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4. Goodwill Messages 05
6. RSC-IW-SRSM-2019 Committee 31
8. Invited Lectures 33
9. Oral Presentations 39
Uka Tarsadia University, popularly known as UTU has been established in 2011
by Bardoli Pradesh Kelavani Mandal, with an objective of meeting the growing
demand for quality education. The University offers a comprehensive array of
academic programs across the disciplines of Applied Science viz. Chemistry,
Physics, Mathematics, Biotechnology, Microbiology etc., Management,
Commerce, Engineering and Technology, Architecture, Design, Computer
Science, Pharmacy, Nursing, Physiotherapy and others that lead students to
self-enrichment and productive careers in their respective professions,
government, business and industry. The University being located near the
town of Bardoli, Gujarat on a 120 acre land assures educational opportunities
to over 10,000 students. UTU has epitomized excellence in imparting the
research oriented education in the state of Gujarat, having well experienced
dynamic faculty members and equipped with adequate and state-of-art
infrastructure linked with internet (Wi-Fi) facilities.
MISSION
To serve the society by creation, augmentation, dissemination and
perpetuation of knowledge through highest level of learning and research.
VISION
To become a preeminent education hub that is responsive to the changing
needs of a knowledge-based global society.
OBJECTIVES
To impart holistic education in the context of dynamic global challenges.
To mobilize resources which promote acquisition, retention and application
of knowledge.
To provide a platform for economic development through collaboration
with academic institutes and industries.
02
About GSBTM
The State Government of Gujarat, in its resolve and continued endeavors for socio-economic up-liftment of
society, has identified Biotechnology as most potential tool for development. The State intends to promote
biotechnology sector by building appropriate image, encouraging entrepreneurship, strengthening
organizational colorations and forecasting business partnerships. For facilitating the development of
biotechnology in the State, Government of Gujarat has constituted Gujarat State Biotechnology Mission,
under the aegis of Department of Science and Technology.
Vision
To realize and harness the potential of Biotechnology as a human endeavor for the highest intellectual pursuit
and as an effective future delivery system for creating a disease free, nutritionally secure society living in safe,
clean environment, leading to overall socio-economic growth, welfare and progress of humanity.
Mission
GSBTM will promote, support and facilitate the development of biotechnology in the state by promoting
research and development in the field of biotechnology, by generating the quality human resource in the field
of biotechnology and by supporting the development of biotechnology industries by taking effective
measures and policy and planning level. To promote, support and facilitate the overall development of
Biotechnology in the State To provide institutional, legal, financial and policy support To facilitate networking
among stakeholders at Regional, National and International level To facilitate the infrastructure development
and R&D activities To create scientific awareness, sensitization, socio-ethical acceptance and adoption to the
potentials and application of biotechnology.
About GUJCOST
The Gujarat Council on Science and Technology (GUJCOST) was established in September, 1986, to play a
catalytic role in promoting the use of Science and Technology in the development process of the State. The
S&T Council was constituted with a view to develop technologies appropriate to and in harmony with present
conditions. The Council has been catalyzing interaction between developers and users of technologies, by
bringing on a common platform to training Scientists and Engineers on the one hand and policy makers as
well as administrators on the other.
Vision
"Gujarat Council on Science and Technology shall act as a focal forum to inculcate scientific temper for
attaining new heights in research and development for welfare of masses and to improve the quality of their
life as well as to solve important issues of socio-economic development of the state by acting as organic link
between science, technology and economy.”
Mission
"GUJCOST will dedicated to educating young minds, assisting teachers and increasing public understanding of
science and technology along with its research and development programmes.”
05
Messages
06
Messages
07
Messages
08
Messages
Prof. D. R. Shah
Provost,
Uka Tarsadia University,
Bardoli
The Department of Chemistry right from its inception has been devoted towards the
creation of an up-to-date academic environment for its students and research
scholar. This research scholar meet – 2019 will bring together people of varied
experiences and provide an opportunity for all the participant to share their
thoughts and contribution to science. Mutual participation and high quality
deliberations in this meet would create inspiring learning environment resulting into
innovative ideas for all of us.
Advances in Chemical Sciences offer solution for numerous problems of society and
thereby promote human wellbeing. It is expected that this endeavour of the
organizers will create a ways to link the people from different area of research. Also
Uka Tarsadia University has always strived hard to inculcate a culture of innovation
and creativity in our students and faculty members. Also the university has been in
the forefront in organising national as well as international conferences, seminars
and workshops on the subject relevant to different areas of education. This research
scholar meet is another step in our endeavour to provide a platform to the scholars,
academics and industries to deliberate upon and map the chemical sciences in new
era.
I express my gratitude towards all the dignitaries and academic luminaries for their
active participation in this meet. I also congratulate the Ex-Director Prof. K R Desai,
I/C Director Ajit Joshi, scientific committee, coordinators, students, reviewers and
faculty for their contribution to this meet. I also congratulate all the young scientists
who had participated in this meet and wish them all the best for their future
research endeavours. The proceedings of this meet will be of great source of
information to the scholars, academicians and industrialists.
I wish the meet all success and a pleasent stay of the delegates coming from
different parts of the India.
Prof. D. R. Shah
Provost,
Uka Tarsadia University,
Bardoli
09
Messages
It is a matter of great honour and privilege for us to be associated with the program
that has been organized by Uka Tarsadia University. This is the first time that I have
been to a University in a rural environment.
I am happy to express that the symposium is going to held under the joint-support of
the Royal Society of Chemistry and NASI. The enthusiasm shown by the Faculty and
the students of your University is heart warming. This is reflected in the large
number of posters. I sincerely hope that we will be able to come to your
expectations. I congratulate Uka Tarsadia University for organizing and hosting such
mega event to provide very unique platform to young researcher of our state.
Both the Royal Society of Chemistry (West India Chapter) and the National
Messages
11
Messages
12
Messages
It’s appreciable and delighted news, as the Chemistry Department of Uka Tarsadia
University is organizing Royal Society of Chemistry India West Chapter Symposium and
Research Scholars Meet -2019 (RSC-IW-SRSM-2019) in association with Royal Society of
Chemistry India West and The National Academy of Sciences, India (Mumbai Chapter).
Academic conferences provide opportunities to students to build networks with other
academics and experts in the similar field of studies all around the world and to share
thoughts on recent advances and technological breakthroughs. These also provide
feasibility to meet new people with different cultures and dispositions enlighten the way
of thinking in your field of study. It is an imperative chance to find out what’s new in your
field of study to survive in an academic discipline.
I hope that all the delegates in this symposium will participate with full enthusiasm and
carry out fruitful and valuable interactions with various renowned professors. I also wish
the young generation for their success in basic R&D and entrepreneurships.
Department of Chemistry
It is our proud privilege to welcome you all at Department of Chemistry, UTU. Department
of Chemistry was started in 2011 and we came to exist on 12th April 2016 as separate
independent department of UTU. Presently Department of Chemistry is one of the leading
departments in the university which offers BSc (Hons.) Chemistry, Integrated MSc
Chemistry, post graduate MSc-Organic, Pharmaceutical, Industrial, Analytical Chemistry
courses. The department was started with 30 students and today we have well over 1000
students enrolled in BSc, MSc and Ph.D. degrees.
Over the years, department has progressed at rapid pace with development in both
spheres of infrastructure facilities and academic programmes. The department is also
having all facilities to pursue the PhD program. The faculties of department are having the
experience across the world and along with teaching based on their experience, they are
also actively engaged in various fields of research. In order to nurture the research
atmosphere, department is also having various types of collaborations and MoU signed
with various industries as well as academic institutes.
leading department for developing technological solutions to meet the state challenges
Why?
Alumni Engagement
Entrepreneurship &
Flexible Academic
Collaborations
Engagements
International
Programmes
Start-up Cell
High-Quality
& Outreach
Industrial
How?
Department of Chemistry
Our Authenticity
Graduands’ Pledge
“We the graduates and post-graduates of the Department of Chemistry, UTU, hereby
pledge that we shall, in thought, word and deed ever endeavour to be scrupulously
honest in the discharge of our duties, that in all circumstances, we shall uphold the
dignity and integrity of our profession and the honour of our Institute and the nation
and that we shall devote all our energies to promote the unity and secular ideal of
our country and utilise our knowledge in the service of our nation and society”
Department of Chemistry
Faculty Strength
“We are having versatile subject expert faculty members worked with various national and
international Institutes and Universities across the globe. Based on our exposer with those
Institutes and Universities, trying our best to strengthen our department to make it a role
model for other Institutes and University. We are very actively involved is various
academic as well as research activities for the betterment of students, university and
ultimately society.”
“We believe to work in a team because teamwork is the knack to work together for a
common vision. Our aptitude to direct individual accomplishments toward organizational
objectives. These two are the fuel that allows us to attain uncommon vision”
We are oblige to follow the quote given by Sir A. P. J. Abdul Kalam
“Teaching is a very noble profession that shapes the character, caliber, and future of an
individual. If the people remember me as a good teacher, that will be the biggest
honour for me”
16
“She aspire to make our students not only a good chemist but
also good responsible citizen of country. Being a Gold
Medalist, she is trying her best to impart best part of her
theoretical & practical knowledge to our students. Her area of
interest is in the subject of Physical chemistry which is bridge
connecting chemistry, physics & mathematics.” Ms. Rutu Patel
Teaching Assistant
(MSc from MSU, Baroda,
Gold Medalist)
Mousam, Saranya, Deepika, Vihang and Harshil got summer and winter internship with
fellowship at IIT Gandhinagar and IIT Goa.
25
Apart from regular academic activities, we also organize several extra curricular as
well as co-curricular activates for the overall growth of the students. Where they can
get chance to show their hidden talent. Also they can get a chance to develop their
leader and managing skill.
A session on ‘Interview
Skills & Resume Writing’
was conducted on the
18th of December 2018 at
the Manjula Hall by the
Centre of Humanities and
Development of the Uka
Tarsadia University (UTU).
In honour to Dr Sarvepalli
Radhakrishnan and all the
teachers of the society,
Department of Chemistry,
UTU celebrated Teachers
day on 5th September,
2018.
Self-Defense Workshop
was organised by The
Center of Humanities
and Development, UTU.
29
Patron
Shri Shailesh Patel Prof. D. R. Shah
President Provost
Uka Tarsadia University Uka Tarsadia University
Advisors Convener
Prof. G. Govil (TIFR, Bombay) Prof. K.R. Desai
Prof. A. K. Singh (IIT, Bombay) (UTU, Bardoli)
Secretary
Dr. Ajit Joshi
(I/C Director, Dept. of Chem., UTU)
Organising Secretaries
Dr. Paresh Patel, Dr. Sharad Patil
(Dept. of Chem., UTU)
Coordinators
Dr. Harishchandra Jirimali, Dr. Dharmesh Chejara
Dr. Pramod Patil, Dr. Satyanarayana Battula,
Dr. Anand Patel, Mr. Bhavin Patel
Organising Members
Dr. Parth J Naik Dr. Amrutlal Prajapat
Dr. Sutapa M Roy Dr. Nilesh Pandya
Dr. Chintan R Patel Dr. Jyoti Singh
Dr. Rajamouli Boddula Mr.Dipen H Desai
Mrs. Rutu D Patel Mrs. Nisha Odedara
Mrs. Meghna Panchal Ms. Shivani Tandel
Expert Talk by
Prof. G. Govil (TIFR, Mumbai)
Prof. A. K. Singh (IIT Mumbai)
Prof. K. P. Mishra (Ex-BARC, Mumbai)
Prof. Vimal KumarJain (UM-DAE-CEBS, Mumbai)
Prof. Prakash M. Bhate (ICT, Mumbai)
Prof. Atul Chaskar (Mumbai University)
Prof. Arnab Dutta (IIT Gandhinagar)
32
Invited Lecture
Invited Lecture
Invited Lecture
Invited Lecture
Reactive oxygen species (ROS) have amazing chemical properties and determine
the survival and death of both normal and cancer cells. There exists a delicate
balance between ROS and antioxidant defense in normal functioning of cells. A
pathological situation arises when there is imbalance between ROS and built in
defenses. Cancer cells are known to possess increased ROS level than that in
normal cells. Increased ROS are known to cause damage to DNA, proteins and lipids
which is reflected in the incidence of mutation in genes and alterations in other
vital cellular molecules leading to transformation and malfunctioning of cells. At
present point of time, it is widely accepted that ROS play a significant role in cell
homeostasis maintenance, signaling, tissue protection against external insults by
controlling cells proliferation through inducing apoptosis and defending against
cancer. ROS are capable of changing their roles in normal physiological functions,
induction of cancer (carcinogenesis) and in toxic responses of tumor cells to chemo
and radiotherapies. Thus at low and moderate levels ROS affect some of the most
essential mechanisms of cell survival such as proliferation, angiogenesis and tumor
invasion, at higher levels these agents can expose cells to detrimental
consequences of oxidative stress including DNA damage and apoptosis that result
in therapeutic outcomes on cancer. In more recent years, new knowledge has
accumulated to suggest that cancer treatment is often limited due to tiny amount
of cancer stem cells (CSC) in the core of tumor mass which are resistant to drugs
and radiation treatments. Interestingly, both normal and cancer stem cells,
maintain low ROS levels perhaps by augmenting endogenous antioxidants ensuring
their survival to therapies Evidently, understanding the new aspects on molecular
mechanisms and signaling pathways modulating creation and therapy of cancers by
ROS are critical in developing new and effective therapeutic strategies for cancer
treatments. This talk describes a general overview and rationale of paradoxical
action of ROS in creation and therapy of cancer including our research
contributions in this field.
37
Invited Lecture
Dr Atul Chaskar
National Centre for Nanosciences and
Nanotechnology, University of Mumbai
Invited Lecture
Grubbs second generation (GII) and Hoveyda-Grubbs type catalysts (ZC) are well known
metathesis catalysts for their high activity and tolerance to the heteroatoms in substrate
molecules.[1] An idea behind this work is to immobilize the ZC and GII, on SBA-15 (SBET =
863 m2/g, V = 0.920 cm3/g, D = 6.8 nm) and to apply these hybrid catalysts in cardanol
metathesis and cardanol cross metathesis with ethene and cis-1,4-diacetoxy-2-butene
(DAB). The ZC catalyst was attached to the sieve surface by non-covalent interactions[2] and
GII catalyst was attached to the surface via phosphine linkers.[3]
R=
OH
N N N N
Cl Cl
Ru Ru O
R Cl Ph Cl
P O S N
Ethene DAB O
OH OH
Cardanol cross metathesis is depicted in the Scheme 1. There are two reasons for the study
of cardanol metathesis. Firstly, CNSL are produced in a large quantity but chemical
transformations of cardanol are not much known. Secondly, as a natural product it may
serve as a renewable source of phenolic compounds. The given hybrid catalysts proved to be
active in cardanol metathesis even without protecting OH groups. In metathesis of cardanol
high conversion (78%) was obtained by using ZC/SBA-15. Both ZC/SBA-15 (1 wt % Ru) and
GII/SBA-15 (0.3 wt% Ru) catalysts proved to be highly active and selective in cardanol cross
metathesis with ethene and DAB, however Ru leaching was lower in case of GII/SBA-15
(0.5% with respect to the original content of Ru) as compared to ZC/SBA-15 (2.5%). The low
Ru leaching gives an opportunity for obtaining products free of catalyst residues with
applications as a detergent precursor and as fragrance and flavor agents.
References:
1 Grubbs, R. Angew. Chem. Int. Ed., 2006, 45, 3760-3765.
2. Balcar, H.; Shinde, T.; Žilková, N.; Bastl, Z. Beilstein J. Org. Chem. 2011, 7, 22-28.
3. Bek, D.; Balcar, H.; Žilková, N.; Zukal, A.; Horáček, M.; Čejka, J. ACS Catal. 2011, 1, 709-718.
46
A well known Pudovik reaction requires the assistance of either acid/ base catalyst to
produce α-hydroxyphosphonates from aldehydes and dialkyl phosphates/ H-
phosphonates. The same reaction occur in absence of catalyst when aldehyde with the
environment of 2-oxo group in 2OA. The resultant α-hydroxy-β-oxophosphonates
(HOP), unlike regular hydroxyphosphonates, display variety of transformations into
various products oxoesters, phosphates and acids respectively at various conditions.
This typical behavior is owing to enhanced electrophilicity of HOP by the presence of 2-
oxo group which is enough able to switch the reactions in diverse directions at various
conditions.
Herein, we synthesize the Pd/ Mn(Mn1.36Pd0.64)O4 nanocomposite using the facile sol-
gel technique and the structure, morphology, optical, electrochemical and magnetic
properties were elucidated. The composite formation, phase identification and
crystalline structures of the cubic crystalline Pd and Mn(Mn1.36Pd0.64)O4 nanoparticles
of the composites were confirmed by the X-ray diffraction. Porous and nanosized
globular shape morphologies were revealed using SEM and TEM images. The observed
optical band gap from the diffuse reflectance spectra is found to be 2.22 eV.
Electrochemical performance was estimated from the cyclic voltammetric analysis. The
Symmetric nature of the voltammetry cure shows that the nanocomposite is a promising
entrant for fast redox reactions with enhanced specific capacitance. Magnetization curve
explores the paramagnetic behavior of the samples at room temperature. Band structure
and spin-polarized partial density of states of Mn(Mn1.36Pd0.64)O4 crystal structure
confirm the half-metallic and magnetic behavior.
Strontium sulfate is main source of strontium element and its widely used in various
manufacturing industries in the form of nano range crystal size such as ceramic,
cosmetic, textile, paint etc. In present work ultrasound assisted reactive crystallization
process has been used to produce strontium sulfate from strontium chloride
hexahydrate, sodium sulfate and ethylene disodium salt dihydrate (EDTA). For this
purpose various operating parameters such as equimolar concentration of reactant,
temperature, EDTA concentration, ultrasound amplitude and ultrasound duration have
studied in details for percentage yield and crystal size. Multi-response optimization for
maximization of percentage yield and minimization of the crystal size was done by using
taguchi method with grey relational analysis. The optimize condition obtained 0.02M
equimolar concentration of reactant, 30oC temperature, 50mg of EDTA concentration,
50% ultrasound amplitude and 20min ultrasound duration. At the multi-response
optimized condition resulted to 91 percentage yield and crystal size 615.1nm. Compare
to conventional process large amount of percentage yield increase with relatively
smaller size of crystals observed in multi-response optimized experiment.
This manuscript presents a novel nanosensor system for the rapid detection of alkaline
phosphatase (ALP) activity in biological samples. The nano-assembly was designed by
functionalizing vitamin B6 cofactor pyridoxal 5’-phosphate (PLP) over the surface of
BSA stabilized CdS quantum dots through the interaction of free amine present in BSA
with the aldehyde group of PLP. Upon addition of ALP, the functionalized PLP
converted to pyridoxal followed by the emission of QDs was restored. Without any
noticeable interference other tested bioactive analytes, this nano-assembly can be
applied to detect ALP activity down to 0.09 U/mL and also successfully tested to
determine the ALP activity in in real water and biological samples such as human
serum plasma with good recoveries.
51
Biomimetic complexes are getting importance in the field of biosensors, bio-fuel cells,
artificial photosynthesis and bio-catalysis due to their high stability. In the present
study In(III) complexes with the succinic acid and some amino acids (Serine and
Glycine) were synthesised. The prepared complexes were characterized
electrochemically at the dropping mercury electrode (DME) at constant ionic strength
KNO3 (μ = 1.0 M) and 308 OK temperature. Triton X-100, (0.002%) was used as
maximum suppressor. The complexes of In(III) showed a reversible electrochemical
behaviour and diffusion controlled electron transfer phenomena involving three
electrons. A cathodic shift in half-wave potential is observed as a function of glycine
concentration. The magnitude of the shift in half-wave potential is greater in presence
of glycine and serine than obtained for simple In(III)-succinic acid system. Overall
formation constant calculated by Schaap and Mc-Master.
Keywords: CL-362 Polarographic analyser, In(III),succinic acids ,amino acids.
52
Polyurethanes have gain a lot of significance due to its wide range of application.
Generally most of the diols or polyols used for the polyurethane synthesis are
synthesized from petroleum resources. By keeping environmental aspect in mind, the
current work reports the synthesis of polyol from vegetable oil. The structure of the
synthesized polyol was confirmed by the spectroscopic techniques and it was further
used in the preparation of wood protective polyurethane coating. The coating
performance of the prepared wood coating was evaluated by the measurement
mechanical, thermal and chemical properties.
Keyword: Coating, Polyol, Polyurethane Vegetable oil, wood.
53
The burial of municipal solid waste in landfills is the most common disposal alternative in
most countries. Landfill leachate is generated by excess rainwater percolating through the
waste layers in a landfill. A combination of physical, chemical, and microbial processes in the
waste transfer pollutants from the waste material to the percolating water. An
understanding of leachate composition is critical for making projections on the long-term
impacts of landfills. To know the amount of pollution five sampling locations were decided:
In the study, these five samples were analyzed in the laboratory for the parameters namely
Phosphate, Nitrite, Nitrate, Chloride, Fluoride, Alkalinity, TDS/TSS, Ammonia, Ammonical
Nirogen, Iron, COD, Phenol. From the result of analysis, the leachate sample was found to
have the maximum pollution in it, the mixture sample was taken from the place where the
leachate used to get accumulate in the Auranga river, and the sample of Auranga river was
taken a bit far from that place of MSW disposal site to know about the amount of pollution
created by this leachate in the Auranga river. The parameter of underground water was
analyzed by comparing it with drinking water standard and underground water from other
place where there was no site of solid waste. By examining analytical results it is clearly seen
that Nitrate(90), Phenol(7.2), Iron(446.8), Alkalinity(1800), Ammonical Nitrogen(178.2),
COD (1560) parameters in the mg/L (concentration), found above the inland surface water
discharge standards, are responsible for polluting the Auranga river as well as ground water
at the disposal site nearby Auranga river. Whereas the water sample taken from residential
area, far away from MSW-leachate site, is free from pollution. The results from data analysis
show that, the water is certainly unfit for drinking purpose without any kind of treatment,
even for other surface water usage purposes, it could not be considered quite acceptable.
The present study reports the thermal degradation of zeolitic materials. The key starting
material is Bagasse Fly Ash (BFA) which is an agricultural detritus. The zeolitic material
was synthesized viz. Conventional Zeolitic Bagasse Fly Ash (CZBFA) and Electrolyte
treated Conventional Zeolitic Bagasse Fly Ash (ECZBFA) from BFA using hydrothermal
method. The thermal study will focus on the thermal characteristics of the sorbents in the
form of the kinetic parameters of the thermal degradation. The Coats and Redfern method
has been employed for estimation of various kinetic parameters viz. order of
decomposition (n), energy of activation (E*), pre-exponential factor (A). The other
thermodynamic parameters also carried out using thermal degradation data viz. entropy
of activation (S*), enthalpy of activation (H*) and free energy of activation (G*). The
results of thermodynamic analysis shows that the native BFA shows higher activation
energy than that of CZBFA and ECZBFA.
Key words: zeolitic materials, TGA, Thermal degradation, Coats and Redfern method.
54
Oxiranes can serve as versatile precursor in the synthesis of natural products and drug
molecules and are considered as important intermediates in synthetic organic chemistry.
This information leads in development of methodologies allowing the epoxidation of
carbon–carbon double bonds. The most efficient methods used for this purpose is
epoxidation of chalcone. We employed urea hydrogen peroxide as epoxidant and
epoxidation of coumarinyl chalcones was carried out to afford the titled compounds.
Ultrasound accelerate many organic reaction and this prompts us to investigate the
reaction using Ultrasound technique and the reaction was carried out in shorter reaction
time (15-45 minutes) with high yield (71-90%). This method is found to be
advantageous in terms of mild conditions, no toxic solvents used, especially; the reaction
time is much shorter compared with the conventional method.
Keywords: Oxiranes, Coumarinyl Chalcones, Epoxidation, Ultrasound.
REFERENCES:
[1] S. D. Pardeshi, K. S. Vadagaonkar, J. J. Lade, L. Melone, A. C. Chaskar, chem. select., 2017, 2 , 5409. [2] S.
D. Pardeshi, P. A. Sathe, K. S. Vadagaonkar, L. Melone, A. C. Chaskar, Synthesis., 2017, 50, 361.[3] S. D.
Pardeshi, P. A. Sathe, K. S. Vadagaonkar, A. C. Chaskar, Adv. Synth. Catal., 2017, 359, 4217.
56
Nowadays, metal pollution has become a major concern in ecology in the world. Metal ions
such as Cu2+ , Hg2+ , Pb2+ , Cd2+ , Al3+ , Mn2+ and Co2+ exhibit toxic nature even at trace levels,
inhibiting various biochemical pathways in the living systems. Therefore, there is a big
challenge to analytical chemists to develop a facile, sensitive and selective analytical
methods for real-time monitoring of trace level metal ions at minimal sample volumes.
Since the traditional analytical techniques (ICP-MS, XRF, ICP-AES etc) are very expensive,
laborious, and time consuming, and importantly they required tedious sample pre-
treatment prior to their identification by analytical technique. In this connection, metallic
nanoparticles (Au and Ag NPs) have shown remarkable performance in developing
miniaturized analytical platforms for colorimetric detection of wide variety chemicals due
to their unique physico-chemical properties which mainly depends on the size of NPs due
to their surface plasmon resonance (SPR). To tune their recognition ability towards specific
metal ion, gold and silver nanoparticles have been modified with various dithiocarbamate
derivatives and used as probes for the colorimetric detection of heavy metal ions (Cu2+,
Hg2+ , Pb2+ , Al3+) via aggregation mechanism. Functionalized Au and Ag NPs were
characterized by UV-visible, FT-IR, TEM and DLS. The specific metal ion has shown great
ability to induce colour change and SPR peak shift of functionalized metal NPs, showing
wider linear range with lower detection limits from micro molar to nanomolar range. The
develop methods are free from interference and exhibited good accuracy and precision. The
developed probes were successfully utilized for the rapid, selective and sensitive detection
of heavy metal ions in drinking, tap, canal and river water samples. Overall, colorimetric
sensing ability of Au and Ag NPs was successfully tuned by modifying their surfaces with
different dithiocarbamate derivatives.
The drug (quercetin) interaction with 0.015 to 0.24 g∙L-1 of chitosan (Chi) and
functionalized chitosan (f-Chi) have been analyzed by using physicochemical properties
performed at T= 298.15K and 0.1mPa. The physicochemical parameters (PCPs), viscosity
(η), density (ρ), surface tension (γ) and relative viscosity (ηr), friccohesity (σ), surface
excess concentration (Γ), surface area (Amin) illustrated stronger interaction of quercetin
with Chi and f-Chi. Hydrophilic-hydrophobic interactions to monodisperse the quercetin
with increasing carbon atom of f-Chi is predicted through these PCPs. In case of MChi
(methionine functionalized chitosan) at higher concentration (0.24 g∙L-1), the density,
viscosity, and friccohesity value increases with quercetin due to decrease in cohesive forces
and increase in intermolecular forces. The Γmax values are higher with higher
hydrophobicity and stronger binding forces which produced greater internal pressure and
lower surface area. In case of MChi with enhanced surface activities, the quercetin strongly
interact with f-Chi by decreasing cohesive forces with stronger shear due to intermolecular
forces like van der Waal forces and electrostatic interactions. The antioxidant activity of Chi
and f-Chi with and without quercetin inferred that high surface area shows high scavenging
of free radicals. The drug (quercetin) interaction with 0.015 to 0.24 g∙L-1 of chitosan (Chi)
and functionalized chitosan (f-Chi) have been analyzed by using physicochemical
properties performed at T= 298.15K and 0.1mPa. The physicochemical parameters (PCPs),
viscosity (η), density (ρ), surface tension (γ) and relative viscosity (ηr), friccohesity (σ),
surface excess concentration (Γ), surface area (Amin) illustrated stronger interaction of
quercetin with Chi and f-Chi. Hydrophilic-hydrophobic interactions to monodisperse the
quercetin with increasing carbon atom of f-Chi is predicted through these PCPs. In case of
MChi (methionine functionalized chitosan) at higher concentration (0.24 g∙L-1), the
density, viscosity, and friccohesity value increases with quercetin due to decrease in
cohesive forces and increase in intermolecular forces.
Reference:
S. Sabir; C. B. Pandey; A. K. Yadav; B. Tiwari; J. L. Jat, J. Org. Chem., 2018, 83,12255.
In recent years there has been development in the field of electro optic chromophore
which tends to exploration the field like ultrafast optical communication. The potential
material (Halogen derivative) simulated shows the immense increase in the first order
hyperpolarizability values and the other potential materials shows the certain pattern of
change in the value of hyperpolarizability.
The phenomenon such as resonance (+R) effect and inductive(-I) effect exerted by
halogen atom in para position pushes the electrons in opposite direction in long
conjugated π bonds in structure which enables the ligand to donate the electron and thus
increase in value of hyperpolarizability. Hence the halogen-based chromophore that is
TRIBRDIBAM engineered using the Gaussian 09W and the various characteristics have
been analysed using the first set of density functional theory and certain arrangements of
the atoms in this chromophore gives the enhanced value of 1st order hyperpolarizability,
dipole moment hence making it suitable candidate for ultrafast laser space
communication application.
Ozone is a powerful oxidizing agent which is studied for the removal of many organic
pollutants. However, some emerging pollutants, such as pesticides, pharmaceuticals
and short chain carboxylic acids, are difficult to mineralize using only ozone.
Therefore, in this work, the modified manganese catalyst has been used to alleviate the
ozonation process in the aqueous system. The study of operating parameters such as,
the effects of catalyst, pH and the radical scavengers on the degradation of a model
pollutant (e.g. Phenol) was evaluated. The contribution of hydroxyl radicals and
molecular ozone on the oxidation of phenol was studied for both homogeneous and
heterogeneous catalytic systems. The heterogeneous catalyst shows a rather complex
mechanism as compared to homogenous catalyst. In presence of manganese catalyst,
the ozone decomposition and successive generation of hydroxyl radical is faster as
compared to homogeneous catalytic system. The effect of change in pH 3-9 was not
showing any major difference in the degradation of pollutant. It was observed that, the
surface of the catalyst undergoes multiple oxidation reaction and plays the major role
in generation of the hydroxyl radicals.
A considerable amount of phenol degradation was
observed even at low catalyst dose. The rate constants
of the homogeneous and heterogeneous catalytic
reactions have been calculated and compared in this
work. In addition to that, the percentage contribution of
the molecular ozone and the hydroxyl radicals for the
degradation of the model pollutant has been evaluated.
61
References
1. P. Someshwar, S. Mahesh, G. Ravinder, M. Vithal, Y. T. Tao, RSC Advances, 2015, 5,
58504.
2. G. Ravi, N. K. Veldurthi, S. Palla, V. Radha, P. Someshwar, M. Vithal, Photochemistry and
Photobiology, 2013, 89, 824.
62
In today’s scenario, the discovery of various fungicidal and bactericidal drugs has become
essential because of enhanced microbiological and clinical resistance of microbes. So,
keeping this in mind, some novel Cu(II) complexes of bidentate ligand were synthesized
which operate as antimicrobial agent. The bidentate ligand is synthesized after
condensation reaction of 1 mole of phenylcarbamate and 1 mole of thiosemicarbazide in
ethanolic medium.The ratio of metal salt to multi donor atom containing ligand was 1:2.
The conventional condensation metod was employed to synthesize metal complexes. The
different techniques such as melting point, elemental analysis, 1H-NMR, mass, electronic
spectra, molar conductance, magnetic moment, infra-red, UV-visible, electron
paramagnetic resonance and molecular modeling study were utilized for structural
elucidation and for characterization of the ligand and its complexes. Well diffusion
method was carried out for biological investigation of all the synthesized compounds at
different concentration against different pathogenic fungi C.Krusei, C. Parapsilosis and
bacteria E. coli and S. aureus. The experimental results shows enhanced inhibition zone
than free bidentate ligand, which confirms that after complexation the biological activity
enhances.
Keywords: Thiosemicarbazide, metal complexes, spectroscopic, molecular modeling,
antimicrobial study
Farm, Surat-39500
Laccases have vast prospective for biotechnological applications due to their outstanding
bioremediation potential. These include abundant applications in effluent detoxification,
enzymatic conversion of chemical intermediates, wine clarification degradation of textile
dyes, biosensors and organic synthesis,herbicide and insecticide degradation, where
enzymatic catalysis could offer as a more environmentally alternative than the presently
used chemical processes. In the present study, two potential microbes were isolated on
solid medium containing guaiacol and ABTS for laccase activity out of 10 microbes. Two
cultures PHP7 and PKD5 were selected for further investigation. Molecular
characterization was carried out using 16S rRNA gene technology of PHP7 revealed as
Bacillus cereus (KU878970.1).Partial amplification of laccase gene contain conserved
domain of multicopper oxidase family. Further research work can be performed on these
isolates PHP7 and PKD5 by upscale the production of laccase in command to meet the
difficulty of the necessity for higher enzyme titer for the bioremediation of textile dyes.
Trindane (1) and its higher homologue Dodecahydrotriphenylene (DDHTP) (2) have
attracted attention for construction of higher polycyclic hydrocarbons. Oxidation of
trindane using RuCl3/NaIO4 was reported by S. Ranganathan, where oxidation takes
place in benzene ring of trindane to give a highly oxygenated product (3) [1]. Here we
report our results on similar oxidation of DDHTP wherein only benzylic oxidation takes
place giving keto products (5) and (6) instead of the expected ring cleavage product (4).
Mixture of decahydrotriphenylene-1-one (5) and octahydrotriphenylene-1,5-dione (6)
were isolated and characterized. It is reported that DDHTP gives only (5) in the presence
of CrO3 . To the best of our knowledge (6) is not reported. The chemistry of this reaction
will be discussed.
The higher surface areas of the Gold nanoparticle (AuNPs) could induce the activities in
the proteins molecules, and their interfacial linkages could be very dynamic in
engineering the biochemical activities. Similarly, the globular protein and flavonoids have
been the most effective biomolecule as an effective networking with AuNPs to develop
functional nanobioconjugates with higher biological potentials in engineering. Thus, the
AuNPs-BSA and AuNPs-Fv conjugates could offer distinct physical and chemical activities
and acts as excellent scaffolds for employing them as carrier systems. In general, the
AuNPs-BSA and AuNPs-Fv conjugates holds great potential for biomedical applications in
sensing, diagnostic, therapeutic delivery control of protein activity and in imaging
applications. We are synthesised AuNPs and functionalised with BSA and flavonoids and
their AuNP-bioconjugates confirmed by using UV-vis spectroscopy, TEM, DLS, FTIR, TGD-
TA and DSC analysis.
67
Highly conjugated photo responsive complexes of Eu(III), Tb(III) and Gd(III) with bis-
chalconeligands were synthesized andcharacterized by IR, 1H NMR, 1H-1H COSY, 13C
NMR, mass spectral analyses, single crystal XRD data and thermo gravimetric analysis.
The lanthanide complexes of prepared ligands are more flexible than other tridentate
ligands [1], and have several synthetic and structural advantages over other lanthanide
complexes. These complexes have not been investigated systematically for their PDC. In
this study, automated docking was used to determine the orientation of the synthesised
molecules that response to few radiations. These initial results will be presented during
the conference.
References:
1. S Rai, PN Patel, AChadha. Crystallography Reports2016, 61/7, 1086.
68
This study reports the extraction of silicone present in the bagasse fly ash (BFA) which
is primary building block of MCM-41(Mobil Composition of matter no. 41). The
extraction was performed by conventional alkali reflux technique and combine this
with microwave irradiation method. The combined method found best for the
extraction of the silicone form BFA. The MCM-41 was synthesized from the extracted
silicone and Cetyl trimethyl ammonium bromide (CTAB) as a structure-directing agent.
The obtained product was characterized by the advance analytical techniques such
small angle X-ray diffraction (SAXRD), X-Ray florescence (XRF) scanning electron
microscopy (SEM), transmission electron microscopy (TEM), Fourier transform
infrared spectroscopy (FTIR), and nitrogen absorption–desorption measurement
(BET-BJH). It was confirmed that the synthesized material exhibited a well-ordered
mesostructure with high surface area, large pore volume and pore diameter in
nanometre range. The removal efficiency towards cadmium ion was performed
through synthesized MCM-41 at optimized sorption condition. Therefore, the material
could be potentially used as a low-cost and efficient adsorbent candidate to treat
cationic metal contaminant from industrial waste water.
Treatability study are carried out to identify suitable coagulant and its dosage, for
primary treatment of effluent with aim to remove suspended solids and reduction in COD
before biological treatment. Conventionally, alum, lime, PAC, Polyelectrolytes are
commonly used as coagulant. In this study, the use of greener oxidantFerrate for
treatability study of sugar mill effluentis explored. Ferrate is referred to a supercharged
iron molecule in which iron is in the plus six oxidation state and is also commonly known
as Iron (VI). Contemporarily, Ferrate is under intense study by the scientist due to its
potential to replace alum, polymers and ferric chloride in removal of metals, nonmetals,
organic components, color, odor and natural organic materials (NOM). A single
application of ferrate has the ability to work as an oxidant, coagulant and disinfectant. In
this study, we have synthesized ferrate by wet chemical method, explored it for the
treatment of sugar mill effluent and treatment efficiency is calculated. The effluent also
given primary treatment with conventional method using alum and subsumed the
comparison study. The obtained results clearly indicates preeminence of Ferrate in
comparison to conventional treatment with alum and its potential to be used as
alternative in primary treatment of sugar mill effluent.
Waste water generated by pesticide and chemical industries is certainly a serious matter with
reference to Indian context. Wastewater contains toxic and non-biodegradable compounds.
Existing wastewater treatment methods: adsorption on activated carbon, extraction, and
chemical oxidation. Limitations of existing methods: limited applicability and low efficiency.
The need of research into alternative treatment techniques. Cavitation has the potential to
degrade the complex chemicals like pesticides with the help of higher temperature, high
pressures, high kinetic energy and radicals generated by it. A promising way to achieve the
degradation is by combination of cavitation with advanced oxidation processes (AOPs)
based on production of hydroxyl radicals under mild experimental conditions.
Nickel Sulfide (NiS) is an inorganic semiconductor compound, mainly used in the field of
super-capacitors and fuel cells as an electrode. In the present study, NiS nano-crystalline
powder and thin film were prepared by using chemical method. Nickel Acetate used as a
Nickel source. For the Sulphur source we have used four source viz. Thiourea, Sodium
Sulfide ,Thioacetamide and Sodium Thiosulfate. NiS powder was prepared using solid
state method and Thin films were prepared using dip coating method. The prepared
powder and thin films were heated at 200 oC. The structural properties of the prepared
material and films were studied using X-ray Diffraction method. The optical properties
were studied using UV-Visible spectroscopy. The energy band gap and the broad (hkl)
peak indicated the prepared material is nano-crystalline.
Activated carbon is having a larger pores size than normal carbon. Because of this
characteristic, the surface to volume ratio of material increases leading to high
absorption capacity. The Activated Carbon can be synthesized using raw materials such
as wood, rice husk, coal, peat, sugarcane bagasse, coconut shells, neem leaf etc. To
enhance the efficiency of the Activated Carbon, one needs to increase the pores size.
Carbonization and activation are two major processes used to prepare Activated Carbon.
The Activated Carbon has a vast range of application such as distilled alcoholic beverage
purification, fuel storage, gas purification, chemical purification, mercury scrubbing etc.
The paper reviews the synthesis methods and its applications in industries, medical
science environmental science and analytical chemistry.
Lead Sulphide (PbS) is a P-type semiconductor having direct band-gap and a large
excitation Bohr radius of 18 nm. PbS is widely used in solar cells, photo detectors, optical
filters, gas sensors etc. In literature deposition of PbS thin film is reported by various
physical and chemical methods such as chemical bath deposition, electro-deposition, dip
coating, thermal evaporation, molecular beam epitaxy etc. Among these methods,
solution growth technique is beneficial because it is easy to set up and costly instruments
such as vacuum systems are not required. Particularly, dip coating is a simple and low-
cost method for thin film preparation. The dip coating method consists of major two
steps; (i) dip casting of substrate into the precursor solution and (ii) thermolysis of the
film. These steps are repeated multiple times to attain the desired thickness. Here, we
have successfully synthesized PbS thin films using low cost dip coating method. Lead
acetate is used as lead source; Thiourea is used as Sulphur source and Methanol is used
as solvent for preparation of PbS thin film. The structural and optical properties of the
prepared films are analyzed using X-Ray Diffraction (XRD) profiles, Raman Spectroscopy
and UV visible spectroscopy. XRD profiles of the prepared films reveals pure cubic phase.
UV-visible spectroscopy reveals the direct band gap of the prepared film.
PbS is (VI-III) groupof inorganic material which has optical band gap of 0.5-2.0 eV and
hence, it has wide application in many optoelectronic devices such as photodetector,
solar cell,gas sensor, etc. The structural prpperties of lead Sulfide (PbS) nano crystlline
grown by solid state reaction method and are investigated by X-Ray differaction. In the
present work we have used Lead Acetate as a Lead source. For sulfer Sources we Have
used four inorganic compound Viz Thiourea. The brode peak of ( 1 1 1 ) and ( 2 0 0
)plane from XRD pattern suggests the prepared material is in nano crystalline nature.
80
Heavy metals are widely used in textile industries during manufacturing and processing.
Heavy metals are toxic water pollutant. Their mobility in the aqueous ecosystem affects
mankind, animals and vegetation. Heavy metals are not only toxic but they are non-
biodegradable also. Thus, removal of heavy metals from the effluent is one of the major
quests to the research community. There are noticeable methods which include heavy
metal removal from wastewater in literature. This paper reviews the recent methods used
to remove heavy metal from wastewater such as chemical precipitation, ion exchange,
adsorption, membrane filtration, coagulation, flotation and electrochemical treatment etc.
Hydrogels are 3D polymeric networks, which are hydrophilic and cross-linked via covalent
or non-covalent interactions. Because of their soft nature with similar physical properties
to soft tissues attracts more attention in biomedical application but due to its weak
mechanical strength and non-healable nature, its application are still restricted in
biomedical field. This article introduces a simple approach of preparing self-healable guar
gum-graft-acrylic acid (GG-PAA) hydrogel using first time L-alanine as a cross-linking agent
which alters the various properties of hydrogel such as mechanical strength (G’=90,570Pa).
A series of guar gum (GG) based hydrogel were synthesized by varying the concentration of
L-alanine (from 0.4-1% w/v) which was used as a cross-linking agent. Hydrogel was
characterized by HRSEM and Rheology studies which explore the morphology and
mechanical strength of hydrogel; further it was investigated that synthesized GG based
hydrogel showed good swelling ability with excellent self-healing property. The highly
water soluble drugs have a tendency to burst rapidly into human body which is undesirable
and thus, this hydrogel may be helpful to overcome this problem too and found fruitful
applications in biomedical field.
Keywords: Hydrogel, L-alanine, self-healing, Rheology, drug delivery.
Schiff bases derived from various heterocycles were reported to possess cytotoxic,1
anticonvulsant,2 antiproliferative3 , anticancer and antifungal activities.4 Mannich
reaction is an important tool for synthesis of novel compounds. A process for preparing
2-(4'-aminophenyl) 5-amino benzimidazole, a known intermediate used in the synthesis
of azo dyes, is disclosed wherein p-nitrobenzoic acid is condensed with aniline, and the
N(4'-nitrobenzoyl) aniline produced is dinitrited to N(4'-nitrobenzoyl) 2,4-dinitroaniline;
the latter is reduced to the corresponding triamine, which, upon cyclodehydration,
results in the 2-(4'-aminophenyl) 5-amino benzimidazole.
Reference: Paresh N Patel, et. al., J Chem Crystallogr (2016) 46: 245.
83
The dissertation is a comparative study between two different methods for the
preparation of biodegradable films based on polysaccharide.Biodegradable films were
prepared using sodium alginate (SA) and carboxymethyl cellulose (CMC) as main
components of the film. In study one, film was obtained using the blend of these two
polymers followed by addition of CaCl2 as a cross-linking agent and glycerin as a
plastisizer. In study two sodium alginate/carboxymethyl cellulose (NaCMC)-based bio-
composite films were prepared by solution casting method and process has been
optimized in terms of weight ratios of these polymers (i.e. 1.5% sodium alginate and
1.5% NaCMC). The optimum combination was selected on the basis of good tensile
strength and low moisture sensitivity, Further this film was treated with aqueous
solution of potassium aluminium sulphate (potassium alum) to reduce water vapour
permeability and moisture content. In both the study the mechanical and
physicochemical properties have been improved. Film biodegradability was not affected
either due to the cross linking or by alum treatment. The designed films may have
potential applications to be a substitute for the currently used polyethylene-based films.
Luminescent materials gained immerse importance in the field of display devices and
biological field. Research on highly emissive red and blue phosphors for warm white LEDs and
smart full color displays are highly imperative. To achieve the same a great deal of effort has
been devoted to syntheses of Ln complexes due to their unique optical properties (a line like
(4f-4f) emission spectrum and capable emitting different spectral windows). Among all Ln
complexes, red-emitting phosphorescent emitters (Eu(III) complexes) are efficient and widely
used in OLEDs and LEDs. Unfortunately, low absorption coefficients or oscillator strength of
lanthanides restricts the use of practical applications; however the same can be overcome by
using antenna effect (IQE up to 100%). In the present study, the design strategy of ancillary
ligands for obtaining highly emissive Eu complexes as well as single molecule white emissive
Eu complexes.
The complexes are characterized by NMR, Mass, FT-IR and elemental analysis. Thermal
stability, photophysical, electrochemical and theoretical analysis was carried out. The fully
energy transfer process leads to the efficient characteristic red emission at 612 nm and
partial energy transfer leads to tunable emission (in different polarity of solvents), which
gives the white emission by balancing the red, blue, green (RGB) emission. The detailed
results will be presented and discussed.
Key Words : Fluorene, bipolar, antenna, Eu3+ metal ion.
A simple colorimetric sensor L was prepared through condensation reaction and showed
naked eye colour change from colourless to light yellow brown, and was selective towards F-
anion in DMSO with a stability constant of 1.876358 x 106 M-1. Jobs plot suggested that it
binds F- anion in 1:1 ratio. Besides this it showed real life analysis with toothpaste and on test
paper kit, which ensured the ability of the receptor to detect fluoride in the field of food and
healthcare industries as well as in other bio-relevant purposes.
HO
N
N
H2N
OH
Water effluents from textile industries are a major source of water pollution. This waste
streams contain numerous toxic dyes, which are harmful for aquatic life. Therefore, there is a
need to find economical and bio-friendly methods to degrade textiles dyes. In this study,
methyl red dye was used for degradation using ferrous sulphate and calcium hydroxide as a
flocculants. The oxidation and subsequent degradation of the dye was found to be dependent
on both, the amount of Fe+2 ions as well as calcium hydroxide. A systematic study was
carried out using 10 different sets of methyl red solution with various doses of flocculants.
Optimization of dose was also studied and it has been found that the rate of degradation was
enhanced with dose of flocculants, whereas some had an inhibitory effect. The rates of
degradation were found to fit to first order kinetics. After the treatment of dye, analysis was
studied using UV-visible, conductometer and pH-meter.
Polymeric materials containing heterocyclic ring in the main chain were synthesized by
high temperature polycondensation reaction of substituted s-triazine and different diols.
All polymers were obtained in good yield and were characterized by solubility, viscosity
measurement, FTIR and NMR spectral analysis. Thermal stability was studied by TGA
technique. The synthesized polyester showed good thermal stability along with good
solubility in common organic solvent.
88
Understanding the nature of localized surface plasmons (LSPs) that occur at the
geometrically bounded surface of anisotropic metal nanoparticles in focalizing the
enhanced electromagnetic fields increases with the advent of more complex/exotic
nanostructures. Recently, variety of metal archimedean solids were obtained utilizing
the mild reducing as well as stabilizing effect of the amphiphilic polymer, poly vinyl
pyrrolidone (PVP). The most interesting aspect 'universal solubility' of these PVP coated
metal nanoparticles, which has not been looked upon carefully till now, has been
effectively utilized in our present synthesis approach for size tuning as well as reshaping
along with self-organization with exceptional colloidal monodispersity, thereby provides
a relatively simple but effective paradigm for the easy fabrication of plasmonic
metamaterials. The precise morphology correlated plasmonic signatures before and
after tuning/reshaping of these as-prepared gold nanostructures in the presence of
foreign agents were extensively studied using electron microscopy and spectroscopy
measurements in detail. The modified electron density distribution around both
nitrogen and oxygen components of PVP molecules in the different surrounding reaction
medium or in the presence of foreign ions were detailed through systematic FTIR, and
NMR studies, signifying the strong structure correlated plasmonic eigen modes,
illustrating the direct visualization of plasmons and their intriguing hybridization
mechanism in complex size/shaped metal nanostructures encourage us to quantitatively
identify the efficient plasmonic coupling mechanisms.
Chiral alcohols are the key chiral building blocks to many enantiomerically pure
pharmaceuticals. The biocatalytic approach in asymmetric reduction of corresponding
prochiral ketones to the preparation of these optically pure substances is one of the most
promising routes. The stereoselective reduction of different kinds of prochiral ketones
catalyzed by various plants and microorganisms was studied in this work. We are trying to
develop sustainable bio-catalyst based methodology for the quantitative reduction of
ketones in to optically pure chiral alcohols. Various optimization studies were in order to
enhance the yield and ee of the product. Initial data will be presented as a poster the the
said symposium.
Multicomponent domino reactions (MDRs) serve as a rapid and efficient tool for the
synthesis of versatile heterocycles, particularly those containing structural diversity and
complexity, by a one-pot operation. These reactions can dramatically reduce the
generation of chemical wastes, costs of starting materials, and the use of energy and
manpower. Moreover, the reaction period can be substantially shortened. We have
synthesised several cyclohexanol derivatives by MDRs. All the prepared molecules are
characterised by various spectroscopic techniques, i.e. NMR, HRMS, Single Crystal XRD.
This presentation covers recent advances on multicomponent domino reactions for the
construction of five-, six-, and seven-membered heterocyclic skeletons and their
multicyclic derivatives.
Biginelli Reaction
Dr. Sharad Patil* Pratik Pipaliya, Pooja Rathod, Yash Mehta
Department of Chemistry; Uka Tarsadia University; Bardoli - 394350
Ionic liquids have increased popularly in last couple of decades as solvent for its greener
approach. Here a novel three-component, one-pot condensation yielding 4-phenyl-3,4
dihydrobenzo[g]quinazoline-2,5,10(1H)-trione is reported in halogen free ionic liquid
(HFIL). Components of reaction are aldehyde, urea, and β-keto esters in presence of HFIL
Nmethyl- 2-pyrrolidonium hydrogen sulfate [HNMP]+[HSO4]−. Comparative reactions
were performed under conventional heating and sonication in HFIL. Solvent utility of HFIL
makes purification and separation process artless task offering an advantage of five times
recyclability without degrading its activity. The use of HFIL is advantageous over
conventional solvent due to very short reaction time and halogen-free volatile solvent
utility and recyclability. Latterly these compounds applied as disperse dye on polyester and
nylon fiber were found to give moderate color and fastness properties.
Polymeric materials containing heterocyclic ring in the main chain were synthesized by high
temperature polycondensation reaction of substituted s-triazine and different diols. All
polymers were obtained in good yield and were characterized by solubility, viscosity
measurement, FTIR and NMR spectral analysis. Thermal stability was studied by TGA technique.
The synthesized polyester showed good thermal stability along with good solubility in common
organic solvent.
94
Polyesters containing coumarin ring in the main chain were synthesized by high
temperature polycondensation reaction using cetrimide as an initiator. The synthesized
polyesters were characterized by various techniques like FTIR, NMR and fluorescence.
The inherent and reduced viscosities were checked by ubbelohde solution viscometer. The
relative solubility of these polyesters were determine in a variety of solvents. Thermal
stability was studied by TGA and DTA techniques. The obtained polyesters possess high
thermal stability with good solubility in common organic solvents.
Protein C, a blood coagulation factor XIV. It plays an important role in regulating anti-
coagulation, inflammation, maintaining the permeability of blood vessel in human and
other animals. Activated protein contains 419 amino acid in multiple domain. Deficiency
of protein C leads to dangerous blood clot, Deep vein thrombosis (DVT) purpura
fulminans. It may be inherited or acquired. In November 2001 FDA approved
Drotrecogin alfa activated, it is recombinant form of human activated protein C.
It is marketed as Xigris by Eli Lily Company. But in October 2011 Xigris
was withdrawn from the market due to its higher mortality in trial among adults. e-
health statistical ratio shows that 3539 people had serious risk of bleeding among them
422 had died .
My hypothesis is to produce inactivated form of protein C by using
suitable expression system and purify the expressed product by affinity chromatography.
This recombinant product will be administered to deficient patient to reduce mortality
and sepsis, which was caused by activated form of protein C.
Photoluminescence is light emission from any form of matter after the absorption of
photons(Electromagnetic radiation). It is one of many forms of luminescence (light
emission)and is initiated by photo excitation (excitation by photons). It can be utilized to
produce the white emission by mixing of the primary colors (RGB). In addition, can be
utilized to find (sensing) the hazards by luminescence quenching process. In the part of
that we have synthesizedBenz-imidazole based blue emissive fluorophores for sensing
application. Fast and reliable chemical sensors for the trace detection of hazardous
chemical species have attracted special attention in recent years due to their possible
applications in environmental cleaning and home land security.
The detection process is based on the luminescence of certain materials, called
luminophores. The sensor transmits invisible UV light at a wavelength of 375 nm. This
excites the luminophores contained in the object so that they emit light in the visible range
of the electromagnetic spectrum.
Luminophores can be attached to labels or mixed with a variety of materials for detection
purposes. Thus, for example, paper contains optical brighteners that are excited by the UV
light and reflect light (mostly blue) to the sensor.
In this work, a new imidazole-based sensitive and selective sensor was synthesized. It was
observed that the synthesized new fluorescent sensor had high selectivity and sensitivity
to picric acid. Currently working on luminescence sensor on Imidazole molecule.
Luminescence is spontaneous emission of light by a substance not resulting from heat; it is
thus a form of cold-body radiation.The synthesized ligand shown blue emission in UV
light. This fluorescence was decreases by using the picric acid. The synthetic procedures
and detailed study will be presented and discussed.
HIGHLIGHTS: Photoluminescence,Sensor.
REFERENCES
[1] J. R. Lakowicz, Principles of Fluorescence Spectroscopy, 70 3rd edn., Springer, 2006.
[2] T. W. Bell and N. M. Hext, Chem. Soc. Rev., 2004, 33, 589-598. [c] H. Lu, L. Xiong, H.Liu,
M. Yu, Z. Shen, F. Li and X. You, Org. Biomol. Chem., 2009, 7, 2554-2558.
Presenting an efficient microwave assisted solvent free synthetic approaches for coumarin
derivatives using metal catalyst via pechmann condensation. The synthesized compounds
were characterized by IR, 1H-NMR, 13C-NMR and elemental CHN analysis. The proposed
microwave assisted solvent free synthesis on inorganic support provide the products in high
yield with shorter reaction time, quick and easy isolation of product and excellent
chemoselectivity. The products were tested for antimicrobial activity.
98
Helicobacter pylori, which is spiral, gram negative human pathogen cause infection in
stomach and forms colonies which results in peptic ulcer, chronic ulcer, gastric cancer,
MALT(Mucosa Associated Lymphoid Tissue)and inflammation occurs through
interaction of Vac A(Vacuolating toxin) and Cag A( Cytotoxic associated toxin)with
surface receptor molecule this response in immune inhibition, apoptosis.Cag PAI is 40 kb
genomic region response for pathogenicity in human. It involves type IV secretion system
(T4SS) used to deliver DNA as well as protein substrate from donor to target cell through
conjugation and through pilus formation.To understand how thesesequence is
responsible for pathogenicity which is donethrough computational method, we
haveretrivedHelicobacter pylori sequence such as Hp0522, Hp0523,Hp0524, Hp0525,
Hp0526, Hp0527, Hp0528, Hp0529, Hp0531, Hp0532, Hp0533, Hp0534. Then by using
Clustal W software multiple sequence alignment is done. From the alignment we get
conserved genes region that analysed by Motif software such as “FMM”. By analysing this
helps to understand the molecular bases of infection and pathogenesis which can further
used to design novel drugsto prevent the infection. Drugs such as acetazolamide and
methazolamide and enzymes which plays a centrol role in H.pylori are Urease and
carbonic analysic which inhibit the growth of bacteria and decrease itspathogenicity of
infection in human body.
Keywords : Type IV Secretion System, Multiple Sequence Alignment, Motif, Helicobacter
pylori
The reaction was performed in a 300 ml glass batch reactor equipped with
temperature and speed monitoring facility. The desired quantities of acetone (i.e. 250
ml) and the catalyst were charged before the heating was started. The agitation was
started, typically after 5 min, when the desired reaction temperature was attained.
This time was considered as the zero reaction time. The samples were re-moved after
specific time intervals and were cooled through a coil immersed in chilled water to
prevent acetone evaporation during the sampling. Various experiments were carried
out to study the effect of RPM on the kinetics of the reaction.
99
Tadalafil is a human PDE5 inhibitor for ED, PAH and BPH. Plasmodium falciparum PDEs
(pfPDEs) display a significant role in the cell cycle of Plasmodium falciparum growth.
Both the catalytic sites of PfPDEs and hPDE5 display only 41-47% sequence homology.
So as to this, it has been studied for the therapeutic utility as an antimalarial agent. The
structure activity relationship supports the hypothesis that the developed compounds
kill the parasite via inhibition of plasmodial PDE activity. It also proves that these
derivatives (Series 1 and 2) inhibit the hydrolysis of cyclic nucleotides of the parasite,
validating the cAMP/cGMP pathways as therapeutic targets against Plasmodium
falciparum.
The novel chalcones (3a-e and 4a-e) were prepared by aldol condensation of various 5-
aryl-2-furancarboxaldehyde (1a-e) respectively with acetophenone(2a) and 2-acetyl
naphthalene(2b). Both the series of chalcones (3a-e and 4a-e) were then treated with
hydroxylamine hydrochloride and obtained as iso oxazole (5a-e and 6a-e) heterocyclic
compounds. All the derivatives were characterized by IR, NMR and LC-MS spectral
features. The elemental content of all the compounds also determined. The
antimicrobial activities of all the iso oxazole derivatives was evaluated against common
microbes.
100
Allylic alcohols represent an important and highly versatile class of chiral building blocks
for organic synthesis. We have synthesised several allylic alcohols by catalytic reduction
of chalcones. All the prepared compounds were characterised by NMR, HRMS, IR and UV
spectroscopy. This abstract of poster presentation summarizes the methods developed
for the catalytic asymmetric synthesis of enantioenriched allylic alcohols. These include:
dynamic kinetic resolution (DKR/DKAT), nucleophilic 1,2-addition to carbonyl groups,
allylic substitution, oxidation of C-H bonds, the addition of O nucleophiles to π systems,
reduction of unsaturated carbonyl compounds, and an alternative route from
enantioenriched propargylic alcohols. Furthermore, these catalytic asymmetric
processes have been exemplified by their applications in the syntheses of complex
molecules such as natural products and potential therapeutic agents. The review about
allylic alcohols and initial results of our work will be presented during the RSC-IW-SRSM
– 2019.
Reference: Alexandre Lumbroso, et. al., Angew. Chem. Int. Ed. 2013, 52, 2 – 45.
The objective of the present study is to achieve Cefixime maximum therapeutic efficacy.
cefixime-loaded lauryl succinyl chitosan nanoparticles were prepared by water-in-oil-in-
water (w/o/w) double emulsion solvent evaporation technique with different
formulation variables such as concentrations of drug and polymer. The effects of these
variables on surface morphology, particle size distribution, encapsulation efficiency and
in vitro release behavior were examined. To observe the nature of nanoparticles, X-ray
diffraction studies were carried out. The release data obtained were determined using
various kinetic models and Korsmeyer–Peppas model showed an acceptable regression
value for all compositions. The in vitro drug release studies were carried out in various
buffer solutions (pH 1.2, 3.0, 5.0, 6.8, 7.4, 8.0, 1.2-7.4). The results showed marked
retardation of cefixime release and higher percentage of polymer gave longer drug
release profile. This may definitely provide a useful controlled-release drug therapy and
also prove to be effective over a long period of time.
Keywords: LSC, Cefixime, pH sensitive, Release kinetics
Fluoro-quinolones are a group of antibiotics that have been extensively used in treating
several bacterial diseases. These fluoroquinolone compounds have been synthesized
and are being used as antibacterials since 1962. They have antibacterial activity against
both gram-negative and gram-positive strains. The primary mechanism of their
antibacterial action is inhibition of the coiling of the long DNA chain into the restrained
space inside the bacterial cells. Compounds consisting of an azomethine group (with the
general structure R2 C=NR’) are known as Schiff bases. The immense chelating abilities,
of Schiff bases have attracted extreme attention in terms of analytical and biological
applications. In the present work, two drugs belong to fluoroquinolone group viz.
Ofloxacin and Ciprofloxacin were used to form Schiff bases. These antibiotic drugs-
derived Schiff bases were used as ligands and dissolved in methanol to react with
respective transition metal (CuCl2 ) salts. The resulting metal-chelate complexes were
characterized using UV-VIS spectroscopy, FTIR Spectroscopy, NMR Spectroscopy etc.
These chelate complexes show better antibacterial activity in terms of higher Zone-of-
Inhibition for both gram-negative and gram-positive bacteria.
102
A simple, accurate, rapid and precise spectrophotometric method has been developed for
simultaneous estimation of Loratadine and Betamethasone in synthetic mixture. This method
was based on UV spectrophotometric determination of two drugs, using First order derivative
method. Loratadine and Betamethasone were scanned separately in the wavelength range of
200-400 nm. From the overlay derivatised spectra of two drugs, it is evident that Loratadine
and Betamethasone show a zero crossing point at 239.2 nm and 247.2 nm. These two
wavelengths were employed for the determination of Loratadine and Betamethasone. The
method showed good reproducibility and recovery with % RSD less than 2. Method was found
to be rapid, specific, precise and accurate, can be successfully applied for the routine analysis
of Loratadine and Betamethasone in synthetic mixture, and combined dosage form without
any interference by the excipients. The method was validated according to ICH guidelines.
104
Present research work describes a Simple, Precise, Accurate, Fast and Economical two
Spectrophotometric methods for simultaneous estimation ofFebuxostat (FEB) and
Diacerein(DIA) in Synthetic Mixture. Method A is first order derivative spectrophotometric
method, in which261.4nm (Zero crossing point for FEB) was used for DIA and 295.1nm (Zero
crossing point for DIA) was used for FEB. Method B is area under curve (AUC), in the
wavelength range of 309.2-319.2nm for FEB and 251.1 -261.1 nm for DIA. Linearity for
detector response was observed in the concentration range of 2-12μg/ml for FEB and DIA by
both the methods. For Method A accuracy was assessed by %recovery studies and was found
to be 100.69 ±0.86 % and 101.99 ±0.81 % for FEB and DIA respectively. For Method B
accuracy was assessed by %recovery studies and was found to be 101.98 ± 0.49 % and 100.98
± 0.80 % for FEB and DIA respectively.The developed method was validated with respect to
Linearity, Accuracy (%recovery), Precision, LOD, LOQ and Assay. The results were validated
statistically as per ICH Q2 R1 guideline and were found to be satisfactory. The proposed
methods were successfully applied for the determination of for FEB and DIA in combination.
A variety of Schiff base ligands were synthesized from S-Triazine and Aldehyde via
conventional practice. Reaction was divided into four different stages to get desire
outcome. After complete synthesis of compound, Structures of these compounds were
confirmed by IR and NMR Spectral analysis. The novel synthesized compounds were
evaluated for antimicrobial activity against a diversity of bacterial strains and some of
this composite has shown significant antimicrobial activity.
Ayurveda- the traditional Indian medicine has illustrated herbal wealth of Indian
medicinal plants, as number of different plants and its extract and minerals shows anti-
aging as well as wound healing activities. Pseudarthria viscida is an important
constituent of herbal formulation Dashmoolarista. Whole plant is important and
consider for many ethnobotanical activities. The aim of this study is formulation and
physicochemical evaluation of ointment prepared from P. viscida plant extract. The
formulation of ointment was done under levigated condition by incorporating extract
with previously prepared jelly base. Thus prepared ointments was further evaluated for
its physicochemical parameter like color, odor, texture, viscosity, spreadability, pH,
Extrudability, diffusion study, loss on drying, solubility, washability and non-irritancy.
This ointment was also tested for stability under different temperature range and result
shows great stability as there were no changes in texture, spreadability, and diffusion
capacity of ointment. Thus, the formulations can be useful for different tropical
application as ointment. Evaluation of ethnobotanical potential of this ointment was
also done for normal and diabetic wound as well.
106
Water effluents from textile industries are a major source of water pollution. This
waste streams contain numerous toxic dyes, which are harmful for aquatic life.
Therefore, there is a need to find economical and bio-friendly methods to degrade
textiles dyes. In this study, methyl red dye was used for degradation using ferrous
sulphate and calcium hydroxide as a flocculants. The oxidation and subsequent
degradation of the dye was found to be dependent on both, the amount of Fe+2 ions as
well as calcium hydroxide. A systematic study was carried out using 10 different sets
of methyl red solution with various doses of flocculants. Optimization of dose was also
studied and it has been found that the rate of degradation was enhanced with dose of
flocculants, whereas some had an inhibitory effect. The rates of degradation were
found to fit to first order kinetics. After the treatment of dye, analysis was studied
using UV-visible, conductometer and pH-meter.
107
The present investigation is carried out during 2007 to 2009 for the determination of
Total hardness (TH), Calcium (Ca) and magnesium (Mg) levels in groundwater samples
of Valsad district situated in South Gujarat, India. For the collection of water samples
fifteen sampling stations of the area were selected. Water samples shows TH level from
70 to 1060 mg/l with a mean value of 368 mg/l. The desirable limit of TH is 300 mg/l
and permissible limit is 600 mg/l as per IS standard. The lowest value of TH (70 mg/l)
was reported at S12 station (Sutharpada village) whereas the highest value of 1060
mg/l was recorded at S1 station (Tithal). The permissible limit for Calcium (Ca) is 200
mg/l and for Magnesium (Mg) is 90 mg/l as per IS standards. Water samples of
sampling stations of S1 (Tithal) and S2 (Dhamdachi) is not desirable for drinking
purpose as level of TH, Ca and Mg are beyond permissible limit.
Key words: Groundwater, Total Hardness (TH), Ca and Mg.
The present work investigates the application of ultrasound and microwave operated
individually or in combination for depolymerization of aqueous solution of guar gum. In
addition, intensification aspects due to the use of an initiator, potassium persulfate
(KPS), has been investigated. The extent of depolymerization has been analyzed in
terms of the reduction in intrinsic viscosity. Also, the effectiveness of treatment
approach has been analyzed on the basis of kinetic rate constant, limiting intrinsic
viscosity and the time required for the desired extent of viscosity reduction. The kinetic
rate constant has been found to increase with an increase in the temperature and KPS
loading. For the individual operation involving irradiations, the rate was found to be
higher in the case of ultrasound as compared to the microwave irradiations. In the case
of sequential approach, microwave followed by ultrasound was more effective as
compared to the approach of ultrasound followed by microwave. The obtained results
clearly established that ultrasound in combination with KPS was the most effective
approach for depolymerization. The work has also enabled to understand the effective
role of KPS and operating temperature in intensifying the viscosity reduction of guar
gum polysaccharides.
Shri Bhagubhai Patel Shri Kiritbhai Patel Professor D. R. Shah Professor K. R. Desai
President; BPKM Secretary; BPKM Provost; UTU Ex-Director; Dept. Chem.
Department of Chemistry
Uka Tarsadia University
Bardoli Mahuva Road; Bardoli – 394 350 ; Gujarat (INDIA)
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Write us on : director.dchem@utu.ac.in