
: Proce;sing ; · '
! .

TOTAL $ I .. $ $
\
Fimoted Direct Co~t Torol for entire proposed project period. $
=

barks

l.qui?ment co$tS for the second year ore. for a more complete analysis of the degree of coniugate
. :~e
\ movements through the use of on analog signal correlator•
I
·) Equi,?ment costs for the thi:rd year ore not estima:ed ot this time, but ore contingent upon the
results of the preceding two years work. It may be odvontogeous to examine other pommeters
of EOG ond EEG 'with the aid of o scanner system (analog to digital do~o reduction) connected
to IBM punched cord outpl.t equipment.
C00021812

ADDENDUM TO

PSYCHOPHYSIOLOGIC AND VERBAL CORRELATES OF ALTERED CONSCIOUSNESS


~ ~~~~ill-

All research carried out in this project iholl indude signed stotetTients of _

in(ormed cvnsent by the subjects and also provide for confidentiality of dora. The$e

procedures will be carried· out occordin9 t-> the standard policies of both"

. ----·~ -1 ··- ..